Clinical trials: Drug Drug Interaction
Drug-drug Interaction Study
A Study to Assess the Effect of Ceftobiprole on the PK of Pitavastatin and on Plasma Levels of Coproporphyrin
The goal of this clinical study was to determine the effect of the test drug ceftobiprole (a drug approved for the treatment of bacterial infections) on the elimination of pitavastatin (a drug approved for the treatment of…
- Trial name
- NCT06808646
- Testing
- pitavastatin, pitavastatin single dose combined with ceftobiprole
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Gout Chronic, Gout
Drug-Drug Interaction Study of ABP-671 in Gout Patients
This is a open-Label, Within-Subject Drug-Drug Interaction Study of ABP-671 Added to Stable Allopurinol Therapy in Gout Patients.
- Conditions
- Gout Chronic, Gout, DDI (Drug-Drug Interaction)
- Trial name
- NCT07367971
- Testing
- ABP-671 plus allopurinol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Atom Therapeutics Co., Ltd
HIV Infections, Contraception
Kuwa Free! - Live Free!
The study investigators are conducting foundational pharmacokinetic (PK) and qualitative studies, among 15-24 years old (inclusive) adolescent girls and young women living with HIV (AGYWLHIV) already on oral antiretroviral…
- Conditions
- HIV Infections, Contraception, Drug-drug Interaction
- Trial name
- NCT05044962
- Testing
- Cabotegravir/ Rilpivirine, Etonogestrel (ETG) implant, Intramuscular depo-medroxyprogesterone acetate (IM DMPA)
- Where
- Kenya
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Drug Drug Interaction
KF2025#1 Trial: Ketamine, Cannabidiol and Cobicistat Interaction Study
Ketamine is a dissociative anesthetic developed approximately 60 years ago. Both ketamine and its isomer, esketamine, have been used for over 20 years in the treatment of treatment-resistant depression.
- Trial name
- KF2025#1 (NCT07462559)
- Testing
- Ketamine 10 mg/ml oral solution, UK special, Cobisistat Tybost 150 mg, Cannabidiol Epidyolex 100 mg/ml
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Drug Drug Interaction (DDI)
Study on the Drug Interaction Between Buagafuran and Voriconazole
This study is a non-randomized, open label trial aimed at evaluating the drug interaction between Buagafuran capsules and voriconazole tablets in Chinese adult healthy participants.The research period is 7 days in total.
- Trial name
- NCT07457203
- Testing
- Buagafuran, Voriconazole
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Beijing Union Pharmaceutical Factory Ltd
Drug Interaction
KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism
Carvedilol is a non-selective beta-blocker in common clinical use, used to treat hypertension, heart failure, and angina pectoris symptoms associated with coronary artery disease.
- Trial name
- KF2022#4 (NCT06566794)
- Testing
- Caffeine Tablet, Bupropion Hydrochloride Capsels, Repaglinide Capsels
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Drug Interactions, Food-drug Interaction
KF2024#1-trial: Esketamine Interaction Study
Esketamine is a drug which is used for depression treatment, to relieve pain and, in larger doses, in anesthesia. Spravato nasal spray is the only esketamine product on the market used for the treatment of depression, but the…
- Trial name
- NCT06726382
- Testing
- Esketamine Nasal Spray, Esketamine 28 mg, Cobicistat 150 MG
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Drug Interaction, GERD (Gastroesophageal Reflux Disease)
A Study to Investigate the Effect of Linaprazan Glurate on the Pharmacokinetics of Amoxicillin
This is an open, single arm, single-center Phase I trial designed to evaluate the effect of seven days repeated oral doses of linaprazan glurate on the pharmacokinetics (PK) of repeated doses of amoxicillin in healthy male and…
- Conditions
- Drug Interaction, GERD (Gastroesophageal Reflux Disease), Safety, and Tolerability
- Trial name
- NCT07308041
- Testing
- Drug Drug Interaction
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cinclus Pharma Holding AB
Drug-Drug Interactions
Effect of Dexamethasone on CYP Enzyme Activity in Healthy Male Subjects
Purpose: The purpose of this study is to understand how dexamethasone affects the activity of drug-metabolizing enzymes in the body and how this may influence interactions with other medicines, such as voriconazole.
- Trial name
- NCT07426042
- Testing
- Dexamethasone, CYP Probe Cocktail, voriconazole
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Min Kyu Park
Drug Interaction
Drug Interaction Study of ZYN002 Transdermal Gel and Probe Substrates
This study is an open-label drug-drug interaction (DDI) study of ZYN002 transdermal gel and multiple drugs.
- Trial name
- NCT06930872
- Testing
- Part 1, Part 2
- Where
- Australia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Harmony Biosciences Management, Inc.
Risk Factors, Polypharmacy
Telecommunication Technology-based Online Survey
The aim of this study is to identify and assess new health-associated risk factors, including clinical-pharmacological risk factors. The cohort is built using telecommunication approaches.
- Conditions
- Risk Factors, Polypharmacy, Drug Interactions, Self Medication
- Trial name
- NCT06159699
- Testing
- Online Survey, Genetic Testing
- Where
- Russia
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Drug Interaction
Drug Interactions in Hospital Information System. The PRoSIT System..
The French Public Health strategy 2018-2022 aims to reduce inappropriate prescriptions, as potentially dangerous for individuals and collectively.
- Trial name
- PROSIT (NCT04463576)
- Testing
- Discharge Prescription
- Where
- France
- Volunteers
- 5,769 people
- Sponsor
- University Hospital, Bordeaux
ALL, Childhood, Pediatric Cancer
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia
A five-year prospective observational cohort study. The study is focused on observing the relation between static germline variants and therapeutic response in Indian children with acute lymphoblastic leukemia (ALL).
- Conditions
- ALL, Childhood, Pediatric Cancer, Toxicity, Drug, Adverse Drug Event
- Trial name
- MPGx-INDALL (NCT05512169)
- Where
- 2 sites in India
- Volunteers
- 556 people
- Sponsor
- University of Geneva, Switzerland
Aging, Adverse Drug Interaction
MinMed: Do Older Adults do Better With Less Medication
Many health care providers believe "less-is-more" for older adults, and evidence suggests minimizing certain medications might improve health outcomes.
- Conditions
- Aging, Adverse Drug Interaction, Frailty
- Trial name
- NCT05307666
- Testing
- Medication minimization
- Where
- Canada
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Drug-drug Interaction Study
Drug-drug Interaction Study of Rifampin and Anaprazole Sodium
A drug-drug interaction study designed to evaluate the drug-drug interaction between rifampin capsules and anaprazole sodium enteric-coated tablets in healthy adult subjects
- Trial name
- NCT07330531
- Testing
- Anelazol Sodium Enteric-coated Tablets, Rifampicin Capsules
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Xuanzhu Biopharmaceutical Co., Ltd.
Fall, Fall Accident
The Geriatric Emergency Department Pharmacologic Harm Prevention Project
The goal of this project is to determine whether pharmacogenomic testing (using participants' DNA) can help optimize medication prescribing and reduce side effects in older adults taking five or more medications.
- Conditions
- Fall, Fall Accident, Poly Pharmacy, Adverse Drug Events
- Trial name
- GREAT PHARM (NCT07216846)
- Testing
- DNA care pathway
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Florida Atlantic University
Healthy, Drug Drug Interaction
Drug to Drug Interaction Study of KBP-5074 in Healthy Subjects
Open-label, parallel, 2-arm, fixed-sequence study to investigate the effect of coadministration of a CYP3A4 inhibitor (Cohort 1, itraconazole multiple dose) and CYP3A4 inducer (Cohort 2, rifampin multiple dose) on the plasma PK…
- Trial name
- NCT04606537
- Testing
- Itraconazole, Rifampin, KBP-5074
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KBP Biosciences
Drug Interaction
Evaluation of Vamorolone CYP3A4 Induction on Midazolam (a Sensitive CYP 3A4 Substrate) Pharmacokinetics
The purpose of this study was to investigate how vamorolone affects the CYP3A4 enzyme in humans by measuring the pharmacokinetics of midazolam and its metabolite, 1'-hydroxymidazolam, in healthy subjects.
- Trial name
- NCT06689527
- Testing
- Vamorolone, Midazolam
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Santhera Pharmaceuticals
Frailty, Emergency Department Visit
Association Between Geriatric Frailty and Medication Related Problems in the Emergency Department to Help Clinical Pharmacists Prioritise Patients
The healthcare systems are under increasing pressure due to a rise in emergency consultations, staff shortages, an ageing population and rising costs.
- Conditions
- Frailty, Emergency Department Visit, Elderly, Drug Drug Interaction
- Trial name
- DISARMED (NCT07282379)
- Testing
- Pharmaceutical analysis based on the Electronic Patient Record
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Pharmacie des Hopitaux de l'Est Lemanique
CDK4/6 Inhibitor, Breast Cancer
Pharmacogenomic and Circulating Biomarkers for CDK4/6 Inhibitors
The goal of this research study is to reduce adverse effects of anti-cancer medications known as kinase inhibitors, while preserving their therapeutic benefits. There have been major advances in the way cancers are treated.
- Conditions
- CDK4/6 Inhibitor, Breast Cancer, CYP3A4 Protein, Human, Drug Interaction
- Trial name
- NCT07100054
- Testing
- Whole gene sequencing, Drug-drug interaction analysis, Biomarker analysis
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's