Clinical trials: Downs Syndrome
Down Syndrome
Early Ultrasound and Maternal Biochemical Markers to Evaluate the Risk of Down Syndrome During the First Trimester
The aim of the study is to evaluate the risk of Down syndrome during the first trimester of the pregnancy. The risk assessment is evaluated using early ultrasound and maternal biochemical markers.
- Trial name
- NCT00287417
- Testing
- echography, blood sample
- Where
- 7 sites in France
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Depression
Co-Designing and Evaluating Additional Mothers and Babies Program Content for Expectant and New Parents of Children With Down Syndrome
Goal: This R34 study will pilot an adaptation for the Mothers and Babies (MB) program for expectant and new parents of infants with Down syndrome (MBDS).
- Trial name
- MBDS (NCT07469176)
- Testing
- Mothers and Babies, Mothers and Babies Down Syndrome
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Down Syndrome
Phosphoproteomic Profile of Children With Down Syndrome
One of the major causes of cognitive disorders limiting the learning abilities of children with Down's syndrome is excess activity of the DYRK1A protein kinase, whose gene is located on chromosome 21.
- Trial name
- PEPS (NCT06279208)
- Testing
- Blood sample
- Where
- 9 sites in France
- Volunteers
- 60 people
- Sponsor
- Perha Pharmaceuticals
Trisomy 13, Trisomy 18
Multiple Gestation Study
The objectives of the clinical study are to demonstrate the accuracy of our new NATUS diagnostic method to determine the genetic health of the developing fetuses in a multiple gestation pregnancy from a maternal blood sample.
- Conditions
- Trisomy 13, Trisomy 18, Trisomy 21, Sex Chromosome Abnormalities
- Trial name
- NCT02278536
- Where
- 8 sites in United States, India and 1 more
- Volunteers
- 354 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Language Disorder
Parent Child Interaction Therapy vs Conventional Parent Led Therapy in Down Syndrome
To determine the effect of Parent child interaction therapy vs Conventional Parent Led Therapy in the management of language disorders in Children with Down Syndrome
- Trial name
- NCT07128810
- Testing
- Parent Child Interaction Therapy, Conventional Parent Led Therapy
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Alzheimer's Disease in Down Syndrome
Goal Attainment Scaling (GAS) Sub-Study
This is an optional sub-study that will enroll participants from LIFE-DSR parent protocol. The aim is to assess change over 16 months in individuals with Down syndrome through individualized goals set by their caregivers.
- Trial name
- NCT06484426
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- LuMind IDSC Foundation
Down Syndrome
Rivastigmine Study in Adolescents With Down Syndrome
The purpose of this study is to determine if short term use of rivastigmine can improve functional abilities (for example, language, memory, and executive function) in adolescents with Down syndrome.
- Trial name
- DS-Riv (NCT01084135)
- Testing
- Rivastigmine
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Duke University
Down Syndrome, Adaptive Behavior
Life Skills Improved in Children With Down Syndrome After Using Assistive Technology
Enhancing independence and quality of life are key modifiable outcomes that are short- and long-term goals for children with Down syndrome (DS) and for their parents.
- Conditions
- Down Syndrome, Adaptive Behavior, Quality of Life
- Trial name
- NCT05343468
- Testing
- The MapHabit System
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- MapHabit, Inc.
Down Syndrome, Cardiovascular Risk Factor
Vascular Health and Risk Factors in Children With Down Syndrome
This is a prospective, multicenter, cross-sectional study to evaluate prevalence of vascular risk factors in children with Down Syndrome and to determine the association between vascular disease risk factors and objective markers…
- Conditions
- Down Syndrome, Cardiovascular Risk Factor, Atherosclerosis
- Trial name
- NCT04735874
- Testing
- Evaluate vascular disease risk factors in children with Down Syndrome, Determine the associations between cardiovascular disease risk factors and markers of early atherosclerosis in children with Down Syndrome
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Utah
Down Syndrome
Parent Supported Weight Reduction in Down Syndrome
The purpose of this study is to determine whether a nutrition and physical activity education program for families of overweight or obese adolescents with Down syndrome is more effective when behavioral lifestyle change…
- Trial name
- NCT01256112
- Testing
- Parent Supported Behavioral Intervention, Nutrition/Activity Education (NAE)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Trisomy 21 in Fetus
Clinical Performance of NIPT in Multiple Gestation Pregnancies
This study plans to evaluate the clinical performance of the MaterniT21 PLUS and/or GENOME Laboratory Developed Test, in the detection of fetal trisomy 21 in circulating cell-free DNA extracted from maternal blood samples…
- Trial name
- NCT04488393
- Testing
- MaterniT21 PLUS and GENOME Laboratory-Developed Tests
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of Pennsylvania
Down Syndrome
Drumming Lessons' Influence on Children With Down Syndrome
The goal of this clinical trial is to learn if drumming lessons can increase self-control in children with Down syndrome. The main question it aims to answer is whether 2 months of drumming lessons can improve the behavioral…
- Trial name
- NCT07156318
- Testing
- 2 months of drumming lessons given by a professional drummer with extensive experience working with children with Down syndrome, Lessons after measurement
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University
Down Syndrome
Motor Intervention Whit the Intorus Tool on Children With Down Syndrome
The goal of this clinical trial is to test in people with down syndrome how does the INTORUS tool influence their psychomotor development.
- Trial name
- NCT05740046
- Testing
- INTORUS
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- University of Extremadura
Down Syndrome, Fetal Aneuploidy
Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies
Whole blood samples will be collected from high-risk pregnant women to validate the clinical performance of the SEQureDx Trisomy 21 Test.
- Trial name
- NCT01555346
- Where
- 29 sites in United States, Canada
- Volunteers
- 3,062 people
- Sponsor
- Sequenom, Inc.
Down Syndrome
Neuromuscular Characteristics of Individuals With Down Syndrome (DS)
Evaluation of muscle strength and central activation of muscle in individuals with Down Syndrome
- Trial name
- NCT00643955
- Testing
- muscle strength
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Down Syndrome, Obstructive Sleep Apnea of Newborn
Early Detection and Treatment of Obstructive Sleep Apnoea in Infants With Down Syndrome
Interventional, comparative, open-label, single-center study to demonstrate that early (from 6 months of age) and systematic (every 6 months) screening for Obstructive Sleep Apnoea (OSA) by polysomnography (PSG) in infants with…
- Trial name
- RESPIRE21 (NCT03210675)
- Testing
- Polysomnography (PSG)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Institut Jerome Lejeune
Pregnancy, Down Syndrome
An Interactive Informed Consent and Education Program for Pregnant Women
The purpose of this study is to determine whether an interactive education program for prenatal testing is effective in improving pregnant women's understanding of and expectations towards prenatal screening and diagnosis.
- Trial name
- NCT01176019
- Testing
- Information about Prenatal Screening and Diagnosis
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Down Syndrome, Obstructive Sleep Apnea
Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome
The purpose of this research study is to develop a way of predicting with computers how surgery on the airway will affect night time breathing called Obstructive Sleep Apnea (OSA) in children with Down Syndrome.
- Trial name
- DYMOSA (NCT01902407)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Down Syndrome, Trisomy 21
Cognitive Orientation to Daily Occupational Performance and Conductive Education Approaches on Down Syndrome
This study will be conducted to investigate and compare the effects of Cognitive Orientation to Daily Occupational Performance (CO-OP) and Conductive Education (CE) on fine motor skills, activity, and participation limitations in…
- Trial name
- NCT03687619
- Testing
- CO-OP, Conductive Education
- Where
- Cyprus
- Volunteers
- 12 people
- Sponsor
- Eastern Mediterranean University
Down Syndrome
Caregiver-Involved Nutrition Education in Down Syndrome
This single-arm, quasi-experimental pre-post study evaluated an 8-week online nutrition education program for individuals with Down syndrome and their caregivers in Ataşehir, Istanbul, Türkiye.
- Trial name
- NCT07330128
- Testing
- Caregiver-Involved Nutrition Education
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Hülya YILMAZ ÖNAL