Clinical trials: Diuretics
Congestive Heart Failure
A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients
Objective: To establish which combination of diuretics is the most effective in promoting diuresis in congestive heart failure patients.
- Trial name
- NCT00690521
- Testing
- Treatment of Furosemide + Hydrochlorothiazide, Treatment of Furosemide + Metolazone
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of New Mexico
Acute Heart Failure (AHF), Heart Failure
Urinary Chloride and Sodium Changes and Residual Congestion in Acute Heart Failure
The goal of this observational study is to learn how changes in urinary sodium and chloride levels relate to fluid overload and short-term outcomes in patients hospitalized with acute heart failure (AHF).
- Conditions
- Acute Heart Failure (AHF), Heart Failure, Congestion
- Trial name
- CLORINA-IC (NCT07597512)
- Where
- 4 sites in Spain
- Volunteers
- 223 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Secondary Hyperparathyroidism, Chronic Kidney Disease
The Effect of Diuretics on Mineral and Bone Disorder in Chronic Kidney Disease Patients
Chronic kidney disease (CKD) patients often have associated systemic hypertension due to volume retention, as one of the mechanisms, therefore the use of diuretics is widespread in this population.
- Trial name
- NCT03082742
- Testing
- Hydrochlorothiazide, Furosemide
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- University of Sao Paulo General Hospital
Congestive Heart Failure
A Prospective, Single-center, Open-label, Pilot Study to Compare the Effectiveness and Safety of Diuretics Add-On Strategy in Chronic Heart Failure Patients (DIOS 1)
To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients
- Trial name
- NCT01817803
- Testing
- furosemide/no spironolactone, metolazone/no spironolactone, furosemid/spironolactone
- Sponsor
- Yonsei University
Hypertension
DORADO - Fixed Doses of Darusentan as Compared to Placebo in Resistant Hypertension
This is a research study of a new experimental drug called darusentan. Darusentan is not currently approved by the U.S. Food and Drug Administration (FDA) for use in the United States, which means that a doctor cannot prescribe…
- Trial name
- NCT00330369
- Testing
- Darusentan
- Where
- 115 sites in United States, Argentina and 9 more
- Volunteers
- 352 people
- Sponsor
- Gilead Sciences
Heart Failure
An Automated Continual Water Removal System in Patients With Advanced Diuretic Resistant Heart Failure
This study will assess the functionality and tolerability of an automated continual water removal system in up to 8 patients with HF and diuretic resistance.
- Trial name
- ACWR-HF (NCT05140759)
- Testing
- automated continual water removal system
- Where
- 3 sites in Georgia, Israel and 1 more
- Volunteers
- 3 people
- Sponsor
- Paragate Medical LTD
Gitelman Syndrome
Input of the Use of Indometacin in Gitelman Syndrome as Compared to Potassium Sparing Diuretics
Gitelman syndrome is a rare renal disease where the kidneys are unable to normally retain some salts (sodium, potassium and magnesium).
- Trial name
- GITAB (NCT01146197)
- Testing
- TREATMENT
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure
Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure
Working Hypothesis: a treatment with thiamine improves functional status and heart function of patients with congestive heart failure when on a diuretic treatment.
- Trial name
- NCT00770107
- Testing
- Thiamine
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Luzerner Kantonsspital
Edema
Correlation of Clinical and Laboratory Findings and Diuretic Efficacy in Patients With Edematous States in the Emergency Department
The aim of the study is the characterization of parameters from medical history, physical examination and diagnostics, which correlate with and could be used to predict diuretic efficacy.
- Trial name
- NCT03967717
- Testing
- Characterization of parameters of medical history, examination and diagnostics.
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- University of Cologne
Fluid Overload
Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit.
- Trial name
- GODIF (NCT04180397)
- Testing
- Furosemide, Isotonic saline
- Where
- 29 sites in Australia, Czechia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Morten H. Bestle
Healthy Male and Female Volunteers
Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers
In this study the gender specificity of the effects of furosemide in female and male volunteers will be investigated. The main objective is gender-specific comparison of the pharmacokinetic parameters of furosemide in relation to…
- Trial name
- NCT01156220
- Testing
- Furosemide, aminohippurate sodium
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Renal Insufficiency, Chronic Hypertension
Spironolactone in CKD Enabled by Chlorthalidone: PILOT
Highly prevalent among patients with chronic kidney disease (CKD) and poorly controlled blood pressure (BP), is a modifiable risk factor to abrogate both kidney failure progression and cardiovascular (CV) disease.
- Trial name
- SPICE PILOT (NCT05222191)
- Testing
- Spironolactone, Chlorthalidone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Indiana Institute for Medical Research
Heart Failure Acute
Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients
Acutely decompensated heart failure (ADHF) is highly prevalent and has a high (financial) burden on the health care system. Treatment often consists of the administration of IV decongestive agents.
- Trial name
- TAILOR-AHF (NCT06092437)
- Testing
- Urine sodium guided diuretic algorithm, Usual care
- Where
- 2 sites in Netherlands
- Volunteers
- 556 people
- Sponsor
- Zuyderland Medisch Centrum
Heart Failure, Acute Heart Failure
Randomized Controlled Trial of urinE chemiStry Guided aCute heArt faiLure treATmEnt (ESCALATE)
This is a randomized trial of protocolized diuretic therapy guided by urinary sodium compared to structured usual care in ED patients with AHF.
- Trial name
- ESCALATE (NCT04481919)
- Testing
- Protocolized diuretic therapy
- Where
- 2 sites in United States
- Volunteers
- 474 people
- Sponsor
- Vanderbilt University Medical Center
Pulmonary Embolism
Diuretic Vascular Filling in the Initial Management of Acute PE With Right Ventricular Dysfunction Normotensive
Pulmonary embolism (PE) is a serious disease with frequent intra hospital mortality remains high. If anticoagulation is perfectly codified, the remainder of the initial management has been less studied.
- Trial name
- NCT02531581
- Testing
- Furosemide, NaCl 9% isotonic
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Decompensated Heart Failure
Assessment of Coronary Flow Reserve in Heart Failure Patients After Ultrafiltration Versus Diuretics
The purpose of this research study is to compare the effects (good and bad) of ultrafiltration treatment with standard intravenous (in your vein) diuretic therapy (furosemide, torsemide, bumetanide) on your heart function and…
- Trial name
- NCT01457053
- Testing
- Loop diuretics (furosemide, torsemide, bumetanide), Ultrafiltration
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- University of Cincinnati
Congestive Heart Failure
A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)
To compare the effectiveness and safety of diuretics add-on strategy in chronic heart failure patients
- Trial name
- NCT02047422
- Testing
- Furosemide, metolazone, furosemid/spironolactone
- Sponsor
- Yonsei University
Acute Kidney Failure
The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury
The primary objective is to safely determine if the investigators can identify the severity of Acute Kidney Injury (AKI) early in the course of the disease.
- Trial name
- NCT01275729
- Testing
- Furosemide
- Where
- 4 sites in United States
- Volunteers
- 96 people
- Sponsor
- University of Chicago
Cardiac Surgery, Diuresis
Natriuresis-guided Depletion After Cardiac Surgery
Fluid overload (FO) is a common complication after cardiac surgery, associated with increased morbidity and mortality. Loop diuretics, especially furosemide, are routinely used to manage FO, but their use is often empirical.
- Conditions
- Cardiac Surgery, Diuresis, Congestion, Venous, Sodium Depletion
- Trial name
- EASY-CS (NCT07077772)
- Testing
- Furosemide intravenous titration based on natriuresis, Furosemide intravenous titration based on clinical examination
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Chronic Kidney Insufficiency, Hemodialysis Treatment
Clinical Trial to Compare Effectiveness of Diuretics in Hemodialysis Patients With Residual Renal Function
Introduction: Chronic kidney disease is characterized by a progressive deterioration of renal function. At the end of the progression, when complications occur (overhydration, electrolyte imbalances or retention of uremic…
- Conditions
- Chronic Kidney Insufficiency, Hemodialysis Treatment, Diuresis Preserved
- Trial name
- RRF (NCT01977430)
- Testing
- Hydrochlorothiazide and furosemide
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Corporacion Parc Tauli