Clinical trials: Drug Abuse, Intravenous
Intravenous Drug Abuse, S Aureus Colonization
PWID; Longitudinal S Aureus Colonization Pattern and the Impact on Infection Frequency by Regular Showers With Chlorhexidine
People who inject drugs (PWID) have increased risk of Staphylococcus aureus (S. aureus) colonization, skin and soft tissue infections (SSTI), and systemic infections like septicaemia and endocarditis.
- Trial name
- NCT03940729
- Testing
- Chlorhexidine Topical
- Volunteers
- 61 people
- Sponsor
- Lund University
Human Immunodeficiency Virus, Substance Abuse, Intravenous
BRIDGE: Improving HIV Service Delivery for People Who Inject Drugs
Scaling up integrated, cost-efficient HIV services for people who inject drugs (PWID) in Needle Syringe Programs (NSPs) is urgently needed in Kazakhstan, where only one-third of the estimated 19,000 HIV-positive PWID are ever…
- Trial name
- NCT02796027
- Testing
- BRIDGE
- Where
- 2 sites in United States, Kazakhstan
- Volunteers
- 616 people
- Sponsor
- Columbia University
Histiocytosis
Histiocytosis in Injecting Drug Users
The goal of this observational study is to describe a new disease condition of histiocytosis related to injecting drug use, its preconditions, symptoms, signs, findings, and prognosis in a detailed and systematic patient series…
- Trial name
- NCT06573671
- Testing
- Chitotriosidase, Mass spectrometry, scanning electron microscope with energy-dispersive X-ray spectroscopy
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Tampere University Hospital
Addiction, Substance Abuse Drug Chronic
Stage III Community-based Efficacy Trial for Mothering From the Inside Out
This is a Stage III community-based randomized clinical efficacy trial testing Mothering from the Inside Out (MIO), the first evidence-based parenting intervention designed to be delivered by addiction counselors in addiction…
- Conditions
- Addiction, Substance Abuse Drug Chronic, Child Neglect, Child Neglect Emotional
- Trial name
- NCT02955199
- Testing
- Mothering From the Inside Out (MIO), Parent Education
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Yale University
Endocarditis
Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL)
The purpose of this study is to determine the safety and compliance of initial intravenous (IV) antibiotics followed by oral antibiotic therapy following uncomplicated IVDA endocarditis.
- Trial name
- OPTIMAL (NCT05156437)
- Testing
- Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin, Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- West Virginia University
Cocaine-Related Disorders, Opioid-Related Disorders
The Therapeutic Workplace Initiation Study
The primary purpose of the study is to determine if the central feature of the Therapeutic Workplace, the abstinence reinforcement contingency, is critical to initiate cocaine abstinence in injection drug using methadone patients…
- Conditions
- Cocaine-Related Disorders, Opioid-Related Disorders, Heroin Dependence, Substance Abuse, Intravenous
- Trial name
- NCT00249470
- Testing
- Abstinence & Work, Work Only
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Johns Hopkins University
Gram-Positive Bacterial Infections, Gram-Positive Bacteraemia
Substance Use Disorder (SUD)-Associated Infections' Treatment With Dalbavancin ENabling OUtpatient Transition
The Investigators aim to study the outcomes of serious infections due to vancomycin susceptible infections in gram-positive organisms susceptible to vancomycin in people who use drugs (PWUD).
- Conditions
- Gram-Positive Bacterial Infections, Gram-Positive Bacteraemia, Substance Use Disorders, Intravenous Substance Abuse
- Trial name
- SUDDEN-OUT (NCT04847921)
- Testing
- Dalbavancin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Hepatitis C, Drug Abuse, Intravenous
The TAP Study: Treating People Who Inject Drugs in Community-Based Settings Using a Social Network Approach
This study will investigate the feasibility of treating people who inject drugs (PWID) with hepatitis C virus (HCV) in community-based settings with a 12-week course of oral therapy combination of sofosbuvir plus ledipasvir.
- Trial name
- TAP (NCT02363517)
- Testing
- Sofosbuvir/ledispasvir fixed dose combination (SOF + LDP)
- Where
- Australia
- Volunteers
- 420 people
- Sponsor
- Macfarlane Burnet Institute for Medical Research and Public Health Ltd
Drug Abuse, Intravenous
Case Management in HCV Infected PWID
To study the impact of case management on the outcome of the care of chronic hepatitis C in people who inject drugs (PWID). By creating the function of case manager, the investigators will target all the barriers to care of the…
- Trial name
- CM-HCV (NCT03106194)
- Testing
- case management
- Where
- Belgium
- Volunteers
- 441 people
- Sponsor
- Hasselt University
HIV, Substance Abuse, Intravenous
Contingency Management in the Delivery of HAART to Drug Users in Chennai, India
Drug use (DU) is a major risk factor for HIV infection in many regions of the world. However, as highly active antiretroviral therapy (HAART) has been rolled out in South and South East Asia, less than 2% of individuals initiated…
- Trial name
- NCT01031745
- Testing
- Contingency, Prize bowl drawings
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Johns Hopkins University
Healthy
A Study to Characterize the Abuse Liability of Intravenous Oxycodone Alone or in Combination With Intravenous Naltrexone in Healthy, Non-Dependent, Recreational Opioid Users
The main purpose of this study is to simulate if oxycodone and naltrexone combination capsules (ALO-02) were to be tampered with by dissolving and then injecting intravenously for the purpose of getting high.
- Trial name
- NCT01825447
- Testing
- Oxycodone + Naltrexone, Oxycodone
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Pfizer
Bacterial Infection
: Bacterial Infections in Injecting Drug Users
Bacterial infections in people who inject psychoactive substances
- Trial name
- NCT04550767
- Where
- France
- Volunteers
- 117 people
- Sponsor
- University Hospital, Montpellier
HIV Infections, HIV Seronegativity
Effectiveness of AIDSVAX B/E Vaccine in Intravenous Drug Users in Bangkok, Thailand
The purpose of this study is to determine if the vaccine, AIDSVAX B/E, will protect intravenous drug users from becoming infected with HIV.
- Trial name
- NCT00006327
- Testing
- MN rgp120/HIV-1 and A244 rgp120/HIV-1
- Where
- Thailand
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- VaxGen
Intravenous Drug Abuse, HIV Infections
Reducing Health Problems Associated With Injection Drug Use
The purpose of this study is to develop and test an intervention to reduce bacterial and viral infections among injection drug users.
- Trial name
- NCT01128920
- Testing
- Skin and Needle Hygiene Intervention, No intervention - assessment-only condition
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Northern Colorado