Clinical trials: Donor Sites
Burns, Skin Graft Complications
Suprathel Versus Xeroform for the Management of Skin Graft Donor Sites
The investigators aim to study whether Suprathel, a synthetic temporary skin substitute developed by PolyMedics Innovations GmBH aids in the management of patient pain and wound healing when compared to the current standard…
- Conditions
- Burns, Skin Graft Complications, Skin; Deformity
- Trial name
- Suprathel (NCT04014400)
- Testing
- Suprathel or Xeroform donor site application
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Evaluate the Safety and Effectiveness of Mesenchymal Stem Cell Conditioned Medium-derived Pleiotropic Factor in Treating Donor Sites
Mesenchymal Stem Cell-derived Pleiotropic Factor in the Treatment of Donor Sites
Skin grafting is a standard treatment for deep wounds, but care of the donor site after transplantation is very important. The means of accelerating wound healing can increase overall patient satisfaction.
- Trial name
- NCT04234750
- Testing
- mesenchymal stem cell conditioned medium-derived pleiotropic factor
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Chinese PLA General Hospital
Breast Cancer
Decellularized, Whole Donor Nipple-Areola Complex Reconstruction Grafts
The goal of this study is to evaluate safety and healing time after nipple-areolar complex (NAC) reconstruction with the BioAesthetics' decellularized human nipple-areolar complex (dcl-hNAC) graft in patients who have had…
- Trial name
- NCT04534010
- Testing
- NACgraft
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Stanford University
Burn Scar, Scar
CO2 Laser Revision for Burn Related Donor Site Scars
Scarring from burn wounds remains a chronic and often severe sequela of burn injury. Burn wounds may be left to heal by secondary intention or treated with surgical skin grafting; in both circumstances, significant scars likely…
- Conditions
- Burn Scar, Scar, Skin Graft Scar
- Trial name
- NCT04456127
- Testing
- Fractional CO2 Laser
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medstar Health Research Institute
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission
Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies
This pilot phase II trial studies how well giving vorinostat, tacrolimus, and methotrexate works in preventing graft-versus-host disease (GVHD) after stem cell transplant in patients with hematological malignancies.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities, Adult Acute Myeloid Leukemia With Del(5q)
- Trial name
- NCT01789255
- Testing
- vorinostat, tacrolimus, cyclosporine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Pediatric Patients, Hematologic Malignancy
TCR Alpha/Beta and CD19-deplete Haplo-HSCT
This is an open label, interventional, non-randomized, phase II trial of TCR alpha/beta and CD19-depeleted allogeneic HCT in pediatric patients with hematologic disease.
- Conditions
- Pediatric Patients, Hematologic Malignancy, Other Hematologic Condition
- Trial name
- NCT05288595
- Testing
- CliniMACS Plus Instrument
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hematological Malignancies
Observational Study of the Combination of Post-transplant High Dose Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Acute Graft-versus-Host Disease in Patients Eligible to Allogeneic Hematopoietic Stem Cell Transplant
This observational study is proposed to observe the effect of high-dose, post-transplantation cyclophosphamide after a T cell-replete, HLA-matched PBSC graft from an HLA-identical or mismatched donor.
- Trial name
- NCT02300571
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Hcc
Salvage Living Donor Liver Transplantation for HCC Beyond All Criteria Yield Equivalent Results to Milan Criteria
The present study aims to evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients.
- Trial name
- NCT04069416
- Testing
- living donor liver transplantation
- Volunteers
- 241 people
- Sponsor
- Ain Shams University
Breast Cancer, Chronic Myeloproliferative Disorders
Collecting and Storing Tissue and DNA Samples From Patients Undergoing a Donor Stem Cell Transplant
RATIONALE: Collecting and storing samples of blood, urine, and tissue from patients undergoing a donor stem cell transplant to test in the laboratory may help the study of graft-versus-host disease in the future.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00900406
- Testing
- gene expression analysis, microarray analysis, polymorphism analysis
- Where
- 3 sites in United States
- Volunteers
- 190 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Hematologic Neoplasms, Relapse
Amplifying Graft-Versus-Tumor Effect by Donor Regulatory T-Cell Depletion Before Donor Lymphocytes Infusion
The investigators have previously shown that depletion of CD4+CD25+FoxP3+ regulatory T cells (Treg) enhances the alloreactivity of T lymphocytes, as attested by an accelerated GVHD after allogeneic hematopoietic stem cell…
- Trial name
- ILD-Treg (NCT00987987)
- Testing
- donor lymphocyte infusion
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Burns
Microcurrent for Healing Autogenous Skin Donor Sites
This single-center, prospective, randomized, and controlled study evaluated the efficacy of silver-coated dressing with active microcurrent in comparison to silver-coated dressing with sham microcurrent on wound-closure time for…
- Trial name
- NCT00558701
- Testing
- Microcurrent stimulator, Silverlon Wound Contact Dressing
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- United States Army Institute of Surgical Research
Colorectal Cancer, Liver Metastases
The Swedish Study of Liver Transplantation for Non-resectable Colorectal Cancer Metastases
To evaluate if the addition of liver transplantation primarily utilizing liver grafts from extended criteria donors not utilized for approved indications to conventional treatment of non-resectable/ non-abatable colorectal liver…
- Conditions
- Colorectal Cancer, Liver Metastases, Colorectal Liver Metastases
- Trial name
- SOULMATE (NCT04161092)
- Testing
- Liver transplantation Ltx, Best alternative care
- Where
- 2 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Vastra Gotaland Region
Pain, Postoperative, Burns
Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain
Donor site pain study comparing post-operative donor site pain and opioid consumption after use of Lidocaine, Liposomal Bupivicaine or regional nerve block for split thickness skin graft harvesting in patients with less than 20%…
- Trial name
- NCT03854344
- Testing
- Lidocaine Hydrochloride, Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Kansas Medical Center
Skin Graft
Compare of Petrolatum Gauze, Allevyn, and New Dressing, Betafoam® in the Management of Split-Thickness Skin Graft Donor Site
This study is a randomized, controlled, multi-centre, open-label, phase IV study. Total 81 patients will be enrolled in this study.
- Trial name
- NCT02543034
- Testing
- Betafoam Wound Dressing, Petrolatum Gauze, Allevyn Wound Dressing
- Where
- South Korea
- Volunteers
- 105 people
- Sponsor
- Mundipharma Korea Ltd
Burns
Evaluation of Dermafill Dressing for Donor Sites
The purpose of the study is to compare one type of dressing against the current standard dressing that is used to cover the unburned area of the skin where a piece of skin is removed to cover another part of the body that was…
- Trial name
- NCT00137163
- Testing
- Dermafill Dressing
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- United States Army Institute of Surgical Research
Hematological Malignancies, CMV Infection
CMV Specific T Cell Therapy After Allogeneic Stem Cell Transplantation.
Viral infections remain an important cause of morbidity and mortality after allogeneic stem cell transplantation (SCT), especially after myelo-ablative conditioning and if the donor is antigen-mismatched or haplo-identical..
- Trial name
- NCT03067155
- Testing
- CMV-specific T cells, Standard anti-viral therapy
- Where
- 8 sites in Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Ghent
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Stem Cell Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy and radiation therapy used to kill tumor cells.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT00004904
- Testing
- anti-thymocyte globulin, filgrastim, cladribine
- Where
- United States
- Sponsor
- Northwestern University
Gingival Recession, Mucogingival Surgery
Role of Manuka Honey in Lowering Pain and Boosting Healing After Gum Graft Surgery.
The goal of this clinical trial is to learn if medical grade Manuka Honey works to lower pain and improve healing sites after gum grafting surgery.
- Trial name
- NCT07016373
- Testing
- Palatal Plate without Manuka Honey, Palatal plate with Manuka Honey
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Nancy Mouradian
Wound Closure, Wound Care
Safety Study of Microlyte DualGuard
The primary purpose of this research is to evaluate the safety and effectiveness of Microlyte® DualGuard wound dressing in the healing of partial thickness donor site wounds, also known as skin graft donor sites.
- Trial name
- SAGGA (NCT07695688)
- Testing
- Microlyte DualGuard, Allevyn Foam (Standard of Care Control)
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Imbed Biosciences
Organ Donation
Investigating Affective Attitude Question-behaviour Effects on Intention to Become an Organ Donor
The investigators aim to experimentally manipulate presence of questions on positive or negative affective attitudes to see if including these moderate as intention to become an organ donor.
- Trial name
- NCT02825862
- Testing
- Question-behaviour effect (for affective attitudes), Question-behaviour effect (negatively-worded attitudes)
- Where
- 4 sites in India, Ireland and 2 more
- Volunteers
- 999 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland