Clinical trials: Drug Resistant Epilepsy
Epilepsy Intractable
Neural Mechanisms of Spatial Representations Beyond the Self
Spatial navigation is a fundamental human behavior, and deficits in navigational functions are among the hallmark symptoms of severe neurological disorders such as Alzheimer's disease.
- Trial name
- NCT05406349
- Testing
- Self-navigation task, Observation task
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston University Charles River Campus
Epilepsies
VNS Algorithm for Advanced Dosing
The goal of this clinical trial is to compare the standard programming of the VNS device (Control) to a modified programming (Augusta Way) in adults with epilepsy.
- Trial name
- NCT07725601
- Testing
- Rapid Titration VNS programming, Standard VNS programming
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Fernando Vale
Epilepsy Intractable
Neural Computations of Goal-directed Decision-making
The purpose of this research is to better understand how the human brain accomplishes the cognitive task of making goal-directed decisions.
- Trial name
- NCT06489561
- Testing
- Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cedars-Sinai Medical Center
Epilepsy (Treatment Refractory), Epilepsy
Retinal OCT Changes and Biomarkers in Drug-Resistant Epilepsy
This prospective, longitudinal observational study investigates whether epilepsy involves a progressive neurodegenerative process.
- Trial name
- NCT07716930
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Kemal Tutkavul
Epilepsy Intractable
A Multifaceted Assessment of Eating Behaviors, Anthropometric Measurements and Body Composition in Pediatric Patients With Drug-resistant Epilepsy on a Ketogenic Diet and Healthy Children
The goal of this observational study is to compare the prevalence and severity of eating behaviors-such as food neophobia, picky eating, food fussiness, meal repetition and variety, and food texture preferences-between healthy…
- Trial name
- NCT07714226
- Where
- 2 sites in Poland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Drug Resistant Epilepsy
Temporal Interference for Drug Resistant Epilepsy
This single-center prospective study aims to investigate the treatment efficacy of temporal interference (TI) in drug-resistant epilepsy patients aged 6-60.
- Trial name
- TIE (NCT06708143)
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xuanwu Hospital, Beijing
Focal Drug-resistant Epilepsy
Multimodal Study of the Human Brain Epilepsy Tissue
The TIPI2 study is a blood and tissue collection protocol to create an annotated biorepository to support research in drug-resistant epilepsy. The aim of the study will be to identify new pathophysiological pathways.
- Trial name
- TIPI² (NCT06022055)
- Testing
- Blood and tissue collection
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Drug-Resistant Epilepsy, Epilepsy
Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy
The goal of this study is to investigate the effects of a non-invasive, low intensity focused ultrasound (LIFU) stimulation on seizure frequency and the epileptogenic network in drug-resistant epilepsy.
- Conditions
- Drug-Resistant Epilepsy, Epilepsy, Epilepsy (Treatment Refractory), Epilepsy Comorbidities
- Trial name
- NCT07680842
- Testing
- Target optimization using LIFU, Serial LIFU stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Drug Resistant Epilepsy
Biomarkers of Response to SEEG Thermocoagulation
Drug-resistant focal epilepsy is a severe neurological disease that affects one-third of patients with epilepsy. Surgery is the only potentially curative treatment.
- Trial name
- THALPO (NCT07399327)
- Testing
- Quality of life questionnaires (QOLIE, EFIQUACEE for children), psychiatric questionnaires (NDDIE, GAD-7, PCL-5) at Visit 1 (V1), V5, V6 and V7, Resting state SEEG recording 30min before and 30 min after RFTC, Blood sample at Visit 1 (V1), V2, V4 and V5
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Refractory Epilepsy in Children, Refractory Epilepsy
Cannabidiol as add-on Therapy for Children With Refractory Epilepsy (CBD-uN1que), a High-quality Individualized Approach: a Series of N-of-1 Trials
The goal of this clinical trial is to learn if cannabidiol ("CBD-oil") works to treat severe epilepsy in children. It will also learn about the safety of cannabidiol.
- Conditions
- Refractory Epilepsy in Children, Refractory Epilepsy, Epilepsy
- Trial name
- CBD-uN1que (NCT07668856)
- Testing
- Cannabidiol (CBD) oral solution
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht
Drug Resistant Epilepsy
Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial
The aim of the proposed pilot study is to investigate patient tolerability and efficacy of moderate term, repeated exposure of Pulsed Low-Intensity Focused Ultrasound (PLIFUS) in patients with drug-resistant temporal lobe…
- Trial name
- LIFUS (NCT03868293)
- Testing
- Focused ultrasound
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Drug Resistant Epilepsy
Fluorescence Guided Focal Cortical Dysplasia Surgery
Epilepsy is one of the most common neurological disorders, with one of the highest morbidity rates of all diseases. Despite the development of new anticonvulsant drugs, around a third of patients suffer from drug-resistant…
- Trial name
- FLUOFOCODYS (NCT07657975)
- Testing
- 5-ALA (Gliolan)
- Where
- 2 sites in France
- Volunteers
- 5 people
- Sponsor
- Hospices Civils de Lyon
Drug Resistant Epilepsy
Epileptogenic Network Visualisation With Advanced MRI
The goal of this clinical trial is to improve non-invasive identification of epileptogenic networks in drug-resistant epileptic patient.
- Trial name
- EPIVAM (NCT06059157)
- Testing
- Advanced MRI
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Drug Resistant Epilepsy
CANnabinoids for Drug Resistant Epilepsy (DRE) in Adults and Children
Epilepsy is a neurological disorder affecting more than 50 million people globally, including more than 260,000 Canadians. Cannabidiol (CBD) reduces seizure frequency and improves quality of life for adults and children with Drug…
- Trial name
- CAN-DRE (NCT07023744)
- Testing
- CBD Isolate, CBD CHE
- Volunteers
- 90 people
- Sponsor
- University of Manitoba
Intractable Epilepsy
Characterization and Analysis of Evoked Cortical Responses in Participants With Medication-intractable Epilepsy
The goal of this project is to study how the brain reacts to a small electrical signal. Researchers will be using a novel combination of recording electrodes. The researchers will measure the brain response from these electrodes.
- Trial name
- NCT07014592
- Testing
- stimulating probes and electrodes
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Michigan
Epilepsy Intractable
5-SENSE Score Validation Study
The purpose of this study is to assess how well a new scoring system called the 5-SENSE score can predict where seizures start in the brain using Stereoelectroencephalography (SEEG).
- Trial name
- NCT06138808
- Testing
- Stereoelectroencephalography (SEEG)
- Where
- 19 sites in United States, Australia and 10 more
- Volunteers
- 400 people
- Sponsor
- Duke University
Patients With Drug-resistant Focal Epilepsy, SEEG as Part of Presurgical Evaluation
Links Between Epileptic Activity, Sleep Disruption and Mental Content During Sleep
Interactions between epilepsy and sleep are numerous and bidirectional. Sleep can facilitate epileptic activity and seizures in several syndromes, while sleep deprivation increases cortical excitability and seizure…
- Trial name
- EPIDREAM 3 (NCT07605858)
- Testing
- Direct Electric Stimulation (DES)
- Where
- 2 sites in United States, France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Refractory Epilepsy, Drug Resistant Epilepsy
Leucine Enriched Essential Amino Acid Powder as an Add-on to a Classic Ketogenic Diet in Refractory Epilepsy
The main purpose of this study is to evaluate the safety and tolerability of a Leucine-Enriched Essential Amino Acid (LEAA) Powder as an add-on to a classic ketogenic diet (KD) in pediatric and adult patients with refractory…
- Trial name
- NCT06387186
- Testing
- Leucine-Enriched Essential Amino Acid powder
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Elizabeth Anne Thiele
Epilepsy, Refractory Epilepsy
Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application
This is a prospective, placebo-controlled, double-blinded randomized study of self-administered auditory intervention in a naturalistic home environment.
- Conditions
- Epilepsy, Refractory Epilepsy, Music
- Trial name
- SONATA (NCT06425029)
- Testing
- Experimental Intervention (Music A), Active Comparator Intervention (Music B), Active Comparator Intervention (Music C)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Epilepsy
Assessment of MRI-guided HIFU for Patients With Drug-resistant Focal Epilepsy
The goal of this clinical trial is to assess the feasibility, safety, and tolerance of MRI-guided High-Intensity Focused Ultrasound (HIFU) for the treatment of drug-resistant focal epilepsy in adult patients with MRI-visible…
- Trial name
- EPIFUS (NCT07591350)
- Testing
- MR-guided HIFU thermoablation, EEG, MRI
- Volunteers
- 13 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris