Clinical trials: Drinking, Alcohol
Alcohol Use Disorder
The Effects of Exenatide, a GLP-1 Agonist, on Alcohol Self-Administration in Heavy Drinkers
A double-blind, randomized, placebo-controlled, crossover design trial was used to test the effect of exenatide on alcohol self-administration and craving following a priming dose of alcohol.
- Trial name
- NCT03645408
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Alcohol Use Disorder
Enhancing the Effects of Alcohol Treatment With Lamotrigine
This study will help determine the tolerability and efficacy of the mood-stabilizing anticonvulsant lamotrigine in youth with alcohol use disorder.
- Trial name
- NCT04770493
- Testing
- Lamotrigine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Brown University
Posttraumatic Stress Disorder, Depression
Trauma Survivors Outcomes and Support Study IV
After traumatic injuries some people have difficulty returning to the routine of their everyday activities and may experience physical and emotional pain.
- Conditions
- Posttraumatic Stress Disorder, Depression, Suicide, Traumatic Brain Injury
- Trial name
- TSOS IV (NCT01625416)
- Testing
- Stepped Care Management
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of Washington
Insomnia, Alcohol; Harmful Use
Insomnia Treatment and Problems (the iTAP Study)
This project aims to evaluate the efficacy of insomnia treatment in improving insomnia symptoms and alcohol-related problems among heavy-drinking young adults.
- Trial name
- iTAP (NCT03627832)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep Hygiene
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Post Traumatic Stress Disorder, Alcohol Abuse
Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD
Objective: Evaluate the efficacy and physiological effects of sublingual buprenorphine (SL-BUP; Subutex) combined with extended-release injectable naltrexone (XR-NTX; Vivitrol) in the treatment alcohol use disorder of comorbid…
- Trial name
- NCT03852628
- Testing
- 2mg Buprenex and 380mg Vivitrol
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Alcohol Use Disorder, Alcoholism
Varenicline and Bupropion for Alcohol Use Disorder
The COMB study is a randomized double-blind placebo-controlled multicenter trial in Sweden on the efficacy of varenicline and bupropion, in combination and alone, for treatment of alcohol use disorder (AUD).
- Conditions
- Alcohol Use Disorder, Alcoholism, Alcohol Dependence
- Trial name
- NCT04167306
- Testing
- Varenicline Tartrate 1 mg b.i.d, Bupropion Hydrochloride 150 mg b.i.d
- Where
- 4 sites in Sweden
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Alcohol Use, E-cigarette Use
Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use
A high priority research area for the Food and Drug Administration Center for Tobacco Products (FDA CTP) is determining who will start using tobacco products and who will stop using tobacco products.
- Conditions
- Alcohol Use, E-cigarette Use, Cigarette Use
- Trial name
- NCT07010601
- Testing
- Experimental Tobacco Marketplace, Hypothetical Novel Nicotine Product Purchase Tasks
- Where
- United States
- Volunteers
- 737 people, healthy volunteers welcome
- Sponsor
- Mark J Rzeszutek, PhD
Behavioral Flexibility, Healthy Volunteers
Flexibility, Alcohol Misuse, and Excitation
The goal of this study is to learn whether a single non-invasive brain stimulation alpha-transcranial alternating current stimulation (alpha-tACS) session changes measures of excitability in the prefrontal cortex.
- Conditions
- Behavioral Flexibility, Healthy Volunteers, High Risk Alcohol Use
- Trial name
- FLAME (NCT06634771)
- Testing
- 10 Hz transcranial alternating current stimulation (tACS)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cancer, Alcohol Use
Evaluating an mHealth Intervention for Reducing Alcohol Use Among Adolescent and Young Adult Cancer Survivors
The objective of this study is to adapt and test the feasibility of a 4-week motivational interviewing mHealth intervention, Tracking and Reducing Alcohol Consumption (TRAC), to reduce alcohol use among adolescent and young adult…
- Trial name
- NCT05087875
- Testing
- TRAC: Tracking and Reducing Alcohol Consumption, No intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Carolyn Lauckner
Alcohol Use, Drug Use
Testing the Effectiveness of a Graphic Novel Health Education Curriculum for Patients With Addiction
This study deploys a strategy to develop and evaluate a training-efficient, multimedia patient-centered Health Education Toolkit to promote shared decision making between counselors and patients.
- Trial name
- NCT02378181
- Testing
- Health Education Toolkit, Treatment-as-usual
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- Treatment Research Institute
Heavy Drinking, Harmful; Use, Alcohol
A PPG Sensor-Based Feedback Intervention for Heavy Drinking Young Adults
Heavy alcohol use among young adults is a significant public health problem. Advances in technology may offer an innovative solution.
- Trial name
- NCT05090995
- Testing
- Behavioral Self-Management and Feedback, Behavioral Self-Management
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Maternal Behavior, Alcohol Drinking
Adapting and Testing a Behavioural Intervention to Prevent FASD and Adverse Infant Outcomes
South Africa (SA) has a long history of social and health disparities, resulting in the world's highest rate of fetal alcohol spectrum disorder (FASD; 111.1 per 1,000), where lifelong negative cognitive and physical effects…
- Conditions
- Maternal Behavior, Alcohol Drinking, Fetal Conditions
- Trial name
- MaRISA+ (NCT05747599)
- Testing
- Intervention with contingent incentives and text-based support
- Where
- South Africa
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- RTI International
Alcohol Abstinence
Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD)
Guanfacine may preferentially reduce craving and improve cognitive control in women with Alcohol Use Disorder (AUD), compared to men.
- Trial name
- NCT03137082
- Testing
- Guanfacine XR 3mgs/daily
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stony Brook University
Alcohol Use Disorder
Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate)
This study will evaluate the behavioral effects of alcohol during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- BED[IN]:36 (NCT03575403)
- Testing
- Alcohol, Duloxetine (60 MG), Methylphenidate
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Alcohol Use Disorder
Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy
The purpose of this study is to evaluate the safety and efficacy of dutasteride in reducing drinking and heavy drinking in men and women with alcohol use disorder.
- Trial name
- NCT04098302
- Testing
- Dutasteride Capsules
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- UConn Health
Smoking Cessation, Alcohol Drinking
Development and Pilot Testing of a Multimodal Web-based Program to Address Heavy Drinking During Smoking Cessation
The overall objective of this project is to develop and pilot-test a web-based smoking cessation program that specifically addresses heavy drinking (HD).
- Trial name
- NCT03068611
- Testing
- Standard Web-based Smoking Cessation, Alcohol-focused Web-Based Smoking Cessation
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Brown University
Acquired Immunodeficiency Syndrome, HIV/AIDS
Technological Intervention for Reducing Alcohol Use Among People Living With HIV/AIDS
While advances in medication have led to greatly improved outcomes for people living with HIV/AIDS, less than one-third of all people living with the disease are adherent enough to their medication to achieve viral suppression.
- Conditions
- Acquired Immunodeficiency Syndrome, HIV/AIDS, Alcohol Drinking
- Trial name
- TRAC (NCT03746600)
- Testing
- Project TRAC: Tracking and Reducing Alcohol Consumption
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Carolyn Lauckner
Alcohol Use Disorder
Effects of Pioglitazone on Stress Reactivity and Alcohol Craving
The purpose of this study is to examine the effects of pioglitazone on stress-induced relapse risk in a laboratory model and to examine the effects of pioglitazone on drinking, stress/anxiety, and alcohol craving in the natural…
- Trial name
- NCT05107765
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- The University of Texas Health Science Center, Houston
Alcohol Drinking, Opioid Use, Unspecified
Opioid Modulation and Neural Reward Activation in Healthy Adults
This is a double blind study of the effects of opioid antagonism on the brain's reward response. The investigators will recruit participants to undergo two scans, one on active medication and one on placebo.
- Trial name
- NCT04854551
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Alcohol Use
Evaluating a Brief Negotiational Intervention for Alcohol Use Among Injury Patients in Tanzania
A brief negotiational interview (BNI), administered in an Emergency Department setting for both hazardous and harmful drinkers has been shown to cost-effectively reduce a patient's alcohol intake and re-injury rate up to 3 years…
- Trial name
- BNI (NCT02828267)
- Testing
- Brief Negotiational Intervention, Standard Booster, Personalized Booster
- Where
- Tanzania
- Volunteers
- 75 people
- Sponsor
- Duke University