Clinical trials: Drug Mechanism
Parkinson Disease
Action Regulation Behavioral
Parkinson's disease (PD) is a neurodegenerative disorder involving a part of the brain that is responsible for motor control, which not only results in changes or disruptions in movement, but also cognitive dysfunctions.
- Trial name
- NCT06489483
- Testing
- Action Regulation Movement Task
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Hematologic Diseases, Treatment
Systematic and Mechanism-based Approach to Rational Treatment Trials of Blood Cancer
This observational study evaluates if drug response testing can be performed within 7 days and analyzes the value of ex-vivo drug screening for hematological malignancies as a biomarker to predict outcome, clinical course and…
- Trial name
- SMART (NCT03488641)
- Testing
- ex-vivo drug response assay
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- German Cancer Research Center
Bipolar I Disorder
Potentiation of Quetiapine Treatment With Lithium or Aripiprazole in Bipolar 1 Nonresponders Patients
The purpose of this study is to determine whether Bipolar I Disorder refractory treatment with Quetiapine monotherapy could be better potentiated with Lithium or Aripiprazole.
- Trial name
- ARIQUELI (NCT01710163)
- Testing
- Lithium, Aripiprazole
- Where
- 2 sites in Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo
Breast Cancer Organoids
Breast Cancer Treatment Based on Organ-like Culture
Based on the breast cancer organ platform, this experiment establishes a drug sensitivity test method that is closer to the body tumor in breast cancer, provides a basis for the accurate treatment of breast cancer, and discusses…
- Trial name
- NCT03925233
- Testing
- Trastuzumab, Doxorubicin Hydrochloride, Epirubicin hydrochloride
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
Lipoma
Association of Beta-2 Adrenergic Agonist and Corticosteroid Injection in the Treatment of Lipomas
The purpose of this study is to test whether injected medications will increase the amount of fat released by a fat cell. We will compare prednisolone (a synthetic cortisone) combined with isoproterenol (a drug given for asthma)…
- Trial name
- NCT00624416
- Testing
- Prednisolone synthetic cortisone and Isoproterenol together
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Cocaine Dependence
Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence; however, both animal and human studies…
- Trial name
- NCT01953432
- Testing
- Doxazosin
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Breast Cancer; HER2-positive; Metastatic
Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)
The study will evaluate the efficacy and safety of trastuzumab deruxtecan (also known as T-DXd, DS-8201a), either alone or in combination with pertuzumab, in treating patients with Human epidermal growth factor receptor 2…
- Trial name
- NCT04784715
- Testing
- Trastuzumab deruxtecan, Taxane, Pertuzumab
- Where
- 283 sites in United States, Argentina and 25 more
- Volunteers
- 1,157 people
- Sponsor
- AstraZeneca
Epilepsy Intractable
Neuronal Mechanisms of Learning and Utilizing Abstract Representations
The purpose of this study is to examine how memories of past experiences are used to guide behavior in novel situations through the cognitive process of abstraction.
- Trial name
- NCT07454785
- Testing
- Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system; Blackrock Cerestim stimulator
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Cedars-Sinai Medical Center
Ischemic Stroke, Acute
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE
A combination therapy proposed to be evaluated in this trial, consisting of three already registered compounds with a validated disease mechanism and with known safety profiles, targets key proteins in the dysregulated signal…
- Trial name
- REPO-STROKE II (NCT05762146)
- Testing
- Riociguat, Propylthiouracil, Perphenazine
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Maastricht University
Non-small-cell Lung Cancer (NSCLC) Stage IV
A Phase III Trial of Recombinant Human Apo-2 Ligand for Injection
The trial is to evaluate the efficacy and safety of recombinant human Apo-2 ligand in treating patients with advanced retreated non-small cell lung cancer
- Trial name
- NCT03083743
- Testing
- Recombinant human Apo-2 ligand for Injection
- Where
- China
- Volunteers
- 417 people
- Sponsor
- Shanghai Gebaide Biotechnology Co., Ltd.
Non Muscle Invasive Bladder Cancer
A Prospective Open Label Comparative Dose Ranging Study Evaluating the Effect of Pre-TURBT Intravesical Instillation of Mitomycin C (MMC) Mixed With TC-3 Gel in Patients With Non Muscle Invasive Bladder Cancer (NMIBC)
This study is a prospective randomized open labeled dose ranging comparative study. Twenty four (24) patients with NMIBC who meet the inclusion/exclusion criteria will be recruited for the study following the initial diagnostic…
- Trial name
- NMIBC TURBT HG (NCT01799499)
- Testing
- TC-3 hydrogel
- Where
- Israel
- Sponsor
- UroGen Pharma Ltd.
Heart Failure, Sleep Disorders
Melatonin Supplementation to Improve Sleep in Patients With Heart Failure
The purpose of this study is to determine whether melatonin can improve sleep, quality of life and markers of heart failure in patients with heart failure.
- Trial name
- NCT00869869
- Testing
- melatonin
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Carotid Artery Plaques, Atherosclerosis
Effects of Rosa Roxburghii Tratt Freeze-Dried Powder on Carotid Atherosclerotic Plaques: A Real-World Study
This study aims to evaluate the effectiveness and safety of Rosa roxburghii freeze-dried powder in reducing carotid atherosclerotic plaques.
- Conditions
- Carotid Artery Plaques, Atherosclerosis, Ischemic Stroke
- Trial name
- RRC-AS (NCT07840950)
- Testing
- Rosa Roxburghii Freeze-Dried Powder, Conventional Anti-Atherosclerosis Therapy
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Healthy
Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of Consciousness
Psilocybin (active compound of "magic mushrooms") is a prototypical psychedelic substance that acts via agonism on serotonin (5-HT) 2A receptors. Psilocybin is rapidly metabolized into its active metabolite psilocin.
- Trial name
- PDR (NCT06796361)
- Testing
- Ketanserin 40mg plus Psilocybin 40mg, 40mg Psilocybin, 20mg Psilocybin
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Solid Tumor
A Window of Opportunity Study to Investigate Mechanisms of Actions of Novel Therapeutic Agents in Patients With Resectable Solid Tumor Malignancies
This is a single-institution, single arm, open label, window of opportunity clinical trial that will act as a Master Protocol with a primary objective to assess pharmacodynamic effects of the novel study drugs in subjects with…
- Trial name
- NCT03471286
- Testing
- Epacadostat
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Monosymptomatic Nocturnal Enuresis
Study on Chinese and Western Medicine in MNE Children
Monosymptomatic nocturnal enuresis (MNE) is a common pediatric developmental disorder. MNE refers to urinary incontinence in the sleep state in children aged ≥5 years, without other LUT symptoms, and without bladder dysfunction.
- Trial name
- NCT03733873
- Testing
- Desmopressin, Suoquan
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Children's Hospital of Fudan University
Multimorbidity, Chronic Asthma
Impact of Multi-Component Intervention on Suspected Asthma Population
Study Participants: Suspected asthma population, defined as individuals whose score of asthma screening questionnaire used in ECRHS study exceeds 0 and whose age is 35 and above.
- Conditions
- Multimorbidity, Chronic Asthma, Population Medicine
- Trial name
- POPMIX-Asthma (NCT06457009)
- Testing
- Multi-component Intervention Package
- Where
- China
- Volunteers
- 9,194 people
- Sponsor
- Peking Union Medical College
Cervix Neoplasms
Healing Touch and Relaxation Therapies in Cervical Cancer Patients
The purpose of this study is to evaluate the effects of healing touch and relaxation therapy on cervical cancer patients undergoing chemotherapy and radiation treatment.
- Trial name
- NCT00084123
- Testing
- Healing Touch Therapy, Relaxation Therapy, Standard Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Metabolic Syndrome
Effects of Pioglitazone Treatment on Sympathetic Nervous System Function in Metabolic Syndrome Obesity
An abdominal distribution of fat is associated with the greatest heart disease risk, because commonly, several risk factors of metabolic origin cluster in these individuals.
- Trial name
- NCT00408850
- Testing
- Pioglitazone, sugar pill
- Where
- Australia
- Volunteers
- 44 people
- Sponsor
- Baker Heart Research Institute
Diabetes Mellitus, Diabetes Mellitus, Type 2
The Efficacy and Safety of DWP16001 in Combination With Metformin in T2DM Patients Inadequately Controlled on Metformin
Therapeutic Confirmatory Study to Evaluate the Efficacy and Safety of DWP16001 in Combination with Metformin in Patients With Type 2 Diabetes Mellitus who Have Inadequate Glycemic Control on Metformin Alone.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- NCT05505994
- Testing
- DWP16001, Dapagliflozin
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.