Clinical trials: Donor Nephrectomy
Renal Disease
Comparison of Low Versus Normal Pressure Pneumoperitoneum - With Profound Low Versus Normal Pressure Pneumoperitoneum -With Profound Muscle Relaxation- During Laparoscopic Donor Nephrectomy
As both patients with end-stage kidney disease and society benefit tremendously from live kidney donation, the safety and well-being of kidney donors are highly important objectives in live kidney donation.
- Trial name
- LEOPARD2 (NCT02146417)
- Testing
- Low pressure pneumoperitoneum, Normal pressure pneumoperitoneum (12 mmHg), Deep neuromuscular block
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Radboud University Medical Center
Living Donors
Postoperative Analgesia After Laparoscopic Living Donor Nephrectomy
The aim of the study is to investigate if perioperative administration of pregabalin vil reduce postoperative pain and the postoperative need for intravenous opioids compared with todays standard treatment which consist of…
- Trial name
- NCT01059331
- Testing
- Pregabalin, Sugar pill
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Living Kidney Donation
The Living Kidney Donor Safety Study
The main goal of this study is to understand the long-term effects of kidney donation on blood pressure, kidney function, and patient-reported health-related quality of life.
- Trial name
- LKD (NCT00936078)
- Where
- 13 sites in Australia, Canada
- Volunteers
- 1,438 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Pain, Postoperative
Study Evaluating the Effects of Toradol and Lyrica for Pain Control After Donor Nephrectomy
The investigators will assess how the use of toradol and pregabalin affects return to bowel function and see if there is a difference in length of hospital stay.
- Trial name
- NCT03669081
- Testing
- Ketorolac, Pregabalin, Saline
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Utah
Renal Transplant Donor of Left Kidney, Donor Nephrectomy
Robotic Single Port Donor Nephrectomy
Feasibility study on robotic-assisted single-site donor nephrectomy utilizing da Vinci instrumentation and Single-Site platforms.
- Conditions
- Renal Transplant Donor of Left Kidney, Donor Nephrectomy, Robotic Surgery, Single-port
- Trial name
- NCT01925677
- Testing
- da Vinci® Single-Site™
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Kidney Donation
Study of Prospective Assessment of Living Kidney Donors: Pre and Post Donation
This is a prospective assessment of 80 living kidney donors.
- Trial name
- NCT00813579
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Kidney Transplantation
Donor Recipient Kidney Function Following Open Surgical vs. Laparoscopic Kidney Donation
This study will evaluate the differences between open surgical kidney donation and laparoscopic kidney donation on kidney donors and recipients.
- Trial name
- NCT00100516
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Kidney Diseases, Kidney Transplant Failure and Rejection
The Microbiota in Kidney Donation and Transplantation
The human gastrointestinal tract harbours ~40 trillion microbial cells, far outnumbering the cell number, and therefore the genetic content of its host.
- Conditions
- Kidney Diseases, Kidney Transplant Failure and Rejection, Urinary Tract Infections
- Trial name
- NCT04388930
- Testing
- Pre-operative assessment - blood, urine, & faecal sample, Post-operative day 3 assessment - blood, urine, & faecal sample, Post-operative week 4-6 assessment - blood, urine, & faecal sample
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Royal Free Hospital NHS Foundation Trust
Living Donors, Nephrectomy
Conventional Laparoscopic Versus Laparoendoscopic Single Site Donor Nephrectomy in Living Donor Kidney Transplantation
Laparoscopic nephrectomy (removal of the kidney) is the most common procedure for people donating a kidney to be used for living donor kidney transplantation.
- Conditions
- Living Donors, Nephrectomy, Kidney Transplantation, Surgery, Laparoscopic
- Trial name
- NCT01236326
- Testing
- Laparoendoscopic single site donor nephrectomy, Conventional laparoscopic donor nephrectomy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Weill Medical College of Cornell University
Transplant;Failure,Kidney
The Learning Curve for Retroperitoneoscopic Donor Nephrectomy
Purpose: The aim of the study is to identify a precise learning curve for pure retroperitoneoscopic donor nephrectomy (RDN). Methods: Data from 172 consecutive kidney donors who underwent pure RDN between January 2010 and July…
- Trial name
- NCT05790746
- Where
- Turkey (Türkiye)
- Volunteers
- 172 people
- Sponsor
- Samsun Liv Hospital
Nephrostomy; Complications, Pneumoperitoneum
A Trial Comparing Deep Versus Moderate Neuromuscular Block - in Low Pressure Pneumoperitoneum
Live kidney transplantation is first choice for patients with end-stage kidney disease. Therefore, the safety and well-being of kidneys donors are highly important objectives in live kidney donation.
- Conditions
- Nephrostomy; Complications, Pneumoperitoneum, Observation of Neuromuscular Block
- Trial name
- LEOPARD-3 (NCT02602964)
- Testing
- Deep neuromsucular block
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Radboud University Medical Center
Postoperative Pain, Kidney Transplant; Complications
Thread Embedding Acupuncture vs Sham on Acute Pain and Quality of Life After Laparoscopic Nephrectomy of Living Donor
This randomized, double-blind controlled study aims to evaluate the effectiveness of thread implantation acupuncture at EX-B2 L1 in reducing postoperative pain and improving quality of life in patients undergoing laparoscopic…
- Trial name
- NCT07243301
- Testing
- Thread implantation acupuncture
- Where
- Indonesia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Kidney Transplantation
Medical Economic Evaluation and of Quality of Life of the Kidney Living Donors.
The main objective of this multicentre study is to conduct the evaluation of cost-efficiency of various techniques of kidney taking with regard the quality of life of the kidney living donors.
- Trial name
- DOVIREIN (NCT02830568)
- Testing
- open donor nephrectomy, standard and hand-assisted laparoscopic donor nephrectomy, laparoscopic robotic-assisted nephrectomy
- Where
- 24 sites in France
- Volunteers
- 268 people
- Sponsor
- Central Hospital, Nancy, France
Quadratus Lumborum Block, Surgical Wound Infiltration
Surgeon Infiltration QL Block Comparison
The purpose of this study is to learn if using a Quadratus Lumborum (QL) plane injection technique (also called a "nerve block") that numbs the nerves going to the abdominal area improve pain control after surgery compared to…
- Trial name
- NCT03496610
- Testing
- Liposomal Bupivicaine, QL Block
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University
End Stage Kidney Disease
Evaluation of a Website on Living Kidney Donation for Hispanics
The purpose of this study is to increase understanding about living kidney donation (LKD) among Hispanic/Latino patients and public by increasing knowledge and positive attitudes about LKD.
- Trial name
- NCT01859871
- Testing
- Website Intervention
- Where
- 2 sites in United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Kidney Function Test
Development of a Bayesian Estimator for Calculating Plasma Iohexol Clearance
In kidney transplantation, donor selection is based in part on the assessment of the functional capacity of the kidneys. For this purpose, it is recommended to measure the glomerular filtration rate (GFR) by a reference…
- Trial name
- CLIO (NCT05136963)
- Testing
- Iohexol, pharmacokinetics
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Transplant, Kidney Diseases
Donor Outcomes Following Hand-Assisted and Robotic Living Donor Nephrectomy: a Retrospective Review
1.1. Background: Renal transplantation is the treatment of choice for eligible patients with end-stage renal disease. It provides better outcomes in terms of life expectancy and quality of life than dialysis (Liu, Narins, Maley…
- Trial name
- NCT04182607
- Testing
- kidney transplant
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Methodist Health System
Patients Awaiting a Living Kidney Donation
Desensitization With Bortezomib Before a Living Kidney Donation
The investigators plan to study the role of bortezomib for desensitizing patients awaiting a living kidney donation who have a titer of Donor Specific anti human leucocyte antigen (HLA) Antibody (DSA) between 1000 and 3000 MFI…
- Trial name
- VELDON (NCT01842074)
- Testing
- Bortezomib
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Renal Failure Chronic, Surgery
Laparoscopic Donor Nephrectomy Score, a New Scoring System for Preoperative Prediction of Difficulty of Laparoscopic Donor Nephrectomy
The goal of this multicenter observational study is to develope and validate a new scoring system for preoperative prediction of difficulty of Laparoscopic Donor Nephrectomy. Healthy living kidney donors will be enrolled.
- Trial name
- LAPDOCTOR (NCT05769686)
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jacopo Romagnoli
Living Kidney Donors Undergoing VAMS-nephrectomy
Effect of Oral Pregabalin on Hyperalgesia and Post-operative Pain in Patients Undergoing Nephrectomy Surgery: Sex Differential Study
Hyperalgesia is known to be caused by the excitatory amino acid through NMDA receptor. GABA, an inhibitory amino acid, alters the opioid receptor sensitivity against pain resulting hyperalgesia.
- Trial name
- NCT02340455
- Testing
- Pregabalin_male, Pregabalin_female
- Where
- South Korea
- Sponsor
- Yonsei University