Clinical trials: Donor
Burns
Evaluation of Silverlon Dressing for Autogenous Skin Donor Sites
The purpose of this study is to compare one type of dressing against the current standard dressing that is used to cover an unburned area of the skin where a piece of skin is removed to cover another part of the body that was…
- Trial name
- NCT00137215
- Testing
- Silverlon
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- United States Army Institute of Surgical Research
Delayed Function of Renal Transplant
A Study of the Activity of Eculizumab for Prevention of Delayed Graft Function In Deceased Donor Kidney Transplant
The purpose of this study is to determine if Eculizumab is safe and effective in the prevention of delayed graft function following deceased donor kidney transplantation.
- Trial name
- NCT01403389
- Testing
- Eculizumab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Schroppel, Bernd, M.D.
End Stage Renal Disease, Living Donor Kidney Transplantation
Social Networks and Renal Education: Promoting Transplantation
There are significant and persistent disparities in access to kidney transplantation and as a result most patients with end stage renal disease receive hemodialysis (HD).
- Conditions
- End Stage Renal Disease, Living Donor Kidney Transplantation, Renal Dialysis
- Trial name
- SNARE (NCT03536858)
- Testing
- COACH (Communicating about Choices in Transplantation)
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Temple University
Brain Death, Heart Failure
Intravenous Thyroxine for Heart-Eligible Organ Donors
This randomized controlled trial will evaluate whether intravenous thyroxine infusion given to brain-dead organ donors who are eligible to donate hearts for 12 hours will result in more hearts transplanted than saline placebo
- Trial name
- NCT04415658
- Testing
- Thyroxine, Saline
- Where
- 14 sites in United States
- Volunteers
- 838 people
- Sponsor
- Washington University School of Medicine
Renal Transplant
IVIG/Rituximab vs Rituximab in Kidney Transplant With de Novo Donor-specific Antibodies
The objective of this study was to compare two strategies of de novo donor specific antibodies (DSA) and antibody-mediated rejection (AMR) prevention in renal transplant recipients: high dose intravenous immunoglobulin…
- Trial name
- NCT04033276
- Testing
- Rituximab, intravenous immune globulin
- Where
- 2 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Liver Cirrhosis(Who Will Undergo Planed Liver Transplantation)
The Comparison of Changes of QTc, Tp-e Interval, and Tp-e/QT Ratio, Tp-e/QTc Ratio on the ECG During Living Donor Liver Transplantation Under Desflurane and Total Intravenous Anesthesia -Randomized Controlled Trial
Prolonged corrected QT interval (QTc) has been observed in about half of patients with liver cirrhosis. Marked prolongation of QTc (ie, 500 msec) has been considered to be a risk factor for fatal ventricular arrhythmia, such as…
- Trial name
- NCT03864276
- Testing
- inhalation (desflurane) group, total intravenous (propofol) anesthesia
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Yonsei University
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant
This randomized phase I trial studies the side effects of vaccine therapy in preventing cytomegalovirus (CMV) infection in patients with hematological malignancies undergoing donor stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT01588015
- Testing
- tetanus-CMV fusion peptide vaccine, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- City of Hope Medical Center
Preterm Infant, Growth Delay
The Milk, Growth and Microbiota Study
Late preterm infants, who are born at 34, 35 or 36 weeks gestation, often have difficulty feeding, establishing growth, and fighting off infection.
- Conditions
- Preterm Infant, Growth Delay, Microbial Colonization, Breastfeeding
- Trial name
- MGM (NCT03220282)
- Testing
- Donor milk, Preterm infant formula
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of California, San Francisco
Graft Versus Host Disease, Leukemia
Donor Lymphocyte Infusion After Stem Cell Transplant in Treating Patients With Haematological Cancers
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and melphalan, before a donor stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Graft Versus Host Disease, Leukemia, Lymphoma, Myeloma
- Trial name
- ProT4 (NCT01240525)
- Testing
- CD4 DLI, No DLI
- Where
- 11 sites in United Kingdom
- Volunteers
- 114 people
- Sponsor
- University College, London
Chronic Myeloproliferative Disorders, Leukemia
Donor Stem Cell Transplant, Pentostatin, and Total-Body Irradiation in Treating Patients With Hematological Cancer
RATIONALE: Giving low doses of chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Myelodysplastic Syndromes
- Trial name
- NCT00816413
- Testing
- cyclosporine, mycophenolate mofetil, pentostatin
- Sponsor
- University of Nebraska
Reproductive Issues
Maternal KIR and Fetal HLA Influence Reproductive Success in ART-oocyte Donor.
The present project is an ambispective study designed to answer how HLA-F SNPs, as well as KIR-HLA-C compatibility, influence reproductive outcomes in oocyte donation cycles.
- Trial name
- NCT05606679
- Testing
- Analysis combinations of maternal KIR and HLA-C genotypes
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- IVI Madrid
Haematologic Disease
Phase I Study of CTL Anti-DP Infusion Post-hematopoietic Stem Cell Transplantation
For several decades, allogeneic hematopoietic stem cell trans-plantation (allo-HSCT) has remained an important strategy in the management of patients with high-risk hematological malignancies.
- Trial name
- CTL-DP 01 (NCT04180059)
- Testing
- CTL 19
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Nantes University Hospital
Clostridium Difficile
Randomized Clinical Trial of Standard FMT Treatments
This is a single center, randomized, parallel assignment, double-blinded, efficacy and safety study to be conducted in subjects with recurrent C. difficile Infection (RCDI).
- Trial name
- FMT (NCT04729790)
- Testing
- PRIM-DJ2727
- Sponsor
- The University of Texas Health Science Center, Houston
Acute Myeloid Leukemia
Haplo-SCT vs ASCT With or Without Decitabine in AML CR1
A multicentre, prospective, open-label clinical study, including a randomized controlled study in low or intermediate-risk group patients, and a cohort study of maintenance treatment with decitabine after ASCT.
- Trial name
- NCT02059720
- Testing
- HSCT
- Where
- China
- Volunteers
- 212 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Leukemia, Myeloid, Acute, Myelodysplastic Syndromes
Prophylactic Application of Donor-derived TCM After Allogeneic HSCT
PACT is a non-randomized multicentre phase I/II study to evaluate the feasibility and safety of the prophylactic administration of donor derived TCM.
- Trial name
- PACT (NCT02758223)
- Testing
- TCM allogeneic humane central memory T cells, cryopreserved
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Wuerzburg University Hospital
Graft vs Host Disease, Hematologic Neoplasm
Bone Marrow Transplant Studies for Safe and Effective Treatment of Leukemia
Bone marrow transplants (BMT) are one of the accepted therapies used to treat leukemia. However, BMT have risks of complications. One potentially life-threatening complication is known as graft-versus-host disease (GVHD).
- Conditions
- Graft vs Host Disease, Hematologic Neoplasm, Leukemia, Multiple Myeloma
- Trial name
- NCT00001623
- Testing
- Allogeneic Bone Marrow Transplant
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Tagraxofusp and Azacitidine for Maintenance Treatment in Patients With CD123 Positive AML and MDS Following Donor Hematopoietic Cell Transplant
This phase Ib trial tests the safety, side effects, best dose and effectiveness of tagraxofusp in combination with azacitidine as maintenance therapy in treating patients with CD123 positive acute myeloid leukemia (AML) and…
- Trial name
- NCT06498973
- Testing
- Azacitidine, Biospecimen Collection, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- City of Hope Medical Center
Pouchitis, Inflammatory Bowel Diseases
Faecal Microbiota Transplantation From Normal Pouch Function Donor in the Treatment of Chronic Pouchitis
Patients with chronic pouchitis is disabled by bloody diarrhoea and abdominal pain often followed by fever. Pouchitis is an inflammation in a pouch, a reservoir formed by the small intestine in the management of the chronic…
- Conditions
- Pouchitis, Inflammatory Bowel Diseases, Ulcerative Colitis
- Trial name
- NCT04820413
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 3 people
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
Infertility
Usefulness of Medroxyprogesterone Acetate in Follicular Phase in Oocyte Donors. Undergoing Ovarian Stimulation
The purpose of this study is to determine whether Medroxyprogesterone Acetate (MPA) administration in follicular phase prevents premature luteinization with equal efficiency as GnRH antagonists and otains similar clinical results…
- Trial name
- NCT03300960
- Testing
- Provera 10 mg., Ganirelix (GnRH antagonist)
- Where
- Spain
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Elective Reconstructive Surgery, Pain, Post Operative
The Efficacy and Safety of Lower Limb Nerve Blocks in Postoperative Analgesia for the Free Flap Donor Sites
The use of free fibular flaps and anterolateral thigh (ALT) flaps for repairing the oromandibular defects is well established, whereas few attentions were focused on postoperative analgesia for the donor area.
- Trial name
- NCT03071185
- Testing
- femoral nerve block, common peroneal nerve block
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xia Zhang
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.