Clinical trials: Drug
Cerebral Infarction, Stroke
CHInese Medicine NeuroAid Efficacy on Stroke Recovery
CHIMES is a double blind, placebo controlled, randomized, multicenter study to test the hypothesis that NeuroAid is superior to placebo in reducing neurological deficit and improving functional outcome in patients with cerebral…
- Trial name
- CHIMES (NCT00554723)
- Testing
- NeuroAid
- Where
- 24 sites in Hong Kong, Malaysia and 4 more
- Volunteers
- 1,100 people
- Sponsor
- CHIMES Society
Melanoma
The Impact of a Prevention Program on Sun Risks in Primary School in Tropical French Region
Sun exposure during childhood can cause the development of skin cancer in later years, in particular melanoma, which is the most lethal.The worldwide incidence of melanoma is on the rise, with nearly 290,000 new cases diagnosed…
- Trial name
- PRESOLRE (NCT05367180)
- Testing
- MISOLRE prevention program on sun risks, "Vivre avec le Soleil" prevention program on sun risks, Sun protection equipment
- Where
- Reunion
- Volunteers
- 1,452 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Joint Discomfort, Quality of Life (QOL)
Product Responsiveness to Enhanced Bioavailability Curcumin Dietary Supplements in Adults
The goal of this clinical trial is to evaluate whether distinct formulations of bioavailable curcumin supplements can improve joint comfort in adults who experience self-reported discomfort.
- Trial name
- NCT07196046
- Testing
- Supplement 2, Supplement 3, Supplement 1
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ultra Botanica LLC
Smoking Cessation, Nicotine Addiction
Innovative Digital Therapeutic for Smoking Cessation
This study is comparing the efficacy of two smoking cessation apps.
- Conditions
- Smoking Cessation, Nicotine Addiction, Drug Addiction, Drug Dependence
- Trial name
- NCT03694327
- Testing
- CT-101-M, QuitGuide
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- My Digital Study
Stress Urinary Incontinence, Urinary Incontinence
Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence
This is a multicentered, double-blind, randomized controlled, surgical trial of 358 women with inadequate symptom relief of stress urinary incontinence (SUI) or stress predominant mixed urinary incontinence (MUI) after…
- Conditions
- Stress Urinary Incontinence, Urinary Incontinence, Mixed Urinary Incontinence
- Trial name
- BASIS (NCT06480227)
- Testing
- Solyx Single-incision Sling, Bulkamid Transurethral Bulking Agent
- Where
- 7 sites in United States
- Volunteers
- 358 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Sepsis
Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial
PALETTE is a perpetual adaptive platform to efficiently study sepsis interventions within 'treatable traits' in all-ages patients enabling prompt evaluation of pandemic treatments.
- Trial name
- PALETTE (NCT06381661)
- Testing
- Tocilizumab, Baricitinib, Anakinra
- Where
- 19 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sunscreening Agent
Sun Protection Factor Assay
To evaluate the Sun Protection Factor efficacy on human skin.
- Trial name
- SPF Assay (NCT02822261)
- Testing
- Coppertone (BAY987516)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Bayer
Diabetes Mellitus, Skin and Connective Tissue Diseases
Treatment Effects of Two Pharmaceutical Skin Care Creams for Xerotic Feet Among Persons with Diabetes
Introduction Diabetic foot-ulcers leads to decreased quality of life, risk of major amputation, and resource demanding health-care.
- Trial name
- NCT06427889
- Testing
- Canoderm, Oviderm, Decubal
- Where
- Sweden
- Volunteers
- 98 people
- Sponsor
- Malmö University
Healthy Adult Subjects
Clinical Pharmacology Study of Oral Edaravone in Healthy Adult Males (Drug Interaction Study and Preliminary Regimen-Finding Study)
Cohort 1: To evaluate the drug interactions, safety, and tolerability of oral edaravone when coadministered with rosuvastatin, sildenafil or furosemide in healthy adult males Cohort 2: To evaluate the pharmacokinetics, safety…
- Trial name
- NCT04481789
- Testing
- MT-1186, Rosuvastatin, Sildenafil
- Where
- Japan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Shionogi
Acute Coronary Syndrome
Efficacy and Safety of Lornoxicam in Patients With Acute Coronary Syndrome
The purpose of this study is to determine whether nonsteroidal antiinflammatory drug lornoxicam in combination with low dose aspirin (100mg/day) is effective and safe in patients with Acute Coronary Syndrome without persistent…
- Trial name
- PLEA (NCT00997750)
- Testing
- Lornoxicam
- Where
- Russia
- Volunteers
- 85 people
- Sponsor
- Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation
Graft Vs Host Disease, Extracorporeal Photopheresis
Photopheresis in GvHD After Hematopoietic Transplantation: Characteristics of the Procedure and of the Cell Product
This is an observational study on extracorporeal photopheresis,an established therapy for the treatment of Graft versus Host Disease (GvHD) post allogeneic haemopoietic stem cell transplantation.
- Trial name
- 3594 (NCT05718674)
- Testing
- Extracorporeal Photopheresis
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Interdisciplinary Communication, Management, Medication Therapy
Minimizing Harm From ADEs by Improving Nurse-Physician Communication
The purpose of this research study is to examine the clinical processes of care involved with the sharing and communicating of medication management information in the inpatient setting between nurses, pharmacists and physicians.
- Trial name
- MED-COMM (NCT00574990)
- Where
- 3 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Intracanal Medication, Bromelain
Effect of Bromelain Versus Calcium Hydroxide as an Intracanal Medication on the Intensity of Postoperative Pain and Bacterial Load Reduction in Necrotic Single Rooted Lower Premolars
the aim of the study is to compare the effect of bromelain vs calcium hydroxide as intracanal medication on intensity of pain and bacterial load in necrotic single lower premolars
- Conditions
- Intracanal Medication, Bromelain, Calcium Hydroxide, Bacterial Load Reduction
- Trial name
- NCT05687760
- Testing
- bromelain, Calcium hydroxide
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
NSCLC
Relatrilfa-α Plus Single-Agent Chemotherapy as Neoadjuvant Therapy for Resectable Stage II-III NSCLC (Phase 2)
This is a single-center, single-arm, phase 2 trial evaluating the efficacy and safety of retlirafusp alfa combined with single-agent chemotherapy as neoadjuvant treatment for patients with resectable stage II-III EGFR/ALK…
- Trial name
- NCT07550920
- Testing
- Drug: Retlirafusp alfa, Drug: Single-agent Chemotherapy, Procedure: Radical Surgery
- Volunteers
- 18 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Rheumatoid Arthritis
Safety, Tolerability and Efficacy Study of the New Medication ASK8007 to Treat Patients With Rheumatoid Arthritis
The purpose of this study is to investigate the safety and tolerability of the new medication ASK8007, and to study whether it has a beneficial effect on joint inflammation in patients with rheumatoid arthritis.
- Trial name
- NCT00411424
- Testing
- ASK8007
- Where
- 10 sites in Belgium, Hungary and 4 more
- Volunteers
- 54 people
- Sponsor
- Astellas Pharma Inc
Osteoarthritis, Rheumatoid Arthritis
The Standard Care Versus Celecoxib Outcome Trial
The Standard Care versus Celecoxib Outcome Trial (SCOT) is a large streamline safety study designed to compare the cardiovascular safety of celecoxib versus traditional non-selective Non Steroidal Anti-Inflammatory Drug (NSAID)…
- Trial name
- SCOTLSSS (NCT00447759)
- Testing
- Celecoxib, Diclofenac
- Where
- 10 sites in Denmark, Netherlands and 1 more
- Volunteers
- 7,297 people
- Sponsor
- University of Dundee
Effect of Drug
Comparison of Preserved and Preservative-free Latanoprost 0.005% in Primary Open Angle Glaucoma and Ocular Hypertensive Patients, at Guinness Eye Centre, Lagos.
It is a randomised, double-blinded clinical trial in which consenting participants who meet the inclusion criteria would be randomised into 2 groups.
- Trial name
- NCT05606796
- Testing
- Latanoprost 0.005% Ophthalmic Solution
- Where
- Nigeria
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Uzoma Chinyei Joan
Stress
Evaluation of Mind-body Educational Program to Enhance Resiliency and Reduce Burnout in First Year Residents
This prospective pilot study evaluated the benefits of a stress management and resiliency training program for residents (SMART-R).
- Trial name
- NCT02621788
- Testing
- Stress Management and Resiliency Training for Residents (SMART-R)
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pharmacological Action
Test of a New Gel-based Colon Cleansing Agent Compared to Moviprep
Crossover study comparing Moviprep (for bowel cleansing) with a new gel-based colon cleansing agent before colonoscopy
- Trial name
- NCT03904303
- Testing
- A 06 ad
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Increased Drug Resistance
Prevalence and Level of Thienopyridine Resistance Seen in a Contemporary Percutaneous Coronary Intervention or Coronary Artery Bypass Graft Population
The primary objective of this prospective clinical registry is to determine the prevalence and level of thienopyridine resistance seen in a population undergoing contemporary percutaneous coronary intervention (PCI) or coronary…
- Trial name
- VASP (NCT01408927)
- Testing
- Thienopyridine resistance testing, Aspirin resistance testing, Genetic polymorphism assessment
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Medstar Health Research Institute