Clinical trials: Drug Mechanism
Prader-Willi Syndrome, Aggression
Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome
This is a placebo-controlled clinical trial to assess whether Guanfacine Extended Release (GXR) reduces aggression and self injurious behavior in individuals with Prader Willi Syndrome (PWS).
- Conditions
- Prader-Willi Syndrome, Aggression, Self-Injurious Behavior, Pathologic Processes
- Trial name
- PWS-GXR (NCT05657860)
- Testing
- Guanfacine Extended Release
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Maimonides Medical Center
Cognitive Impairment
An fMRI Study of Jianpi Yishen Huatan Granules for Cognitive Impairment After Acute Cerebral Infarction
The purpose of this study is to explore the pathogenesis of cognitive impairment after acute cerebral infarction by applying the multimodal function MRI to dynamically observe the changes of the value of NAA,Cho,Cr,FA in a…
- Trial name
- NCT02752867
- Testing
- Jianpi Yishen Huatan Granules
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
Aging, Athletic Injuries
Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health
Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability.
- Conditions
- Aging, Athletic Injuries, Physical Inactivity, Knee Injuries and Disorders
- Trial name
- NCT05344001
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Marquette University
Prostate Cancer
PET/CT Imaging Study of the Safety and Diagnostic Performance of [68Ga]RM2 in Patients With Primary Prostate Cancer
The aim of this study is to investigate safety and diagnostic performance of the 68Ga labeled PET tracer [68Ga]RM2 for detection and localization of primary prostate cancer confirmed by histopathology of the prostate as a…
- Trial name
- NCT02483884
- Testing
- [68Ga]RM2, PET/CT
- Where
- 2 sites in Austria, Finland
- Volunteers
- 30 people
- Sponsor
- Lantheus Biosciences Ltd.
Neuromuscular Agents, Peripheral Nervous System Agents
A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in Europe (PLATINUM EU)
The purpose of this study is to assess the safety and efficacy of NT 201 compared with placebo in participants with moderate to severe platysma prominence.
- Conditions
- Neuromuscular Agents, Peripheral Nervous System Agents, Physiological Effects of Drugs, Acetylcholine Release Inhibitors
- Trial name
- PLATINUM EU (NCT07210463)
- Testing
- NT 201
- Where
- 26 sites in France, Germany and 2 more
- Volunteers
- 300 people
- Sponsor
- Merz Aesthetics GmbH
Leukemia, Leukemia, Myeloid
Natural Killer Cell (CYNK-001) Infusions in Adults with AML
This study will find the maximum tolerated dose or the maximum planned dose of CYNK-001 which contains natural killer (NK) cells derived from human placental CD34+ cells and culture-expanded.
- Conditions
- Leukemia, Leukemia, Myeloid, Leukemia, Myeloid, Acute, Neoplasms by Histologic Type
- Trial name
- CYNK001AML01 (NCT04310592)
- Testing
- CYNK-001
- Where
- 10 sites in United States
- Volunteers
- 27 people
- Sponsor
- Celularity Incorporated
Upper Respiratory Tract Infection, Acute Tracheobronchitis
A Registry Study of 100 Thousand Cases of Pediatric Patients on Reduning Injection（a Chinese Medicine Injection）Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in February 2018.
- Trial name
- NCT03461692
- Testing
- patients under 14 years of age using Reduning injeciton
- Volunteers
- 100,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Nasopharyngeal Carcinoma
To Investigate the Molecular Mechanism of Traditional Chinese Medicine Constitution Using Next-generation Sequencing in Nasopharyngeal Carcinoma
To investigate the molecular mechanism of traditional Chinese medicine constitution, the investigators proposed a randomized, double-blind, placebo-controlled, phase II trial to recruit 120 patients with nasopharyngeal cancer.
- Trial name
- NCT03578575
- Testing
- Danggui Buxue Tang
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- China Medical University Hospital
Methamphetamine Use Disorder
Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]
This study will evaluate the behavioral effects of methamphetamine during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- NCT04178993
- Testing
- Methamphetamine, Methylphenidate, Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Craig Rush
Safety Issues, Effect of Drugs
Safety of Autologous Cord Blood Cells for Preterm Infants.
To assess the safety of autologous volume- and red blood cell (RBC)-reduced non-cryopreserved umbilical cord blood (UCB) cell infusion to preterm infants.
- Conditions
- Safety Issues, Effect of Drugs, Neonatal Death
- Trial name
- NCT03760900
- Testing
- Autologous Umbilical Cord Blood Stem Cells Therapy
- Volunteers
- 15 people
- Sponsor
- Guangdong Women and Children Hospital
Sedentary Behavior
Reduce Sedentariness and Enhance Psychological Well-being of Office Workers With TCM-based Intervention
The goal of this clinical trial is to test the effects of a TCM-based anti-sedentariness program on workplace sitting time, perceived stress, and cortisol in office workers.The main questions it aims to answer are: 1.
- Trial name
- NCT06183125
- Testing
- Traditional Chinese Medicine-based program
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Migraine Disorders
Tai Chi for the Prophylaxis of Episodic Migraine: the Efficacy Examination and Mechanism Exploration
The proposed study aims to examine the clinical efficacy of 24-week Tai Chi training in the prophylaxis of episodic migraine comparing with standard prophylactic medication in Hong Kong Chinese women, and to explore the mechanism…
- Trial name
- NCT05690737
- Testing
- Tai Chi training, Standard prophylactic medication
- Where
- 2 sites in Hong Kong
- Volunteers
- 220 people
- Sponsor
- The Hong Kong Polytechnic University
Beta Cell Dysfunction
Related Mechanisms of RBP4 in Glycolipid Metabolism
Retinol binding protein 4 ( RBP4 ) is a newly discovered adipokine secreted by adipose tissue, which leads to insulin resistance ( IR ) and participates in the occurrence of T2DM.
- Trial name
- NCT05576168
- Testing
- overexpression STRA6/miRNA3
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Anesthesia, Drug Effects
Neural Mechanisms of Sevoflurane Induced Anesthesia: an EEG fMRI Study in Healthy Volunteers
In imaging functional connectivity (FC) analyses of the resting brain, alterations of FC during unconsciousness have been reported.
- Trial name
- NCT02149927
- Testing
- Sevoflurane
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Drug Resistance, Bacterial, Antimicrobial Drug Resistance
Fecal Microbiota Transplantation (FMT) to Decolonize Antibiotic - Resistant Bacteria (ARB) - New Protocol
The aim of the study is to assess the safety and efficacy of new protocol fecal microbiota transplantation (FMT) in the eradication of antibiotic resistant bacteria, including those featuring of resistance to new generation…
- Trial name
- STOP-ARB2 (NCT06156956)
- Testing
- Fecal Microbiota Transplantation
- Where
- 5 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Human Biome S.A.
Systemic Lupus Erythematosus (SLE), Juvenile SLE
Relevance of Monitoring Blood and Salivar Levels of Drugs Used in Rheumatic Autoimmune Diseases
No drug treatment is completely free of risk and lack of response, adverse events and poor adherence may affect its effectiveness.
- Conditions
- Systemic Lupus Erythematosus (SLE), Juvenile SLE, Cutaneous Lupus
- Trial name
- NCT03122431
- Testing
- Thalidomide, Hydroxychloroquine reduced, standard dose of HCQ
- Where
- Brazil
- Volunteers
- 93 people
- Sponsor
- University of Sao Paulo General Hospital
Multiple Myeloma
Transcriptomics and Epigenetics Analysis in Drug-Resistance of Multiple Myeloma
Multiple Myeloma (MM) is the more common hematological neoplastic disease second only to Hodgkin lymphoma. In MM patients, mutated genes are mainly KRAS (23%), NRAS (20%), FAM46C (11%), DIS3 (11%) e TP53 (8%).
- Trial name
- TEDROMM (NCT05888636)
- Testing
- ChIP-seq, NGS, ATAC-seq
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Regina Elena Cancer Institute
Nausea and Vomiting, Nausea
Broadening Antiemetics Research by Comparing the Effectiveness of Fosaprepitant and Metoclopramide
The study team proposes a double-blind, comparative effectiveness, randomized controlled trial (RCT) to address the following goal: to determine the relative efficacy and adverse event profile of fosaprepitant compared to the…
- Conditions
- Nausea and Vomiting, Nausea, Vomiting
- Trial name
- BARF RCT (NCT06740812)
- Testing
- Fosaprepitant for Injection, Metoclopramide Injection
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- Montefiore Medical Center
Gastroenterology
A Randomized Clinical Trial of Shenbai Granules in Reducing Recurrence of Colorectal Adenoma
This study evaluates Shenbai Granules in Prevention of Colorectal Adenomatous Polyp Recurrence After Colonoscopy.Half of participants will receive Shenbai Granules,while the other half will receive a placebo.
- Trial name
- NCT03616444
- Testing
- Shenbai Granules
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Jiangsu Famous Medical Technology Co., Ltd.
Atrial Fibrillation, Permanent Atrial Fibrillation
Rate Control in Atrial Fibrillation II
The RATAF II study is a randomized, prospective, parallel group study, designed to compare the effects of two different drug regimens for rate control in permanent AF (atrial fibrillation).
- Trial name
- RATAFII (NCT02695992)
- Testing
- Metoprolol, Diltiazem
- Where
- Norway
- Volunteers
- 122 people
- Sponsor
- Asker & Baerum Hospital