Clinical trials: Double-blind Randomized Controlled Study
Chronic Rhinosinusitis Without Nasal Polyps
A Study of the Efficacy and Safety of Brensocatib in Participants With Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
The primary purpose of the study is to evaluate the efficacy of brensocatib at 10 and 40 milligrams (mg) once daily (QD) compared with placebo in improving clinical symptoms of CRSsNP.
- Trial name
- BiRCh (NCT06013241)
- Testing
- Brensocatib, Mometasone furoate nasal spray (MFNS)
- Where
- 100 sites in United States, Argentina and 13 more
- Volunteers
- 288 people
- Sponsor
- Insmed Incorporated
Nonalcoholic Steatohepatitis (NASH)
To Evaluate the Safety, Tolerability, Pharmacokinetics and Food Effects of IMM-H014 in Healthy Subjects
This study will evaluate the safety, tolerability and pharmacokinetics (PK) of escalating single- and multiple-oral doses of IMM-H014 on fasted condition, and characterize PK of IMM-H014 on an empty stomach (fasted condition) and…
- Trial name
- NCT06216041
- Testing
- IMM-H014, IMM-H014 ( FE)
- Where
- China
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Changchun Intellicrown Pharmaceutical Co. LTD
Healthy
A Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability of Single- and Multiple-Ascending Doses of MH-001 in Healthy Volunteers
First-in-Human study to demonstrate the safety and tolerability of single- and multiple-ascending doses of MH-001 in Healthy Volunteers (HVs)
- Trial name
- NCT06780254
- Testing
- MH-001
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Vespina Lifesciences Inc.
Helicobacter Pylori Infection
Study of the Usefulness of the Probiotic 'Lactobacillus Reuteri' in the Therapy of Quadruple Eradication of Helicobacter Pylori Infection in Usual Clinical Practice.
Helicobacter pylori is a Gram-negative bacterium with a helical bacillus shape that it's able to penetrate and colonize the stomach mucosal lining by infecting it. The eradication treatment of H.
- Trial name
- NCT03150394
- Testing
- GASTRUS
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Dr. Luis Fernandez
Hyperhidrosis, Palmar Hyperhidrosis
Clinical Study to Assess the Efficacy and Safety of AT-5214 in the Treatment of Subjects With Palmar Hyperhidrosis
This is a multicenter, randomized, double-blind, placebo-controlled, parallel group comparison study of AT-5214 in subjects with moderate to severe primary palmar hyperhidrosis (sweaty palms).
- Trial name
- NCT04263623
- Testing
- Dexmecamylamine HCl
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Atacama Therapeutics
Schizophrenia
Study of CYR-101 in Patients With Schizophrenia
This Phase II study will test whether CYR-101, a CNS-active compound with novel pharmacological profile and devoid of dopamine D2 receptor binding properties, is efficacious when administered orally in the management of patients…
- Trial name
- NCT00861796
- Testing
- CYR-101
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Cyrenaic Pharmaceuticals
Seasonal Allergic Rhinitis
A Study to Evaluate the Safety & Effectiveness of a Nasal Spray to Treat Seasonal Allergies
The Purpose of this study is to determine if one allergy medication (0.15% azelastine hydrochloride) is more effective than Placebo alone
- Trial name
- NCT00719862
- Testing
- 0.15% azelastine hydrochloride Nasal Spray
- Where
- 34 sites in United States
- Volunteers
- 481 people
- Sponsor
- Meda Pharmaceuticals
Gallbladder Inflammation
Vitamin C Efficacy in Reducing Post Operative Pain
Opioids are the corner stone in the treatment of post operative pain. Because of the several side effects of opiods, non-steroidal anti-inflammatory drugs are usually added postoperatively to decrease the total requirements of…
- Trial name
- NCT01322061
- Testing
- Ascorbic Acid
- Where
- Lebanon
- Volunteers
- 80 people
- Sponsor
- American University of Beirut Medical Center
GI Health
Radicle GI Health™: A Study Assessing the Impact of Health and Wellness Products on Gastrointestinal (GI) Health
A randomized, double-blind, placebo-controlled study assessing the impact of health and wellness products on GI health and related health outcomes.
- Trial name
- NCT06999642
- Testing
- GI Health Active Product
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Seropositive RA
The BCD-089 (aIL6R) in Patients With Active Rheumatoid Arthritis
The study is Phase II randomized, double-blind, placebo-controlled clinical trial to evaluate efficacy and safety, pharmacokinetics and pharmacodynamics of 2 dosing regimens (qw and q2w, s/c) of monoclonal antibody to IL6R…
- Trial name
- AURORA (NCT03455842)
- Testing
- BCD-089, 162 mg, s/c, qw, BCD-089, 162 mg, s/c, q2w
- Where
- 4 sites in Belarus, Russia
- Volunteers
- 105 people
- Sponsor
- Biocad
Diabetes Mellitus Type 2
A Study of Taspoglutide in Patients With Inadequately Controlled Diabetes Mellitus Type 2 and Cardiovascular Disease
This randomized, double-blind, placebo-controlled parallel arm study will assess efficacy and safety and the effects of taspoglutide on cardiovascular events in patients with inadequately controlled type 2 diabetes mellitus and…
- Trial name
- NCT01018173
- Testing
- taspoglutide
- Where
- 288 sites in United States, Australia and 23 more
- Volunteers
- 2,118 people
- Sponsor
- Hoffmann-La Roche
Pneumococcal Immunization
Study of a 4-Dose Regimen of a 21-valent Pneumococcal Conjugate Vaccine in Healthy Infants From Approximately 2 Months of Age
This study is a Phase 3, randomized, modified double-blind study which aims to measure whether PCV21 vaccine (investigational pneumococcal conjugate vaccine) is safe and can help the body to develop germ-fighting agents called…
- Trial name
- NCT06736041
- Testing
- PCV21 vaccine, Prevnar 20 vaccine, M-M-R II vaccine
- Where
- 112 sites in United States, Australia and 4 more
- Volunteers
- 1,714 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Obesity &Amp; Overweight
Phase Ib Clinical Study on the Efficacy and Safety of MDR-001 in Patients Who Are Obesity or Overweight
This is a 12 weeks, multicenter, randomized, double-blind, placebo, parallel-controlled Phase Ib trail comparing the efficacy and safety of MDR-001 tablet versus placebo as an adjunct to a reduced calorie diet and increased…
- Trial name
- NCT07110766
- Testing
- MDR-001
- Where
- China
- Volunteers
- 24 people
- Sponsor
- MindRank AI Ltd
Atopic Dermatitis
A Clinical Study of HRS-8797 in Healthy Participants
The purpose of this phase I study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-8797 in healthy participants.
- Trial name
- NCT07698756
- Testing
- HRS-8797
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Chengdu Suncadia Medicine Co., Ltd.
Hypertriglyceridemia
Evaluation of Efficacy and Safety of Omacor, Co-Administered With Atorvastatin, in Subjects With Hypertriglyceridemia
The purpose of this study is to evaluate the efficacy and safety of Omacor (omega-3-acid ethyl esters) combined with atorvastatin for lowering non-high-density lipoprotein cholesterol (non-HDL-C) in hypertriglyceridemic subjects.
- Trial name
- NCT00435045
- Testing
- Lovaza (omega-3-acid ethyl esters) [formerly known as Omacor] plus atorvastatin, atorvastatin
- Volunteers
- 245 people
- Sponsor
- GlaxoSmithKline
Acute Myeloid Leukemia
Dociparstat in Combination With Standard Chemotherapy for the Treatment of Acute Myeloid Leukemia
Phase 3 study to evaluate the efficacy and safety of dociparstat sodium in adults with newly diagnosed untreated acute myeloid leukemia (AML) with adverse or intermediate genetic risk.
- Trial name
- AML (NCT04571645)
- Testing
- Dociparstat, Control
- Where
- 14 sites in United States
- Volunteers
- 9 people
- Sponsor
- Jazz Pharmaceuticals
Plaque Psoriasis
Study of CRx-191 to Assess Activity in Plaque Psoriasis
CRx-191 is a proprietary synergistic combination drug candidate being evaluated by CombinatoRx for topical psoriasis therapy. CRx-191 was identified via a proprietary screening assay for novel drug combinations demonstrating…
- Trial name
- NCT00557739
- Testing
- mometasone furoate, nortriptyline HCl
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Zalicus
Class II Canine, Intermaxillary Strength
Study Evaluating the Laser Diode Effect on the Kinetics of Orthodontic Tooth Movement (Protocol CINELASER)
It is a single-center, prospective clinical study of a medical device, controlled, randomized, non-stratified, double-blind (neither the patient nor the parents know which area is irradiated / practitioner who performs the…
- Conditions
- Class II Canine, Intermaxillary Strength, Elastics II, Multi Fasteners Orthodontic Treatment
- Trial name
- CINELASER (NCT02181439)
- Testing
- (LLLT Low Level Laser Therapy) SiroLaser advance
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Nantes University Hospital
Rheumatoid Arthritis
A Study of the Effects of Oral Prednisone in Patients With Rheumatoid Arthritis (MK0000-088)
The study will compare the effects of prednisone vs placebo on synovial blood flow and overall DAS (disease activity score) in patients with rheumatoid arthritis.
- Trial name
- NCT00746512
- Testing
- Prednisone 15 mg, Prednisone 7.5 mg
- Volunteers
- 45 people
- Sponsor
- Merck Sharp & Dohme LLC
Cutaneous Lupus Erythematosus (CLE)
This Study Will Evaluate the Effect and Safety of 626 in Patients With CLE
This study aims to evaluate the efficacy and safety of subcutaneous (SC) 626 versus placebo in adult participants with cutaneous lupus erythematosus (CLE).
- Trial name
- NCT07900867
- Where
- 2 sites in China
- Volunteers
- 140 people
- Sponsor
- Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
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