Clinical trials: Drug Interaction Study
Healthy Participants
A Study to Evaluate the One-way Interaction of Calcium Carbonate, Omeprazole, or Rifampin on ACP-196
The study will evaluate one-way interaction of calcium carbonate, omeprazole, or rifampin on ACP-196.
- Trial name
- NCT04914936
- Testing
- ACP-196, Calcium carbonate, Omeprazole
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Acerta Pharma BV
Asthma; Eosinophilic
Interaction Between Benralizumab and Basophils in Eosinophilic Asthma
In this study, investigators want to evaluation of the impact of benralizumab (Fasenra®, Astra Zeneca) on different cell populations, including basophils and innate lymphoid cells, and several biomarkers, such as miRNAs, cadena α…
- Trial name
- BASEAS (NCT04742504)
- Testing
- BENRALIZUMAB
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Epilepsy
An Open-label Extension Study to Investigate Possible Drug-drug Interactions Between Clobazam and Cannabidiol
This study consisted of 2 parts: a double-blind (DB) phase and an open-label extension (OLE) phase. Only the OLE phase is described in this record. The OLE phase was a safety study.
- Trial name
- NCT02564952
- Testing
- GWP42003-P, Clobazam
- Where
- 6 sites in Spain, United Kingdom
- Volunteers
- 18 people
- Sponsor
- Jazz Pharmaceuticals
Healthy Volunteers
A Study of the Interaction of TAK-279 With Substances That Have an Impact on Metabolism in Healthy Adults
The main aim of this study is to find out how the body of a healthy adult processes TAK-279 (pharmacokinetics) when substances that either hinder or help the human metabolism such as erythromycin, phenytoin and efavirenz are…
- Trial name
- NCT05995249
- Testing
- TAK-279, Erythromycin, Phenytoin
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Takeda
Essential Hypertension
A Study to Evaluate the Effect of Fimasartan on Pharmacokinetics, and the Safety of Digoxin in Healthy Male Volunteers
The purpose of this study is to evaluate the effect of fimasartan on pharmacokinetics, and the safety of digoxin.
- Trial name
- NCT00991783
- Testing
- Digoxin + Fimasartan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Healthy Male Volunteers
Evaluation of Pharmacokinetic Interaction Between Micronized Fenofibrate and Pitavastatin
To evaluate pharmacokinetic drug interaction by comparing the steady-state pharmacokinetic characteristics of each arms after repeated administrating Lipilfen cap. 160mg and Livalo tab.
- Trial name
- NCT01767610
- Testing
- micronized fenofibrate 160mg, pitavastatin Ca 2mg, micronized fenofibrate 160mg plus pitavastatin Ca 2mg
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hanlim Pharm. Co., Ltd.
Dermatitis Atopic
An Open-label, DDI Study to Investigate the Effects of Amlitelimab on the PK of Selected Cytochrome P450 Substrates
This is an open-label, single group, 2-period, Phase 1, single-sequence study. The study duration will be up to 342 days. The treatment period will be up to Week 29, where Week 29 is defined as End of Treatment (last amlitelimab…
- Trial name
- NCT06686628
- Testing
- Amlitelimab, Midazolam, Caffeine
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Sanofi
Healthy
An Interaction Study to Assess Drug Levels in Healthy Adult Subjects
To date, no study has investigated whether there is a drug interaction between the protease inhibitor fosamprenavir and the entry inhibitor maraviroc.
- Trial name
- NCT00764465
- Testing
- Maraviroc, Fosamprenavir, Ritonavir
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Garden State Infectious Disease Associates, PA
Healthy Volunteers
Drug-drug-interaction Study of Ramipril, Amlodipine and Atorvastatin
Study to determine the potential pharmacokinetic interaction of ramipril (and ramiprilat), atorvastatin as atorvastatin calcium trihydrate and amlodipine as amlodipine besilate at steady state after a multiple oral administration…
- Trial name
- NCT04262765
- Testing
- Ramipril, Amlodipine and Atorvastatin
- Where
- Jordan
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Midas Pharma GmbH
Brain Disease
Temporal Disorders in Left and Right Brain-Damaged Patients
Time is an important function that permeates our everyday activities but it has been so far significantly under-investigated in neurological patients.
- Trial name
- NCT04424199
- Testing
- Rightward Attentional Shift (R-PA), Leftward Attentional Shift (L-PA)
- Where
- Italy
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Gene and Diet Interaction
Diet Quality and Genetic Association With Body Mass Index: Results From Three Observational Studies
Background In the most recent genome-wide association study (GWAS), of the 97 body mass index (BMI)-associated single nucleotide polymorphisms (SNPs) identified, more than half of the SNPs were highly enriched for expression in…
- Trial name
- NCT03577639
- Volunteers
- 11,700 people
- Sponsor
- Harvard School of Public Health (HSPH)
Healthy Subjects
A Study to Evaluate Orally-Administered Oseltamivir and Intravenous Zanamivir in Healthy Subjects
This study is a 4 period study to see if there is any interaction between Orally-Administered Oseltamivir and Intravenous Zanamivir in Healthy Thai Adult Subjects
- Trial name
- NCT00540501
- Testing
- Oseltamivir and Intravenous Zanamivir
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
A Drug-drug Interaction Study of DP-R213
The purpose of this study is to learn about the effect of raloxifene on how the body absorbs and processes cholecalciferol and how cholecalciferol affects raloxifene when they are taken together.
- Trial name
- NCT02654093
- Testing
- Cholecalciferol, Raloxifene, Cholecalciferol and Raloxifene co-administration
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Alvogen Korea
Drug Drug Interaction (DDI)
A Open-label, Drug-Drug Interaction With SB_MDZ in Healty Adult Subjects
This clinical trial is a phase 1, open-label, fixed-sequence, drug-drug interaction study to investigate the effect of single and multiple oral doses of SB17170 on the pharmacokinetics of SB_MDZ in healthy adult subjects.
- Trial name
- NCT06846684
- Testing
- SB17170, SB_MDZ
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- SPARK Biopharma
VA Drug Interaction
Genetic Determinants of Clindamycin/Rifampin Interaction
Main objective- To study the influence of the polymorphisms of nuclear receptor proteins pregnane X receptor (PXR), Liver X receptor alpha (LXRα), and Cytochrome P450 (CYP450) on the clindamycin clearance during…
- Trial name
- CLINDA-RIFAM (NCT03267225)
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Dr Valerie ZELLER
Drug Induced Constipation
Study in Healthy Volunteers to Investigate the Effects of Quinidine on the Pharmacokinetics of NKTR-118
Study in healthy volunteers to investigate the effects of Quinidine on the Pharmacokinetics of NKTR-118
- Trial name
- NCT01533155
- Testing
- Nektar 118, Quinidine, Morphine
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Tinea Pedis, Tinea Cruris
Study Evaluating the Drug Interaction Potential of Luliconazole Cream 1% in Participants With Tinea Pedis and Tinea Cruris
This is an open-label, maximal use study to evaluate whether luliconazole in plasma acts as an inhibitor of cytochrome P2C19 (CYP2C19) as measured by circulating levels of omeprazole before and after treatment with a maximum dose…
- Trial name
- NCT02394340
- Testing
- Omeprazole 40 mg, Luliconazole Cream 1%
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Bausch & Lomb Incorporated
Healthy
Investigation of Pharmacokinetic Drug-drug Interaction of BI 409306 and Donepezil in Healthy Male and Female Subjects
Part I: To investigate whether and to what extent donepezil affects single dose pharmacokinetics of BI 409306 Part II: To investigate whether and to what extent BI 409306 affects the single dose pharmacokinetics of donepezil
- Trial name
- NCT02635750
- Testing
- BI 409306, Donepezil
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Drug Interaction Study
Drug Cocktail Interaction Study of St. John's Wort Dry Extract Ze 117
This Study evaluates the Effect of St. John's Wort dry Extract Ze 117 on Several Cytochrome P450 Enzymes and on Transporter P-Glycoprotein in Healthy Volunteers.
- Trial name
- NCT03482817
- Testing
- Ze 117, Probe drug cocktail
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Max Zeller Soehne AG
Healthy Volunteers
Pharmacokinetic Study of ASP1517 With Kremezin®
The objective of this study is to evaluate the effect of Kremezin® on the pharmacokinetics of single dose of ASP1517 in healthy non-elderly adult male subjects when administered concomitantly or in a time separated manner.
- Trial name
- NCT02693613
- Testing
- ASP1517, Kremezin®
- Where
- Japan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
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