Clinical trials: Drug Monitoring
Intensive Care Unit, Antibiotic Therapy
Therapeutic Monitoring of Antibiotics in Intensive Care Patients: a Cohort Study PopTDM-ICU
Intensive care patients are exposed to serious infections. Mortality linked to these infections remains high and antibiotic therapy treatment optimization is one of the key points of therapeutic success .
- Conditions
- Intensive Care Unit, Antibiotic Therapy, Pharmacokinetic
- Trial name
- NCT05367011
- Volunteers
- 2,500 people
- Sponsor
- Poitiers University Hospital
Psoriasis Vulgaris
Therapeutic Drug Monitoring of Ixekizumab in Psoriasis Patients
Biologics, such as ixekizumab, are currently the most effective treatment option for patients with moderate-to-severe psoriasis.
- Trial name
- BIOLOPTIM-IXE (NCT04083612)
- Testing
- Venapuncture, Patient questionnaires
- Where
- 7 sites in Belgium
- Volunteers
- 49 people
- Sponsor
- University Hospital, Ghent
Major Depressive Disorder
Relevance of a Telemedicine Monitoring in the Management of Depression
Major depressive disorder (MDD) is a common chronic disease. It is the main cause of morbidity and disability in the world with, among other things, an increase in cardio-metabolic risk and a reduction in life expectancy…
- Trial name
- TELEDEP (NCT06076317)
- Testing
- Telemedicine session
- Where
- France
- Volunteers
- 836 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mental Disorders
Enhanced Medication Reconciliation For Serious Mental Illness
The purpose of this study is to evaluate the clinical utility of a decision support tool, the Patient Medication Profile(TM), developed by Sano Informed Prescribing on medication reconciliation and identification of drug-related…
- Trial name
- NCT03169868
- Testing
- Sano Patient Medication Profile
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Precera Bioscience, Inc.
Diabetes, Foot Ulcer
Preventing Amputations by Tailored Risk-based Intervention to Optimize Therapy
The PATRIOT study will evaluate a risk-based personalized behavioral intervention to improve foot self-care, self-monitoring, and modifiable risks for amputation such as blood glucose, blood pressure and cholesterol in order to…
- Trial name
- PATRIOT (NCT02356757)
- Testing
- Personalized Behavioral Intervention, Current Best Practice
- Where
- United States
- Volunteers
- 406 people
- Sponsor
- VA Office of Research and Development
Drug Monitoring, Inflammatory Bowel Diseases
Influence of HLA-DQA1*05 Genotype in Adults With Anti-TNF Treatment With Proactive Therapeutic Drug Monitoring.
HLA-DQA1*05 variant carriers are at risk of developing antibodies against infliximab and adalimumab with reduced TNF antagonist persistence.
- Trial name
- Proa-DQ (NCT05986903)
- Testing
- Tumor necrosis factor (TNF)-alpha inhibitors
- Where
- Spain
- Volunteers
- 280 people
- Sponsor
- Hospital del Rio Hortega
Hospitalization
Continuous Wireless Monitoring for Patients in the Internal Medicine UOC. Randomized Controlled Trial (GreenLineH-T)
Monocentric prospective controlled randomized in open-label study. The study involves the enrollment of 300 patients (150 patients undergoing continuous monitoring and 150 as a control), aim of the study is to evaluate in these…
- Trial name
- GreenLineH-T (NCT06293768)
- Testing
- continuous wireless monitoring system of Vital Signs (Win@Hospital) + continuous system for continuous monitoring of blood sugar (Dexcom G6)(only for diabetic patients)
- Where
- Italy
- Volunteers
- 208 people
- Sponsor
- Fadoi Foundation, Italy
Rheumatoid Arthritis, Tocilizumab
Therapeutic Drug Monitoring of Tocilizumab in Rheumatoid Arthritis
Rationale: A wide range of serum trough concentrations is observed in tocilizumab-treated rheumatoid arthritis (RA) patients, while 1 mg/L tocilizumab is sufficient to block systemic interleukin-6 receptor.
- Trial name
- NCT03781310
- Testing
- Tocilizumab
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Depression
Physiologic Monitoring of Antidepressant Treatment Response
Study Objectives: to identify neurophysiologic effects of venlafaxine treatment in normal controls using quantitative EEG (QEEG) cordance to examine the effects of venlafaxine on different rating scales measuring mood and anxiety…
- Trial name
- Ven Nls I (NCT00759317)
- Testing
- venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Melanoma, Lung Cance
Intensive Medicines Monitoring Study of Toripalimab Monoclonal Injection (Tuoyi) .
This study was a prospective, single-arm, multi-channel, multicenter, non-interventional real-world study to evaluate the safety and efficacy of Toripalimab injection in the treatment of unresectable or metastatic melanoma with…
- Conditions
- Melanoma, Lung Cance, Breast Cancer
- Trial name
- NCT04234620
- Testing
- Toripalimab injection
- Where
- 25 sites in China
- Volunteers
- 800 people
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
ECMO Treatment, ARDS
Hemodynamic Monitoring and Fluid Responsiveness in Venovenous Extracorporeal Membrane Oxygenation (VV ECMO) - "HemodynamECMOnitoring-VV Study"
In extracorporeal membrane oxygenation (ECMO), blood is drawn out of the body via tubes, oxygenated in an artificial lung; and then pumped back into the blood vessels.
- Conditions
- ECMO Treatment, ARDS, Pneumonia, Intensive Care
- Trial name
- NCT06593717
- Testing
- Transthoracic Echocardiography, Uncalibrated Pulse Contour Analysis, Transpulmonary Thermodilution/Calibrated Pulse Contour Analysis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Soil-transmitted Helminth Infections
Validating Egg-based Diagnostics and Molecular Markers for the Spread of Anthelmintic Resistance
Soil-transmitted helminths (STHs) are a group of parasitic worms that infect millions of children in sub-tropical and tropical countries, resulting in malnutrition, growth stunting, intellectual retardation and cognitive…
- Trial name
- StarwormsWP1 (NCT03465488)
- Testing
- Albendazole Pill 400mg (GSK)
- Where
- 4 sites in Brazil, Ethiopia and 2 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Ghent
Focal Epilepsy
Efficacy of Probenecid on Cluster Seizures During Anti Seizure Medication Withdrawal in Presurgical Focal Epilepsy Video-EEG Monitoring
ProbCluster trial aims at making the proof of concept of antiseizure efficacy of the old antigout PBN in SC, in which Panx1 involvement is relevant on SC pathophysiology and in which efficient therapies are still lacking.
- Trial name
- PROBCLUSTER (NCT07318870)
- Testing
- Probenecid
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Hypertension
Impact of Training of GPs on Adherence of Hypertensive Individuals to Antihypertensive Medication
This study aims to assess the impact of training General Practitioners (GPs) on adherence to antihypertensive medication among hypertensive individuals. It also aims to assess risk factors for non-adherence.
- Trial name
- NCT00330408
- Testing
- GP training
- Where
- Pakistan
- Volunteers
- 178 people
- Sponsor
- Aga Khan University
Medication Adherence
Smart Capsule for Automatic Adherence Monitoring
In pharmacotherapy trials in drug-dependent populations, medication compliance is a significant issue, as rates tend to be low and adherence to medication may predict improved outcomes (Baros et al, 2007; McRae et al, 2004…
- Trial name
- NCT02344238
- Testing
- ID Capsule, Riboflavin, Prompts
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Systemic Lupus Erythematosus, Lupus Nephritis
Therapeutic Drug Monitoring of Mycophenolate Mofetil in Lupus Nephritis
Systemic lupus erythematosus (SLE) is an inflammatory, chronic, and multisystem autoimmune disease characterized by periods of activity and remission.
- Conditions
- Systemic Lupus Erythematosus, Lupus Nephritis, Drug Monitoring, Mycophenolic Acid
- Trial name
- LUPUS-MONITOR (NCT07493655)
- Testing
- Therapeutic Drug Monitoring, Standard clinical care
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of Maranhao
Immune Checkpoint Inhibitors, Cardiotoxicity
Cardiac Magnetic Resonance Monitoring of Immune Checkpoint Inhibitor-related Cardiotoxicity
This study is a prospective cohort clinical research that analyzes the changes in CMR parameters before and after immune checkpoint inhibitors (ICIs) therapy in patients with gynecologic malignancies.
- Trial name
- NCT06132984
- Testing
- Cardiac magnetic resonance
- Where
- China
- Volunteers
- 22 people
- Sponsor
- West China Second University Hospital
Type I Diabetes, Pediatrics
Food is Medicine in Pediatric Patients With Diabetes
The objective of this randomized controlled trial is to evaluate the effect of novel Food is Medicine Programming in the form of medically tailored pre-packaged meals for pediatric patients with Type 1 Diabetes.
- Conditions
- Type I Diabetes, Pediatrics, Food Insecurity
- Trial name
- NCT07535502
- Testing
- Community Servings, PedsQL Survey, Nutrition Counseling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Massachusetts, Worcester
Diabetes Mellitus, Dysglycemia
The Effect of Continuous Glucose Monitoring in Surgical Patients With Diabetes.
The goal of this randomised controlled trial to investigate the effect of continuous glucose monitoring (CGM) compared to standard point-of-care (POC) blood glucose measurements in surgical patients with diabetes in patients.
- Conditions
- Diabetes Mellitus, Dysglycemia, Perioperative Complication
- Trial name
- WARD-glucose (NCT06314061)
- Testing
- Dexcom G7 Continuous Glucose Monitoring (CGM) System (G7)
- Where
- 3 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Christian S. Meyhoff
Schizophrenia
Effect of Genotyping for CYP450 Polymorphisms Versus Intense Clinical Monitoring on Antipsychotic Drug Treatment
The purpose of this study is to determine whether genotyping for CYP2D6 and 2C19 polymorphisms or intense clinical monitoring of treatment and adverse effects improves the antipsychotic treatment in patients with schizophrenia.
- Trial name
- NCT00707382
- Testing
- (1) Genotyping for CYP4502D6 and 2C19 polymorphisms, (2) Intense clinical monitoring, (3) Control
- Where
- Denmark
- Volunteers
- 311 people
- Sponsor
- Gesche Jurgens