Clinical trials: Drug Monitoring
Sepsis, Hemodynamic Instability
Therapeutic Drug Monitoring in Patients With Difficult-to-Treat Gram-Negative Bacterial Infections
A prospective, open-label, randomized controlled trial will be conducted to evaluate a novel TDM-guided therapy in management of DT-GNB infections.
- Conditions
- Sepsis, Hemodynamic Instability, Bacterial Infections, Therapeutic Drug Monitoring
- Trial name
- TDM-RCT (NCT05942157)
- Testing
- Therapeutic Drug Monitoring (TDM)
- Where
- Singapore
- Volunteers
- 810 people
- Sponsor
- Singapore General Hospital
Critical Illness, Therapeutic Drug Monitoring
Anti-Xa Level With Thromboprophylactic Dosage Nadroparin in Critically Ill COVID-19 and Non-COVID-19 Patients
Primary objective The objective of this study is to compare anti-Xa levels obtained with a standard high dose thrombosis prophylaxis in COVID-19 intensive care-patients compared with anti-Xa levels obtained with a normal dose…
- Conditions
- Critical Illness, Therapeutic Drug Monitoring, Venous Thromboembolism
- Trial name
- NADRO (NCT05926518)
- Testing
- blood sampling
- Where
- Netherlands
- Volunteers
- 62 people
- Sponsor
- Rijnstate Hospital
Infection, Bacterial, Beta-lactam Antibiotics
External Validation of the Beta-lactam Target Non-attainment (BATMAN) Risk Score in Adult ICU Patients: a Diagnostic Multivariate Predictive Risk Model
Intensive care (IC) patients regularly get infections. Sometimes it is even the reason of admission to the intensive care unit. To treat these infections, we give medicines called antibiotics, such as β-lactams antibiotics.
- Conditions
- Infection, Bacterial, Beta-lactam Antibiotics, Critical Care, Risk Model
- Trial name
- BATMAN (NCT05542771)
- Where
- 6 sites in Netherlands
- Volunteers
- 130 people
- Sponsor
- Chantal Kats
Therapeutic Drug Monitoring, Critical Illness
Pharmacokinetic of Posaconazole in Critically Ill Patients
The posaconazole pharmacokinetic in critically ill patients will be studied in a prospective, non-interventional, monocentric observational trial.
- Trial name
- NCT05275179
- Testing
- Posaconazole Therapeutic Drug Monitoring
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pharmacokinetics, Antibacterial Agents
Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients
Multidrug resistance towards Gram-negative pathogens makes essential the re-examination of older compounds. Temocillin is a penicillin originally marketed in the 1980s but then largely abandoned.
- Conditions
- Pharmacokinetics, Antibacterial Agents, Infections, Bacterial, Infection
- Trial name
- TEMODELTA (NCT03557840)
- Testing
- temocillin
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Paul M. Tulkens
Pharmacokinetics, Anti-Bacterial Agents
Population Pharmacokinetics and Pharmacodynamics of Beta-lactams of Interest in Adult Patients From Intensive Care Units
Antibiotics are still most often administered on an empiric fashion, as defined for the general population with dosages only adapted based on weight and renal and/or hepatic functions.
- Conditions
- Pharmacokinetics, Anti-Bacterial Agents, Infection, Bacterial, Infections, Respiratory
- Trial name
- Pop-PK/PD (NCT03440216)
- Testing
- blood sampling, Tissue sampling (lung), Collection of fluid samples
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Université Catholique de Louvain
Therapeutic Drug Monitoring
The Association Between Non-vitamin K Antagonist Oral Anticoagulant Therapy and Acute Stroke Severity and Post Stroke Short-term and Long-term Outcomes.
Non-vitamin K antagonist oral anticoagulant (NOAC) is the first line therapy to prevent thromboembolism in atrial fibrillation (AF) patients.
- Trial name
- NCT05283174
- Testing
- Blood sampling to test drug level
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- National Taiwan University Hospital
Therapeutic Drug Monitoring, Subarachnoid Hemorrhage
Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC)
A recent prospective observational clinical study conducted in an intensive care unit of a third level US university hospital showed that 94% of patients with ES and 50% of those with EC had an ARC for a duration of at least one…
- Conditions
- Therapeutic Drug Monitoring, Subarachnoid Hemorrhage, Intracerebral Hemorrhage
- Trial name
- TANDEM (NCT04132115)
- Testing
- Piperacillin/tazobactam, Meropenem, Daptomycin
- Where
- 2 sites in Italy
- Volunteers
- 104 people
- Sponsor
- Azienda Sanitaria-Universitaria Integrata di Udine
Drug Monitoring of Antiinfectives in Critically Ill Patients Receiving Extracorporeal Life Support
Drug Monitoring in Critically Ill Patients During Extracorporeal Life Support
About 70% of critically ill patients require antiinfective therapy. Optimal antibiotic dosing is key to improve patient survival, reduce toxic effects and minimise the emergence of bacterial resistance.
- Trial name
- NCT04127305
- Testing
- No Intervention
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Goethe University
Pupil, Analgesics
Validation of Pupillary Response to Nociceptive Stimulation in Cardiac Surgery During Extracorporeal Circulation Period
The relationship between the target effect site concentration of remifentanil and the pupil diameter and reactivity in response to a standard noxious stimulus in cardiac surgery during extra corporeal circulation will be…
- Conditions
- Pupil, Analgesics, Opioid Use, Dose-Response Relationship, Drug
- Trial name
- DOLOCEC (NCT03568396)
- Testing
- Pupillometer
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Tours
Anticoagulants, Quality of Life
Quality of Life and Efficacy Evaluation of Patient Self-monitoring Their Oral Anticoagulation Therapy
The purpose of this study is to determine whether self-management of oral anticoagulation therapy with warfarin has an effect on patient's quality of life following a specific training program led by pharmacists.
- Conditions
- Anticoagulants, Quality of Life, Drug Monitoring, Pharmacy
- Trial name
- ESCAPE (NCT01033279)
- Testing
- Self-monitoring and adjustment of oral anticoagulation
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Montreal Heart Institute