Clinical trials: Drinking, Alcohol
Alcohol Use Disorder
Effects of Pioglitazone on Stress Reactivity and Alcohol Craving (Pilot)
The purpose of this study is to assess the effect of pioglitazone on stress- and alcohol-related measures in treatment-seeking individuals with alcohol use disorder (AUD) and elevated levels of stress and anxiety.
- Trial name
- NCT03860753
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center, Houston
Binge Drinking, HIV
Better Than Study: Targeting Heavy Alcohol Use With Naltrexone Among Men Who Have Sex With Men (MSM)
This is a double-blind, placebo-controlled trial of 120 binge-drinking MSM to 12 weeks of naltrexone 50mg, to be taken in anticipation of heavy drinking.
- Trial name
- SayWhen (NCT02330419)
- Testing
- Naltrexone, Medical Management (MM) counseling for alcohol use:, Urinalysis for novel alcohol biochemical markers:
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Use Disorder
HLAB-002 of ANS-6637 for Alcohol Use Disorder
Primary: The primary objective of this study was to evaluate the effects of 2 different doses of ANS-6637, 200 mg (given as 2 x 100 mg tablets) and 600 mg (given as 2 x 300 mg tablets) once a day, and matched placebo, on alcohol…
- Trial name
- NCT03970109
- Testing
- ANS-6637
- Where
- 3 sites in United States
- Volunteers
- 43 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Dependence
Glutamatergic Modulation of Disordered Alcohol Use
Alcohol use disorders remain a significant public health problem. The pharmacological facilitation of behavioral treatment represents a promising strategy for addressing disordered drinking.
- Trial name
- NCT02539511
- Testing
- CI-581a, CI-581b, Motivational Enhancement Therapy (MET)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder, Alcohol Drinking
Pitolisant Effects on Alcohol Self-Administration in Heavy Drinkers
This is a double-blind, randomized, placebo-controlled, crossover design trial that will test the effect of pitolisant on alcohol self-administration and craving following a priming dose of alcohol.
- Trial name
- NCT04596267
- Testing
- Pitolisant
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Boston Medical Center
Substance Use Disorder
Project IMPACT: In-the-Moment Protection From Automatic Capture by Trigger
Despite conscious intentions to remain abstinent, persons with substance use disorders often find that negative emotions and environmental cues automatically "trigger" drinking and other substance use.
- Trial name
- NCT02579317
- Testing
- Resonance Breathing, Non-Resonance Breathing
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Rutgers, The State University of New Jersey
Alcohol Consumption
Testing Brief Personalized Feedback Integrating Lab-based Alcohol Cue Information
This study aims to develop a brief intervention that uses information from a lab-based cue reactivity protocol to create personalized feedback targeting high-risk alcohol use among young adults who drink alcohol.
- Trial name
- Project ACE (NCT05873556)
- Testing
- Lab-based Cue Reactivity Personalized Feedback Intervention (PFI)
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Washington
Alcohol Drinking, Craving
Cognitive Interference Task on Alcohol Craving and Consumption
The purpose of this study is to test a brief task of playing the game Tetris to reduce alcohol cravings and alcohol use. Women who are seen at primary care and recruited through the community will be asked to rate alcohol craving…
- Trial name
- NCT04924283
- Testing
- Tetris and Assessments, Assessment Only
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Human Immunodeficiency Virus (HIV)
Alcohol Monitor Validation
This study will validate a wrist-worn alcohol monitor (BACtrack Skyn) in both laboratory and real-life settings.
- Trial name
- NCT03617705
- Testing
- Skyn Monitor Lab Session 1, Skyn Monitor Field Test with EMA App, Skyn Monitor Lab Session 2
- Where
- 2 sites in United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Florida
Alcohol Use Disorder
Exploration of Gemfibrozil as a Treatment for AUD
This study will examine the efficacy of the medication gemfibrozil in reducing alcohol consumption in individuals with an alcohol use disorder who are seeking treatment for alcohol-related problems.
- Trial name
- NCT03539432
- Testing
- Gemfibrozil 600 MG
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The Mind Research Network
Alcohol Drinking, Alcohol Intoxication
Mindfulness-Based Intervention and Transcranial Direct Current Brain Stimulation to Reduce Heavy Drinking
Alcohol use disorder (AUD) impacts millions of Americans and is associated with significant behavioral, social, economic, medical, and neurobiological dysfunction, yet current behavioral treatments for AUD are only modestly…
- Conditions
- Alcohol Drinking, Alcohol Intoxication, Alcoholism
- Trial name
- MBItDCS (NCT02861807)
- Testing
- Brain stimulation with mindfulness-based relapse prevention
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of New Mexico
Alcohol Abuse
Buproprion for Binge Drinking
The present proposal is an innovative and translational clinical trial derived from exciting preclinical findings to test the hypothesis that treatment with the melanocortin activator bupropion can reduce binge drinking in…
- Trial name
- NCT03169244
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Use Disorder
Cannabidiol Effects on Blood Alcohol Level and Intoxication
The main objectives of this study were to test if 2 different doses of Cannabidiol (compared to placebo) alter 1) breath alcohol concentration, 2) craving and subjective responses to alcohol or 3) cognitive performance following…
- Trial name
- NCT06105138
- Testing
- 200mg Cannabidiol oral solution, 30mg Cannabidiol oral solution
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Alcohol Use Disorder
Deep Brain Stimulation for Alcohol Use Disorder
The purpose of this clinical study is to investigate the safety, tolerability, and feasibility of Deep Brain Stimulation (DBS) of the limbic pallidum in participants with severe alcohol use disorder (AUD) who have advanced but…
- Trial name
- NCT05522751
- Testing
- DBS
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Khaled Moussawi
Insomnia, Alcohol; Harmful Use
The Insomnia Treatment and Problems Study for Veterans
This project aims to evaluate improvement of insomnia as a mechanism of improvement in alcohol use outcomes.
- Trial name
- iTAP-V (NCT03804788)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygeine
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Smoking Cessation, Alcohol Consumption
Smoking Cessation in Alcoholics
Most alcohol-dependent individuals are heavy smokers. The aim of this study is to evaluate whether a specific smoking cessation program (based on cognitive-behavioral therapy) for inpatient alcohol-dependent smokers is more…
- Trial name
- NCT00963482
- Testing
- Cognitive-behavioural smoking cessation program, Autogenic training
- Where
- Switzerland
- Volunteers
- 103 people
- Sponsor
- University Hospital, Basel, Switzerland
Alcohol Use Disorder
Pilot Human Laboratory Study of Alcohol Approach Bias Modification (AABM) for Alcohol Use Disorder (AUD)
The overall goal of the proposed project is to improve the treatment of individuals with Alcohol Use Disorder (AUD). We will conduct a pilot feasibility trial of Approach Bias Modification (AABM) training of heavy-drinking…
- Trial name
- ADP + AABM (NCT03898323)
- Testing
- Alcohol Approach Bias Modification
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Underage Alcohol Use
Alcohol Intervention for First Year College Students
While a large focus of research on U.S. college drinking has focused on the prevalence of and problems related to heavy-episodic drinking, less has focused on college students who are either abstainers or lighter drinkers (i.e.…
- Trial name
- NCT03750838
- Testing
- Text Messaging Intervention
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
Alcohol Dependence
A Multicenter, Randomized, Double-blind, Placebo-controlled, 3-parallel-group Comparison Trial to Investigate the Effect of Nalmefene on Alcohol Consumption Reduction in Patients With Alcohol Dependence (Phase 3 Trial)
The efficacy, safety, and dose-response of nalmefene hydrochloride at 10 mg and 20 mg in patients with alcohol dependence will be evaluated in a multicenter, randomized, double-blind, placebo-controlled, 3-parallel-group…
- Trial name
- NCT02364947
- Testing
- Nalmefene hydrochloride
- Where
- 7 sites in Japan
- Volunteers
- 678 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Alcohol Use Disorder, Nicotine Use Disorder
Neurobiology of Alcohol and Nicotine Co-Addiction
This proposal addresses the critical absence of information about the neurobiology of recovery from Alcohol Use Disorder (AUD) in alcohol and nicotine users.
- Trial name
- NAUD (NCT03338933)
- Testing
- magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development