Clinical trials: Drug Use
Opioid-Related Disorders, Drug Abuse
OUD Smartphone Services
The purpose of the research is to check whether services and materials made available through a smartphone app are helpful to people who have been diagnosed with opioid use disorder (OUD).
- Trial name
- NCT06134882
- Testing
- Contingency management, Cognitive-Behavior Therapy Modules, Peer Contingency Management (CM) Guide
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Western Michigan University
Cocaine Use Disorder, Substance Use Disorders
Multiple Ascending Dose Study of TMP-301 in Healthy Subjects
A PHASE 1, RANDOMIZED, PLACEBO CONTROLLED, MULTIPLE ASCENDING DOSE (MAD) STUDY TO EVALUATE THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS OF TMP-301 IN HEALTHY SUBJECTS.
- Conditions
- Cocaine Use Disorder, Substance Use Disorders, Healthy Volunteers
- Trial name
- NCT06025396
- Testing
- Cohort 1 - TMP-301, Cohort 2 - TMP-301, Cohort 3 - TMP-301
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tempero Bio, Inc.
Cancer
Impact of the COVID-19 Pandemic on Drug Use and Monitoring of Cancer Patients
The COVID-19 pandemic has profoundly changed the organisation of care. Teleconsultation has replaced hospital medical consultations in order to reduce the risk of patient exposure to the virus.
- Trial name
- ONCORAL-Covid (NCT05069662)
- Testing
- Directive Interview
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hospices Civils de Lyon
Drug Addiction, HIV
The Cedar Project: Impact of mHealth for HIV Prevention Among Young Indigenous People Who Use Illicit Drugs
This study will examine the effect of a culturally-safe two-way supportive text message intervention to reduce HIV vulnerability among young Indigenous people who use illicit drugs in a community-based setting.
- Trial name
- NCT02437123
- Testing
- The Cedar Project mHealth intervention
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University of British Columbia
Smoking, Tobacco
A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers
The goal of this study is to evaluate the rate of end of study complete cigarette reduction in health adult consumers of cigarettes when given access to a heated tobacco product (HTP).
- Trial name
- NCT07710820
- Testing
- 31237616, 31237617, 31237571
- Where
- 9 sites in United States
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Diabetes Mellitus Type I, Diabetes Mellitus Type II
A Primary Care, EHR- Based Strategy to Promote Safe and Appropriate Drug Use
This study seeks to evaluate a low-literacy strategy in a primary health care setting for promoting safe and effective prescription medication use among English and Spanish-speaking patients with diabetes.
- Trial name
- NCT01669473
- Testing
- EHR Based Strategy to promote Safe and Appropriate Drug Use
- Where
- 2 sites in United States
- Volunteers
- 541 people
- Sponsor
- Northwestern University
Tobacco Use
CSD1805: Study to Assess Nicotine Uptake and Product Use Behavior in Moist Snuff Consumers Using Two Moist Snuff Products
The purpose of this study is to compare nicotine uptake and product use behavior during and following use of two moist snuff products in generally healthy, adult moist snuff users.
- Trial name
- NCT03688776
- Testing
- 1805AA, 1805AB
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Sunscreening Agents
To Assess the Safety of a Sunscreen Product
The objective of this study was to assess the safety and appropriateness of a sunscreen product for use on sport users, under supervised outdoor use conditions.
- Trial name
- NCT02803320
- Testing
- SPF 50 Y65 110 (BAY 987516)
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Bayer
Opioid-use Disorder
Technology for MAT in Primary Care - Phase 1
With over 72,000 overdose deaths in 2017, of which 47,600 are attributable to opioid overdose, the opioid epidemic has become North America's most widespread behavioral public health problem.
- Trial name
- NCT05006846
- Testing
- Opioid Addiction Recovery Support Software Platform
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Q2i, LLC
Relapse/Recurrence, Substance Use (Drugs, Alcohol)
Mindfulness-based Relapse Prevention for Peer Workers
Adapt and test the effectiveness of MBRP for substance use peer workers compared to a standard of care (referral to 12-step) control condition on substance use, relapse risk, and burnout among peers in a pilot hybrid type 1…
- Conditions
- Relapse/Recurrence, Substance Use (Drugs, Alcohol), Burnout
- Trial name
- MBRP (NCT07741825)
- Testing
- Mindfulness Based Relapse Prevention, Standard of Care
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Texas at Austin
Asthma
Open-Label Trial of the Use of Minocycline in the Treatment of Asthma
The tetracycline minocycline has, in addition to its anti-infective properties, anti-inflammatory properties which may be of use in the treatment of asthma.
- Trial name
- NCT00536042
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- State University of New York - Downstate Medical Center
Tobacco Use, Tobacco Smoking
Tobacco Cessation at FDNY
At the Fire Department of the City of New York (FDNY) World Trade Center Health Program, 36% of participants in the low dose computed tomography (LDCT) lung cancer screening program are current smokers, despite referral to the…
- Conditions
- Tobacco Use, Tobacco Smoking, Tobacco Use Cessation
- Trial name
- NCT05997225
- Testing
- opt out enrollment, tailored counseling, varenicline started prior to target quit date, opt in enrollment, non-tailored counseling, varenicline started prior to target quit date
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Cocaine Dependence, Substance Use Disorders
Transcranial Magnetic Stimulation for Cocaine Addiction
Background: Cocaine use disorders (CUD) is a complex brain disorder, involving several brain areas and neurocircuits. Effective treatments for CUD are still needed.
- Conditions
- Cocaine Dependence, Substance Use Disorders, Chemical Addiction, Mental Disorder
- Trial name
- BRAINSWITCH (NCT03333460)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
HIV Infections, Drug Use
Scaling up an Evidence-based Intervention for Antiretroviral Therapy for PWID in Vietnam: an Implementation Trial
The purpose of this study is to compare two implementation approaches [Standard Approach (SA) vs. Tailored Approach (TA)] for scaling-up the evidence-based systems navigation and psychosocial counseling integrated intervention…
- Trial name
- SNaPR01 (NCT03952520)
- Testing
- Standard Approach (SA), Tailored Approach (TA)
- Where
- Vietnam
- Volunteers
- 1,000 people
- Sponsor
- University of North Carolina, Chapel Hill
Patients With Diffuse Large B-cell Lymphoma Treated With CART-cells
Quality Of Life and Drug Use in Patients With CAR-T Cells
CAR-T cells are a major therapeutic innovation in the management of patients with relapsed or refractory diffuse large B cell lymphoma (DLBCL) in 3rd line or more.
- Trial name
- QOLD CAR-T (NCT04914091)
- Testing
- Semi-structured interviews and self-administered questionnaires
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Motivational Interviewing, Alcohol Use Disorder
ClientBot: a Conversational Agent That Supports Skills Practice and Feedback for Motivational Interviewing
This multi-stage study includes qualitative interviews, usability research, and a randomized training study of technology implementation in a real-world clinical setting.
- Trial name
- NCT05479890
- Testing
- ClientBot
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Lyssn.io, Inc.
Local Anesthetic Drug Adverse Reaction, Local Infiltration
: Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
Anesthetics with vasoconstrictors decrease pulpal blood flow but the impact of intranasal local anesthetics on blood flow is unknown.
- Conditions
- Local Anesthetic Drug Adverse Reaction, Local Infiltration, Pulp Disease, Dental
- Trial name
- NCT03368391
- Testing
- tetracaine HCl and oxymetazoline HCL, 2% Lidocaine with 1:100,000 epinephrine, 3% Mepivacaine with 1:100,000 epinephrine
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Dysmenorrhea
Music and Puzzle Use in Dysmenorrhea Relief
The aim of this clinical trial is to evaluate whether interventions such as listening to music and doing puzzles are effective in reducing menstrual pain, menstrual symptoms, and perceived stress in young women with dysmenorrhea…
- Trial name
- NCT07081789
- Testing
- Music Listening, Puzzle Activity
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Alcohol Use Disorder, Depression
Project VALOR: Veteran Stress and Wellbeing
This study will examine the efficacy of an internet-based brief intervention designed to reduce risky behavior veterans as the move into their second year post-Army.
- Trial name
- NCT06095817
- Testing
- Internet Delivered Brief Intervention (IDBI)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cornell University
Depressive Disorder, Treatment-Resistant, Stress Disorders, Post-Traumatic
Ketamine Infusions for PTSD and Treatment-Resistant Depression
The relationship between depression and trauma is well established. Co-occuring depression and post-traumatic stress disorder (PTSD) are associated with more severe symptoms and lower levels of functioning.
- Trial name
- NCT02577250
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Minneapolis Veterans Affairs Medical Center