Clinical trials: Drug Interaction Study
HIV
A Two Way Cross Over Pharmacokinetic Interaction Study Between Raltegravir and Amlodipine in Healthy Volunteers
The purpose of the study is to look at the levels of an HIV medication (raltegravir) in the blood, and how it is affected if raltegravir is taken at the same time as another medicine for high blood pressure (amlodipine).
- Trial name
- NCT01841593
- Testing
- Raltegravir, Amlodipine
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- St Stephens Aids Trust
Solid Tumor
A Study of the Safety and Tolerability of the Addition of CHR-2797 to Paclitaxel in Patients With Advanced or Refractory Tumours
The treatment of cancer often involves the use of more than one drug at the same time. In this study, patients are treated with the already marketed drug paclitaxel (administered every 3 weeks by infusion)and with the…
- Trial name
- NCT00737555
- Testing
- CHR-2797
- Where
- 2 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Chroma Therapeutics
Rheumatoid Arthritis
A Study to Evaluate the Pharmacokinetics of ASP1707 and Methotrexate in Patients With Rheumatoid Arthritis
The primary purpose of the study is to evaluate the effect of ASP1707 twice daily on the pharmacokinetics of once weekly oral methotrexate (MTX).
- Trial name
- NCT02867306
- Testing
- ASP1707, methotrexate (MTX)
- Where
- Moldova
- Volunteers
- 10 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Pharmacokinetics
Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects
A DDI study consisting of 4 parts conducted as an open label, fixed sequence study in healthy adult subjects.
- Trial name
- NCT06379958
- Testing
- leramistat 40mg, Itraconazole 200 mg, Phenytoin 100 Mg Oral Capsule
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Modern Biosciences Ltd
Healthy Adult Subjects
Clinical Pharmacology Study of Oral Edaravone in Healthy Adult Males (Drug Interaction Study and Preliminary Regimen-Finding Study)
Cohort 1: To evaluate the drug interactions, safety, and tolerability of oral edaravone when coadministered with rosuvastatin, sildenafil or furosemide in healthy adult males Cohort 2: To evaluate the pharmacokinetics, safety…
- Trial name
- NCT04481789
- Testing
- MT-1186, Rosuvastatin, Sildenafil
- Where
- Japan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Shionogi
Breast Cancer, AI (Artificial Intelligence)
Exploring the Potential of Artificial Intelligence for Earlier Breast Cancer Detection: A Retrospective Multi-Reader Study Based on AI-Assisted Mammographic Interpretation (EARLIEST-AI)
EARLIEST-AI Study type: Two-phase, multi-reader, blinded retrospective observational study based on data from a single clinic. The primary objective of the study is to assess the sensitivity and specificity of radiologists and…
- Conditions
- Breast Cancer, AI (Artificial Intelligence), Early Detection of Cancer
- Trial name
- EARLIEST-AI (NCT07556900)
- Where
- Estonia
- Volunteers
- 785 people
- Sponsor
- Mammograaf Radioloogiakliinik
Healthy Volunteer
A Study to Assess Multiple Ascending Dose, Drug-Drug Interaction, and Asian Pharmacokinetic Study of ABBV-1088
This study will assess the safety, tolerability, and pharmacokinetics of ABBV-1088 in healthy adult Western, Han-Chinese and Japanese participants.
- Trial name
- NCT06579300
- Testing
- ABBV-1088, Itraconazole (ITZ)
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- AbbVie
Healthy Participants
A Study to Evaluate the One-way Interaction of Calcium Carbonate, Omeprazole, or Rifampin on ACP-196
The study will evaluate one-way interaction of calcium carbonate, omeprazole, or rifampin on ACP-196.
- Trial name
- NCT04914936
- Testing
- ACP-196, Calcium carbonate, Omeprazole
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Acerta Pharma BV
Pharmacokinetics, Pharmacodynamics
A Phase I Study in Young Healthy Women to Investigate the Effects of Laquinimod on Standard Oral Contraceptive When Both Treatments Are Given Together
This is a single center, randomized, double blind, placebo controlled, 2-way crossover drug-drug interaction (DDI) study to assess the effect of laquinimod on the PK and PD of ethinylestradiol (EE) and levonorgestrel (LNG) a…
- Trial name
- NCT02085863
- Testing
- laquinimod
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Opioid Dependence, Methadone Withdrawal Syndrome
Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients
The primary objective of this study is to assess QTc (an interval of the heart rhythm) interaction effects between lofexidine and methadone.
- Trial name
- NCT01558934
- Testing
- Lofexidine HCl
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- USWM, LLC (dba US WorldMeds)
Cancer
VEG113971: An Open-Label Study of the Effects of Ketoconazole or Esomeprazole on Pazopanib PK
The purpose of this study is to determine how dosing with ketoconazole (Nizoral) or esomeprazole (Nexium) affects the pharmacokinetics of oral pazopanib.
- Trial name
- NCT01205230
- Testing
- pazopanib
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- GlaxoSmithKline
Eye Tracking, ICU
Eye-Tracking Interactive Agent in Non-verbal ICU Patients
The goal of this clinical trial is to determine whether an eye-tracking interactive agent can ameliorate communication impairments and reduce the incidence of complications among non-verbal patients in the intensive care unit…
- Conditions
- Eye Tracking, ICU, Communication Barriers, Non-Verbal Communication
- Trial name
- NCT07429695
- Testing
- eye-tracking interactive agent, conventional techniques
- Volunteers
- 54 people
- Sponsor
- Shanghai Zhongshan Hospital
Polycystic Ovary Syndrome
Single Ascending Dose, First-in-Human Study on Safety, Tolerability and Pharmacokinetics of BAY1161116
This study will be conducted in a single center, double-blind with 6 dose escalation groups to evaluate the safety, tolerability, and pharmacokinetics of single ascending doses of BAY1161116.
- Trial name
- NCT03119077
- Testing
- BAY1161116, Itraconazole
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bayer
Healthy
Pharmacokinetic Study of Primaquine and Dihydroartemisinin-Piperaquine in Healthy Subjects
The observed changes of P. falciparum sensitivity to artemisinin leads to the intensification of early detection as well as treatment monitoring in malaria infection.
- Trial name
- NCT01525511
- Testing
- A, B
- Where
- Thailand
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy
Investigating the Effect of Itraconazole on the Pharmacokinetics of AZD4144 in Healthy Participants
The purpose of the study is to assess the pharmacokinetics (PK) of AZD4144 when administered alone and in combination with itraconazole in healthy participants.
- Trial name
- NCT07685600
- Testing
- AZD4144, Itraconazole
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Subjects
A 2-Part Study to Assess Potential Metabolism-Based Drug-Drug Interactions of E2006 When Coadministered With Itraconazole, Rifampin, Midazolam, or Bupropion
This study will be a single center, open-label, drug-drug interaction study in healthy male and female subjects. The study will consist of 2 parts.
- Trial name
- NCT02085967
- Testing
- rifampin 600 mg, itraconazole 200 mg, midazolam 2 mg with bupropion 75 mg
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
General Population (no Specific Condition or Disease)
Collection of Stool From Healthy Donors for the ex Vivo Study of Shifts of Microbiome Induced by Dairy Phages and Antibiotics: a Model of Bacteria/Host Interaction (DAIRY-SHAPE)
The gut microbiota plays a crucial role in health through its involvement in pathogen defense, immune regulation, and nutrient digestion.
- Trial name
- DAIRY-SHAPE (NCT07212400)
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Healthy Adult Subject
A Single-center, Randomized, Open-label, Parallel-design Clinical Study to Evaluate the Pharmacokinetic Effects of Itraconazole, Fluconazole or Efavirenz on a Single Dose of Clifutinib in Healthy Participants
Evaluate the pharmacokinetic effects of itraconazole, fluconazole, or efavirenz on a single - dose of Clifutinib and the safety of the combination therapy in healthy participants.
- Trial name
- NCT07341672
- Testing
- Clifutinib, Itraconazole, fluconazole
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Stress
Comparing the Stress-Reducing Effects of a Robotic Pet and a Weighted Toy
The goal of this trial is to learn whether interacting with a robotic pet (Paro) or holding a weighted sensory toy can reduce stress in healthy adults after an acute stressful experience.
- Trial name
- NCT06975007
- Testing
- Paro Robotic Companion Seal, Weighted Sensory Toy
- Where
- New Zealand
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Auckland, New Zealand
Healthy
Drug Interaction Study of Colchicine and Theophylline
Colchicine is a supressor of hepatic CYP1A2 and theophylline is a sensitive CYP1A2 probe substrate. When the two are co-administered the potential exists for a clinically significant drug interaction.
- Trial name
- NCT01601132
- Testing
- theophylline, colchicine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Takeda
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