Clinical trials: Drug Use Disorders, open to volunteers
Spinal Cord Injury, Spinal Cord Injuries
Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury
This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injury
- Trial name
- NCT04460872
- Testing
- Testosterone Enanthate, Locomotor Training
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- North Florida Foundation for Research and Education
Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD)
Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions
Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is a major barrier to accessing HR services).
- Conditions
- Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD), Reduction of Substance Use-related Stigma, Non-substance-using People With a Friend or Family Member Who Uses Opioids
- Trial name
- NCT06823453
- Testing
- Peer Harm Reduction Support Champion Intervention
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Geriatric Assessment, Adjuvant Drug Therapy
Aspects of Adjuvant CDK4/6 Inhibitors in Older Breast Cancer Patients - Focusing on Geriatric Screening
Older breast cancer patients should not be categorically excluded from adjuvant therapies, including the recommended CDK4/6 inhibitors (CDK4/6i) administered in combination with endocrine therapy.
- Conditions
- Geriatric Assessment, Adjuvant Drug Therapy, Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Trial name
- FUTURE (NCT07273357)
- Where
- 5 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Region Jönköping County
Coronary Artery Disease
The PIONEER-IV Study is Comparing Clinical Outcomes Between Angiography-derived Physiology Guidance to Usual Care in an All-comers PCI Population With Unrestrictive Use of the HT Supreme Sirolimus-eluting Stent
PIONEER-IV is a prospective, single-blind (patient), randomized, 1:1, controlled, multi-center study comparing clinical outcomes between angiography-derived physiology guidance to LRDP and usual care in an all-comers patient…
- Trial name
- PIONEER-IV (NCT04923191)
- Testing
- Angiography-derived physiology guidance/Local routine diagnostic procedure (LRDP) and usual care
- Where
- 19 sites in Belgium, Ireland and 3 more
- Volunteers
- 2,540 people
- Sponsor
- National University of Ireland, Galway, Ireland
Thyroid Cancer, Thyroid
A Study to Collect Information About the Use of Redifferentiating Medications as a Standard Treatment for Thyroid Cancer
The purpose of this study to learn more about the use of redifferentiating medications as a standard treatment for radioactive iodine/RAI-refractory thyroid cancer. This study is a registry study.
- Conditions
- Thyroid Cancer, Thyroid, Refractory Thyroid Cancer
- Trial name
- NCT05733013
- Testing
- Surveillance Visit
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Dementia, Potentially Inappropriate Medication Use
e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most
The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational…
- Conditions
- Dementia, Potentially Inappropriate Medication Use, Mild Cognitive Impairment (MCI)
- Trial name
- e-ALIGN (NCT07454824)
- Testing
- e-ALIGN Patient-Portal Deprescribing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Medication Abuse, Harm Reduction
Evaluation of Clinical Decision Support in Opioid Tapering
The 2022 Center for Disease Control and Prevention (CDC) clinical practice guideline for prescribing opioids for pain recommends that when tapering a patient's opioid dose, doses should be decreased at a slow rate to reduce the…
- Conditions
- Medication Abuse, Harm Reduction, Opioid Use Disorder, Opioid Prescribing
- Trial name
- NCT06527079
- Testing
- Observational study without a prospective intervention
- Volunteers
- 200,000 people
- Sponsor
- University of Colorado, Denver
Graft vs Host Disease, Mesenchymal Stem Cell Transplantation
Use of Bone Marrow Stem Cells (MesenCell) for the Treatment of Patients With Chronic Graft-versus-host Disease
The purpose of this Phase I clinical trial is to evaluate the safety and potential treatment response of bone marrow-derived mesenchymal stem cells (MesenCell) in adult patients with moderate or severe chronic graft-versus-host…
- Trial name
- NCT07826676
- Testing
- Mesenchymal Stem Cell Infusion
- Where
- 4 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Pontifícia Universidade Católica do Paraná
Glaucoma, Open-Angle Glaucoma
Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication Use
The objective of this study is to evaluate whether reduction in topical medication with the injection of a sustained release capsule (Durysta) leads to a reduction in ocular surface inflammation, indicated by levels of caspase-1…
- Conditions
- Glaucoma, Open-Angle Glaucoma, Ocular Hypertension, Glaucoma Suspect
- Trial name
- NCT07217678
- Testing
- Durysta, Bimatoprost Intracameral Implant 10 µg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Miami
Vestibular Migraine, Dizziness
Chinese Real-world Study of Treatment of Vestibular Migraine
Vestibular migraine is a phenotype of migraine, characterized by more prominent vertigo symptoms compared to headache. Treatments for VM are mainly divided into two categories: acute treatment and preventive treatment.
- Conditions
- Vestibular Migraine, Dizziness, Vertigo
- Trial name
- NCT07203248
- Testing
- CGRP R Inhibitor; CGRP Inhibitor, none-CGRP
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Healthy, Melasma (Facial Melasma)
COMPARISON OF A COSMETIC SERUM AND 4% HYDROQUINONE FOR TREATING MELASMA OVER 84 DAYS
The goal of this clinical trial is to compare the dermatological tolerance and skin-lightening efficacy of a cosmetic depigmenting serum to a 4% hydroquinone-based product in adult male and female subjects aged 18-65 years with…
- Conditions
- Healthy, Melasma (Facial Melasma), Epidermal Melasma
- Trial name
- NCT07071363
- Testing
- Depigmenting Cosmetic Serum (Applied Morning and Evening)
- Where
- Mauritius
- Volunteers
- 40 people
- Sponsor
- Laboratoire Dermatologique ACM
Severe Mental Illness, Substance Use Disorder (SUD)
A Study to Investigate Health Related Quality of Life With a Pharmacist Intervention Compared to Treatment as Usual in Participants With Severe Mental Illness and Substance Use Disorder Receiving Treatment From FACT Teams.
The study aims to evaluate the impact of integrating a clinical pharmacist into Flexible Assertive Community (FACT) teams on health-related quality of life and pharmacotherapy for individuals with severe mental illness and…
- Trial name
- pharmaFACT (NCT07597863)
- Testing
- Clinical Pharmacist Intervention
- Where
- Norway
- Volunteers
- 160 people
- Sponsor
- Sykehuset Innlandet HF
Breast Cancer, Adjuvant Treatment
Evaluating the Use of a Medication 'Switch' vs Guideline-directed Interventions for Relieving Side Effects of Aromatase Inhibitors Among Breast Cancer Patients
Researchers have learned that about 50% of women do not finish the standard 5-year breast cancer treatment with an aromatase inhibitor.
- Conditions
- Breast Cancer, Adjuvant Treatment, Early Stage Breast Cancer
- Trial name
- SWIVEL (NCT07071038)
- Testing
- Switch, Guideline Directed Intervention (GDI)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Coronary Artery Disease, Diabete Mellitus
Assessment and Management of Multiple Drug Use in Elderly Chronic Disease Patients
The purpose of this observational study is to understand the impact of polypharmacy on the prognosis of elderly patients with chronic diseases.
- Conditions
- Coronary Artery Disease, Diabete Mellitus, Chronic Kidney Disease, Hypertension
- Trial name
- NCT07180368
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xijing Hospital
Gingivitis
Evaluation of the Effect of the Toothpaste on Delicate Gums
The goal of this study is to learn if a toothpaste works to alleviate gingivitis in adults. It will also learn about the safety of the product.
- Trial name
- NCT07494747
- Testing
- Gingivitis toothpaste, Regular toothpaste
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Lacer S.A.
Apnea of Prematurity
MICropsampling for CAffeine in PREMature Newborns
Caffeine is one of the top five most prescribed drugs in neonatology. Caffeine has many beneficial impacts on preterm infants (cardiac, neurologic and pulmonary). One of these beneficial impacts is to prevent apnea.
- Trial name
- MICCAPREM (NCT07779915)
- Testing
- collection of an extra drop of capillary blood
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Limoges
Parkinson Disease
A Trial to Test the Use of Dapansutrile, an Anti-inflammatory Medication, in People With Parkinson's Disease
In Parkinson's disease (PD), there is inflammation in the brain, the gut and the blood, which is thought to contribute to the development and progression of the disease.
- Trial name
- DAPA-PD (NCT07157735)
- Testing
- dapansutrile
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Opioid Use Disorder, Overdose, Drug
The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study
The goal of this clinical trial is to develop and test the CROSSROADS intervention. CROSSROADS is designed for people who have recently survived an opioid and/or stimulant-related non-fatal overdose and had contact with staff…
- Conditions
- Opioid Use Disorder, Overdose, Drug, Overdose, Substance Use (Drugs, Alcohol)
- Trial name
- CROSSROADS (NCT07216963)
- Testing
- Community Paramedic Standard of Care (CP SOC), CROSSROADS
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Substance Abuse, HIV
Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral System
Women involved in the carceral system (WICS) are at higher risk for both HIV and substance use than the general public. WICS are also more likely to engage in behaviors both before and after release that put them at risk for HIV…
- Trial name
- PA-Links (NCT07432555)
- Testing
- Tool to provide re-entry support and improve linkage to healthcare and social services
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Temple University
People Who Use Opioids/People With Opioid Use Disorder (OUD)
Prescribe to Prevent HIV: A Hybrid Trial Helping Addiction Clinics Prevent HIV & Infections Through Safer Drug Use Support
In the U.S., an estimated 3.6 million people who inject drugs (PWID) face a growing yet preventable health crisis, with rising cases of serious injection-related infections (SIRI), including HIV, due to limited access to two…
- Trial name
- P2PH (NCT07073924)
- Testing
- Implementation strategy bundle
- Where
- 4 sites in United States
- Volunteers
- 536 people
- Sponsor
- University of Pittsburgh