Clinical trials: Donor
Hematologic Malignancies
Thymoglobulin in Unrelated Hematopoietic Progenitor Cell Transplantation
This is a randomized trial for patients undergoing hematopoietic progenitor cell transplantation (HPCT) from an unrelated donor.
- Trial name
- NCT01217723
- Testing
- Anti-Thymocyte Globulin (Rabbit), Patients will receive a standard preparative regimen (i.e. one that does not contain Thymoglobulin)
- Where
- 10 sites in Canada
- Volunteers
- 198 people
- Sponsor
- McMaster University
Ovarian Hyperstimulation Syndrome
The Role of Cetrotide Acetate in Prevention of Ovarian Hyperstimulation Syndrome (OHSS) in Oocyte Donors
This pilot study aims to address whether the prophylactic use of Cetrorelix Acetate after a long gonadotropin-releasing hormone (GnRH) agonist protocol post-hCG (human chorionic gonadotropin) administration can significantly…
- Trial name
- NCT00867659
- Testing
- Cetrotide acetate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Center for Reproductive Medicine
Acute Pain
Transversus Abdominis Plane Block for Postoperative Analgesia in Living Donor Hepatectomy
Living donor organ transplantation has increased in recent years due to an increased need for organs. The objective of this study was to investigate the effects of a TAP block on postoperative analgesia and opioid consumption in…
- Trial name
- NCT02645903
- Testing
- Transversus Abdominis Plane Block, standard general anesthesia
- Volunteers
- 50 people
- Sponsor
- Inonu University
Crohn Disease
Phase 1b/2a Trial of Allogeneic HSCT From an HLA-partially Matched Related or Unrelated Donor After TCRab+ T-cell/CD19+ B-cell Depletion for Patients With Monogenic and/or Early-onset Medically Refractory Crohn Disease
This research study is investigating whether alpha beta T-cell depleted hematopoietic stem cell transplant (HSCT) can be an immune system replacement for Crohn disease patients and whether this is safe and effective for patients…
- Trial name
- NCT06986382
- Testing
- CliniMACS® TCR α/β Reagent Kit and CliniMACS® CD19 System, Prednisone/Methylprenisolone, Palifermin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Stanford University
Sickle Cell Trait
Mobilization and Handling of Stem Cells for Transplant From Healthy Volunteers With Sickle Cell Trait
This study will examine the effects of granulocyte colony-stimulating factor (G-CSF) on bone marrow stem cells in healthy volunteers with sickle cell trait and determine if cells collected for transplantation from donors with…
- Trial name
- NCT00005782
- Testing
- Granulocyte colony-stimulating factor, Leukapheresis
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Transversus Abdominis Plane (TAP) Block Catheter, DIEP or Free MS-TRAM Breast Reconstruction
TAP Block in DIEP or Free MS-TRAM Donor Site: A RCT
Breast reconstruction using a patient's own abdominal tissue is one of the most common methods for restoring mastectomy defects for breast cancer patients.
- Conditions
- Transversus Abdominis Plane (TAP) Block Catheter, DIEP or Free MS-TRAM Breast Reconstruction, Local Pain Management, Abdominal/ Donor Site
- Trial name
- NCT01398982
- Testing
- Bupivacaine (study group), Isotonic saline (control group)
- Where
- Canada
- Volunteers
- 93 people
- Sponsor
- University Health Network, Toronto
Covid19, Kidney Transplant; Complications
Multicenter CTS Pre-and Post-Transplantation Covid-19 Serum Studies
The Covid-19 Serum Study is a prospective case-control study in 1. kidney or liver transplanted patients being hospitalized due to an infection with Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) after…
- Conditions
- Covid19, Kidney Transplant; Complications, Kidney Transplant Failure and Rejection, Liver Transplant; Complications
- Trial name
- NCT04694573
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Heidelberg University
Palatal Wound
Clinical and Histological Outcomes of Allogenic Amnion Chorion Membrane in the Healing of Free Gingival Graft Donor Site
The purpose of this study is to compare an allogenic amnion chorion membrane to a collagen dressing in palatal wound healing after harvesting free gingival graft (FGG).
- Trial name
- NCT03713073
- Testing
- Allogenic amnion chorion membrane, Collagen dressing
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chronic Myeloproliferative Disorders, Leukemia
Donor Stem Cell Transplant or Donor White Blood Cell Infusions in Treating Patients With Hematologic Cancer
RATIONALE: A peripheral stem cell transplant or an umbilical cord blood transplant from a donor may be able to replace blood-forming cells that were destroyed by chemotherapy or radiation therapy.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00281879
- Testing
- anti-thymocyte globulin, filgrastim, busulfan
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- OHSU Knight Cancer Institute
Lactating Women - Human Milk Donors
Single-center Evaluation of Human Milk Quantity and Quality Over Five Years
This single-center retrospective observational study includes all human milk donors collaborating with the milk bank at České Budějovice Hospital between 2021 and 2025.
- Trial name
- HUMBLE (NCT07309146)
- Testing
- No Interventions
- Where
- Czechia
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Relapsed Pediatric ALL, Acute Graft-Versus-Host Disease (Gvhd) Grade IV (Diagnosis)
TCDαβ/CD45RA Haploidentical Transplantation in Children With Leukemia
This is a multi-center clinical study in China using CliniMACS TCRα/β+ and CD45RA+ T cell depleted stem cell grafts from haploidentical donors for hematopoietic stem cell transplantation in children.
- Conditions
- Relapsed Pediatric ALL, Acute Graft-Versus-Host Disease (Gvhd) Grade IV (Diagnosis), Relapsed Pediatric AML
- Trial name
- NCT04033627
- Testing
- In Vitro T cells depletion using CliniMCAS system
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Children's Medical Center
Scar, Cicatrix
Clinical Safety and Scar Prevention Study of a Topical Antifibrotic Compound FS2.
The study will investigate the safety and effectiveness of daily post surgical scar management, using a moisture-balancing base product containing different amounts of a novel (NCE) antifibrogenic compound FS2, a natural…
- Conditions
- Scar, Cicatrix, Hypertrophic Scar, Skin Graft Scar
- Trial name
- FS2 (NCT04186273)
- Testing
- Fibrosis-Inhibiting-Compound-FS2, Vehicle moisture balancing base
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
CMV Viremia, Immunosuppression-related Infectious Disease
Virus-specific Activated T Lymphocytes From a Donor in Hematopoietic Progenitor Transplanted Patients
Marrow transplanted immunocompromised patients with cytomegalovirus (CMV) viral infection will be treated with CMV activated T-Lymphocytes. T-Lymphocytes will be obtained through an apheresis from a compatible donor.
- Trial name
- NCT04018261
- Testing
- Activated T-Lymphocytes
- Where
- 7 sites in Spain
- Volunteers
- 26 people
- Sponsor
- Banc de Sang i Teixits
Hematologic Diseases, Stem Cell Transplant Complications
DSAs in Patients Undergoing Allo-HSCT From Mismatched Donors
Retrospective observational multicentric, spontaneous non-interventional non-pharmacological Italian study. The primary objective is analysis of Anti-HLA antibodies and DSAs searching and monitoring activities in haematological…
- Trial name
- AIBT_DSAs (NCT04888286)
- Where
- 25 sites in Italy
- Volunteers
- 912 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Related Donors Donating PBSC to a Family Member, Healthy Donors
MGTA-145 + Plerixafor in the Mobilization of HSCs for Allogeneic Transplant in Hematologic Malignancies
This research study tests a new medicine for mobilizing stem cells so they can be collected and used for allogeneic stem cell transplant for treatment of hematological malignancies.
- Conditions
- Related Donors Donating PBSC to a Family Member, Healthy Donors, Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia
- Trial name
- NCT04762875
- Testing
- MGTA-145, Plerixafor
- Where
- 8 sites in United States
- Volunteers
- 7 people
- Sponsor
- Ensoma
Breast Milk Collection
Investigating Lipid Peroxidation Products in Donor Human Milk
This study will quantify lipid peroxidation products (malondialdehyde, 4 hydroxy-2-nonenal, hexanal, and 8-iso-PGF2α), fatty acid content, and antioxidant capacity in donor human milk sampled from two neonatal units in the UK.
- Trial name
- LIMIT (NCT03573531)
- Testing
- Laboratory analysis
- Where
- 3 sites in United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bournemouth University
Bone Marrow Donor
Subconjunctival Injection of Allogeneic Mesenchymal Stem Cells in Severe Ocular Chemical Burn
The objective of this pre-clinical study is to demonstrate the robustness of Bone Marrow derived Mesenchymal Stem Cells (BM-MSC) production, to treat patients with severe eye burns.
- Trial name
- SYMBOLpreclini (NCT03967275)
- Testing
- bone marrow harvest
- Where
- France
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
COVID-19 Respiratory Infection
COVID-19 Seroprevalence in Pregnant Women and Blood Donors
The study aims to measure the SARS-CoV-2 seroprevalence (ie. the proportion of people with antibodies against the virus) in pregnant women and blood donors in an administrative area of France, and to determine whether these…
- Trial name
- CoVERED (NCT04893057)
- Where
- France
- Volunteers
- 797 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
No Disease or Condition is Being Studied
ANI-Guided Fentanyl Infusion During Living Donor Liver Resections
Thу goal of this study was to learn whether intraoperative analgesia nociception monitoring (ANI) could be beneficial during intraoperative monitoring for patients undergoing living donor liver resections.
- Trial name
- NCT06619977
- Testing
- Analgesia nociception monitoring (ANI)
- Where
- Ukraine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bogomolets National Medical University
End-stage Kidney Disease
Increasing Equity in Transplant Evaluation and Living Donor Kidney Transplantation
Living donor kidney transplantation (LDKT) is the optimal treatment for end-stage kidney disease (ESKD). But, the evaluation process for a kidney transplant is lengthy, time consuming, and burdensome to the patient.
- Trial name
- NCT02342119
- Testing
- Talking About Living Kidney Donation, Kidney Transplant Fast Track
- Where
- United States
- Volunteers
- 1,315 people
- Sponsor
- University of Pittsburgh
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