Clinical trials: Donor
Kidney Transplant, Kidney Donor
Transforming Curiosity Into Donation
This is a multi-step study that will first create a preliminary living donor drop-out risk index (LD-DROP) by retrospectively identifying factors that contribute to the discontinuation of living donor evaluation.
- Conditions
- Kidney Transplant, Kidney Donor, Drop Out, High Risk
- Trial name
- NCT07793890
- Testing
- Living Kidney Donor Support
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Graft-Versus-Host Disease
Multi Donor Mismatched Stem Cell Transplantation (MDT)
The proposed research focuses on the development of innovative protocol of mismatched stem cell transplantation with combined 2 different haplo stem cell transplantation (SCT) donors which are mismatched to the recipient (and…
- Trial name
- NCT00716690
- Testing
- Multi donor stem cell transplantation
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Solid Tumor, Adult, Healthy Donors
A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.
Primary Objective: This is a study to investigate the feasibility of harvesting, expanding, and selecting T lymphocytes from cancer patients and healthy volunteers.
- Conditions
- Solid Tumor, Adult, Healthy Donors, COVID-19 Donors
- Trial name
- NCT00571389
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- BioCytics, Inc.
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Cyclophosphamide and/or Mycophenolate Mofetil With or Without Tacrolimus in Treating Patients Who Are Undergoing a Donor Bone Marrow or Peripheral Stem Cell Transplant for Hematologic Cancer
RATIONALE: Giving low doses of chemotherapy, such as fludarabine, and radiation therapy before a donor bone marrow or stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00255710
- Testing
- filgrastim, cyclophosphamide, fludarabine phosphate
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
B-Cell Lymphoid Malignancies, Hematologic Malignancy
Transplantation of Hematopoietic Stem Cells From HLA-compatible Donors in Patients With B-Cell Lymphoid Malignancies
This research study is being conducted to treat patients with B-cell lymphoid malignancies. These types of cancers include diffuse large cell (DLBCL) non-Hodgkin's lymphoma (NHL), mantle cell NHL, any indolent B cell NHL (such as…
- Conditions
- B-Cell Lymphoid Malignancies, Hematologic Malignancy, Non-Hodgkin Lymphoma
- Trial name
- NCT04684979
- Testing
- Hematopoietic Stem Cells from HLA-compatible Related, Hematopoietic Stem Cells from HLA Unrelated
- Where
- United States
- Sponsor
- Baptist Health South Florida
Aplastic Anemia
Reduced Toxicity Fludarabine (Flu) + Cyclophosphamide (CPM) + Rabbit Antithymocyte Globulin (rATG) Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia (SAA)
Anti-thymocyte globulin (ATG) has been used in severe aplastic anemia as a part of the conditioning regimen. Among the many kinds of ATG preparations, thymoglobulin had been found to be more effective in preventing graft versus…
- Trial name
- NCT00882323
- Testing
- Cyclophosphamide, Fludarabine, Thymoglobulin
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- The Korean Society of Pediatric Hematology Oncology
Complication of Anesthesia
Respiratory Complications Among Living Liver-donors
Recently, there are increasing reports about pulmonary complications within living liver donors postoperatively. In this retrospective study, the investigators will highlight the risk factors and incidence of pulmonary…
- Trial name
- NCT03862664
- Testing
- Collection of data
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Ain Shams University
Hematologic Neoplasms
Studyof Allogeneic Hematopoietic Stem Cell Transplantation From One Haplotype Mismatch Related Donor or From an Unrelated Donor in Elderly Patients
Allogeneic (Allo) hematopoietic stem cell transplantation (HSCT) is a recognized curative procedure for hematological malignancies.
- Trial name
- HAPLOMUD (NCT02623309)
- Testing
- Allogeneic (Allo) hematopoietic stem cell transplantation
- Where
- 14 sites in France
- Volunteers
- 108 people
- Sponsor
- Institut Paoli-Calmettes
Corneal Disease
Evaluation of Biosynthetic Constructs to Replace Donor Corneas
Constructs made from cross-linked Human Recombinant Collagen type III are being used instead of human donor corneas in 6 patients at Deep anterior lamellar cornea grafting.
- Trial name
- NCT02374723
- Testing
- NuCornea, donated human corneas
- Sponsor
- Region Östergötland
Acute Leukemia, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplant
This pilot phase II trial studies how well high dose cyclophosphamide, tacrolimus, and mycophenolate mofetil work in preventing graft versus host disease in patients with hematological malignancies undergoing myeloablative or…
- Conditions
- Acute Leukemia, Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Diffuse Large B-Cell Lymphoma
- Trial name
- NCT03128359
- Testing
- Busulfan, Cyclophosphamide, Fludarabine Phosphate
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- City of Hope Medical Center
Relapsed Hematologic Malignancy, Multiple Myeloma
Len/Dex/DLI in Relapsed Multiple Myeloma After Allogeneic Stem Cell Transplant
Multiple Myeloma (MM) is a morbid disease which can only be cured with an allogeneic hematopoietic stem cell transplant (HSCT). Approximately 50% of allotransplanted patients will relapse, with a median survival of 5 years.
- Trial name
- NCT03413800
- Testing
- Lenalidomide-Dexamethasone-DLI
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Kidney Donor
Quadratus Lumborum Block Versus Transversus Abdominus Plane Block for Pain Management After Donor Nephrectomy
To evaluate quadratus lumborum block effect on post operative pain scores during the first 24 hours after surgery as compared to transversus abdominis plane block after laparoscopic donor nephrectomy patients.
- Trial name
- NCT03476850
- Testing
- QL Block, TAP Block
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Liver Transplantation, Postreperfusion Syndrome
Ascorbic Acid to Prevent Postreperfusion Syndrome in Liver Transplantation
The goal of this clinical trial is to test the efficacy of intravenous ascorbic acid in preventing the postreperfusion syndrome in liver transplantation.
- Conditions
- Liver Transplantation, Postreperfusion Syndrome, Ascorbic Acid
- Trial name
- VITACTOH (NCT05754242)
- Testing
- Ascorbic acid, 0.9% Saline solution
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Postoperative Complications
Prospective Biomechanical Analysis of Donor-site Morbidity Following Microvascular Fibula Transplantation
Pre- and postoperatively patients who underwent free fibula flap were examined regarding donor-site morbidity of the lower extremities.
- Trial name
- NCT02265991
- Testing
- Fibula Explantation
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Infertility, Female
Uterus Transplantation From Live Donors With Robotic Assisted Surgery - Gothenburg II
The study is a follow up of NCT01844362. Uterus transplantation will be performed from live donors to patients with uterine factor infertility. If will be performed before transplantation.
- Trial name
- UTX-robot (NCT02987023)
- Testing
- uterus transplantation
- Where
- Sweden
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Cancer
Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy
RATIONALE: Vaccines may help the body build an effective immune response to kill cytomegalovirus infections. PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy in treating patients who have…
- Trial name
- NCT00509691
- Testing
- cytomegalovirus pp65-specific cytotoxic T lymphocytes, polymerase chain reaction, diagnostic laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Minimal Residual Disease,Acute Leukemia, Hypomethylating Agents, Donor Lymphocyte Infusion, Allogeneic Hematopoietic Cell Transplantation
HMA+DLI vs DLI Preemptive Therapy Based on MRD for AL Undergoing Allo-HSCT
Allogeneic hematopoietic cell transplantation (Allo-HSCT) is an effective therapy for acute leukemia, but relapse is the most common problem affecting long-term survivors of allo-HSCT.
- Trial name
- NCT03662087
- Testing
- HMA+DLI, DLI
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Myelodysplastic Syndrome, Acute Myeloid Leukemia
Safety Study of 5-Azacitidine and Standard Donor Lymphocyte Infusion (DLI) to Treat Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) Relapsing After Allogeneic Stem Cell Transplantation
This open label phase-II trial evaluates hematological response of an additional treatment with 5-Azacitidine to common DLI in patients with MDS or AML relapsing after allogeneic stem cell transplantation.
- Trial name
- NCT00795548
- Testing
- 5-Azacitidine
- Where
- 6 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Liver Transplantation
Influence of Genetic Polymorphism of Donor on Tacrolimus Concentration in Liver Transplant
To study the influence of donor's ABCB1、CYP3A4、CYP3A5、POR genetic polymorphism on tacrolimus blood concentration in liver transplant recipients.
- Trial name
- NCT03140462
- Where
- 2 sites in Taiwan
- Volunteers
- 96 people
- Sponsor
- National Taiwan University Hospital
Infertility
Study of Dual Trigger Ovulation in Oocyte Donors
The project is a randomized, controlled, prospective study of oocyte donors comparing the safety and efficacy of triggering ovulation using a combination of two drugs-GnRH agonist and very low dose hCG-versus triggering ovulation…
- Trial name
- DUALTRIGGER (NCT01443546)
- Testing
- HCG, Lupron Trigger, Dual Trigger
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
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