Clinical trials: Drug Drug Interaction
Drug-Drug Interaction
Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK
The main goal of this clinical study is to test how CYP2B6 genetic variations and efavirenz (cornerstone in HIV-1 therapy) dictate the disposition (PK) of CYP2B6 substrate (methadone) and PK and effect (PD) of CYP1A2 substrate…
- Trial name
- NCT05789173
- Testing
- Methadone and Tizanidine, Efavirenz, Methadone and Tizanidine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Indiana University
Drug Interaction Research
Clinical Study on Drug Interactions of Flonoltinib Maleate Tablets
This study is a single center, open label, fixed sequence drug interaction study to evaluate the effects of CYP3A4 inhibitor itraconazole and CYP3A4 inducer rifampicin on the pharmacokinetic characteristics of a single oral dose…
- Trial name
- NCT07768111
- Testing
- 75mg Flonoltinib, 100mg Flonoltinib
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chengdu Zenitar Biomedical Technology Co., Ltd
Drug Interactions
Study to Determine Potential for Drug-drug Interactions When Co-administering Deupirfenidone (LYT-100) and Nintedanib
This is a trial of up to 60-day duration for safety, tolerability, and pharmacokinetics in healthy volunteers administered deupirfenidone (LYT-100) alone or in combination with nintedanib .
- Trial name
- NCT06717100
- Testing
- Nintedanib 150 MG [Ofev]
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- PureTech
Chronic Hepatitis B Liver Fibrosis, DDI (Drug-Drug Interaction)
Drug-Drug Interaction Study Between Hydronidone and Entecavir, Tenofovir Disoproxil Fumarate, Tenofovir Alafenamide, and Tenofovir Amibufenamide
The proposed indication for Hydronidone Capsules is chronic hepatitis B-associated liver fibrosis, which in clinical practice typically requires concomitant use with antiviral agents for chronic hepatitis B.
- Trial name
- NCT07295873
- Testing
- Entecavir, Tenofovir Disoproxil Fumarate（TDF）, Tenofovir alafenamide（TAF）
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Beijing Continent Pharmaceutical Co, Ltd.
Healthy, PK Drug-drug Interaction Study
Study to Investigate the Safety, Tolerability and Pharmacokinetics of QEV-817 Oral Suspension
This study has been designed to assess the safety, tolerability, and pharmacokinetics of a therapeutic dose of hydrocodone bitartrate with and without an oral dose of doxapram hydrochloride in healthy volunteers who are…
- Trial name
- NCT06585163
- Testing
- Hydrocodone Bitartrate, Hydrocodone Bitartrate + Doxapram Hydrochloride
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Quivive Pharma, Inc.
Healthy Volunteers, Drug-Drug Interaction (DDI)
A Drug-Drug Interaction Study Between NTQ5082 Capsules and Midazolam Oral Solutio
This is a single-center, non-randomized, open-label, single-sequence, self-controlled drug-drug interaction study in healthy participants.
- Trial name
- NCT07745439
- Testing
- NTQ5082, Midazolam
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Drug Drug Interaction, Pharmacokinetic Profiles
Pharmacokinetic Effect of Y-3 for Injection on Rosuvastatin Calcium Tablets in Healthy Participants
The primary objective of this study is to evaluate the effect of Y-3 for injection on the pharmacokinetics of rosuvastatin calcium tablets (a sensitive BCRP probe substrate) in healthy participants, in order to assess the…
- Conditions
- Drug Drug Interaction, Pharmacokinetic Profiles, Safty
- Trial name
- NCT07692685
- Testing
- Use of rosuvastatin calcium tablet alone or combined with Y-3 for injection
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Neurodawn Pharmaceutical Co., Ltd.
Contraception, Pharmacogenomic Drug Interaction
Oral Contraceptive Pill (OCP) Pharmacogenomics
The goal of this clinical trial is to evaluate how differences in specific parts of our DNA can influence how individual bodies break down the hormones contained within oral contraceptive pills, which could affect how well these…
- Trial name
- NCT06334315
- Testing
- Desogestrel / Ethinyl Estradiol Pill
- Where
- 2 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Yale University
Drug Interactions, Primary Prevention
LDL-C Optimization Using Inclisiran in Patients in Which Drug-Drug Interactions Limit LDL Lowering
Drug-drug interactions often limit statin optimization in a population of patients prescribed cytochrome P3A4 inhibitors, which include immunosuppressive agents, protease inhibitors, and antifungals.
- Conditions
- Drug Interactions, Primary Prevention, Cardiometabolic Syndrome, LDL-Cholersterol Lowering
- Trial name
- SOLVE-LDL-C (NCT06865885)
- Testing
- Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Healthy Volunteer, Pharmacokinetics
Safety and PK of Ceftibuten-ledaborbactam Etzadroxil Fixed-dose Combination
This is a Phase 1, open-label, three-part, study in approximately 96 healthy adult participants between 18 and 55 years of age (both inclusive) (16 participants in Part 1, 20 participants in Part 2 and , and approximately 60…
- Conditions
- Healthy Volunteer, Pharmacokinetics, Safety, Drug-Drug Interaction (DDI)
- Trial name
- NCT06733675
- Testing
- Ledaborbactam etzadroxil, Ceftibuten, Ceftibuten-ledaborbactam etzadroxil
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Obesity, Overweight and/or Obesity
A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or Obesity
This study looks at how a study medicine called PF-08653944 affects how quickly the stomach empties food after eating. It is being done in adults who are overweight or have obesity.
- Conditions
- Obesity, Overweight and/or Obesity, Overweight, Drug Interaction
- Trial name
- NCT07508241
- Testing
- PF-08653944, Acetaminophen
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cancer (Solid Tumors), Interaction Drug Food
Dietary Supplements Among Cancer Patients: Tolerance, Impact on Medications, and Potential Drug Interactions
The goal of this observational study is to To assess the prevalence and patterns of dietary supplement use among patients with cancer and to analyze the impact of these supplements in the context of anticancer medical treatments…
- Trial name
- Dietary Supple (NCT07670234)
- Testing
- Dietary Supplement Use Assessment
- Where
- Morocco
- Volunteers
- 1,000 people
- Sponsor
- Centre Mohammed VI de la Recherche et de l'Innovation (CM6RI)
Drug-drug Interactions, Geriatric Disease
Impact of an Artificial Intelligence Platform on Inappropriate Medication Use in Older Adults
Polypharmacy in the older adults is common and promotes the risk of drug interactions. The hypothesis evoked is that a virtual platform with artificial intelligence applied to the health, and in particular to the good use of the…
- Trial name
- PING (NCT04710615)
- Testing
- Synapse platform
- Where
- 5 sites in France
- Volunteers
- 178 people
- Sponsor
- University Hospital, Bordeaux
Pediatric Disorder, Genetic Predisposition
Pharmacogenomic Contributions to Trihexyphenidyl Biotransformation and Response in Children With Dystonic Cerebral Palsy
This study looks at how a medicine called trihexyphenidyl works in children with dystonic cerebral palsy. The study aims to understand how trihexyphenidyl is broken down and used in the body of pediatric patients and whether this…
- Conditions
- Pediatric Disorder, Genetic Predisposition, Dystonia, Secondary, Dystonia
- Trial name
- TRIKE2 (NCT06554288)
- Testing
- Trihexyphenidyl
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Drug Interaction Study
Drug Cocktail Interaction Study of St. John's Wort Dry Extract Ze 117
This Study evaluates the Effect of St. John's Wort dry Extract Ze 117 on Several Cytochrome P450 Enzymes and on Transporter P-Glycoprotein in Healthy Volunteers.
- Trial name
- NCT03482817
- Testing
- Ze 117, Probe drug cocktail
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Max Zeller Soehne AG
Cardiovascular Diseases, Multimorbidity
Factors of Potentially Dangerous Drug Interactions in Patients With Cardiovascular Diseases and Multimorbidity
This prospective observational registry aims to evaluate the prevalence and clinical significance of potentially dangerous drug interactions in outpatients with cardiovascular diseases and multimorbidity.
- Conditions
- Cardiovascular Diseases, Multimorbidity, Drug Interactions
- Trial name
- FARMISS (NCT07607574)
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Pharmacogenomic Drug Interaction
Trial of Precision Medicine in Emergency Departments
The objectives of this study are to (1) test the feasibility of the clinical implementation of preemptive pharmacogenetic (PGx) testing in the emergency department (ED) and (2) determine if PGx testing (with appropriate decision…
- Trial name
- TOPMEDs (NCT06448091)
- Testing
- Panel-based pharmacogenetic genotyping
- Where
- 3 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Florida
Drug-drug Interaction,SHR3680
Drug-durg Interaction of SHR3680 With Digoxin, Rosuvastatin Calcium and Metformin Hydrochloride
The DDI study had been designed to investigate the effect of SHR3680 on the pharmacokinetics of digoxin, Rosuvastatin calcium and metformin hydrochloride.
- Trial name
- NCT04621669
- Testing
- SHR3680, digoxin, Rosuvastatin calcium
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Pharmacokinetic Profiles, Y-3 for Injection
Pharmacokinetic Effect of Y-3 on Repaglinide，Warfarin and Omeprazole in Healthy Participants
The primary goal of this clinical trial is to evaluate the effect of Y-3 for injection on the pharmacokinetic profile of the sensitive finger substrates repaglinide tablets, warfarin sodium tablets, and omeprazole enteric-coated…
- Conditions
- Pharmacokinetic Profiles, Y-3 for Injection, Drug-drug Interaction, Repaglinide Tablets
- Trial name
- NCT07068841
- Testing
- sequentially single use of repaglinide, warfarin and omeprazole or combined with Y-3
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Neurodawn Pharmaceutical Co., Ltd.
Drug Interactions, Drug Kinetics
Opioid Drug Interaction Study
This study will examine the effects of doses of opioid/placebo and doses of alprazolam/placebo, alone and in combination. The primary outcomes are pharmacodynamic measures (subjective ratings of drug liking and other…
- Trial name
- NCT06757140
- Testing
- Alprazolam, Oxycodone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Shanna Babalonis, PhD