Clinical trials: Drug Distribution
Healthy
A Study of the Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Potential
This is an open-label, Phase I, single-center, single-dose administration study to determine the absolute bioavailability, clearance, and volume of distribution of GDC-0449 (Part A) and to determine the routes of excretion and…
- Trial name
- NCT00991718
- Testing
- GDC-0449 oral capsules (non-labeled), GDC-0449 IV injection (labeled), CDC-0449 oral suspension (labeled)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Genentech, Inc.
Breast Cancer Patients
Catheter Tip Position and Contrast Distribution Following Paravertebral Catheter Insertion: a CT Study
This retrospective study aims to assess the impact of paravertebral catheter insertion depth on the final anatomical position of the catheter tip.
- Trial name
- NCT07064317
- Where
- Belgium
- Volunteers
- 31 people
- Sponsor
- Ziekenhuis Oost-Limburg
Cleft Lip and Palate
the Relationship Between Cleft Lip and / or Palate (Different Types) and ABO Blood Groups.
Direct benefit of the research to assess the relationship between cleft lip and / or palate (different types) and ABO blood groups.
- Trial name
- NCT03217890
- Volunteers
- 376 people
- Sponsor
- Cairo University
Healthy, Psoriasis
Distribution of Secukinumab (AIN457) Into Dermal Interstitial Fluid After a Single Subcutaneous Administration of 300 mg
The proposed exploratory study aims to understand the in vivo skin distribution properties of subcutaneously (s.c.) administered AIN457 in psoriatic and healthy skin using open flow microperfusion (OFM).
- Trial name
- OFM ISF (NCT01539213)
- Testing
- secukinumab (AIN457)
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Gestational Diabetes Mellitus in Pregnancy
Carbohydrates Distribution in Pregnancy Study
Hypothesis: Patients with Gestational Diabetes Mellitus (GDM) have a high risk to develop complications during pregnancy, puerperium and in the newborn.
- Trial name
- CHiPS (NCT03378908)
- Testing
- Intervention Treatment
- Where
- 2 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Germans Trias i Pujol Hospital
Obstetric Labour, Premature, Premature Labor
Absorption, Distribution, Metabolism And Excretion Study For GSK221149A
This is a phase one study investigating the absorption, distribution, metabolism and excretion of GSK221149A in six healthy women of non-child bearing potential.
- Trial name
- NCT00457925
- Testing
- GSK221149A
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bruxism
Analysis of Occlusal Force Distribution in Digital and Conventional Occlusal Splint
Each eligible patient will be randomly into one of two groups: Group A: The digital splint group, digital splint will be constructed to each patient.
- Trial name
- splint (NCT06652217)
- Testing
- Digitally manufactured occlusal splint., conventionally manufactured occlusal splint
- Volunteers
- 24 people
- Sponsor
- Cairo University
Malaria
Community-Effectiveness of the Distribution of Insecticide-Treated Bed Nets Through Social Marketing Antenatal Care Services in Malaria Control in Rural Burkina Faso
The study aims at assessing which of two distribution channels for insecticide treated bendnets (ITNs), social marketing vs. social marketing coupled with free distribution through ante-natal care, is most effective in reaching…
- Trial name
- NCT00355225
- Testing
- ITN distribution channel
- Sponsor
- Heidelberg University
Coccydynia
Chair-Integrated Foam Modifications in Coccydynia
The aim of this study is to evaluate the effects of chairs with different ergonomic designs on quality of life, discomfort, and pain in individuals with coccydynia (tailbone pain).
- Trial name
- NCT07533617
- Testing
- Ergonomic Chair with Foam Type A, Ergonomic Chair with Foam Type B, Ergonomic Chair with Foam Type C
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- KTO Karatay University
Healthy
Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula
Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers.
- Trial name
- NCT02429817
- Testing
- Technetium-99m - Diethylenetriaminepentaacetic acid, Aeroneb Solo, Jet Nebulizer
- Where
- Belgium
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Gait, Body Awareness
Effects of Basic Body Awareness Therapy on Gait and Plantar Pressure in Healthy Young Adults
This interventional study will evaluate the effects of Basic Body Awareness Therapy (BBAT) on gait and plantar pressure outcomes in healthy young adults.
- Trial name
- NCT07688785
- Testing
- Basic Body Awareness Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Breast Cancer
Exploratory Study of Breast Cancer With ABY025
The aim is to study if breast cancer metastases accumulate the newly developed HER2 binding molecule 111-In-ABY025 and if that shows whether the metastases express HER2.
- Trial name
- ABY0125 (NCT01216033)
- Testing
- 111-In-ABY-025
- Where
- Sweden
- Volunteers
- 7 people
- Sponsor
- Biomedical Radiation Sciences
Healthy
A Study Testing A Radioactive Compound Given Through A Vein With And Without The Non-Radioactive Compound, Given By Mouth, To Characterize Tissue Distribution Using Positron Emission Tomography Scanning
In this study, radioactive PF-06427878 will be administered, through a vein, alone and with 2 different oral doses of non-radioactive PF-06427878 to healthy, adult, male subjects.
- Trial name
- NCT02410525
- Testing
- [11C]PF-06427878, PF-06427878 10 mg, PF-06427878 600 mg
- Where
- 3 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pfizer
Red Blood Cell Distribution Width-to-albumin Ratio, Acute Myocardial Infarction (AMI)
Relationship Between RAR and MACEs in AMI-CS Patients During Hospitalization
This is a retrospective study from double center: Xuzhou Central Hospital and The First People's Hospital of Yancheng. Acute myocardial infarction (AMI) were screened and AMI complicating with cardiogenic shock were included.
- Conditions
- Red Blood Cell Distribution Width-to-albumin Ratio, Acute Myocardial Infarction (AMI), Major Adverse Cardiovascular Events
- Trial name
- NCT07507110
- Testing
- Includ the inclusion/exclusion criteria of AMI-CS
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Xuzhou Central Hospital
Hepatocellular Carcinoma
Surefire Catheter Versus Standard End-hole Microcatheter: A Pilot Study
The Surefire Infusion System is a novel catheter initially developed to prevent reflux of embolic material into non-target vascular territories.
- Trial name
- NCT02446925
- Testing
- Surefire® Infusion System, Standard End-hole catheter
- Volunteers
- 8 people
- Sponsor
- Wright State University
Preterm Labor
The Impact of Cervical Cerclage or Vaginal Progesterone on Vaginal Microbiome Distribution
A comparative evaluation to evaluate the correlation between cervical cerclage or vaginal progesterone and maternal vaginal microbiome distribution during pregnancy
- Trial name
- NCT03253016
- Testing
- vaginal swab -microbiome test and blood test for cytokines
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Western Galilee Hospital-Nahariya
Infertility
Changes in the Distribution of Mitochondria During Oocyte Maturation
Cytoplasmatic maturation is an important event in the general maturation of of the oocyte. Mitochondria is one of the major organelles involved in the process of cytoplasmatic maturation.
- Trial name
- NCT01501292
- Testing
- Fixation and staining, Observation by laser microscopy
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hillel Yaffe Medical Center
Gait Analysis in Healthy Subjects
Effect of Exoskeleton-Assisted Walking on Gait Parameters in Healthy Adults
This study investigated the immediate effects of a single session of EksoNR-assisted walking on gait parameters and plantar pressure distribution in healthy young adults.
- Trial name
- EKSO-GAIT (NCT07499063)
- Testing
- Ekso NR Exoskeleton
- Where
- Poland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The State Academy of Applied Sciences in Koszalin
Pneumonia, Pneumococcal Infections
Serotype Distribution in Hospitalized Adult With Pneumococcal Community Acquired Pneumonia in France
CAP'Hospi is an observational, multicentric study in France which primary objective is to describe the proportion of Community Acquired Pneumonia due to serotypes included in PCV20 among adults hospitalized for CAP
- Conditions
- Pneumonia, Pneumococcal Infections, Community-acquired Pneumonia
- Trial name
- CAP'Hospi (NCT05380193)
- Where
- 5 sites in France
- Volunteers
- 1,017 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Burns, Intensive Care
Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults
This is a prospective, observational, monocentric, phase II (exploratory) cohort study aiming to describe the evolutionary profile of the initial volume of glucose distribution (IDVG) during the first four days of management of…
- Conditions
- Burns, Intensive Care, Emergencies
- Trial name
- INDICIA (NCT06469970)
- Testing
- Glucose 30% Intravenous Solution
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville