Clinical trials: Drug Users
Smoking Behaviors, Smoking ( Cigarette)
A Study to Assess Nicotine Uptake From a Menthol Electronic Nicotine Delivery System Product
This will be a randomized, open-label, 2-way crossover, single-site study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma nicotine…
- Conditions
- Smoking Behaviors, Smoking ( Cigarette), Tobacco Use, Abuse Liability
- Trial name
- NCT07881848
- Testing
- Menthol 5%, Combustible cigarette
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
HIV/AIDS
Translation of Basic Research in Cognitive Science to HIV Risk
A randomized trial was conducted at drug diversion educational programs with a sample of 343 adult drug offenders who volunteered for the study.
- Trial name
- NCT03175250
- Testing
- Health Education, Action Plan, Memory Practice
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- Claremont Graduate University
HIV, HIV Infections
A Trial to Compare Raltegravir Versus Nevirapine as Anchor Drug for HIV+ Chinese IDUs on Methadone Maintenance
This is a pilot randomized controlled Open-label trial to compare raltegravir and nevirapine as anchor Drug in combined antiretroviral therapy(ART) for ART-naive HIV+ Chinese injection drug users who are also on methadone…
- Trial name
- NCT01042652
- Testing
- Raltegravir
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Centers for Disease Control and Prevention, China
Alcohol Misuse, Drug Misuse
Family and Social Intervention for Young People
Research evidence shows that there is a high prevalence of substance use among young people in the UK. Early onset and high levels of use are associated with a range of negative outcomes, including increased risk of later…
- Trial name
- YSBNT (NCT02399865)
- Testing
- Youth Social Behaviour and Network Therapy
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Cannabis Intoxication
Cannabis Impairment Detection Device Study
The goal of this study is to develop a cannabis impairment detection device in adult cannabis users. The main question[s] it aims to answer are: Is the investigational device accurate and reliable at detecting cannabis…
- Trial name
- NCT07122349
- Testing
- Cannabis Impairment Test
- Where
- Canada
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Gaize
Drug Use
Health Status and the Need for Social Return of Drug Abusers in Guangdong Province
This study intends to conduct a secondary analysis of the data from the investigation on the status quo of anti-drug rehabilitation work and management needs in Guangdong Province.
- Trial name
- NCT06132555
- Testing
- Online questionnaire survey, In-depth personal interview, Colloquia
- Where
- China
- Volunteers
- 7,106 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Drug Overdose
Nasal Naloxone for Narcotic Overdose
The goal of this study is to determine if nasal naloxone is inferior to standard care for naloxone administration in a pre-hospital setting.
- Trial name
- NCT01912573
- Testing
- Intranasal (IN) naloxone, Intravenous (IV) naloxone, Intramuscular (IM) naloxone
- Where
- 3 sites in United States
- Volunteers
- 236 people
- Sponsor
- Judith Feinberg
Tobacco Use
Effects of an Oral Nicotine Product in Smokeless Tobacco Users
The purpose of this research study is to find out how three different nicotine pouches and participant's own brand of smokeless tobacco affect blood nicotine levels and how participants feel.
- Trial name
- NCT05280769
- Testing
- oral nicotine pouch - 2 mg, oral nicotine pouch - 4 mg, oral nicotine pouch - 8 mg
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Opioid Overdose, Opioid Use
Machine-Learning Prediction and Reducing Overdoses With EHR Nudges
The goal of this cluster randomized clinical trial is to test a clinician-targeted behavioral nudge intervention in the Electronic Health Record (EHR) for patients who are identified by a machine-learning based risk prediction…
- Conditions
- Opioid Overdose, Opioid Use, Opioid Use Disorder, Opioids
- Trial name
- mPROVEN (NCT06806163)
- Testing
- EHR-Embedded Elevated-Risk Flag, EHR-Embedded Elevated-Risk Flag with Behavioral Nudges, Usual Care
- Where
- United States
- Volunteers
- 1,350 people
- Sponsor
- University of Pittsburgh
Drug Overdose, Substance Abuse
EEG Monitoring in the Emergency Department
This study seeks to investigate whether drug effects in suspected overdose patients could be identified using the electroencephalogram (EEG).
- Conditions
- Drug Overdose, Substance Abuse, Alcohol Abuse
- Trial name
- NCT04070521
- Testing
- Observational EEG Monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
HIV, Medication Adherence
SteadyRx: Smartphone ART Adherence Intervention for Drug Users
Antiretroviral therapy (ART) increases life expectancy and quality of life for individuals infected with HIV, and can reduce the chance of HIV transmission, but a high degree of adherence to ART is required to achieve these…
- Trial name
- NCT02317614
- Testing
- SteadyRx
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
HIV Infections
C2P - Phase III: MPowerment and Community Promise
One of the objectives of the C2P coalition is the successful delivery of a CDC-endorsed community-level HIV prevention program aimed at changing the risk profiles of youth.
- Trial name
- NCT00381784
- Testing
- Printed materials, Peer advocates
- Where
- 7 sites in United States, Puerto Rico
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Opioid Use Disorder, HIV Infections
Medication-assisted Treatment for Injecting Drug Users in Vietnam
HIV continues to spread around the world and new infections in Asia are one of the most important areas for prevention among drug using populations.
- Trial name
- OIT-HCMC (NCT05368675)
- Testing
- medication for opioid use disorder
- Volunteers
- 448 people
- Sponsor
- University of Pennsylvania
Hepatitis C
Registry-based HCV Care Cascade Navigation at Atlanta's Grady Memorial Hospital
This study seeks to implement and evaluate a data-driven case navigation system for hepatitis C virus (HCV) treatment among persons who are either actively injecting drugs or who are receiving opioid substitution therapy (OST).
- Trial name
- EZ-C (NCT03441542)
- Testing
- Data-assisted Case Navigation, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Opinion Research Center
HIV Infection
Use of Incentives to Retain Drug Users in HIV Therapy
In many urban centres including Vancouver's Downtown Eastside, there is a high rate of HIV infection among users of illicit drugs.
- Trial name
- Incentives-2 (NCT01488942)
- Testing
- monetary reinforcer
- Where
- Canada
- Volunteers
- 139 people
- Sponsor
- University of British Columbia
HIV Infections
A Study of Peer Education to Prevent HIV Transmission Among Injection Drug Users and Their HIV Risk Contacts
Injection drug use is the major mode of HIV transmission in many countries. Injection drug users (IDUs) transmit HIV not only through shared drug injection equipment but also through heterosexual and homosexual transmission and…
- Trial name
- NCT00038688
- Testing
- Peer HIV Education Program
- Where
- 3 sites in United States, Thailand
- Volunteers
- 2,610 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Opioid Overdose
Risks and Benefits of Naloxone Prescribing
This investigation is one of the first large-scale, prospective attempts to obtain data on the effectiveness of naloxone distribution among opioid-abusing populations at high risk of unintentional opioid poisoning.
- Trial name
- NCT02535494
- Testing
- Extensive training
- Where
- United States
- Volunteers
- 405 people
- Sponsor
- New York State Psychiatric Institute
HIV
Behavioral Intervention Trial for HIV-infected Injection Drug Users
The purpose of this study is to test whether a ten-session behavioral intervention for HIV-infected injection drug users is effective in reducing sex and injection risk behaviors that put others at risk for HIV infection…
- Trial name
- NCT00146445
- Testing
- Peer Mentoring Intervention
- Where
- 5 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Centers for Disease Control and Prevention
Medication Abuse, Harm Reduction
Clinical Decision Support to Improve System Naloxone Co-prescribing
The objective of this study is to evaluate the impact of a clinical decision support (CDS) alert to facilitate the co-prescribing of naloxone, an opioid overdose reversal agent, with high-risk opioid prescriptions.
- Conditions
- Medication Abuse, Harm Reduction, Opioid Overdose, Opioid Prescribing
- Trial name
- NCT06271668
- Testing
- Naloxone Co-prescribing Clinical Decision Support (CDS)
- Where
- United States
- Volunteers
- 114,272 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Volunteer
A Study of the Abuse Liability Potential of Cenobamate in Recreational Drug Users
This randomized, single-dose, placebo- and active-controlled, crossover study will evaluate the abuse liability potential of cenobamate in recreational drug users with sedative drug use experience.
- Trial name
- NCT03509285
- Testing
- Alprazolam, Cenobamate
- Where
- 2 sites in United States, Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- SK Life Science, Inc.