Clinical trials: Diuretics
Cardio-Renal Syndrome
Kidney Sodium Content in Cardiorenal Patients
Diuretic therapy is the cornerstone of the management of fluid overload in heart failure. Resistance to diuretic therapy is the most common reason for treatment failure in patients affected by the combination of heart failure and…
- Trial name
- NCT04170855
- Testing
- Furosemide Injection
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Heart Failure
Effect of Tolvaptan on Mid- to Long-term Prognosis of Heart Failure Patients
One tolvaptan 15 mg tablet or placebo tablet will be orally administered once daily in the morning for up to 14 days to heart failure patients with volume overload that does not show adequate response to other diuretics such as…
- Trial name
- NCT01439009
- Testing
- Tolvaptan
- Where
- 8 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Diuretic Response in Advanced Heart Failure: Bolus Intermittent vs Continuous INfusion
Loop diuretics are the main therapy for decongestion of patients with advanced acute heart failure. However, these patients often develop diuretic-resistance or even diuretic-refractoriness.
- Trial name
- DRAIN (NCT03592836)
- Testing
- Loop Diuretics
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Turin, Italy
Hyponatremia, Hypertension
Protein Supplementation in Thiazide-induced Hyponatremia
High blood pressure is very common among elderly Canadians. Clinical trials show clear benefit from lowering blood pressure in hypertensive elderly patients.
- Conditions
- Hyponatremia, Hypertension, Blood Pressure
- Trial name
- NCT02614807
- Testing
- Nepro
- Where
- Canada
- Sponsor
- Ottawa Hospital Research Institute
Heart Failure
Effectiveness of Outpatient Intravenous Diuretic Therapy for Treatment of Worsening Heart Failure (OUTPATIENT-WHF)
The purpose of the OUTPATIENT-WHF study is to characterize the effectiveness of outpatient intravenous diuretic therapy as a treatment for worsening heart failure.
- Trial name
- NCT05704595
- Testing
- Initial outpatient management strategy, including outpatient IV diuretics in clinic, Initial hospitalization-based management strategy
- Where
- United States
- Sponsor
- Duke University
Cardiovascular Diseases, Death, Sudden, Cardiac
Diuretics, Hypertension, and Arrhythmias Clinical Trial
To determine whether hypertensive patients with ECG abnormalities and receiving hydrochlorothiazide diuretics were at increased risk of sudden death.
- Conditions
- Cardiovascular Diseases, Death, Sudden, Cardiac, Heart Arrest, Heart Diseases
- Trial name
- NCT00000525
- Testing
- hydrochlorothiazide, diet, potassium supplementation, diet, magnesium supplementation
- Volunteers
- 233 people
- Sponsor
- University of California, San Francisco
Heart Failure
Comparing the Effects of Conivaptan and Diuretics on Plasma Neurohormones and Renal Blood Flow in Patients With Chronic Congestive Heart Failure
The purpose of the study is to compare the effects of conivaptan and diuretics on renal blood flow and neurohormones.
- Trial name
- NCT00924014
- Testing
- Conivaptan, Furosemide, Conivaptan and furosemide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Hennepin County Medical Center, Minneapolis
Idiopathic Nephrotic Syndrome (INS)
Comparison of Efficacy and Safety of Albumin Versus Fresh Frozen Plasma in Managing Diuretic Resistant Edema in Children With Idiopathic Nephrotic Syndrome.
Edema is a major component of nephrotic syndrome (NS), defined by Kidney Disease Improving Global Outcomes (KDIGO) guidelines is, urine protein/creatinine ratio ≥ 2 mg/mg, and hypoalbuminemia ≤ 2.5 g/dl).
- Trial name
- ALB-FFP (NCT07685093)
- Testing
- Human Albumin 20%, Fresh Frozen Plasma
- Volunteers
- 56 people
- Sponsor
- Qamar Shafiq
Hypertension, Grade 1, Hypertension Treatment
Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril
The purpose of this trial is to evaluate if an objective clinical decision of anti-hypertensive therapy can be made using an N-of-1 (single patient) trial design.
- Conditions
- Hypertension, Grade 1, Hypertension Treatment, N of 1 Study Design, Hypertension
- Trial name
- 1HAT (NCT01258764)
- Testing
- Lisinopril, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Scripps Translational Science Institute
Acute Heart Failure, Chronic Kidney Diseases
Empagliflozin in Acute Heart Failure
The objective is to study in a prospective, interventional, single arm, cohort study the potential synergistic diuretic effect of empagliflozin, in addition to furosemide, in hypervolemic patients admitted with acutely…
- Trial name
- DRIP-AHF-1 (NCT05305495)
- Testing
- Empagliflozin 25 MG
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Heart Failure, Congestive
Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts
The DART-HA study is a single-center, open label, trial intended to evaluate the clinical efficacy of standard treatment options for congestive heart failure (observation, diuretic or afterload reduction therapy) in patients…
- Trial name
- DART-HA (NCT06218199)
- Testing
- Furosemide, Torsemide, Bumetanide
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Heart Center Research, LLC
Congestive Heart Failure
Hemodynamic Assessment in Acute Decompensated Heart Failure
This study will assess the ability of a novel optical measurement system to determine changes in the hemodynamic status of heart failure patients admitted to the hospital with a primary diagnosis of acute decompensated heart…
- Trial name
- NCT03535909
- Testing
- Noninvasive Hemodynamic Measurement System
- Where
- 2 sites in United States, Croatia
- Volunteers
- 5 people
- Sponsor
- Rodin Scientific LLC
Heart Failure
Comparison of Oral or Intravenous Thiazides vs Tolvaptan in Diuretic Resistant Decompensated Heart Failure
Broad Objectives: To determine the comparative efficacy of commonly employed strategies to overcome loop diuretic resistance when added to concomitant loop diuretics in hospitalized decompensated heart failure patients with…
- Trial name
- NCT02606253
- Testing
- tolvaptan, Chlorothiazide, Metolazone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University
Acute Heart Failure
Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography
The goal of this clinical trial is to investigate whether a lung ultrasonography (LUS)-guided decongestion strategy in adults hospitalized for acute heart failure (AHF) can improve patient-centered outcomes.
- Trial name
- IcarUS (NCT06465498)
- Testing
- LUS decongestive strategy, PE decongestive strategy
- Where
- 5 sites in Switzerland
- Volunteers
- 222 people
- Sponsor
- Antonio Leidi
Acute Decompensated Heart Failure
Readily Available Urinary Sodium Analysis in Patients With Acute Decompensated Heart Failure
The goal of this clinical trial is to compare physician-guided (SOC) versus nurse-led natriuresis-guided diuretic therapy in patients with acute decompensated heart failure (ADHF).
- Trial name
- EASY-HF (NCT06278792)
- Testing
- Diuretic protocol, Standard of Care
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Ziekenhuis Oost-Limburg
Diuretic Toxicity, Acute Kidney Injury
Risk Factors and Machine Learning Model for Diuretics Related Acute Kidney Injury
Acute kidney injury (AKI) is a series of clinical syndromes in which serum creatinine (Scr) concentrations increase over a short period of time, or urine output decreases.
- Trial name
- NCT05527054
- Testing
- Diuretics
- Where
- China
- Volunteers
- 18,000 people
- Sponsor
- Qianfoshan Hospital
Heart Failure
Diagnosing and Targeting Mechanisms of Diuretic Resistance in Heart Failure
Effective diuresis is the primary goal of most acute decompensated heart failure hospitalizations, but diuretic resistance is common and our ability to detect it is limited.
- Trial name
- NCT02546583
- Testing
- Increased Intravenous Bolus Loop Diuretic Dose (Bumetanide or Furosemide), IV Chlorothiazide
- Where
- United States
- Volunteers
- 458 people
- Sponsor
- Yale University
Acute Kidney Injury
Diuretic Efficacy of Aminophylline and Furosemide Combination vs Furosemide Alone in Critically Ill Adults
The goal of this RCT is to compare the effectiveness of aminophylline and furosemide combination vs furosemide alone in producing effective diuresis in critically ill adults in ICU.
- Trial name
- NCT05933642
- Testing
- Aminophylline, Frusemide
- Where
- Malaysia
- Volunteers
- 132 people
- Sponsor
- University of Malaya
End Stage Renal Disease on Dialysis
Diuretic Use in Hemodialysis Patients With Residual Renal Function
This pilot trial will evaluate the use of diuretic medications (furosemide and chlorthalidone) in participants on dialysis to see if these medications work to preserve existing kidney function, increase urine output, and reduce…
- Trial name
- DIURESED (NCT05915286)
- Testing
- Furosemide, Chlorthalidone
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Diuretic Abuse
Use of Diuretics in Maintenance Hemodialysis Patients Undergoing Bioimpedance-guided Fluid Management
Background.The objective of the present study is to verify whether using diuretics will improve either blood pressure or fluid overload in maintenance hemodialysis patients with residual diuresis kidney function.
- Trial name
- NCT04182854
- Testing
- Furosemid hydrochlorothiazide
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Capital Medical University