Clinical trials: Drug Mechanism
Pre-diabetes
Resveratrol and First-degree Relatives of Type 2 Diabetic Patients
The main objective of the study is to investigate if resveratrol supplementation can improve overall and muscle-specific insulin sensitivity in first-degree relatives of type 2 diabetic patients.
- Trial name
- NCT02129595
- Testing
- resveratrol
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Maastricht University Medical Center
MINS
PeriOperative Medicine - Metabolic Inflexibility as a Mechanism for Myocardial Injury After Non-Cardiac Surgery
The goal of this observational study is to learn whether metabolic inflexibility, which means reduced ability of the body to switch between using fats and sugars for energy, is associated with myocardial injury after non-cardiac…
- Trial name
- POM-MIMICS (NCT07694453)
- Testing
- Pre-operative Metabolic Inflexibility
- Volunteers
- 300 people
- Sponsor
- University College, London
Multiple Myeloma, Recurrent Multiple Myeloma
Immunomodulatory Drugs (Lenalidomide With or Without Pomalidomide) in Combination With a Corticosteroid Drug (Dexamethasone) for the Treatment of Multiple Myeloma
This phase II trial studies the effect of immunomodulatory drug(s) in combination with a corticosteroid drug in treating patients with multiple myeloma or smoldering multiple myeloma.
- Conditions
- Multiple Myeloma, Recurrent Multiple Myeloma, Refractory Multiple Myeloma, Smoldering Multiple Myeloma
- Trial name
- NCT05288062
- Testing
- Bone Marrow Biopsy, Dexamethasone, Lenalidomide
- Where
- 4 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Nicotine Dependence
Smoking Cessation Medications: Efficacy, Mechanisms and Algorithms
The proposed work will advance the understanding and effectiveness of tobacco dependence treatment and result in more smokers quitting successfully.
- Trial name
- NCT00332644
- Testing
- nicotine patch, nicotine lozenge, nicotine patch + nicotine lozenge
- Where
- 2 sites in United States
- Volunteers
- 1,504 people
- Sponsor
- University of Wisconsin, Madison
Lumbar Spinal Fusions
Pregabalin for the Treatment of Pain After Posterior Spinal Fusions
Acute pain management is challenging in patients after spinal fusions, particularly since most have taken analgesics for prolonged periods before choosing the surgical alternative.
- Trial name
- NCT01366196
- Testing
- Pregabalin 150 mg
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Hospital for Special Surgery, New York
Stroke, Cerebrovascular Disorders
Propranolol on Post Stroke Immune Status and Infection
Stroke-associated pneumonia (SAP) is one of the important risk factors influencing poor outcomes and death in stroke patients. Over the past two decades, accumulating evidence suggests that post-stroke brain injury mobilizes the…
- Conditions
- Stroke, Cerebrovascular Disorders, Ischemic Stroke, Brain Diseases
- Trial name
- NCT05375240
- Testing
- Propranolol, Ceftriaxone
- Where
- 2 sites in China
- Volunteers
- 45 people
- Sponsor
- Tianjin Medical University General Hospital
Prescription Opiate/Medication Dependence
CURE Addiction Center of Excellence: Brain Mechanisms of Relapse and Recovery
The proposed project will use fMRI and specific probes of reward and inhibition as biomarkers predicting drug use during and after treatment in 72 subjects addicted to prescription opioids/medications.
- Trial name
- fMRI CURE (NCT01587196)
- Testing
- Vivitrol
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Pennsylvania
Esophageal Squamous Cell Carcinoma
Pembrolizumab Plus Chemo in Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma (Eastern Cooperative Thoracic Oncology Projects 2004, ECTOP-2004)
The purpose of this trial is to evaluate efficacy and safety of pembrolizumab plus standard of care (SOC) chemotherapy with cisplatin and paclitaxel as neoadjuvant treatment in participants with locally advanced esophageal…
- Trial name
- HYPERION (NCT05281003)
- Testing
- Pembrolizumab, Paclitaxel, Cisplatin
- Where
- 2 sites in China
- Volunteers
- 128 people
- Sponsor
- Fudan University
Innate Immunity, Mucosal Immunity
Lung Immune Challenge Study: Controlled Exposure to Inhaled Resiquimod (R848)
Respiratory viral infections can be a cause of significant illness, particularly in vulnerable individuals as seen in the COVID-19 pandemic.
- Conditions
- Innate Immunity, Mucosal Immunity, Asthma, Viral Infection
- Trial name
- NCT06488118
- Testing
- R848, Saline
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Akhilesh Jha
Rheumatoid Arthritis
Experimental Medicine Studies of the Brain in Patients With Rheumatoid Arthritis REALISE
The rationale for this study is to use immune molecule-specific drug treatment to leverage a mechanistic understanding of the brain changes that drive sickness behaviour.
- Trial name
- REALISE (NCT05090124)
- Testing
- Adalimumab
- Where
- 2 sites in United Kingdom
- Volunteers
- 46 people
- Sponsor
- NHS Greater Glasgow and Clyde
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Acute Coronary Syndrome, Fear
Investigating Fear Of Recurrence as a Modifiable Mechanism of Behavior Change
The primary goal of this project is to identify, measure, and influence fear of cardiac event recurrence, a candidate mechanism of change in medication adherence in patients with suspected acute coronary syndrome (ACS).
- Conditions
- Acute Coronary Syndrome, Fear, Medication Adherence
- Trial name
- INFORM (NCT03853213)
- Testing
- Cognitive Bias Modification Training, Attention Control Training
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Columbia University
Epilepsy, Molecular Mechanisms of Pharmalogical Action, Protective Agents
A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935
The purpose of this study is to determine the brain cholesterol 24S-hydroxylase (CH24H) enzyme occupancy of TAK-935 after single oral dose in healthy participants using the positron emission tomography (PET) ligand [18F]MNI-792…
- Trial name
- NCT02497235
- Testing
- TAK-935, [18F]MNI-792 (tracer)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Takeda
Spinal Muscular Atrophy
Short and Long Term Treatment With 4-AP in Ambulatory SMA Patients
The purpose of this study is to assess whether 4-AP (Dalfampridine-ER, Ampyra) improves walking ability and endurance in adult patients with Spinal muscular atrophy (SMA) Type 3 compared to placebo and whether the duration of…
- Trial name
- NCT01645787
- Testing
- 4-aminopyridine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Columbia University
Medication Overuse Headache, Electroacupuncture
Efficacy and Central Mechanisms of Electroacupuncture for Medication Overuse Headache
Acupuncture is commonly used for the prevention of migraine and tension-type headaches, and has been found to be effective in reducing both the frequency and severity of these conditions.
- Trial name
- NCT06802471
- Testing
- electroacupuncture
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Diabetic Macular Edema
Suprachoroidal Sustained-Release OXU-001 Compared to Intravitreal Ozurdex® in the Treatment of Diabetic Macular Edema
The purpose of this clinical trial is to compare safety, tolerability, efficacy, and durability of two dose levels of suprachoroidal sustained-release OXU-001 (dexamethasone microspheres; DEXAspheres®) using the Oxulumis®…
- Trial name
- OXEYE (NCT05697809)
- Testing
- OXU-001, Semi-automated suprachoroidal illuminated microcatheter, Ozurdex® Ophthalmic Intravitreal Implant
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 3 people
- Sponsor
- Oxular Limited
Parkinson Disease, Movement Disorders
Long-Term Follow-up Safety After DDS Implantation With/Without CDNF Infusions
This study is a follow up to the HP-CD-CL-2002 clinical study. It evaluates the long-term safety in patients with Parkinson's disease after implantation of an investigational drug delivery system (DDS) with or without infusions…
- Conditions
- Parkinson Disease, Movement Disorders, Neuro-Degenerative Disease, Nervous System Diseases
- Trial name
- NCT04228653
- Testing
- Renishaw Drug Delivery System
- Where
- 3 sites in Finland, Sweden
- Volunteers
- 15 people
- Sponsor
- Renishaw
Sepsis Abdominal, Gastrointestinal Dysfunction
Efficacy of Fuzheng Tongfu Jiedu Prescription for Treating Gastrointestinal Dysfunction Associated With Sepsis
This study is a single-center, randomized, double-blind, placebo-controlled trial.
- Conditions
- Sepsis Abdominal, Gastrointestinal Dysfunction, Traditional Chinese Medicine
- Trial name
- FZTFJD (NCT06933238)
- Testing
- Fuzheng Tongfu Jiedu prescription (FZTFJD)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Dongzhimen Hospital, Beijing
Substance Use Disorder, Cocaine Use Disorder
Targeting Drug Memories With Methylphenidate
This study aims to identify the neural, behavioral, and pharmacological mechanisms promoting diminished expression of drug-related memories in human drug addiction.
- Trial name
- NCT05978167
- Testing
- Methylphenidate, Memory reconsolidation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia
Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial
The goal of this clinical trial is to learn whether guanfacine or cromolyn sodium can improve symptoms and physical functioning in adults with Postural Orthostatic Tachycardia Syndrome (POTS).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia, Orthostatic Intolerance, Autonomic Nervous System Diseases
- Trial name
- DBPOTS (NCT07757555)
- Testing
- Guanfacine (GFC), Cromolyn Sodium
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University