Clinical trials: Donor Hepatectomy
Anesthesia of Living Donor Hepatectomy
End Tidal Control of Sevoflurane
the study compares the use of end tidal (Et) control of sevoflurane during anesthesia for living donor hepatectomy versus fresh gas (FGF) control.
- Trial name
- EtCntrl (NCT02676934)
- Testing
- End tidal control module in Aisys anesthesia workstation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Hepatectomy
Milrinone During Living Donor Hepatectomy
Maintaining a low central venous pressure during living donor hepatectomy is routine practice. The investigators tried to test the hypothesis that using milrinone to maintain a low central venous pressure (CVP) during is…
- Trial name
- NCT00966745
- Testing
- milrinone
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Seoul National University Hospital
Complication, Postoperative, Regeneration Liver
Randomized Controlled Trial to Study the Outcome of Intravenous Phosphate Supplementation in Live Donors Undergoing Hepatectomy for Living Donor Liver Transplantation (LDLT)
In this study, we aim to analyse the effect of phosphate supplementation on donors undergoing partial hepatectomy for LDLT. In Group A, we are going to supplement phosphate in donors postoperatively from day 1 to day 5.
- Trial name
- NCT04026438
- Testing
- Potassium Phosphate Injection
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatectomy
Hepatic and Portal Vein Transection by Vascular Stapler in Open Living Donor Hepatectomy
To enhance donor safety in living donor liver transplantation (LDLT), the use of vascular staplers for the division of the right portal and hepatic veins in patients undergoing right lobe liver donation has been introduced.
- Trial name
- NCT06910852
- Testing
- Vascular stapler
- Where
- Jordan
- Volunteers
- 17 people
- Sponsor
- Abdalla Bashir, MD
Donor Hepatectomy
Drain vs No Drain After Live Donor Hepatectomy
Prophylactic abdominal drain placement after donor hepatectomy has been a common or even mandatory practice in most transplant centers.
- Trial name
- NCT06769776
- Testing
- No Drain i.e. Omission of abdominal drain placement
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Marengo Asia Hospitals
Quality of Life
Quality of Life and Psychology of Donors After Hepatectomy
Liver donation by a living donor is major surgery and has a profound effect on health-related quality of life and psychology. This study aims at evaluating those aspects of a donor for a period of five years after surgery.
- Trial name
- NCT04150185
- Testing
- Donor hepatectomy
- Volunteers
- 52 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Healthy Donors for Liver Transplantation
Comparison Between Pure Laparoscopic Donor Right Hepatectomy and Convensional Donor Right Hepatectomy
Perioperative clincal outcome between PLDRH and conventional open donor right hepatectomy (ODRH) will be compared retrospectively.
- Trial name
- NCT05040529
- Testing
- pure laparoscopic donor hepatectomy, conventional open donor hepatectomy
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Gangnam Severance Hospital
Donor Hepatectomy, Central Venous Catheter
Spectral Analysis of Central Venous Pressure Waveform
The use of central venous pressure has been abandoned for the assessment of intravascular volume status. The dynamic fluctuation of central venous pressure according to heart rate is quantitatively measured by spectral analysis…
- Conditions
- Donor Hepatectomy, Central Venous Catheter, Hypovolemia
- Trial name
- NCT04733547
- Testing
- Placement of a central venous catheter, Monitoring of central venous pressure, Furosemide-induced hypovolemia before graft procurement
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- JongHae Kim
Antibiotic Prophylaxis, Postoperative Infection
Comparison of 9 Doses vs 3 Doses of Post Operative Antibiotics in Live Liver Donors
Antibiotic resistance is a very serious and dangerous situation in modern world. Judicious use of antibiotics is therefore of extreme importance not just in preventing antibiotic resistance but also it decreases cost of the…
- Trial name
- NCT03765645
- Testing
- Piperacillin + Tazobactam
- Where
- India
- Volunteers
- 126 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Hepatic Transplantation
Clamp-crush Technique Versus Harmonic Scalpel in Living Donor Hepatectomy
The purpose of this study is to determine whether clamp-crush technique for liver parenchymal transection is as safe as Harmonic scalpel device.
- Trial name
- KK_HS (NCT02853981)
- Testing
- Harmonic scalpel, Kelly clamp crush technique
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Cirrhosis, Hepatitis C
Adult-to-Adult Living Donor Liver Transplantation Study
There are two principal purposes of this study: 1) to determine whether it is more beneficial for a liver transplant recipient candidate to pursue a living donor liver transplant (LDLT) or wait for a deceased donor liver…
- Conditions
- Cirrhosis, Hepatitis C, Hepatocellular Carcinoma
- Trial name
- A2ALL-1 (NCT00096733)
- Where
- 9 sites in United States
- Volunteers
- 2,470 people
- Sponsor
- Arbor Research Collaborative for Health
Colorectal Cancer, Liver Metastasis
Liver Transplantation for Colorectal Cancer
This is an observational study that will follow adults with stage IV colorectal cancer whose disease has spread only to the liver (not to other organs) and who are undergoing a liver transplant as part of their cancer treatment.
- Trial name
- NCT07884110
- Testing
- Liver transplantation
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- Pontificia Universidad Catolica de Chile
CVP and SVV During Living Donor Hepatectomy, Surgical Field Grade (Condition of Surgical Field; Bleeding, Tension of the IVC)
Vasodilator-induced Hypovolemia in Living Liver Donors
Induced hypovolemia is known to improve surgical field during living donor hepatectomy. This procedure is conventionally guided by monitoring the central venous pressure (CVP).
- Trial name
- NCT02033967
- Testing
- vasodilator induced hypovolemia
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Seoul National University Hospital
Chronic Liver Disease and Cirrhosis, Liver Transplant; Complications
Magnetic Resonance Cholangiopancreatography in Living Liver Donors and Its Relationship With Post Operative Recipient Biliary Complications
Living donor liver transplantation is widely accepted as an life-saving treatment for patients with end-stage liver diseases. Careful donor selection is essential to maximize the success and minimize the risk of postoperative…
- Conditions
- Chronic Liver Disease and Cirrhosis, Liver Transplant; Complications, Donor Hepatectomy
- Trial name
- NCT07715500
- Testing
- Magnetic Resonance Cholangiopancreatography
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Living Donor Hepatectomy
Transversus Abdominus Plane Block in Living Donor Hepatectomy
Comparing different drugs used in Transversus abdominus plane analgesia after donor hepatectomy. Patients will be divided into three groups; control group, Bupivecaine group, and Dexmedetomedine group according to the used drug
- Trial name
- TAP Donor (NCT02708459)
- Testing
- surgically inserted Transversus abdominus plane catheter, Intravenous morphine, Bupevecaine
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- AlRefaey Kandeel
Healthy
Effect of Preoperative Carbohydrate Loading on Post-operative Insulin Resistance After Donor Hepatectomy.
It's a randomized control trial to compare the effect of preoperative carbohydrate loading versus fasting on post operative insulin resistance after donor hepatectomy in terms of donor outcomes.
- Trial name
- NCT05293444
- Testing
- Maltodextrine, overnight fasting
- Where
- India
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Donor Hepatectomy, Serum Lactate
Effect of Preoperative Carbohydrate Loading on Serum Lactate Levels in Patients Undergoing Donor Hepatectomy
This randomized controlled trial investigated whether preoperative carbohydrate loading reduces perioperative serum lactate levels in patients undergoing donor hepatectomy.
- Conditions
- Donor Hepatectomy, Serum Lactate, Preoperative Carbohydrate Loading
- Trial name
- NCT07723391
- Testing
- Preoperative Carbohydrate Loading
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shifa International Hospital
Liver Failure, Liver Transplant; Complications
Intravenous Ketamine Infusion on Postoperative Analgesia of Living Liver Donors
Because of the insufficiency of cadaveric organs and increasing need for organs, the interest in living donor liver transplantation have been greatly increased.
- Conditions
- Liver Failure, Liver Transplant; Complications, Post Operative Pain
- Trial name
- NCT05441150
- Testing
- Low dose ketamine infusion, 0.9% NaCl infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Inonu University
Right Hepatectomy
Hepatic Hemodynamic Changes and Simulation in Living-Related Liver Transplantation
This 1-year project is intended to study the hemodynamic changes of poratal and hepatic artery during living related liver transplantation.
- Trial name
- NCT00234624
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital