Clinical trials: Drinking, Alcohol
Alcohol Use Disorder, Sexually Transmitted Diseases
Addressing Heavy Alcohol Use Consumption With Kudzu
Drinking multiple alcoholic drinks on a single occasion (binge drinking), has many negative health risks but interventions to address this behavior remain limited.
- Trial name
- A-HACK (NCT03709043)
- Testing
- Standardized kudzu, Sexually transmitted infection testing:, Medical Management (MM) counseling for alcohol use:
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Glenn-Milo Santos
Sexual Behavior, Alcohol Drinking
Men's Sexual Risk Behaviors: Alcohol, Sexual Aggression, and Emotional Factors
Although correct, consistent condom use can greatly reduce sexually transmitted infections and unplanned pregnancies, resistance of condom use is common among young adults.
- Conditions
- Sexual Behavior, Alcohol Drinking, Sexual Aggression, Emotions
- Trial name
- NCT03900650
- Testing
- High provocation manipulation, Low provocation manipulation, Alcoholic beverage
- Where
- United States
- Volunteers
- 420 people
- Sponsor
- Arizona State University
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Alcohol Use Disorder, Alcohol Drinking
Human Laboratory Study of ASP8062 for Alcohol Use Disorder
The primary objective of this study is to evaluate the effects of ASP8062, 25 mg once a day and matched placebo, on alcohol cue-elicited alcohol craving during a human laboratory paradigm after 2 weeks of daily dosing among…
- Conditions
- Alcohol Use Disorder, Alcohol Drinking, Alcohol Use Disorder (AUD)
- Trial name
- NCT05096117
- Testing
- ASP8062
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
Pregabalin as Treatment for Alcohol Use Disorder
The proposed protocol is an 8 week open label outpatient pilot trial of the safety and efficacy of pregabalin (Lyrica) in the treatment of alcohol use disorder.
- Trial name
- NCT03256253
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- New York State Psychiatric Institute
Alcohol Use Disorder
Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control
The purpose of this study is to determine whether the catechol-O-methyltransferase (COMT) inhibitor tolcapone, relative to placebo, reduces alcohol drinking and alcohol cue-elicited brain activation and increases brain activation…
- Trial name
- NCT02949934
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
Alcohol Use, Unspecified
Motivational Interviewing and Neuroimaging With Adolescents
This is a randomized controlled trial to examine the impact of two brief interventions on adolescent and young adult alcohol use behaviors and related brain response.
- Trial name
- MINA (NCT03367858)
- Testing
- Motivational Interviewing (MI), Brief Adolescent Mindfulness (BAM)
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Alcohol Use, Drug Use
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1
This application is a competing continuation of a grant in which we developed and pilot tested a computerized Therapeutic Workplace designed to train and employ adults as data entry operators.
- Conditions
- Alcohol Use, Drug Use, Risk Behavior, Sexual Behavior
- Trial name
- NCT00249496
- Testing
- Contingency management, Employment Only
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Alcohol Use Disorder (AUD), Substance Use Disorders
The Anchor Study: Digitally Delivered Intervention for Reducing Problematic Substance Use
This study aims to validate W-SUDs as a digitally-delivered substance use disorder program through a fully-powered randomized control trial that will test the comparative efficacy of the mobile-app based substance use disorder…
- Trial name
- NCT04925570
- Testing
- W-SUDs, Digitally-delivered Psychoeducation
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Woebot Health
Post Traumatic Stress Disorder, Alcohol Abuse
Kappa Opioid Receptor Antagonism for the Tx of AUD and Comorbid PTSD
Objective: Evaluate the efficacy and physiological effects of sublingual buprenorphine (SL-BUP; Subutex) combined with extended-release injectable naltrexone (XR-NTX; Vivitrol) in the treatment alcohol use disorder of comorbid…
- Trial name
- NCT03852628
- Testing
- 2mg Buprenex and 380mg Vivitrol
- Where
- 2 sites in United States
- Volunteers
- 69 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Alcohol Dependence, Alcohol Abuse
ABT-436 for Alcohol Dependence
The primary efficacy endpoint examines the hypothesis that ABT-436 will decrease the weekly percentage of heavy drinking days during Study Weeks 2 through 12 (Days 8-84) as compared to placebo.
- Conditions
- Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorders, Alcoholism
- Trial name
- NCT01613014
- Testing
- ABT-436
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder
Lacosamide Effects on Alcohol Self Administration and Craving in Heavy Drinkers
This is a double-blind, randomized, placebo-controlled, crossover design trial tested the effect of lacosamide on alcohol self-administration and craving following a priming dose of alcohol.
- Trial name
- NCT03271528
- Testing
- Lacosamide
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Boston Medical Center
Alcohol Drinking, HIV
Behavioral Interventions to Reduce Heavy Drinking Among MSM in HIV Primary Care
The purpose of the present study is to conduct a fully-crossed 2 X 2 X 2 factorial randomized controlled trial with a diverse sample of 224 MSM recruited from 2 urban HIV primary care clinics (one in the Northeast and one in the…
- Trial name
- NCT02709759
- Testing
- Motivational intervention, Brief Advice, Interactive text messaging
- Where
- 2 sites in United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Brown University
Cannabis, Cannabis Use
Marijuana Effects on Simulated Driving Performance
This study will examine the effects of various strains of marijuana on simulated driving performance; the effects of alcohol administration will also be examined to further understand how marijuana-induced driving changes compare…
- Conditions
- Cannabis, Cannabis Use, Marijuana, Marijuana Usage
- Trial name
- NCT03699540
- Testing
- Marijuana, Alcohol, Inactive marijuana
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shanna Babalonis, PhD
Alcohol Use, Unspecified, HIV/AIDS
Mobile Technology to Extend Clinic-based Counseling for HIV+s in Uganda
The EXTEND study is a randomized controlled trial to compare the uptake and acceptability, efficacy, and cost of methods of delivery of an alcohol intervention in reducing unhealthy alcohol use and increasing viral suppression…
- Trial name
- EXTEND (NCT03928418)
- Testing
- In-person counseling session, Live phone call booster session, Technology (IVR or SMS) booster session
- Where
- Uganda
- Volunteers
- 272 people
- Sponsor
- University of California, San Francisco
Alcohol Drinking
Satiety and Alcohol Challenge
The goal of this pilot study is to identify the role of satiety on responses to alcohol drinking using human subject laboratory methods.
- Trial name
- SatTAC (NCT06576674)
- Testing
- Dietary Fiber + Green Tea Extract, Alcohol
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Dependence
Treatment Strategy for Alcohol Use Disorders in Veterans With TBI
The purpose of this research study is to understand the effectiveness of valproate (a common mood stabilizer) to further reduce alcohol misuse when given in addition to attending an alcohol rehabilitation program as well as the…
- Trial name
- AUD (NCT01342549)
- Testing
- Valproate, Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 62 people
- Sponsor
- VA Office of Research and Development
Alcohol Abuse
Study of Mobile Phone Delivered Intervention to Reduce Alcohol Consumption
In this study, the investigators will be developing and testing a mobile phone text message intervention to reduce alcohol use for people at risk of alcohol dependence.
- Trial name
- mROAD (NCT02158949)
- Testing
- mROAD
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Southern California
Alcohol Abuse, Drug Abuse
Effects of Levetiracetam (Keppra) on Alcohol Consumption
The overall goals of this study are to (1) expand knowledge about interactions of levetiracetam with alcohol by assessing the effects of levetiracetam compared to placebo in moderate and heavy social alcohol users and (2) to test…
- Trial name
- NCT01168687
- Testing
- Levetiracetam (Keppra)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Insomnia, Alcohol; Harmful Use
Insomnia Treatment and Problems (the iTAP Study)
This project aims to evaluate the efficacy of insomnia treatment in improving insomnia symptoms and alcohol-related problems among heavy-drinking young adults.
- Trial name
- iTAP (NCT03627832)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I), Sleep Hygiene
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia