Clinical trials: Drug Induced Sleep Disorder
Cardiovascular Diseases, Obesity Prevention
Team-based Learning Intervention to Prevent Risk Factors for Chronic Diseases - a Cluster Randomized Trial
Background: Chronic diseases, such as cardiovascular diseases, diabetes, and cancer, are a major global health issue. Their modifiable risk factors, including poor diet, physical inactivity, irregular sleep, tobacco use, and…
- Conditions
- Cardiovascular Diseases, Obesity Prevention, Sedentary Behaviors, Sleep Perception
- Trial name
- NCT06894134
- Testing
- Team-based learning
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Obstructive Sleep Apnea
DISE vs Muller's Maneuver in OSA Assessment
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder caused by recurrent upper airway collapse during sleep.
- Trial name
- NCT07723417
- Testing
- Drug-Induced Sleep Endoscopy (DISE)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Recurrent Tonsillitis, Obstructive Sleep Apnea
Post-operative Pain Control After Pediatric Adenotonsillectomy
Adenotonsillectomy is one of the most common surgical procedures performed in the pediatric population in the United States. It is generally a well-tolerated procedure with post-operative bleeding risk ranging from 3-5% in…
- Conditions
- Recurrent Tonsillitis, Obstructive Sleep Apnea, Sleep Disordered Breathing, Adverse Reaction to Drug
- Trial name
- NCT02296840
- Testing
- Ibuprofen, Hydrocodone-Acetaminophen
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Emory University
MDMA Discontinuation Syndrome
Study of the Effects of MDMA/Ecstasy on Water Regulation, Sleep, and Cognition.
The purpose of this study is to measure the effects of MDMA on sleep, mood, thinking, and how your body retains water. The researchers are interested in the effects that occur a few hours after taking MDMA as well as effects…
- Trial name
- 2C (NCT01053403)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- California Pacific Medical Center Research Institute
Obstructive Sleep Apnea, Tonsillar Hypertrophy
Tonsillectomy vs. Tonsillotomy in Adults With Obstructive Sleep Apnea
The primary purpose of this randomized controlled trial s to investigate whether surgical reduction of palatine tonsils (tonsillotomy) is a superior treatment compared to complete surgical removal of palatine tonsils…
- Trial name
- NCT06376383
- Testing
- Tonsillectomy, Tonsillotomy
- Volunteers
- 464 people
- Sponsor
- University of Aarhus
Opioid Use Disorder, Maternal Drugs Affecting Fetus
Night Respite for Postpartum Mothers With SUD
This single arm pilot feasibility study will evaluate the implementation of overnight infant respite care and parenting skills to mothers with substance use disorders in the early postpartum period residing in residential…
- Conditions
- Opioid Use Disorder, Maternal Drugs Affecting Fetus, Postpartum Mood Disturbance, Sleep Disorder
- Trial name
- NCT05746507
- Testing
- Night Respite Care
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Massachusetts General Hospital
Elderly, Drug Therapy Syndrome
Stopping Benzodiazepines and Related Molecules Among Elderly Living in Residential Institutions
Intervention randomized controlled open study with 2 parallel arms . The objective of this study is to evaluate the feasibility of stopping the benzodiazepines treatment in elderly living in nursing homes.
- Conditions
- Elderly, Drug Therapy Syndrome, Substance-Related Disorders, Substance Withdrawal Syndrome
- Trial name
- BenzoFree (NCT02715440)
- Testing
- Immediate intervention
- Volunteers
- 116 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obstructive Sleep Apnea
Diagnostic Validation of Drug-Induced Sleep Endoscopy (DISE)
This study aims to validate whether the pattern of airway collapse recorded during Drug-Induced Sleep Endoscopy (DISE) mirrors that of natural sleep, and to develop a model for airway collapse.
- Trial name
- NCT03391141
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Dr. Erica Thaler
OSA - Obstructive Sleep Apnea
Characterizing Bilateral Hypoglossal Nerve Stimulation During Drug-Induced Sleep Endoscopy
The study will investigate the treatment effect of bilateral genioglossus muscle stimulation on upper airway collapsibility during drug-induced sleep endoscopy in patients implanted with the Inspire hypoglossal nerve stimulator.
- Trial name
- BLISS (NCT06661629)
- Testing
- Nerve stimulation
- Sponsor
- University of Pennsylvania
Obesity & Overweight, Respiratory Depression
Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs
Drug overdose is a national crisis. The primary cause of death associated with opioids is opioid-induced respiratory depression.
- Conditions
- Obesity & Overweight, Respiratory Depression, Intranasal Drug Administration, Oxytocin
- Trial name
- ORCHID (NCT07902752)
- Testing
- Intranasal Oxytocin 40 i.u.
- Volunteers
- 100 people
- Sponsor
- George Washington University
Obstructive Sleep Apnea
Pathophysiological Endotyping Using Baseline Polysomnography Data
The study is designed to develop models to predict site of collapse information using routine polysomnography. In an observational study, the investigators will study 1000 patients with obstructive sleep apnea (OSA) who have had…
- Trial name
- NCT05267808
- Testing
- Drug-induced sleep endoscopy
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial
Obstructive sleep apnea is a common disease, associated with cardiovascular disease, cerebrovascular disease, and many other medical conditions. Therefore the precise diagnosis and treatment are important.
- Trial name
- NCT01895348
- Testing
- Propofol, propofol-remifentanil, Dexmedetomidine-remifentanil
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Obstructive Sleep Apnea
Efficacy and Stability of Dexmedetomidine Sedation Compared to Propofol Sedation in the Drug Induced Sleep Endoscopy
Obstructive Sleep Apnea Syndrome affect up 12% in adult population. It is associated with an increase rate of hypertension, metabolic syndrome, depression and adverse cardiovascular events.
- Trial name
- DISERT (NCT03892122)
- Testing
- Propofol Fresenius, Dexmedetomidine
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Ospedale Monsignor R. Dimiccoli, Barletta
Obstructive Sleep Apnea
Drug Induced Submental Ultrasound in Obstructive Sleep Apnea Patients
In this study, submental ultrasound during awake and simultaneous under Drug-induced sleep endoscopy is applied in the diagnostic workup of obstructive sleep apnea patients.
- Trial name
- NCT03285451
- Testing
- submental ultrasonography
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Obstructive Sleep Apnea Syndrome
New Procedures in Treating Patients With Obstructive Sleep Apnea Syndrome
Drug-induced sleep endoscopy (DISE) used as diagnostic tool but not yet as a therapeutic procedures to manage the upper airway of snorers and obstructive sleep apnea patients in conditions that mimic natural sleep, there are many…
- Trial name
- NCT05206916
- Testing
- cryotherapy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Sohag University
Insomnia, Anxiety
Evaluation of Physiological Effects Induced by Low Level Light Irradiation on the Acupoints of the Hand
The goal of this clinical trial is to determine if low-level laser therapy (LLLT) and LED-based low-level light therapy (LLLT) are effective in inducing relaxation and improving sleep quality and anxiety levels in individuals…
- Conditions
- Insomnia, Anxiety, Acupuncture, Low-level Laser Therapy
- Trial name
- Acupuncture (NCT07190417)
- Testing
- LEDs and laser light
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Sleep Apnea, Obstructive, Electroencephalography
Propofolsleep - A Study on Cardiopulmonary and Pharyngeal Reactions While Drug Induced Sleep Endoscopy (DISE)
While Drug Induced Sleep Endoscopy (DISE) in patients with obstructive sleep apnea syndrome (OSAS) apnea and hypopnea occur. Because of the induced phases of apnea in a controlled setting it is possible to evaluate the related…
- Conditions
- Sleep Apnea, Obstructive, Electroencephalography, Echocardiography, Blood Gas Monitoring, Transcutaneous
- Trial name
- NCT03224936
- Testing
- PSI
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Sleep Apnea, Obstructive, Sleep Apnea
Comparison Between Natural Sleep Endoscopy and Drug-induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea
Drug-induced sleep endoscopy (DISE) is the most used technique for identifying the obstruction site associated with obstructive sleep apnea (OSA).
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Sleep Apnea Syndromes, Apnea
- Trial name
- NCT04729478
- Testing
- Drug-induced sleep endoscopy, Natural sleep endoscopy
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- ethisch.comite@uza.be
Obstructive Sleep Apnea
DISE-HNS Effect Study
The purpose of this study is to assess the site, pattern and degree of upper airway collapse before and during hypoglossal nerve stimulation (HNS) treatment using clinical standard drug-induced sleep endoscopy (DISE) and using a…
- Trial name
- DISE-HNS (NCT06372847)
- Testing
- Hypoglossal nerve stimulation implant, Polysomnography, Drug-induced sleep endoscopy (DISE)
- Where
- Belgium
- Volunteers
- 58 people
- Sponsor
- University Hospital, Antwerp
Insomnia, Alcohol Use Disorder
Sleep Treatment for Addiction Recovery
Project STAR aims to examine the feasibility, acceptability, and initial efficacy of a CBT-I supplement to outpatient alcohol and substance use treatment.
- Conditions
- Insomnia, Alcohol Use Disorder, Substance Use Disorders
- Trial name
- STAR (NCT04198311)
- Testing
- CBT-I
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Missouri-Columbia