Clinical trials: Dose-response Relationship
Amphetamine-Related Disorders
Ondansetron for the Treatment of Methamphetamine Dependence - 1
The purpose of this study is to assess ondansetron for the treatment of methamphetamine dependence.
- Trial name
- NCT00040053
- Testing
- Ondansetron
- Where
- 6 sites in United States
- Volunteers
- 154 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Spinal Manipulation
The Role of the Rate of Force Application in Responses to Spinal Manipulation Therapy
The objective of the present study is to determine if spinal manipulations with a constant rate of force application but with different peak force and time to peak force lead to similar responses in healthy adults.
- Trial name
- NCT02550132
- Testing
- Spinal manipulation, Apparatus used to deliver spinal manipulations
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université du Québec à Trois-Rivières
Treatment Resistant Depression
Establishing a Dose-response Relationship With Accelerated Transcranial Magnetic Stimulation
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression.
- Trial name
- NCT04243798
- Testing
- Active TBS-DLPFC
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Stanford University
AIDS Dementia Complex, HIV Infections
Safety and Effectiveness of CPI-1189 in HIV-Infected Males on Combination Anti-HIV Drug Therapy
The purpose of this study is to see if it is safe to give multiple doses of CPI-1189 to HIV-infected, otherwise healthy, males. The study will also look at how CPI-1189 affects the levels of HIV, T cells (cells in the body that…
- Trial name
- NCT00002209
- Testing
- CPI-1189
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Centaur Pharmaceuticals
HIV Infections
An Escalating Dose Tolerance Trial of BG8962 (rCD4) in Patients Who Are HIV Antibody Positive
To determine the maximal safe daily dose of BG8962 (rCD4) which can be administered by continuous subcutaneous infusion (CSCI) over 24 hours; to determine the pharmacokinetics of BG8962 when it is administered by intramuscular…
- Trial name
- NCT00000721
- Testing
- CD4 Antigens
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Shivering, Postoperative Shivering
Optimizing the Paracetamol Dose for Prevention of Post-Spinal Shivering in Lower Limb Orthopedic Surgeries
Shivering is a common and distressing complication following spinal anesthesia, affecting up to 70% of patients. It significantly increases oxygen consumption, places stress on the cardiovascular system, and interferes with…
- Conditions
- Shivering, Postoperative Shivering, Hypothermia
- Trial name
- NCT07855575
- Testing
- Paracetamol 2 g, Paracetamol 1 g
- Volunteers
- 150 people
- Sponsor
- Assiut University
Diabetic Nephropathy, Hypertension
Angiotensin II Antagonism of TGF-Beta 1
Diabetic nephropathy is a frequent microvascular complication that occurs in approximately 40% of patients with either type 1 or type 2 diabetes.
- Trial name
- NCT00320970
- Testing
- Candesartan
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Providence Health & Services
HIV Infections
A Study to Test the Safety of Recombinant Interleukin-2 (rIL-2) in HIV-Infected Children
The purpose of this study is to determine the safety and maximum tolerated dose (the highest dose that can be given safely) of recombinant Interleukin-2 (rIL-2) in HIV-infected children.
- Trial name
- NCT00000849
- Testing
- Aldesleukin
- Where
- 14 sites in United States
- Volunteers
- 27 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Phase I Trial of S-1153 in Patients With HIV Infection
To assess the toxicity profile and determine the maximum tolerated dose (MTD), if possible, of S-1153 administered orally 3 times daily for 14 days. To investigate the clinical pharmacokinetic parameters for S-1153.
- Trial name
- NCT00002214
- Testing
- Capravirine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Lexigen Pharmaceuticals
Prediabetes
Safety and Dose-Response of Bletilla Formosana in Prediabetic Subjects
This study evaluates the safety and preliminary efficacy of Bletilla formosana (BF), a traditional herbal medicine, in adults with prediabetes.
- Trial name
- NCT07704944
- Testing
- Bletilla formosana (BF) powder
- Where
- 3 sites in Taiwan
- Volunteers
- 94 people
- Sponsor
- Chang Gung Memorial Hospital
Skeletal Muscle Relaxation
A Study to Evaluate the Safety, Tolerability and Dose-Response Relationship of HRS-9190 in Healthy Subjects
This is a single-center, open-label and dose-escalation study to evaluate the safety, tolerability and dose-response relationship of HRS-9190 in healthy adults.
- Trial name
- NCT06932315
- Testing
- HRS-9190 for Injection
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Mitochondrial Function, Glucose Intolerance
Dose-response Relationship Between Exercise and Health Outcomes
In this study 11 healthy volunteers will perform high intensity exercise training during 4 weeks. The exercise frequency will increase progressively during the first three weeks, followed by a fourth week with lower exercise…
- Trial name
- NCT04753021
- Testing
- Exercise
- Where
- Sweden
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- The Swedish School of Sport and Health Sciences
Candidiasis, Esophageal, HIV Infections
A Study of the Side Effects of L-743,872 in Men With Candidal Esophagitis
The purpose of this study is to see if it is safe to give L-743,872 to men with candidal esophagitis, an AIDS-related yeast infection in the esophagus.
- Trial name
- NCT00005921
- Testing
- L-743,872
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV Infections
A Study of Dextran Sulfate in HIV-Infected Patients and in Patients With AIDS or AIDS Related Complex (ARC)
To determine the effectiveness and safety of dextran sulfate (DS) as a treatment for patients with AIDS, AIDS related complex (ARC), or asymptomatic HIV infection with or without persistent generalized lymphadenopathy (PGL), and…
- Trial name
- NCT00001009
- Testing
- Dextran sulfate
- Where
- 8 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pertussis, Pregnancy Related
Seroprevalence of Bordetella Pertussis Antibodies and Anti-pertussis Antibody Response After a Single Dose of Tdap in Pregnant Thai Women
This study evaluated the seroprevalence of Bordetella pertussis antibodies and anti-pertussis antibody response after a single dose of reduced-antigen, combined diphtheria, tetanus, and acellular pertussis vaccine (Tdap) in…
- Trial name
- NCT03498300
- Testing
- Tdap vaccine
- Where
- Thailand
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Substance Dependence
Effects of the D3 Antagonist GSK598809 on Food Reward and Reinforcement
This novel compound is a new experimental treatment that may help people to stop compulsive overeating. Compulsive overeating or binge eating is one of the main reasons why people are overweight or obese.
- Trial name
- NCT01039454
- Testing
- GSK598809 Capsules
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections
A Study of LXR015-1 in HIV-Infected Patients
To determine and compare the safety and tolerability of 3 doses of LXR015-1 in HIV-infected patients.
- Trial name
- NCT00002365
- Testing
- LXR015-1
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- LXR Biotechnology
Pneumococcal Infection, Streptococcus Pneumoniae Infection
The Effect of Fractional Doses of Pneumococcal Conjugate Vaccines on Immunogenicity and Carriage in Kenyan Infants
Before the introduction of pneumonia vaccines in 2000, between 700,000 - 1 million children died each year as a result of infection with the bacteria Streptococcus pneumoniae and the resulting diseases, namely, meningitis, sepsis…
- Conditions
- Pneumococcal Infection, Streptococcus Pneumoniae Infection, Invasive Pneumococcal Disease, Protection Against
- Trial name
- FPCV (NCT03489018)
- Testing
- PCV10, PCV13
- Where
- Kenya
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Opioid Withdrawal
Dexmedetomidine in the Treatment of Symptoms Of Acute Opioid Withdrawal
This Phase 1b/2 inpatient study assessed the safety, pharmacokinetics, and early signs of efficacy of escalating doses of BXCL501 versus placebo following discontinuation of morphine maintenance.
- Trial name
- NCT04470050
- Testing
- Dexmedetomidine
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- BioXcel Therapeutics Inc
Multiple Myeloma
Pamidronate Prophylaxis in Multiple Myeloma 30 mg/Month Versus 90 mg/Month
Multiple myeloma is a malignant hematological disease dominated by monoclonal plasma cells in the bone marrow. Major symptoms are related to the bones due to an increased bone resorption and a decreased bone formation leading to…
- Trial name
- NCT00376883
- Testing
- pamidronate
- Where
- 14 sites in Denmark, Norway and 1 more
- Volunteers
- 500 people
- Sponsor
- Nordic Myeloma Study Group