Clinical trials: Driving Pressure
ARDS
Driving Pressure as a Predictor of Mortality in Acute Respiratory Distress Syndrome Patients
The aim of this study is to make analysis of potentially modifiable factors contributing to outcome of mechanically ventilated ARDS adult patient receiving lung protective strategy.
- Trial name
- NCT04778228
- Testing
- mechanical ventilation
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Assiut University
Pulmonary Resection Surgery, One Lung Ventillation (OLV)
BMI-Adjusted PEEP During One-Lung Ventilation in Thoracic Surgery
One-lung ventilation (OLV) is required during many thoracic surgical procedures and is associated with reduced functional residual capacity, atelectasis, ventilation-perfusion mismatch, hypoxemia, and potentially…
- Conditions
- Pulmonary Resection Surgery, One Lung Ventillation (OLV), General Anesthetic
- Trial name
- SIMPLE-PEEP (NCT07851740)
- Testing
- Fixed PEEP, BMI-adjusted PEEP
- Where
- 4 sites in Spain
- Volunteers
- 150 people
- Sponsor
- Jesús Manuel Nieves Alonso
COPD, Ventilator Lung
Best End-Expiratory and Driving-pressure for Individualized Flow Controlled Ventilation in Patients With COPD
Patients with chronic obstructive pulmonary disease (COPD) have a significantly increased risk of postoperative pulmonary complications (PPC).
- Conditions
- COPD, Ventilator Lung, Anesthesia
- Trial name
- NCT05812365
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Obese Patients With Bariatric Surgery, Lung Ultrasound Score
Comparison Between Individualized PEEP Ventilation Guided by Driving Pressure and Conventional Lung Protective Strategy in Obese Patients Undergoing Laparoscopic Bariatric Surgery
this study to compare the ventilation in obese patients either using Driving pressure ventilation technique or conventional protective lung strategy all by using Lung ultrasound score
- Trial name
- NCT06950112
- Testing
- lung ultrasound
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mahmoud Gamal Ahmed Arakeeb
Postoperative Pulmonary Complications (PPCs), One-lung Ventilation (OLV)
Individualized Open Lung Ventilation and Postoperative Pulmonary Complications in Thoracic Surgery
This prospective, single-center, randomized controlled trial aims to evaluate the efficacy of an intraoperative "Individualized Open Lung Ventilation" strategy compared to a standard lung-protective ventilation strategy in…
- Conditions
- Postoperative Pulmonary Complications (PPCs), One-lung Ventilation (OLV), Thoracic Surgery, Video Assisted
- Trial name
- NCT07387822
- Testing
- Standard Lung-Protective Ventilation, Individualized Open Lung Ventilation
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Aerospace Center Hospital
Weaning Failure
Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation
This project focuses on the analysis of the correlation between transpulmonary driving pressure and uneven lung ventilation and regional lung compliance in patients using prolonged mechanical ventilation (PMV), in order to…
- Trial name
- NCT07003672
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Lung Collapse
Open Lung Approach Versus Standard Protective Strategies
The aim of this study was to compare the effects of adding a recruitment maneuver (RM) to low tidal volume (VT) ventilation, with or without an individualized post-RM positive end-expiratory pressure (PEEP) setting in…
- Trial name
- NCT02798133
- Testing
- OLA, RM-5
- Volunteers
- 36 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Driving Pressure, Positive End-expiratory Pressure
Driving Pressure-guided Positive End-expiratory Pressure to Prevent Postoperative Atelectasis in Obese Children: a Prospective, Randomized Controlled Clinical Trial
At present, the use of lung protective ventilation strategies in children is mainly based on adult and intensive care unit data.
- Conditions
- Driving Pressure, Positive End-expiratory Pressure, Postoperative Atelectasis, Obese
- Trial name
- NCT06471491
- Testing
- Driving pressure-guided positive end-expiratory pressure
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Provincial People's Hospital
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
Attention Deficit Hyperactivity Disorder
Expectation of Driving Performance in Young Adults With ADHD Assessed by Driving Simulator and Seat Pressure Mapping
Adolescents suffering of ADHD may have impaired driving performance. The investigators would like to check the differences in driving performance in young adults(aged: 15-18 years) with ADHD by driving simulator and seat pressure…
- Trial name
- NCT01179386
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Acute Respiratory Failure, Mechanical Ventilation Complication
Effect of End-inspiratory Airway Pressure Measurements on the Risk of VILI in Ventilated Patients
Mechanical ventilation may be associated with ventilator-induced lung injury (VILI). Several respiratory variables have been employed to estimate the risk of VILI, such as tidal volumes, plateau pressure, driving pressure, and…
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- P1P2Decay (NCT05991258)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Padova
Sever Chest Trauma, Mechanical Ventilation
Driving Pressure in Trauma
Traumatic chest injuries are responsible for significant morbidity and the cause of trauma-related death in 20%-25% of cases. Thoracic trauma can include multiple injuries, mainly osseous (ribs, sternal fractures, flail chest)…
- Trial name
- NCT03367442
- Testing
- no intervention
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Postoperative Pulmonary Complications, Mechanical Ventilation
Driving Pressure-Guided Individualized PEEP Versus Standard PEEP: Effects on Postoperative Pulmonary Complications in Upper Abdominal Digestive Surgery
This randomized clinical trial compares two methods of setting positive end-expiratory pressure (PEEP) during general anesthesia in adults undergoing upper abdominal digestive surgery who are at moderate or high risk of…
- Trial name
- NCT07885124
- Testing
- Driving Pressure-Guided Individualized PEEP, Standard PEEP
- Where
- Tunisia
- Volunteers
- 210 people
- Sponsor
- Hopital Charles Nicolle
ARDS
Driving Pressure Guided VT in ARDS Patients
A prospective physiologic study, in participants with COVID-19 related or non-COVID-19 related acute respiratory distress syndrome (ARDS) requiring mechanical ventilation less than 48 hours.
- Trial name
- NCT05207267
- Testing
- driving pressure guided tidal volume
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Southeast University, China
Lung Collapse
OLA to Lowest DP in Cardiac Surgery
This study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (PEEP) titrated to best driving pressure (DP) after a RM versus the recommended protective PEEP of 5…
- Trial name
- NCT03133754
- Testing
- DP-PEEP, RM-5
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
One-Lung Ventilation, Postoperative Complications
Driving Pressure and Postoperative Pulmonary Complications in Thoracic Surgery
Pulmonary complications are the most common complication in thoracic surgery and the leading cause of mortality.Therefore, lung protection is utmost important, and protective ventilation is strongly recommended in thoracic…
- Conditions
- One-Lung Ventilation, Postoperative Complications, Driving Pressure, Postoperative Pulmonary Complication
- Trial name
- NCT04260451
- Testing
- ventilation
- Where
- South Korea
- Volunteers
- 1,300 people
- Sponsor
- Samsung Medical Center
Acute Kidney Failure, Mechanical Ventilation Strategies
Driving Pressure Optimization, RV-PA Coupling, and AKI in Mechanically Ventilated Critically Ill Patients
This study evaluates the effect of driving pressure optimization on right ventricular-pulmonary artery (RV-PA) coupling, assessed by TAPSE/PASP ratio, and its association with acute kidney injury (AKI) progression in mechanically…
- Conditions
- Acute Kidney Failure, Mechanical Ventilation Strategies, Right Ventricular (RV) Dysfunction, Critical Illness
- Trial name
- NCT07836387
- Testing
- Driving Pressure-Guided Ventilator Optimization
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Nardin Aymn Boshra
Mechanical Ventilation, Lung Protective Ventilation
Driving Pressure Guided Mechanical Ventilation Versus Lung Protective Ventilation Among Patients Undergoing Elective Surgeries
Patient undergoing surgeries in general anesthesia require support of their breathing by ventilator. Different strategies can be used to manage breathing of the patient.
- Conditions
- Mechanical Ventilation, Lung Protective Ventilation, Driving Pressure
- Trial name
- NCT07092943
- Testing
- Lung protective ventilation, Driving pressure guided ventilation
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Peep Titration in Lung Protective Ventilation
Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery
Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery.
- Trial name
- NCT07044089
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Atelectasis, Postoperative Pulmonary
Driving Pressure-guided PEEP Titration in Robot-assisted Laparoscopic Surgeries
The purpose of this study is to investigate the effect of driving-pressure guided positive end-expiratory pressure (PEEP) titration.
- Trial name
- NCT04327193
- Testing
- Titrated PEEP based on driving pressure, Conventional PEEP
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Seoul National University Hospital