Clinical trials: Drug/Substance Abuse/Addiction
Substance Use Disorder (SUD), Drug Abuse
Adapted RPM-08 for Substance Use Disorder in Pakistan
The goal of this clinical trial is to learn if a culturally adapted Relapse Prevention Module (RPM-08) can reduce relapse risk in people with substance use disorders in Pakistan.
- Conditions
- Substance Use Disorder (SUD), Drug Abuse, Relapse
- Trial name
- NCT07552623
- Testing
- Adapted Relapse Prevention Module (RPM-08), Treatment as Usual (TAU)
- Where
- Pakistan
- Volunteers
- 70 people
- Sponsor
- Universiti Sains Malaysia
Cocaine Abuse, Cocaine-Related Disorders
Medications for Stopping Cocaine Dependence and Preventing Relapse
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found.
- Trial name
- NCT00218023
- Testing
- Modafinil, Levodopa/Carbidopa, Naltrexone HCl
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Substance Use, Substance Abuse
Family Engagement, Cross-System Linkage to Substance Use Treatment for Juvenile Probationers -- Phase 3
Developed from adapting and combining two evidence-based programs, Project CONNECT (a linkage-to-services program that targets barriers within the probation and substance abuse treatment systems) and TIES (a program that teaches…
- Conditions
- Substance Use, Substance Abuse, Substance Use Disorders, Substance-Related Disorders
- Trial name
- NCT03048552
- Testing
- Family CONNECT
- Volunteers
- 22 people
- Sponsor
- New York State Psychiatric Institute
Opioid-Related Disorders, Drug Addiction
Medication Treatment for Opioid Use Disorder in Expectant Mothers
The primary objective of this study is to evaluate the impact of treating opioid use disorder (OUD) in pregnant women with extended-release buprenorphine (BUP-XR), compared to sublingual buprenorphine (BUP-SL), on mother and…
- Conditions
- Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse
- Trial name
- MOMs (NCT03918850)
- Testing
- Buprenorphine Injection, Buprenorphine Sublingual Product
- Where
- 12 sites in United States
- Volunteers
- 140 people
- Sponsor
- T. John Winhusen, PhD
Overdose, Opioid-related Disorders
Phone Interview to Prevent Recurring Opioid Overdoses
There has been a dramatic rise in opioid overdose (OOD) deaths in recent years. Attempts to ameliorate the problem have largely focused on increasing the accessibility of naloxone, an opioid antagonist that is effective in OOD…
- Conditions
- Overdose, Opioid-related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02282306)
- Testing
- TTIP-PRO
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Substance Abuse
Methylphenidate Studies for Drug Abuse Vulnerability Molecular Genentics
Background: Research has shown that several human genes have been associated with vulnerability to substance abuse and dependence.
- Trial name
- NCT00247689
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Domestic Violence, Substance Abuse
Treatment of Intimate Partner Violence and Substance Abuse in a Substance Abuse Treatment Facility
Intimate partner violence is a significant societal problem. There is considerable evidence that a strong relationship between the use of alcohol and other drugs and intimate partner violence exists.
- Trial name
- NCT00847873
- Testing
- substance abuse/domestic violence treatment, Cognitive behavioral therapy addressing substance abuse
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- VU University of Amsterdam
Cocaine Dependence, Cocaine Abuse
Quetiapine for the Reduction of Cocaine Use
This placebo-controlled trial will test the effectiveness of Seroquel XR™ for the treatment of cocaine dependence in non-psychotic individuals who are cocaine dependent.
- Conditions
- Cocaine Dependence, Cocaine Abuse, Cocaine Addiction, Drug Abuse
- Trial name
- AZC (NCT00631748)
- Testing
- quetiapine fumarate, Cognitive-behavioral Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Substance Abuse, Drug Addiction
Integrating Mindfulness-Based Skills Training Into Brief Outpatient Treatment for Substance Abusing Youth
The proposed study will evaluate the clinical effectiveness of integrating mindfulness-based skills training into a standardized brief group intervention for youth (ages 16 to 24) identified as having problematic substance use.
- Trial name
- NCT00244699
- Testing
- MI Alone or Plus Mindfulness-Based Skills Training
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Cocaine-Related Disorders, Heroin Dependence
Treatment Efficacy for Drug Abuse and AIDS Prevention - 1
The purpose of this study is to assess the safety and effectiveness of buprenorphine for treatment of concurrent intravenous heroin and cocaine dependence.
- Trial name
- NCT00000210
- Testing
- Buprenorphine
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cannabis Use Disorder, Cannabis Use Disorders
Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder
The HASHTAG Study is investigating whether the medicine semaglutide can help adults with cannabis use disorder (CUD) reduce their cannabis use. Participants will be randomly assigned to receive either semaglutide or a placebo.
- Conditions
- Cannabis Use Disorder, Cannabis Use Disorders, Cannabis Abuse, Cannabis Dependence
- Trial name
- HASHTAG (NCT07523633)
- Testing
- semaglutide
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Mental and Behavioral Disorders Due to Use of Cocaine: Harmful Use, Opiate Addiction
Recovery Housing and Drug Abuse Treatment Outcome
Reinforcement-Based Therapy (RBT) is an intensive outpatient substance abuse treatment that includes relapse prevention skills training, goal setting, help with finding employment and abstinence-contingent rent payment for…
- Trial name
- NCT03278496
- Testing
- Recovery Housing plus Counseling, Usual Care Referral, Recovery Housing Only
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- Johns Hopkins University
Behavior, Addictive, Adolescent - Emotional Problem
"Juego de LLaves": Study Protocol of a Universal School-based Drug Use Prevention Program (PSIDUP)
"Juego de Llaves" is a universal school-based drug prevention program for adolescents aged 12-15 years. The outcome evaluation is critical to determine the quality of preventive interventions.
- Conditions
- Behavior, Addictive, Adolescent - Emotional Problem, Alcohol Abuse, Smoking Behaviors
- Trial name
- PSIDUP (NCT05442294)
- Testing
- Juego de Llaves
- Where
- Spain
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Susana Al-Halabí
Opiate Substitution Treatment
Buprenorphine and Substance Abuse Services for Prescription Opioid Dependence
This is a randomized trial of two group-based models of care for buprenorphine/naloxone (bup/nx) patients in Substance Use (SU) specialty treatment: Standard Medical Management (SMM) and Intensive Outpatient Treatment (IOT).
- Trial name
- NCT02496403
- Testing
- Standard Medical Management (SMM)
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- Kaiser Permanente
Opioid Related Disorders, Opiate Addiction
Monitoring Patterns of Prescribing to Identify Changes in Access to ER/LA Opioid Analgesics
Changes in prescribing will be compared in prescribers from specialties whose prescribing is hypothesized to be relatively unaffected by the REMS (such as oncologists and hospice providers) versus those for whom the REMS could…
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02920775
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 360,000 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Substance-Related Disorders, Drug Addiction
Family Training Program for Parents of Substance Using Adolescents
This project will modify Community Reinforcement and Family Training (CRAFT; n=15) and Alanon/Naranon Facilitation (ANF; n=15) for use with parents who are concerned about an out-of-treatment adolescent.
- Conditions
- Substance-Related Disorders, Drug Addiction, Substance Abuse
- Trial name
- FTP (NCT01344382)
- Testing
- Community Reinforcement and Family Training, Al-Anon Facilitation
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Treatment Research Institute
Drug Addiction
Importance of Drug User Detection
1. Identify the illicit drugs (morphine, cannabinoids, benzodiazepines, barbiturates, tramadol, cocaine, amphetamine, alcohol, synthetic cannabinoids). 2.
- Trial name
- NCT05803044
- Volunteers
- 200 people
- Sponsor
- Assiut University
Opioid-related Disorders, Opioid Addiction
ER/LA Opioid Analgesics - Surveillance Monitoring of State Medical Examiner Databases
In April 2011, the U.S. Food and Drug Administration (FDA) determined that a class-wide risk evaluation and mitigation strategy (REMS) for all extended-release (ER) and long-acting (LA) opioid medications was necessary to support…
- Conditions
- Opioid-related Disorders, Opioid Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02897414
- Testing
- Surveillance of state medical examiner databases
- Volunteers
- 13,015 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Study to Evaluate the Likeability, Safety, and Abuse Potential of NRP 104 in Adults With Histories of Stimulant Abuse
This research is being done to evaluate if NRP104 is a safe drug. The other purpose is to learn if NRP104 produces a high and any other effects like amphetamine and other stimulant drugs that are abused.
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00248092
- Testing
- NRP104
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Depression, Drug Abuse
Behavioral Therapy Development for Methamphetamine Abuse
The purpose of this study is to evaluate whether a specially developed group counseling approach is better able to help HIV-positive gay and bisexual men (GBM) who use crystal meth to stop using methamphetamines, reduce sexual…
- Conditions
- Depression, Drug Abuse, Sexually Transmitted Diseases
- Trial name
- NCT00252434
- Testing
- Cognitive Behavioral Therapy Development for Methamphetamine Abuse
- Where
- United States
- Sponsor
- University of California, Los Angeles