Clinical trials: Donor
Leukemia
Donor Stem Cell Transplant in Treating Young Patients With Acute Myeloid Leukemia With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory or Relapsed Acute Myelogenous Leukemia
RATIONALE: Giving chemotherapy before a donor stem cell transplant using stem cells that closely match the patient's stem cells, helps stop the growth of cancer cells.
- Trial name
- NCT00553202
- Testing
- anti-thymocyte globulin, busulfan, cyclophosphamide
- Where
- 52 sites in United States, Canada
- Volunteers
- 158 people
- Sponsor
- Children's Oncology Group
Lung Transplant Recipient
BRIDGE - Blocking Receptor of IL-1β for Donor Graft Edema Reduction
This study will determine if primary graft dysfunction (which causes low blood oxygen levels and fluid or inflammation in the lungs) after lung transplant can be prevented through the use of the study drug (IL-1 receptor…
- Trial name
- NCT07410312
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Pain, Postoperative
Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy
The investigators will assess how the use of toradol and pregabalin affects return to bowel function and see if there is a difference in length of hospital stay.
- Trial name
- NCT03669081
- Testing
- Ketorolac, Pregabalin, Saline
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Utah
Kidney Transplantation
Certican (Everolimus) for Recipients of Kidney From HLA-identical Living Donors
Recipients from living donors kidneys HLA-identical were lower risk for acute rejection, graft loss or death. There is no clear definition of what is ideal immunosuppressive regimen for this population.
- Trial name
- NCT01653041
- Testing
- Everolimus
- Where
- Brazil
- Volunteers
- 47 people
- Sponsor
- Hospital do Rim e Hipertensão
Epstein-Barr Virus Infections
Giving Epstein-Barr Virus (EBV) Specific Killer T Lymphocytes to Patients Who Have Had Donor Marrow Grafts
Patients have a type of blood cell cancer or other blood problem that is very hard to cure with standard treatments and s/he will receive a bone marrow transplant.
- Trial name
- ETNA (NCT00058812)
- Testing
- EBV specific T cells
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Baylor College of Medicine
Acute Myeloid Leukemia (AML)
Treatment of Elderly AML Patients With Induction Chemotherapy Followed by G-CSF-Mobilized Stem Cells From Haploidentical Related Donors
The purpose of this study is to test a method of bone marrow transplantation that results in only temporary donor immune function.
- Trial name
- NCT02519712
- Testing
- Induction Chemotherapy, G-PBSC Infusion
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia
Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies
To see if it is possible to use short-duration tacrolimus after a peripheral blood stem cell transplant in certain malignancies that are considered difficult to engraft.
- Conditions
- Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia
- Trial name
- NCT02556931
- Testing
- Fludarabine, Cyclophosphamide, Total body irradiation
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Chronic Lymphocytic Leukemia, Graft vs Host Disease
Donor Th2 Cells to Prevent Graft-Versus-Host Disease in Bone Marrow Transplants
Allogeneic peripheral blood stem cell transplantation (PBSCT) is primarily limited by graft-versus-host disease (GVHD). In murine models, we have demonstrated that donor CD4+ T cells of Th1 cytokine phenotype (defined by their…
- Conditions
- Chronic Lymphocytic Leukemia, Graft vs Host Disease, Hodgkin's Disease, Multiple Myeloma
- Trial name
- NCT00001830
- Testing
- Th2 cells in allo HSCTT, Th2 Cells
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Granulomatous Disease
Stem Cell Transplant Following Low-Intensity Chemotherapy to Treat Chronic Granulomatous Disease
This study will investigate the safety and effectiveness of a modified stem cell transplant procedure for treating chronic granulomatous disease (CGD) in patients with active infection.
- Trial name
- NCT00001765
- Testing
- Nexell Isolex with T-cell Depletion, Baxter isolex 300i
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Disorder of Phosphate, Calcium and Vitamin D Metabolism, Female Infertility Due to Diminished Ovarian Reserve
Vitamin D Influence on Oocyte Donation
Objective: To investigate the correlation between total and bioavailable serum 25-OH vitamin D, ovarian reserve and ovarian response to controlled stimulation in egg donors.
- Conditions
- Disorder of Phosphate, Calcium and Vitamin D Metabolism, Female Infertility Due to Diminished Ovarian Reserve, Hormonal Requirement, Reproductive Disorder
- Trial name
- NCT02341365
- Testing
- vitamin D,AMH, AFC, reproductive outcome egg recipients
- Volunteers
- 269 people
- Sponsor
- IVI Madrid
Liver Transplantation, Liver Preservation for Transplant
OCS Liver PROTECT Trial: Preserving and Assessing Donor Livers for Transplantation
A prospective, phased-pivotal, international randomized trial to evaluate the effectiveness of the OCS™ Liver to preserve and assess donor livers intended for transplantation.
- Trial name
- PROTECT (NCT02522871)
- Testing
- OCS™ Liver System, Control
- Where
- 20 sites in United States
- Volunteers
- 300 people
- Sponsor
- TransMedics
Heart Transplant Failure and Rejection
Impact of Donor and Recipient ST2 / IL-33 Pathway After Heart Transplantation
Evaluate the association between donor soluble protein ST2 (sST2) serum levels and 30-day recipient mortality in order to improve graft screening.
- Trial name
- ISIDORE (NCT03050892)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Kidney Transplant Rejection
Pilot Study of Treatment for Subclinical AMR (Antibody-mediated Rejection) in Kidney Transplant Recipients
This is a pilot study to determine if extended release Envarsus at an optimal level is just as effective as more invasive standard therapies for subclinical (mild) AMR (antibody mediated rejection) in kidney transplant patients.
- Trial name
- NCT03380936
- Testing
- Tacrolimus Extended Release Oral Tablet [Envarsus], Plasma Exchange and IVIG (Intravenous Immunoglobulin )
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Colorado, Denver
Liver Failure
Evaluation of HDL Subfraction Changes and HDL-Associated Enzymes in Liver Failure Patients and Healthy Donors
This study aimed to determine high-density lipoprotein (HDL) subfraction profile and HDL-associated enzyme changes in liver failure patients and healthy donors.
- Trial name
- NCT05958420
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Akdeniz University
Hepatitis C, Heart Transplant
Expanding the Pool in Orthotopic Heart Transplantation
This is an open-label, pilot trial to test the safety and efficacy of transplantation of hearts from HCV seropositive non-viremic (HCV Ab+/NAT-) and HCV seropositive viremic (HCV Ab+/NAT+) donors to HCV seronegative recipients on…
- Conditions
- Hepatitis C, Heart Transplant, Cardiac Transplant
- Trial name
- NCT03222531
- Testing
- sofosbuvir/velpatasvir
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mary E. Keebler, MD
Chronic Liver Disease and Cirrhosis, Frailty
Role of Exercise in Chronic Liver Disease Patients Undergoing Liver Transplantation
The goal of this randomised clinical trial (open label) is to test the effect of supervised aerobic and resistance exercises in chronic liver disease patients being planned for living donor liver transplantation (LDLT).
- Trial name
- NCT06163001
- Testing
- Supervised aerobic and resistance exercises, Dietary supplementation
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Microbial Colonization, Preterm Birth
Matching Donor Human Milk On Maternal Secretor Status (MMOMSS) Study
This study will evaluate the impact of matching donor human milk to the maternal secretor status of very preterm infants (<34 weeks gestation) on the gut microbiome.
- Trial name
- MMOMSS (NCT04130165)
- Testing
- Matched donor human milk
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University of Manitoba
Living Donor Liver Transplantation
A Comparison of Invasive and Non-invasive Measurement of CI and SVR in Liver Transplantation
Patients who are scheduled to receive living donor liver transplantation will be monitored with a radial and femoral arterial line.
- Trial name
- NCT04909645
- Testing
- Clearsight (finger cuff)
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Hodgkin's Lymphoma
Consolidation PET-based and Donor-based After Salvage Therapy in Patients With HL in Relapse or Refractory
PET-based consolidation and donor-based therapy after rescue in patients with Hodgkin's lymphoma refractory at first line therapy, or relapse early or late, undergone a second line chemotherapy.
- Trial name
- NCT00879528
- Testing
- Patients with negative PET after salvage therapy, Patients with positive PET after salvage therapy
- Where
- 39 sites in Italy
- Volunteers
- 264 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Kidney Transplant, Renal Transplant Recipients
Allogeneic Regulatory Dendritic Cell (DCreg) Renal Study
This study will evaluate the safety and feasibility of treatment involving a single infusion of donor-derived regulatory dendritic cells (DCreg) in first time, living donor renal transplant recipients.
- Trial name
- RTB-006 (NCT03726307)
- Testing
- DCreg: 0.5 million cells/kg+SOC, DCreg: 1.2 million cells/kg+SOC, DCreg:2.5 to 5.0 million cells/kg+SOC
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Angus W. Thomson PhD DSc
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.