Clinical trials: Diuretics
Compensated Heart Failure
Single Dose Study to Compare the Pharmacodynamics of Torasemide-PR 10 mg,Torasemide-IR 10 mg and Furosemide-IR 40 mg in Patients With Compensated Heart Failure
This is a randomized, open-label, blinded-endpoint, crossover, single dose study to compare the pharmacodynamics of Torasemide-PR 10 mg, Torasemide-IR10 mg and furosemide-IR 40 mg.
- Trial name
- NCT01549158
- Testing
- torasemide-PR, Furosemide-IR, torasemide-IR
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- Ferrer Internacional S.A.
Diurnal Enuresis, Hypertension
Diuretic Effect Evaluation of Petroselinum Crispum (Parsley) in Hypertensive Patients
The use of alternative therapy, particularly herbal treatment is becoming prevalent among patients. Many herbs are in-use for various ailments such as diabetes, digestive problems, fever, hepatitis and hypertension etc.
- Trial name
- DEEP (NCT03468361)
- Testing
- Natural Product Petroselinum crispum (Parsley)
- Where
- 2 sites in Saudi Arabia
- Sponsor
- Universiti Sains Malaysia
Congestive Heart Failure
Effect of a New Formulation of Torasemide (Prolonged Release)on Myocardial Fibrosis in Patients With Heart Failure.
Torasemide is a loop diuretic (pyridine-sulfonylurea)with a wide experience in the treatment of oedema associated to heart failure, kidney or liver disease and either in the treatment of arterial hypertension (alone or combined…
- Trial name
- TORAFIC (NCT00409942)
- Testing
- Torasemide Prolonged Release, Furosemide
- Where
- 23 sites in Spain
- Volunteers
- 142 people
- Sponsor
- Ferrer Internacional S.A.
BPD - Bronchopulmonary Dysplasia
Impact of Steroid, Diuretic, and Fluid Use on BPD Outcomes
Assess the impact of steroid, diuretic, and fluid practices on BPD outcomes in extreme premature infants in the Banner - University Medical Center Phoenix (BUMCP) neonatal intensive care unit (NICU).
- Trial name
- NCT04971694
- Testing
- No interventions or procedures
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- Pediatrix
Chronic Kidney Disease(CKD), Uncontrolled Hypertension
Intensification of Blood Pressure Lowering Therapeutics Based on Diuretics Versus Usual Management for Uncontrolled Hypertension IN Patients With Moderate to Severe Chronic Kidney Disease
Chronic kidney disease (CKD) is a major public health issue worldwide. Hypertension is the first risk factor in patients with CKD for mortality, cardiovascular disease and end-stage renal disease.
- Trial name
- THINK (NCT05732727)
- Testing
- Antihypertensive algorithm, Standard of care
- Where
- 40 sites in France
- Volunteers
- 720 people
- Sponsor
- University Hospital, Tours
Heart Failure
Systematic Escalation of diuREtics With Natriuresis in Heart Failure Patients: SERENA Trial
The present is a multicenter, prospective, randomized, open-label, blinded end-point trial aiming to investigate the clinical benefit of a stepwise, natriuresis-driven diuretic strategy versus standard diuretic treatment in…
- Trial name
- SERENA (NCT04907123)
- Testing
- Intensive sodiuria-guided diuretic treatment, Standard diuretic treatment
- Where
- Italy
- Volunteers
- 198 people
- Sponsor
- University of Turin, Italy
Renal Function Disorder
Effect of Diuretics on Fluid Status Control and Residual Renal Function in Peritoneal Dialysis Patients
A prospective, randomized, open-label, stratified, controlled clinical trial to evaluate whether long term furosemide therapy (1 year) would preserve urine volume and/or residual renal function (RRF) and improve fluid state in…
- Trial name
- NCT00936923
- Testing
- furosemide
- Where
- China
- Sponsor
- Sun Yat-sen University
Acute Decompensated Heart Failure
Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failure
The purpose of this prospective, randomized, open-label study is to compare two diuretic strategies in patients with acute decompensated heart failure (ADHF): the addition of an oral thiazide diuretic to intravenous bolus (IVB)…
- Trial name
- NCT00904488
- Testing
- Addition of oral Metolazone, Furosemide dose escalation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of North Carolina, Chapel Hill
Diuretic Effect, Aminophylline
Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures
This work aims to investigate the diuretic effect of Aminophylline in comparison to Furosemide in adult patients undergoing cardiac surgical procedures.
- Conditions
- Diuretic Effect, Aminophylline, Furosemide, Cardiac Surgical Procedures
- Trial name
- NCT07348510
- Testing
- Aminophylline, Furosemide
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Cairo University
Acute Decompensated Heart Failure (ADHF)
Comparison of the Effectiveness of Different Diuretic Therapies in the Management of Acute Heart Failure
Acute decompensated heart failure (ADHF) is a clinical syndrome associated with high morbidity and mortality rates. Current guidelines emphasize the importance of oxygenation and diuresis in the management of ADHF.
- Trial name
- NCT07464249
- Testing
- Furosemide Bolus, Furosemide Continuous İnfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Heart Failure
Bioimpedance Analysis in Chronic Heart Failure
The aim of this study is to investigate whether the objective measurement of fluid overload by bioimpedance analysis (Body Composition Monitor-BCM) in patient with acute decompensated heart failure would improve the diuretic…
- Trial name
- NCT02662439
- Testing
- Body Composition Monitor (BCM)
- Where
- Hungary
- Volunteers
- 240 people
- Sponsor
- Peter Studinger
Nocturia
Alpha-blocker Plus Diuretic Combination Therapy as Second-line Treatment for Nocturia in Men
The aim of the present study was to determine whether the combined administration of a diuretic agent, hydrochlorothiazide, at night would improve the frequency of nocturia unresponsive to alpha-blocker monotherapy in men with…
- Trial name
- NCT00700583
- Testing
- combination therapy of terazosin and hydrochlorothiazide
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Seoul National University Hospital
Hypertension
Treatment of Hypertension In Adults With ThiaZIDES: Pragmatic Trial Pilot Study
This proposed pilot study will test methods and feasibility for a large pragmatic clinical trial comparing two inexpensive, first-line drugs for treating high blood pressure to determine if one is superior in preventing serious…
- Trial name
- ThiaZIDES (NCT02591628)
- Testing
- HCTZ prescription conversion to chlorthalidone
- Where
- 2 sites in United States
- Volunteers
- 2,027 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Cirrhosis, Ascites Hepatic
PEriToneal Catheter Versus Repeated Paracentesis for Ascites in Cirrhosis
Insertion of a tunnelated peritoneal catheter (PleurX) allows repeated intermittent small volume fluid drainage at home. The treatment may improve the management of ascites and have a beneficial effect on the quality of life.
- Conditions
- Cirrhosis, Ascites Hepatic, Ascites (Non-Malignant)
- Trial name
- PETRA (NCT03027635)
- Testing
- PleurX, peritoneal tunnelated catheter, Large Volume Paracentesis, Ciprofloxacin 500Mg Tablet
- Where
- Denmark
- Volunteers
- 13 people
- Sponsor
- Nina Kimer
Heart Failure Acute, Heart Failure，Congestive
Effects of Empagliflozin on Clinical Outcomes in Patients With Acute Decompensated Heart Failure
Acute decompensated heart failure is the fastest growing disease in the world and the leading cause of hospital admissions worldwide.
- Conditions
- Heart Failure Acute, Heart Failure，Congestive, Heart Failure; With Decompensation
- Trial name
- EMPA-RESPONSE (NCT03200860)
- Testing
- Empagliflozin 10 MG
- Where
- 5 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen
Chronic Heart Failure, Diuretics Drug Reactions
The Heart Failure Diuresis Efficacy Comparison (DEA-HF) Study
To investigate the effectiveness of three (3) IV diuretic regimens to increase natriuresis in volume-overloaded HF patients, allowing for better decongestion and potentially resulting in improved clinical and biochemical…
- Conditions
- Chronic Heart Failure, Diuretics Drug Reactions, Congestive Heart Failure
- Trial name
- DEA-HF (NCT05904808)
- Testing
- IV Furosemide, IV Furosemide and PO Metolazone, IV Furosemide and IV Acetazolamide
- Where
- Israel
- Volunteers
- 42 people
- Sponsor
- Rambam Health Care Campus
Heart Failure
Spot Urinary Analysis to Assess Loop Diuretic Efficiency in Stable Heart Failure
The primary objective of this study is to assess whether the urinary sodium/creatinine or chloride/creatinine ratio might predict successful downtitration of loop diuretics in patients with stable heart failure without clinical…
- Trial name
- DIPSTICK (NCT02288819)
- Testing
- Weight monitoring, Loop diuretic downtitration
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Hasselt University
Liver Cirrhosis, Cirrhosis
Empagliflozin in Diuretic Refractory Ascites
Ascites is the most frequent complication of liver cirrhosis and results in increased morbidity and mortality but current medical management options are limited.
- Conditions
- Liver Cirrhosis, Cirrhosis, Ascites, Ascites Hepatic
- Trial name
- DRAin-Em 01 (NCT05013502)
- Testing
- Empagliflozin 10 MG
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Stanford University
Hypertension
Hypertension Study: Multinational Torasemide Trial in Mild to Moderate Hypertension.
Primary objective:To demonstrate the no-inferiority in efficacy of treatment with Torsemide-PR in relation to Torsemide-IR in patients with mild and/or moderate hypertension.
- Trial name
- NCT00334386
- Testing
- Torasemide Prolonged Release (loop diuretic), Torasemide Immediate Release (loop diuretic)
- Volunteers
- 388 people
- Sponsor
- Ferrer Internacional S.A.
Hypertension
Learning Implementation of Guideline-based Decision Support System for Hypertension Treatment: Testing Alternative Antihypertensive Regimens Using ACE-Inhibitors, Calcium Channel Blockers and Diuretics (LIGHT-ACD)
This trial aims to compare the efficacy of several guideline-based hypertensive medication regimens initiated with Angiotensin Converting Enzyme Inhibitor/Angiotensin Receptor Blocker [A], Calcium Channel Blocker [C] and Diuretic…
- Trial name
- NCT03587103
- Testing
- Protocol initiate with A, Protocol initiate with C, Protocol initiate with D
- Where
- 3 sites in China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases