Clinical trials: Diverticulitis
Diverticulitis
Diverticulitis: Antibiotics or Close Observation?
Rationale The prevalence of colonic diverticular disease is increasing in Western countries. Approximately 10 to 25% of patients with diverticular disease will eventually develop an episode of acute diverticulitis.
- Trial name
- DIABOLO (NCT01111253)
- Testing
- Amoxicillin-clavulanate
- Where
- 24 sites in Netherlands
- Volunteers
- 533 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diverticulitis
Hospitalization or Ambulatory Treatment of Acute Diverticulitis
The purpose of 01DIVER is to evaluate efficacy and safety of a home treatment protocol for non complicated diverticulitis compared with management in the hospital.
- Trial name
- 01DIVER (NCT01081054)
- Testing
- Ambulatory versus hospitalisation
- Where
- 5 sites in Spain
- Volunteers
- 132 people
- Sponsor
- Hospital Universitari de Bellvitge
Surgery, Diverticulitis
Hartmann's Versus Primary Anastomosis in Left-sided Colon Perforation
The purpose of this multi-center randomized trial is to identify any differences in the complication rates of patients undergoing Hartmann's (end colostomy) versus Primary Anastomosis (with defunctioning ileostomy) for left-sided…
- Conditions
- Surgery, Diverticulitis, Neoplasms, Postoperative Complications
- Trial name
- ColonPerfRCT (NCT01233713)
- Testing
- Hartmann's operation, Primary anastomosis
- Where
- 4 sites in Switzerland
- Volunteers
- 62 people
- Sponsor
- University of Zurich
Surgery, Pancreatitis
Active Versus Non Active Drainage for the Treatment of Infected Intra-abdominal Collection
The Percutaneous drainage of symptomatic intra-abdominal collection (primary or secondary to surgery)is the treatment of choice in the absence of peritonitis signs.
- Conditions
- Surgery, Pancreatitis, Diverticulitis, Appendicitis
- Trial name
- NCT01513421
- Testing
- Percutaneous drainage of intra-abdominal collection
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Colonic Diverticula, Diverticulitis
Pathophysiology of Diverticular Disease
Colonic diverticular disease is a highly prevalent condition in Western populations. The prevalence increases age-dependently from 5% at 40 years to 65% by the age of 85 years (1-3). The majority remain asymptomatic.
- Trial name
- NCT01493349
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- Maastricht University Medical Center
Colonic Diverticulitis
Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis
The purpose of this study is to evaluate if antibiotic therapy is necessary for treatment of uncomplicated colonic diverticulitis.
- Trial name
- NCT01008488
- Testing
- Antibiotic
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Uppsala University
Colon Cancer, Inflammatory Bowel Diseases
Functional Restoration After Abdominal and Pelvic Laparoscopic Surgery: Effect of Perioperative Intravenous Lidocaine
This is a blinded randomized controlled trial in patients undergoing laparoscopic colon surgery. The aim of this study is to assess whether perioperative intravenous lidocaine has an impact on the early post operative physical…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT00982618
- Testing
- Lidocaine, Epidural Block, PCA Morphine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Colon Cancer, Inflammatory Bowel Diseases
Bowel Function After Laparoscopic Colon Surgery: Effect of IV Lidocaine
Patients receiving perioperative intravenous lidocaine, post operative restoration of bowel movement will be faster and decrease pain intensity, opioid consumption and side effects, length of hospital stay; probably as a result…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT01155440
- Testing
- Lidocaine, Thoracic epidural block
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Colon Cancer, Inflammatory Bowel Diseases
Spinal Analgesia for Colonic Resection Using an Enhanced Recovery After Surgery (ERAS) Program
This is a blinded randomized controlled trial in patients undergoing laparoscopic colon surgery. The aim of this study is to assess whether spinal analgesia with a mixture of bupivacaine and morphine provides better pain relief…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT01477190
- Testing
- Spinal analgesia, Patient Control Analgesia (PCA) Morphine
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
Colorectal Cancer, Diverticulitis
End-to-End Compression Anastomosis for Left-sided Colectomy Endo-CAR Study
the purpose of this study is to evaluate the safety and effectiveness of the Niti CAR-device in the creation of colorectal anastomosis
- Trial name
- NCT00497263
- Testing
- Niti CAR
- Where
- Belgium
- Sponsor
- Niti Medical Technologies Ltd.
Diverticulosis, Diverticulitis
Role Of Lactobacillus Reuteri DSM 17938 In The Non-Complicated Diverticular Disease
The aim of this study is to evaluate the effectiveness and the tolerability of the Lactobacillus reuteri in the control of the diverticular disease symptoms and in the prevention of acute diverticulitis episodes.
- Trial name
- ReDiCo (NCT01168154)
- Testing
- Lactobacillus Reuterii
- Where
- 2 sites in Italy
- Volunteers
- 160 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Diverticulitis
Italian Study Group on Complicated Diverticulosis
Patients were recruited over a four year period from 1996 to 1999. Those admitted in the years 1996 and 1997 were retrospectively accrued from the clinical records, while patients treated between 1998 and 1999 patients were…
- Trial name
- GISDIC (NCT01276886)
- Testing
- antibiotic, Colonic resection with or without stoma
- Where
- Italy
- Sponsor
- Gruppo Italiano per lo Studio della Diverticolite Complicata
Sigmoid Diverticulitis (Hinchey I and II), Sigmoid Diverticulosis With Two or More Attacks of Diverticulitis
Laparoscopic Transvaginal Hybrid Anterior Resection: a Prospective Data Collection
Transvaginal hybrid procedures are of interest as an available NOTES-Procedure for the clinical routine. Few authors have demonstrated the feasibility and safety of such procedures (e.g.
- Trial name
- NCT01043731
- Testing
- Laparoscopic transvaginal hybrid anterior resection
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- Cantonal Hospital of St. Gallen
Peritonitis Caused by Perforated Left-sided Colon Diverticulitis
Hartmann vs R/A in Peritonitis by Perforated Diverticulitis
This prospective randomized trial is to prove the equivalence of primary sigmoid resection with end colostomy(Hartmann)(GROUP A) and primary sigmoid resection and immediate anastomosis with diverting stoma (GROUP B)with regard to…
- Trial name
- NCT01239927
- Testing
- Primary sigmoid resection with end colostomy (Hartmann), Primary sigmoid resection and immediate anastomosis with diverting stoma (PRA)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Diverticulitis
Natural History of Sigmoid Diverticulitis: The Geneva Cohort Study
Aim: This is a longitudinal cohort study to assess long-term clinical outcome of patients who were admitted in our institution for a first episode of uncomplicated sigmoid diverticulitis.
- Trial name
- NCT01015378
- Testing
- laparoscopid sigmoid resection
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University Hospital, Geneva
Diverticulitis
LapLAND Laparoscopic Lavage for Acute Non-Faeculant Diverticulitis
The aim of the study is to compare patient outcome following standard of care (Hartmann's or resection with anastomosis and defunctioning stoma) and a 'new therapy' (laparoscopic lavage alone) for the treatment of acute…
- Trial name
- LapLAND (NCT01019239)
- Testing
- Laparoscopic Washout, Hartmann's Procedure/ Primary Resection and Anastomosis
- Where
- Ireland
- Volunteers
- 300 people
- Sponsor
- St Vincent's University Hospital, Ireland
Crohn's Disease, Ulcerative Colitis
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
The purpose of this study is to find out if guided fluid administration with the esophageal monitor is superior to standard fluid administration and whether use of the hetastarch or lactated ringers offers different benefits with…
- Conditions
- Crohn's Disease, Ulcerative Colitis, Rectal Cancer, Colon Cancer
- Trial name
- NCT00467922
- Testing
- Hextend, Lactated Ringers
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Corewell Health West
Diverticulitis
Laparoscopic Versus Open Sigmoid Colectomy for Diverticular Disease
Aim: This is a prospective, randomized comparison of traditional open (OS) and laparoscopic sigmoidectomy (LS) in patients with complicated diverticular disease.
- Trial name
- NCT00453830
- Testing
- laparoscopic sigmoid resection
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Diverticulitis, Colonic, Acute Disease
Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis
The purpose of this study is to compare the efficacy (by assessing the clinical success of treatment) of intravenous antibiotic therapy with ertapenem in patients with acute attacks of sigmoid diverticulitis for 4 vs. 7 days.
- Trial name
- NCT00097734
- Testing
- ertapenem
- Where
- Germany
- Volunteers
- 540 people
- Sponsor
- Klinikum Hanover-Siloah Hospital