Clinical trials: Drug Users
Harm Reduction, Naloxone
Vending Machine Naloxone Distribution for Your Community (VENDY)
Vending machines are an innovative strategy shown to increase access to naloxone, a medication used to reverse opioid overdose. The aim of this proposal is to study the reach of a community-initiated, stakeholder engaged…
- Conditions
- Harm Reduction, Naloxone, Opioid Overdose
- Trial name
- NCT06429436
- Testing
- VENDY
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- University of Colorado, Denver
Hepatitis C, Medication Adherence
Directly Observed Hepatitis C Treatment in Methadone Clinics
Drug users account for a disproportionately large burden of hepatitis C virus (HCV) infection. However, HCV treatment adherence rates in drug users may be suboptimal in patients who use drugs regularly during HCV treatment.
- Trial name
- NCT01442311
- Testing
- enhanced DOT (both pegylated interferon alfa-2a and ribavirin), standard DOT (PEG-DOT control arm)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Albert Einstein College of Medicine
Hepatitis C, Chronic
A Study of PEGASYS (Peginterferon Alfa-2a (40KD)) in Combination With Copegus (Ribavirin) in Patients With Chronic Hepatitis C (CHC) Enrolled in a Methadone Maintenance Treatment Program.
This study will evaluate the safety and tolerability of PEGASYS plus ribavirin in previous intravenous (iv) drug users who have CHC and are currently enrolled in a methadone maintenance treatment program.
- Trial name
- NCT00087594
- Testing
- peginterferon alfa-2a [Pegasys], ribavirin
- Where
- 7 sites in United States
- Volunteers
- 48 people
- Sponsor
- Hoffmann-La Roche
Opioid Overdose, Drug Overdose
Preventing Overdose Using Information and Data From the Environment
The objectives of this project are to leverage surveillance data to predict future overdose outbreaks, and to evaluate the impact of a randomized, statewide, community-level intervention trial to target overdose prevention…
- Trial name
- PROVIDENT (NCT05096429)
- Testing
- PROVIDENT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Brown University
Hepatitis C, Opiate Dependence
A Video-Based HCV Curriculum for Active Injection Drug Users
The investigators hypothesize that a well-designed hepatitis C (HCV) video education curriculum for active drug injectors will lead to measurable improvements in HCV testing rates, HAV and HBV vaccination rates, as well as…
- Trial name
- NCT00241943
- Testing
- Hepatitis C educational video
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Organization to Achieve Solutions in Substance Abuse (OASIS)
Overdose
A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk
Adolescent (ages 10-19) overdose deaths are the third leading cause of pediatric death and continue to rise in the United States.
- Trial name
- NCT07022717
- Testing
- Brief youth overdose prevention education, Information about Naloxone, Usual standard of care
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Boston Medical Center
HIV, Opioid Dependence
Testing a Community-Friendly Risk Reduction Intervention for Injection Drug Users
To conduct a randomized clinical trial (RCT) of a community-friendly behavioral intervention designed to reduce HIV risk behavior among injection drug users (IDUs) in drug treatment by comparing risk-behavior outcomes of four…
- Trial name
- NCT01741350
- Testing
- Community-friendly Health Recovery Program, Time-and-Attention-Matched Control Condition
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- University of Connecticut
Cancer
Liver Function Test (LFT) Elevations in Cancer Patients and Users of Tyrosine Kinase Inhibitor (TKI) Drugs
A retrospective cohort study using the LabRx medical claims database will be performed to address these objectives. The primary objective of this project is to examine the background rates of liver function test (LFT)…
- Trial name
- NCT01098500
- Testing
- Tyrosine kinase inhibitors
- Volunteers
- 3,800 people
- Sponsor
- GlaxoSmithKline
Alcohol-induced Disorders, Drug Users
SBIRT Implementation for Adolescents in Urban Federally Qualified Health Centers
The purpose of this study is to examine the implementation of two evidence-based intervention strategies of SBIRT (Generalist vs. Specialist) for adolescent alcohol, tobacco, other drug use, and HIV risk behaviors.
- Conditions
- Alcohol-induced Disorders, Drug Users, Tobacco Use Disorder
- Trial name
- ST@T (NCT01829308)
- Testing
- The brief interventions are delivered by behavioral health counselors (Specialist), The brief interventions are delivered by the primary care provider (Generalist)
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Pain, Acute Pain
A Clinical Study in Healthy Adults Who Sometimes Take Drugs for Pleasure Which Aims to Evaluate Whether GRT0151Y is Likely to be Abused
The purpose of this clinical study was to evaluate whether healthy adults, who sometimes take drugs for pleasure, are likely to abuse GRT0151Y. This abuse potential is assessed at three different doses of GRT0151Y.
- Trial name
- NCT03768024
- Testing
- GRT0151Y 50 mg capsule, Hydromorphone IR 4 mg
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Opioid Overdose
Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mg
The purpose of this study is to determine the pharmacodynamics (change in minute ventilation) of nalmefene when given as an autoinjector intramuscularly (IM; into the thigh) compared to naloxone when given intranasally (IN; into…
- Trial name
- NCT06719986
- Testing
- Nalmefene HCl injection, Naloxone HCl intranasal
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue Pharma LP
Overdose
Permanent Supportive Housing Overdose Prevention
Permanent supportive housing (PSH), the gold standard intervention for ending chronic homelessness, has expanded rapidly across the U.S. in recent years.
- Trial name
- POP (NCT05786222)
- Testing
- CSH-Delivered Overdose Prevention Support
- Where
- United States
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Food Insecurity, Hypertension
Food Insecurity, Food as Medicine, Hypertension
Development of a user centered design to understand how a tailored food is medicine program based on user preferences and needs improves engagement and clinical outcomes.
- Trial name
- NCT07011251
- Testing
- Food as Medicine Program, Survey
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Alison Gustafson
HIV, AIDS
Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug Users
Primary Objective: This study will evaluate the most effective strategy in achieving HIV virologic suppression among HIV-infected substance users recruited from the hospital setting who are randomly assigned to one of three…
- Conditions
- HIV, AIDS, Substance Abuse, Inpatient
- Trial name
- CTN0049 (NCT01612169)
- Testing
- Patient Navigation (PN) Group, Patient Navigator Plus Contingency Management (PN+CM) Group
- Where
- 12 sites in United States
- Volunteers
- 801 people, healthy volunteers welcome
- Sponsor
- Columbia University
Overdose
Monitoring of Overdose Patients With and Without Supplemental Oxygen in the Emergency Department
This study will compare the data from pulse oximeters to capnographers as they are used to monitor patients who are being observed in the Emergency Department for a suspected overdose of alcohol or other drugs.
- Trial name
- NCT02101424
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hennepin Healthcare Research Institute
HIV
Behavioral Intervention Trial for HIV-infected Injection Drug Users
The purpose of this study is to test whether a ten-session behavioral intervention for HIV-infected injection drug users is effective in reducing sex and injection risk behaviors that put others at risk for HIV infection…
- Trial name
- NCT00146445
- Testing
- Peer Mentoring Intervention
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Centers for Disease Control and Prevention
Depression, Substance-Related Disorders
Antidepressant Medication for Reducing HIV Risk Behavior in Depressed Intravenous Drug Users
This study will evaluate the effectiveness of antidepressant medication treatment in reducing HIV risk behaviors in intravenous drug users with depression.
- Conditions
- Depression, Substance-Related Disorders, HIV Infections
- Trial name
- NCT00228007
- Testing
- Antidepressant Medication
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- Butler Hospital
Wound, Drug Use
Characteristic of Drug Users Chronic Wound
The aim of this study is to describe demographic, clinical, etiological characteristic and evolution of drug addict's chronic wounds .
- Trial name
- TOXIPO (NCT03608384)
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Central Hospital, Nancy, France
Bacterial Infection, HIV
Preventing Bacterial and Viral Infections Among Injection Drug Users
We propose a randomized controlled trial (RCT) of the Skin intervention, compared to an assessment-only condition (both groups receive rapid HIV testing, a review of testing results, and brief HIV prevention counseling) among 350…
- Trial name
- NCT01892358
- Testing
- SKIN Intervention, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 252 people
- Sponsor
- Butler Hospital
Substance Use
Substance Use Screening Among Drug User
The purpose of this research is to improve the ability of primary medical staffs in screening and intervention for alcohol, benzodiazepines, and other illicit drug use.
- Trial name
- NCT02951858
- Testing
- Intervention Group, Control Group
- Volunteers
- 218 people
- Sponsor
- Shanghai Mental Health Center