Clinical trials: Drug Dependence
Alcohol Use Disorder, Alcohol Dependence
Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders
The purpose of this study is to examine the effects of rapamycin (sirolimus) versus a placebo, an inactive substance, on responses to alcohol cues in individuals with alcohol use disorder.
- Trial name
- NCT03732248
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Nicotine Dependence
Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking
The purpose of this study is to evaluate the efficacy of the glycine antagonist, GW468816, compared with placebo on duration of abstinence and rates of relapse in recently quit female smokers in a randomized, double-blind…
- Trial name
- NCT00218465
- Testing
- GW468816
- Where
- 2 sites in United States
- Volunteers
- 264 people
- Sponsor
- Massachusetts General Hospital
Alcohol Dependence, Drug Dependence
LINK: Aftercare Monitoring Project
The prevalence of substance use disorders (SUD) in the VA is rising, making SUD(s) among the most commonly diagnosed disorders in the VA.
- Trial name
- NCT00265512
- Testing
- Telephone Case Monitoring, Continuing Care as Usual
- Where
- 3 sites in United States
- Volunteers
- 667 people
- Sponsor
- VA Office of Research and Development
Alcoholism, Alcohol Abuse
Varenicline Treatment of Alcohol Dependence in Smokers
The purpose of this study is to determine whether varenicline is effective in the treatment of alcohol dependence in smokers.
- Conditions
- Alcoholism, Alcohol Abuse, Smoking, Alcohol Drinking
- Trial name
- NCT01553136
- Testing
- Varenicline
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Yale University
Alcohol Dependence, Insomnia
Pharmacotherapy and Mechanisms of Sleep Disturbance in Alcohol Dependence
Insomnia and other sleep abnormalities are common, persistent, and associated with relapse in alcohol-dependent patients. The overall, long-term objectives of the proposed research are to investigate the neurophysiologic…
- Trial name
- MA (NCT01014533)
- Testing
- Gabapentin dispensed to subject.
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Dr. Kirk Brower
Cannabis, Marijuana Abuse
Dronabinol Interactions With Cognitive Enhancing Drug in Humans
Marijuana use is a major problem among veterans and non-veterans. A patient's use of marijuana while engaged in psychotherapy treatment may affect their memory and, therefore, limit their ability to benefit from treatment.
- Trial name
- NCT00842985
- Testing
- drug condition
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Yale University
Substance Dependence
Stress, Distress Intolerance, and Drug Dependence
This study is designed to evaluate the relative efficacy of a novel treatment (CBT-IC) versus a standard individual drug-counseling treatment.
- Trial name
- NCT00430482
- Testing
- Cognitive Behavioral Therapy, Individual Counseling
- Where
- 2 sites in United States
- Volunteers
- 133 people
- Sponsor
- Boston University Charles River Campus
Opioid Dependence, Communication
The Life STORRIED Study
To compare the effectiveness of 3 strategies to inform patients of their risks associated with misuse of opioid prescriptions after treatment in the ED from renal colic or musculoskeletal back pain.
- Conditions
- Opioid Dependence, Communication, Risk Behavior, Narrative Medicine
- Trial name
- NCT03134092
- Testing
- Probabilistic Risk Communication Tool (PRT), Narrative Enhanced Risk Tool (NERT)
- Where
- 4 sites in United States
- Volunteers
- 1,302 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Prescription Opiate/Medication Dependence
CURE Addiction Center of Excellence: Brain Mechanisms of Relapse and Recovery
The proposed project will use fMRI and specific probes of reward and inhibition as biomarkers predicting drug use during and after treatment in 72 subjects addicted to prescription opioids/medications.
- Trial name
- fMRI CURE (NCT01587196)
- Testing
- Vivitrol
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Pennsylvania
Social Anxiety Disorder, Social Phobia
Paroxetine for Comorbid Social Anxiety Disorder and Alcoholism
The purpose of the study is to determine whether an SSRI, paroxetine, improves social anxiety symptoms and alcohol use in individuals who drink to cope with social anxiety disorder.
- Conditions
- Social Anxiety Disorder, Social Phobia, Alcohol Use Disorder, Alcohol Abuse
- Trial name
- NCT00246441
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Medical University of South Carolina
Nicotine Dependence
Effectiveness of GSK598809, a Selective D3 Antagonist, Added to CBT and NRT for Smoking Cessation and Relapse Prevention
The purpose of this research study is to find out if an investigational drug, GSK598809 can help people who have very recently quit smoking; the investigators want to find out if continuing to take GSK598809 over six weeks can…
- Trial name
- NCT01188967
- Testing
- GSK598809
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Massachusetts General Hospital
Cocaine Dependence
Imaging the Neurobiology of Behavioral and Medication Treatment for Cocaine Dependence
The proposed study will look at cocaine dependent individuals and will consist of three consecutive phases: 1) the 2-week outpatient lead-in phase during which behavioral therapy will be administered; 2) the 15-21 day inpatient…
- Trial name
- COST (NCT01468012)
- Testing
- levodopa carbidopa and entacapone (LCE)
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Drug Addiction
The Role of Sleep in the Treatment of Cannabis Use Disorders
The number of people seeking treatment for marijuana-related problems is on the rise, yet there is no currently accepted medication proven to help them quit.
- Trial name
- NCT01685073
- Testing
- Zolpidem extended-release, MET/CBT
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Methamphetamine Dependence, Methamphetamine Withdrawal
Characterizing Methamphetamine Withdrawal in Recently Abstinent Methamphetamine Users: A Pilot Study
Methamphetamine use has escalated in recent years. Methamphetamine use has also spread throughout the country. Although much information has been gathered on the treatment of cocaine abuse, very little information has been…
- Trial name
- NCT00653263
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Arkansas
Tobacco Dependence, Smoking
Bupropion SR Plus Counseling for Smoking Cessation
The purpose of this study was to determine if bupropion plus counseling was more effective than bupropion alone or counseling alone in helping smokers quit smoking.
- Trial name
- NCT01621009
- Testing
- Active bupropion + counseling, Active bupropion, No counseling
- Where
- United States
- Volunteers
- 463 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cocaine Dependence
Effectiveness of Extended Treatments for Drug Dependence
This study tests the effectiveness of two 24 month, telephone-based adaptive continuing care interventions for patients with cocaine dependence.
- Trial name
- ETDD (NCT00685659)
- Testing
- Intensive Outpatient Treatment, Adaptive telephone-based counseling, Adaptive telephone-based counseling plus incentives
- Where
- 2 sites in United States
- Volunteers
- 332 people
- Sponsor
- University of Pennsylvania
Opiate Dependence
Low Dose Naltrexone-buprenorphine Transfer to Vivitrol Injection in Opioid Dependence
The purpose of this study is to evaluate a very low dose naltrexone-buprenorphine treatment to transfer opioid dependent individuals to extended release naltrexone injection (Vivitrol).
- Trial name
- BUP/NXT-VIVI (NCT01690546)
- Testing
- very low dose naltrexone, extended release naltrexone, buprenorphine/naloxone
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Paolo Mannelli
Methamphetamine, Amphetamine Dependence
Study of Medical Treatment for Methamphetamine Addiction
Currently there are no medications approved for the treatment of methamphetamine addiction. Bupropion is an antidepressant that is approved by the Food and Drug Administration (FDA) for the treatment of depression and for…
- Conditions
- Methamphetamine, Amphetamine Dependence, Pharmacogenetics, Methamphetamine Dependence
- Trial name
- BUP PGx (NCT00833443)
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of California, Los Angeles
HIV Infections, Behavioral Symptoms
Friendship Bench Adaptation to Improve Mental Health & HIV Care Engagement Outcomes Among PLWH and PWID in Vietnam
This project will adapt and pilot a feasible and effective problem-solving therapy designed for low-resource settings to address common mental disorders like depression and anxiety - the Friendship Bench- in a Vietnamese…
- Conditions
- HIV Infections, Behavioral Symptoms, Depression, Anxiety
- Trial name
- VITAL (NCT04790201)
- Testing
- Friendship Bench Delivered by Professional Counselor, Friendship Bench Delivered by Lay Counselor, Enhanced Usual Care
- Where
- Vietnam
- Volunteers
- 77 people
- Sponsor
- University of North Carolina, Chapel Hill