Clinical trials: Down Syndrome (DS)
Down Syndrome (DS)
Awareness of Families With Down Syndrome Children About the Role of Physical Therapy in Egypt
This study explores how much families with children who have Down Syndrome in Egypt know about the benefits and role of physical therapy.
- Trial name
- DS-AWARENESS (NCT06993324)
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Cairo University
Down Syndrome, Motor Performance
Bobath and Vojta Therapy for DS
Different physiotherapy approaches and education programs are applied to minimize motor and mental impairment in children with Down syndrome (DS).
- Conditions
- Down Syndrome, Motor Performance, Bobath Therapy, Vojta Technique
- Trial name
- NCT04536506
- Testing
- Bobath Therapy, Vojta technique
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Pamukkale University
Down Syndrome, Alzheimer's Dementia
Relationship Between Down Syndrome (DS) and Alzheimer's Disease (AD)
In order to treat individuals with Down syndrome (DS) better and more efficiently and to gain more insights on its relation to Alzheimer's disease (AD), a comprehensive understanding is needed for its progression in the early or…
- Trial name
- NCT02759887
- Testing
- biospecimen collection, cognitive assessments, caregiver questionnaire
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Down Syndrome
DS-Connect®: The Down Syndrome Registry
The goal of this study is to develop a registry for Down syndrome (DS) to facilitate research participation by individuals with Down syndrome.
- Trial name
- NCT01950624
- Where
- United States
- Volunteers
- 100,000 people
- Sponsor
- University of Colorado, Denver
Down Syndrome, Congenital Heart Disease
Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS)
The study objective is to compare neurodevelopmental (ND) and behavioral outcomes between children with Down syndrome (DS) who had complete atrioventricular septal defect (CAVSD) repair and children from the same clinical sites…
- Trial name
- CHILD-DS (NCT05312177)
- Testing
- Stanford Binet Intelligence Scales, Fifth Edition, Vineland Adaptive Behavior Scales Third Edition, Peabody Picture Vocabulary Test, Fifth Edition
- Where
- 14 sites in United States, Canada
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Down Syndrome, Obstructive Sleep Apnea
Positive Airway Pressure (PAP) for Children With Down Syndrome (DS) and Obstructive Sleep Apnea Syndrome (OSAS)
Determine the efficacy of family-informed intervention (INT) vs standard clinical care over a period of twelve months in children with obstructive sleep apnea and Down Syndrome.
- Trial name
- NCT04132999
- Testing
- Family-informed intervention, Standard Clinical Care
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Miami
Alzheimer Disease, Down Syndrome
Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)
The primary purpose of this study is to evaluate the safety and tolerability of ION269 in adults with Down syndrome with evidence of brain amyloid positivity.
- Trial name
- NCT06673069
- Testing
- ION269
- Where
- 6 sites in United States, Spain
- Volunteers
- 1 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Down Syndrome,Auxological Indexes, Auxological Parametars, Intrauterine Growth Restriction
Indicators of Growth, Nutritional Status and Comorbide Disorders of Newborns With Down Syndrome
Objective To access predictive values of the auxological parameters and indexes for risk of comorbid malformations in newborns with Down syndrome (DS) Study design In this cohort retrospective study, 141 newborns with proven…
- Trial name
- DownSy (NCT03553706)
- Where
- Croatia
- Volunteers
- 141 people
- Sponsor
- University Hospital of Split
Down Syndrome
The Experience of Caregivers of Children With Down Syndrome
This study will explore how caregivers adjust to having a child with Down syndrome. Primary caregivers 18 years of age and older of a child with Down syndrome may be eligible for this study.
- Trial name
- NCT00695695
- Where
- United States
- Volunteers
- 546 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Down Syndrome (DS), Low Bone Mineral Density
The Impact of Core Stability Versus Respiratory Muscle Strengthening Exercises on Bone Mineral Density in Children With Down Syndrome
Children with Down syndrome often exhibit diminished physical fitness levels and lower bone mass. Numerous factors contribute to this decrease in bone mass density, including decreased levels of leptin, reduced muscle mass and…
- Trial name
- NCT07328165
- Testing
- Core Stability Exercise Group, Respiratory Muscle Strengthening Group, Control /Conventional Physiotherapy Group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Down Syndrome (DS), Down Syndrome (Trisomy 21)
Amyloid Lowering for Alzheimer's in Down's With Donanemab Investigation
The goal of this clinical trial is to learn if donanemab can reduce levels of amyloid in the brain, and if donanemab is safe and well-tolerated in participants with Down syndrome.
- Conditions
- Down Syndrome (DS), Down Syndrome (Trisomy 21), Alzheimer Disease, Amyloid Beta Protein
- Trial name
- ALADDIN (NCT06911944)
- Testing
- Donanemab
- Volunteers
- 60 people
- Sponsor
- Michael Rafii, MD, PhD
Down Syndrome, Down Syndrome (DS)
LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome
The purpose of this study is to evaluate whether levetiracetam can prevent epileptic seizures in patients with Alzheimer's disease associated with Down syndrome.
- Conditions
- Down Syndrome, Down Syndrome (DS), Down Syndrome (Trisomy 21), Alzheimer Dementia
- Trial name
- LESS-AD (NCT07234695)
- Testing
- Levetiracetam 500mg
- Where
- 5 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Down Syndrome (DS)
Suspension Therapy Effects on Mobility and Balance in Down Syndrome
Down syndrome (DS) is one of the most common congenital disorders. Individuals with Down syndrome present with several impairments such as hypotonia, ligament laxity, decreased muscle strength, insufficient muscular…
- Trial name
- STOMP (NCT06748248)
- Testing
- suspension Therapy, Routine Treatment
- Where
- 2 sites in Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Down Syndrome (DS), Supplementation
Effects of Chronic Creatine and Beta-Hydroxy-Beta-Methylbutyrate Supplementation on Oxidative Stress, Inflammation, Muscle Strength, and Body Composition in Individuals With Down Syndrome
Purpose: This study will test whether 8 weeks of creatine and HMB supplementation can improve muscle strength, body composition, balance, and overall health in people with Down syndrome.
- Trial name
- NCT07213063
- Testing
- Nutrition education, Supplement
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Universidad de Burgos
Down Syndrome
Physical Fitness in DS: A Comparison of Cuevas Medak and Rebound Exercises
This randomized clinical trial investigates the comparative effects of Cuevas Medak Exercises Vs Rebound Exercises on physical fitness in DS.
- Trial name
- DownSyndrome (NCT07248449)
- Testing
- Cuevas Medak Exercises
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Down Syndrome-Associated Alzheimer's Disease (DS-AD)
A Study to Evaluate Mivelsiran in Adult Participants With Early-Stage Down Syndrome-Associated Alzheimer's Disease (DS-AD)
The purpose of the study is to evaluate the effect of mivelsiran in adult participants with early-stage DS-AD and to characterize the safety, tolerability, and pharmacodynamics (PD) of mivelsiran.
- Trial name
- NCT07636811
- Testing
- Mivelsiran
- Where
- 10 sites in United States, Spain
- Volunteers
- 58 people
- Sponsor
- Alnylam Pharmaceuticals
Leukemia
Low-Dose Cytarabine in Treating Infants With Down Syndrome and Transient Myeloproliferative Disorder
RATIONALE: Drugs used in chemotherapy, such as cytarabine, work in different ways to stop the growth of abnormal cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00411281
- Testing
- cytarabine, observation
- Sponsor
- Children's Oncology Group
Pediatric Obstructive Sleep Apnea, Down Syndrome (DS)
Pediatric Down Syndrome Post-Approval Study
The purpose of this Post Approval research study is to assess ongoing safety and effectiveness of the Inspire therapy in adolescents and young adults (age 13-18) with Down syndrome and severe sleep apnea.
- Trial name
- NCT06851338
- Testing
- Hypoglossal Nerve Stimulation
- Where
- 6 sites in United States
- Volunteers
- 60 people
- Sponsor
- Inspire Medical Systems, Inc.
Down Syndrome
Effects of (tDCS) Combined With Virtual Reality Versus CPT on Brain, Cognitive, and GMS in Children With DS.
This randomized controlled trial aims to compare the effects of transcranial direct current stimulation (tDCS) combined with virtual reality-based training versus conventional physical therapy on brain activity, cognitive…
- Trial name
- NCT07385066
- Testing
- Conventional Physical Therapy, Experimental group (tDCS + Virtual Reality)
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Superior University
Alzheimer's Disease in Down Syndrome
Goal Attainment Scaling (GAS) Sub-Study
This is an optional sub-study that will enroll participants from LIFE-DSR parent protocol. The aim is to assess change over 16 months in individuals with Down syndrome through individualized goals set by their caregivers.
- Trial name
- NCT06484426
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- LuMind IDSC Foundation