Clinical trials: Donor
COVID-19 Infection, Cancer Patients
COVID19-Convalescent Plasma for Treating Patients With Active Symptomatic COVID 19 Infection (FALP-COVID)
COVID-19 infection has spread worldwide causing several deaths in few months Convalescent Plasma from COVID 19 donors has shown huge activity in small series from Chinese patients and currently many centers from USA and the…
- Conditions
- COVID-19 Infection, Cancer Patients, General Population
- Trial name
- FALP-COVID (NCT04384588)
- Testing
- Convalescent Plasma from COVID-19 donors
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Fundacion Arturo Lopez Perez
T-cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia, in Relapse
Autologous and Donor-derived CD7 CAR-T Therapy in Refractory or Relapsed T-cell Malignancies
This is a multi-center, open-label, non-randomized, phase I/II trial. Patients with refractory or relapsed T-cell malignancies will receive autologous, prior-HSCT donor-derived or new donor-derived CD7 CAR T cells according to…
- Conditions
- T-cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia, in Relapse, Refractory Acute Lymphoblastic Leukemia, T-cell Malignancies
- Trial name
- NCT06316427
- Testing
- Autologous CD7 CAR T-cell, Prior-HSCT donor-derived CD7 CAR T-cell, New donor-derived CD7 CAR T-cell
- Where
- 4 sites in China
- Volunteers
- 80 people
- Sponsor
- Beijing GoBroad Hospital
Female Reproductive Problem, Infertility
Use of Corifolitropin Alfa in Oocyte Donors
The purpose of this study is to determine if corifollitropin alfa (long-term gonadotropin administration) is effective in a controlled ovarian stimulation protocol in oocyte donors compared to daily gonadotropin administration…
- Trial name
- NCT02213627
- Testing
- Corifollitropin alfa, Recombinant FSH, HP-hMG
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Acute Lymphoblastic Leukemia, Myeloblastic Leukemia
Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Calcineurin Inhibitor at Patients With Hemoblastosis
GVHD prevention using a combination of post-transplantation cyclophosphamide in combination with abatacept, vedolizumab and calcineurin inhibitor in children and young adults with hematoloblastosis after myeloablative…
- Conditions
- Acute Lymphoblastic Leukemia, Myeloblastic Leukemia, Biphenotypic Acute Leukemia, Malignant Lymphoma
- Trial name
- NCT05515029
- Testing
- GVHD prevention: post-transplantation cyclophosphamide, abatacept, vedolizumab, calcineurin inhibitor
- Where
- Russia
- Volunteers
- 56 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Cerebral Palsy
Estimation of the Safety and Efficiency Transfusion of HLA Matched CBU in Patients With CP
Cerebral palsy is a disorder of movement and posture resulted from a non-progressive lesion or injury of the immature brain. It is a leading cause of childhood-onset disability.
- Trial name
- CP-HLA2019 (NCT04098029)
- Testing
- Low HLA group CBU infusion, High HLA group CBU infusion, Standard therapy
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- State-Financed Health Facility "Samara Regional Medical Center Dinasty"
MDS
Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Myelodysplastic Syndrome Low Risk
Comparison of survival in patients with or without a matched donor at 36 months
- Trial name
- NCT02757989
- Testing
- transplantation
- Where
- 37 sites in France
- Volunteers
- 79 people
- Sponsor
- Groupe Francophone des Myelodysplasies
Acute Myeloid Leukemia (AML), Relapse
Azacitidine Combined with Donor Lymphocyte Infusion for Acute Myeloid Leukemia Post-transplant Relapse Prevention.
This study is single-center, single-arm, prospective, Phase II clinical trial with the primary objective of assessing the effectiveness of azacitidine combined with donor lymphocyte infusion (DLI) in the prevention of recurrence…
- Trial name
- NCT06754540
- Testing
- Azacitidine (AZA)
- Volunteers
- 51 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Leukemia, Hodgkins Disease
Blood Samples to Evaluate Biomarkers of Donor Chimerism
We are interested in patient-specific factors that may affect the balance of recipient cells and donor cells in patients who receive stem cell transplants.
- Conditions
- Leukemia, Hodgkins Disease, Non-hodgkins Lymphoma, Myelodysplastic Syndrome
- Trial name
- NCT00764829
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Fred Hutchinson Cancer Center
Refractory Multiple Myeloma
Reduced-Intensity Conditioning Followed By Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myeloma
This phase I/II trial studies the side effects of giving reduced-intensity conditioning followed by donor peripheral blood stem cell transplant (PBSCT) and how well it works in treating patients with multiple myeloma (MM).
- Trial name
- NCT00054353
- Testing
- fludarabine phosphate, melphalan, total-body irradiation
- Where
- 2 sites in United States, Italy
- Volunteers
- 16 people
- Sponsor
- Fred Hutchinson Cancer Center
Renal Failure, Renal Transplantation
A Reduced 11-b-HSD Activity, a Novel Mechanism of Salt Sensitivity and Hypertension After Renal Allograft Donation?
Consecutive living-kidney donor candidates (n=100) will be recruited after being accepted for donation according to official guidelines.
- Conditions
- Renal Failure, Renal Transplantation, Living Donors
- Trial name
- NCT01009229
- Testing
- Low and high salt diets
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Donor Hepatectomy
Dexmedetomedine Infusion Versus Fentanyl Infusion for Donor Anlgesia During Living Donor Hepatectomy
To compare between the analgesic effect of dexmedetomedine infusion versus Fentanyl infusion during donor hepatectomy.
- Trial name
- NCT02531529
- Testing
- dexmedetomedine, Fentanyl
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Hematopoietic Stem Cell Transplantation
Standardization of CD3+ T Cell Dose for Patients Receiving Allogeneic Peripheral Blood Stem Cell Transplantation From Matched Related Donors
Stem cells collected from sibling donors for allogenic transplants contain various types of cells. The predominant immune cells are called CD3+ T cells. The amount of these T cells vary vastly from donor to donor.
- Trial name
- NCT00959140
- Testing
- CD3+ T cell depletion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Brain Death, Liver Disease
Pre-recovery Bedside Liver Biopsy in Brain Death Organ Donors
This study's objective is to obtain preliminary data to test the hypotheses that percutaneous liver biopsy in brain death donors is safe and provides reliable histological information.
- Trial name
- PPB (NCT01810640)
- Testing
- Percutaneous Liver Biopsy
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Rutgers, The State University of New Jersey
Sickle Cell Disease, Thalassemia
Effects of Transfusion of Older Stored Red Cells
The purpose of this study is to determine the effects of transfusion of fresh and stored blood on patients. The investigators hope to test: whether a similar effect (older stored blood is associated with worse outcomes) is seen…
- Trial name
- NCT01534676
- Testing
- Transfusion, Blood, Chelation therapy
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Columbia University
Liver Transplantation, Liver Transplant; Complications
EBD RCT Trial in Living Donor Liver Transplantation
This study was designed to demonstrate incidence of biliary complication rates after living donor liver transplantation according to the implantation of external biliary drainage throug duct-to-duct anastomosis site.
- Conditions
- Liver Transplantation, Liver Transplant; Complications, Bile Stricture, Bile Leakage From Biliary Anastomosis
- Trial name
- NCT04622540
- Testing
- External biliary drainage
- Where
- South Korea
- Volunteers
- 124 people
- Sponsor
- Seoul National University Hospital
ALS - Amyotrophic Lateral Sclerosis
Evaluation of Donor-Derived B Cell Infusions in Patients With Amyotrophic Lateral Sclerosis (ALS)
This study is testing whether giving people with ALS specially matched immune cells called B cells from a related donor is safe. Up to 10 participants will each receive two B cell infusions at least 60 days apart.
- Trial name
- NCT07838389
- Testing
- B cell infusion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mark Poznansky
Acute Myeloid Leukemia, B-Cell Non-Hodgkin Lymphoma
CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma
This phase 2 trial studies how well cluster of differentiation 8 (CD8)+ memory T-cells work as a consolidative therapy following a donor non-myeloablative hematopoietic cell transplant in treating patients with leukemia or…
- Conditions
- Acute Myeloid Leukemia, B-Cell Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Hodgkin Lymphoma
- Trial name
- NCT02424968
- Testing
- Anti-Thymocyte Globulin, Cyclosporine, Mycophenolate Mofetil
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Robert Lowsky
Myeloid Chimerism
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels
Background: Sickle cell disease can often be treated with blood stem cell transplants. But for some people the disease returns. This study will give a second transplant to people whose disease has returned but still have some…
- Trial name
- NCT04008368
- Testing
- CliniMACS CD34 Reagent
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Health Status Unknown
Studying Umbilical Cord Blood From African-American Donors
RATIONALE: Studying umbilical cord blood in the laboratory and gathering information about current and previous pregnancies from African-American umbilical cord blood donors may help doctors learn more about the umbilical cord…
- Trial name
- NCT00717535
- Testing
- cryopreservation, questionnaire administration, study of socioeconomic and demographic variables
- Volunteers
- healthy volunteers welcome
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Primary Uterine Infertility
First Clinical Live-Donor Uterus Transplantation Trial In Egypt
More than a decade ago, uterus transplantation (UTx) as a highly experimental procedure was the treatment which had been developed for women suffering from absolute uterine factor infertility (AUFI) [uterus absence (congenital…
- Trial name
- NCT03284073
- Testing
- Uterus transplantation
- Where
- Egypt
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Amro M. Hetta, M.Sc.
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