Clinical trials: Doxycycline
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD Patients
This study investigates if long term use of the antibiotic doxycycline can reduce exacerbations in COPD patients. Half of the patients will receive doxycycline which the other half will receive a placebo.
- Trial name
- NCT02305940
- Testing
- Doxycycline
- Where
- 3 sites in United Kingdom
- Volunteers
- 222 people
- Sponsor
- Imperial College London
Sexually Transmitted Diseases
Doxy-Post-exposure Prophylaxis
The goal of this project is to collect data regarding the ability of various oral doses of doxycycline to penetrate mucosal tissues in men and women to inform the combination of doxycycline with antiretrovirals (ARVs) for the…
- Trial name
- DOXY-PEP (NCT05853120)
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Syphilis Infection, Gonorrhea
The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.
The objective of this research is to evaluate the efficacy and safety of doxycycline in MSM for preventing sexually transmitted infections (gonorrhea, chlamydia, and syphilis) in Thailand Participation in this study will last…
- Conditions
- Syphilis Infection, Gonorrhea, Chlamydia
- Trial name
- ThaiDoxyPEP (NCT07397403)
- Testing
- Doxycycline (200mg/day)
- Where
- Thailand
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bangrak STIs Center
Periodontal Disease, Type 2 Diabetes
Comparison Between aPDT and Systemic Doxycycline on Non-surgical Periodontal Therapy in Type 2 Diabetics
The objective of this study is to evaluate Photodynamic Therapy (PDT) as adjunct on non surgical periodontal therapy in patients with type 2 diabetes. A total of 40 individuals will be selected and divided in two groups.
- Trial name
- NCT01595594
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Periodontitis
Efficacy of Local Doxycycline Gel Delivery Versus Doxycycline Nanoparticles Prepared Gel in The Treatment of Stage II Periodontitis
To evaluate the Efficacy of Local Doxycycline Gel Delivery Versus Doxycycline Nanoparticles Prepared Gel in The Treatment of stage II Periodontitis Materials and methods: forty five patients (n=45) were selected from the…
- Trial name
- NCT06994455
- Testing
- scaling and root planing along with antibiotic intervention, scaling and root planing
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Mansoura University
COVID19
DYNAMIC Study (DoxycYcliNe AMbulatoIre COVID-19)
The aim of the study is to compare a treatment with doxycycline vs a placebo as soon as the patient is confirmed COVID-19 + and before the onset of oxygen dependence with the aim of reducing or even abolishing the cytokine…
- Trial name
- DYNAMIC (NCT04371952)
- Testing
- Doxycycline
- Where
- 6 sites in France
- Sponsor
- Nantes University Hospital
Diabetic Retinopathy
Evaluation of Effect of Doxycycline Verses Placebo on Retinal Function and Diabetic Retinopathy
This 24 month randomized research study will evaluate whether doxycycline can slow the deterioration or improve retinal function among patients with mild to moderate non-proliferative diabetic retinopathy.
- Trial name
- POC2 (NCT00917553)
- Testing
- doxycycline monohydrate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Thomas Gardner
TTR Cardiac Amyloidosis
A Study of Doxycycline and Tauroursodeoxycholic Acid (Doxy/TUDCA) Plus Standard Supportive Therapy Versus Standard Supportive Therapy Alone in Cardiac Amyloidosis Caused by Transthyretin
Cardiac amyloidosis caused by transthyretin either mutated (in ATTRm amyloidosis) or wildtype (in ATTRwt, formerly senile, amyloidosis) is a rare disease but is diagnosed with increasing frequency thanks to the availability of…
- Trial name
- NCT03481972
- Testing
- Doxycycline and tauroursodeoxycholic acid, Standard of care
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Periodontal Disease
Locally Delivered Doxycycline Adjunct to Nonsurgical Periodontal Therapy.
The aim of this clinical study is to asses the effect of ultrasonic periodontal debridement associated to locally delivered doxycycline (20%) by PLGA microspheres on chronic generalized periodontitis treatment.
- Trial name
- NCT02487186
- Testing
- Doxicicline, Full-mouth debridment
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Campinas, Brazil
Amyloidosis; Heart (Manifestation), Senile Cardiac Amyloidosis
Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy
The objective of the study is to determine whether the combination of the bile acid TUDCA, and doxycycline will slow the progression of familial and senile amyloidosis.
- Trial name
- NCT01855360
- Testing
- Tauroursodeoxycholic Acid and Doxycycline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Acne Vulgaris on the Face, Acne Vulgaris
Efficacy of Oral Metformin vs Oral Doxycycline in Treating Acne Vulgaris
The goal of the clinical trial is to learn if oral metformin works to treat moderate to severe acne vulgaris. Investigators will compare this drug to oral doxycycline to see if this drug works to treat acne.
- Trial name
- NCT07357337
- Testing
- oral metformin, Oral doxycycline
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Ghurki Trust and Teaching Hospital
Diabetes Mellitus With Periodontal Disease
The Effect of Topical Doxycycline Gel on HbA1c in Patients With Type 2 Diabetes Mellitus(DM) ®
Aim: The purpose of this study is to investigate the effect of nonsurgical periodontal therapy plus subgingivally doxycycline gel 3% on glycemic control in type 2 diabetes mellitus (type 2 DM) patients who have periodontitis.
- Trial name
- NCT02735837
- Testing
- Doxycycline Group
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Amirhossein Farahmand
Periodontitis, Adult
To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics As an Adjuvant to NSPT
Background: Periodontitis is defined as "an inflammatory disease of the supporting tissues of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the…
- Trial name
- NCT06570863
- Testing
- Antibiotics(doxycycline), Probiotics, Metronidazole gel 25%
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Dr fizza khalid
Suspected Early Lyme Neuroborreliosis
Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis
The investigators will compare doxycycline and ceftriaxone in treatment of patients with suspected early Lyme neuroborreliosis and normal CSF cell count.
- Trial name
- NCT00942006
- Testing
- doxycycline, ceftriaxone
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University Medical Centre Ljubljana
Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS)
Regenerative Medicine for Joint Hypermobility and Instability
This clinical trial is designed to evaluate whether a stepwise injection-based treatment approach can reduce pain and improve function in adults with joint hypermobility, connective tissue laxity, and joint instability.
- Conditions
- Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS), Joint Hypermobility, Joint Instability
- Trial name
- NCT07688096
- Testing
- Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational)
- Volunteers
- 100 people
- Sponsor
- Manhattan Pain Medicine, PLLC
Acne Vulgaris, Pediatrics
Subantimicrobial Doxycycline in Acne
Antibiotic resistance is a public health problem that worsens the more physicians prescribe standard dose antibiotics for acne. Regardless of race, acne vulgaris is one of the most common dermatologic conditions among pediatric…
- Trial name
- NCT05399290
- Testing
- Doxycycline Hyclate
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Helicobacter Pylori Infection
Doxycycline- and Furazolidone-containing Quadruple Regimen is Superior of Tailored Therapy
Doxycycline- and Furazolidone-containing Quadruple Regimen can be a successful rescue treatment for Helicobacter pylori Infection patients after Failure of several therapy.
- Trial name
- NCT02894268
- Testing
- Doxycycline, Furazolidone, Esomeprazole
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sir Run Run Shaw Hospital
Lyme Disease, Borrelia Infection
Persistent Lyme Empiric Antibiotic Study Europe
The purpose of the study is to establish whether prolonged antibiotic treatment of patients diagnosed with proven or presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term…
- Trial name
- PLEASE (NCT01207739)
- Testing
- Doxycycline, Clarithromycin and hydroxychloroquine
- Where
- 2 sites in Netherlands
- Volunteers
- 280 people
- Sponsor
- Radboud University Medical Center
Relapsing Fever, Tick-Borne
Postexposure Prophylaxis With Single Dose Doxycycline for the Prevention of Tick-borne Relapsing Fever
The goal of this clinical trial is to compare standard treatment (5 days of doxycycline) vs single dose doxycycline for the prevention of tick-borne relapsing fever in soldiers who found bite marks on their bodies after an…
- Trial name
- NCT06045481
- Testing
- administration of single dose of doxycycline
- Volunteers
- 526 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
HIV Pre-exposure Prophylaxis, HIV Prevention and Care
MyPrEP Plus: Development and Pilot Testing of Novel Preexposure Prophylaxis Decision Support Tools for Transgender Women
The primary goal of this randomized controlled trial is to learn if a decision support tool called MyPrEP Plus can help transgender women make decisions about taking pre-exposure prophylaxis (PrEP) for HIV prevention.
- Conditions
- HIV Pre-exposure Prophylaxis, HIV Prevention and Care, Mobile Health Technology (mHealth), Adherence
- Trial name
- NCT07146139
- Testing
- MyPrEP Plus Package, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Public Health Foundation Enterprises, Inc.