Clinical trials: Drug-Induced Liver Injury
Liver Injury, Secondary to Immune Checkpoint Inhibitors
Prospective Cohort of Immune Checkpoint Inhibitor-induced Hepatitis
Background and Study Rationale Immune checkpoint inhibitors (ICI) are a breakthrough cancer treatment that boosts the immune system to fight tumors.
- Conditions
- Liver Injury, Secondary to Immune Checkpoint Inhibitors, Cancer Patients
- Trial name
- CO-CHILI (NCT06864481)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Montpellier
Liver Injury, Drug-Induced
Clarify of Predictive Risk Factors of Chemotherapy-induced Liver Injury
The most common toxicity of TP (docetaxel and cisplatin) chemotherapy is chemotherapy-induced liver injury. However, patients don't always experience same chemotherapy-induced liver injury for the same drugs.
- Trial name
- NCT03069820
- Testing
- docetaxel and cisplatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Drug-Induced Liver Injury, Musculoskeletal Diseases
Liver Enzyme Abnormalities and Risk Factors in Taking Herbal Medicine
Herb-induced liver injury is an important issue in musculoskeletal diseases where herbal medicine is most frequently used. The low prevalence of drug-induced liver injury (DILI) gives rise to the need for large-scale patient…
- Trial name
- NCT02299739
- Testing
- Herbal medicine, Acupuncture, Pharmacopuncture
- Where
- South Korea
- Volunteers
- 6,894 people
- Sponsor
- Jaseng Hospital of Korean Medicine
Drug-Induced Liver Injury
Prevalence and Prognosis of Drug-Induced Liver Injury
Drug-induced liver injury (DILI) is an important cause of acute liver damage that occurs when prescription medications, over-the-counter drugs, herbal products, or dietary supplements harm the liver.
- Trial name
- NCT07830901
- Volunteers
- 80 people
- Sponsor
- Assiut University
Drug-induced Liver Injury, Gut Microbiota
Alterations of Gut Microbiota and Serum Biochemical Markers in DILI Patients
Drug-induced liver injury is a leading cause of acute liver failure worldwide and one of the least understood areas in hepatology research.
- Conditions
- Drug-induced Liver Injury, Gut Microbiota, Biochemical Markers
- Trial name
- NCT05465642
- Testing
- Collect stool and blood samples from patients
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Drug-induced Liver Injury
Glucocorticosteroid Therapy on Drug-induced Liver Injury: a Prospective Non-randomized Concurrent Control Trial
The purpose of this study is to assess the safety and efficacy of glucocorticosteroid for treatment of drug-induced liver injury.
- Trial name
- NCT04553003
- Testing
- Glucocorticoids+hepatoprotectant, hepatoprotectant
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Li Yang
Acute Drug-induced Liver Injury, Chronic Liver Disease
A Diagnostic Study on Patients With Drug-induced Liver Injury
This study is a multi-center, prospective, non-interventional cohort study with an estimated enrollment of 600 patients with acute DILI.
- Trial name
- NCT04526548
- Volunteers
- 600 people
- Sponsor
- Drug Induced Liver Disease Study Group
Drug Induced Liver Injury, Tuberculosis (TB)
Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi
OBJECTIVE : To compare the outcome of treatment with silymarin or N-acetyl cysteine in patients taking anti-tuberculous drugs for tuberculosis at Tertiary Care Hospital, Karachi.
- Trial name
- NCT07058090
- Testing
- Silymarin 420 mg, N Acetyl Cysteine, Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)
- Volunteers
- 410 people
- Sponsor
- Liaquat National Hospital & Medical College
Drug-Induced Acute Liver Injury
Macrophage Markers, Soluble CD163 (sCD163) and Soluble CD206 (sCD206) in Paracetamol Overdose
Paracetamol (PCM) is a widely used over-the-counter analgesic, and overdose with PCM is a condition regularly seen in everyday clinical practice.
- Trial name
- NCT03679442
- Testing
- N-acetylcysteine
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Drug Induced Liver Injury
Drug-Induced Liver Injury (DILI) Network Retrospective
The purpose of this study is to establish retrospectively a nationwide registry of patients who have suffered drug-induced liver injury (DILI), and to collect, immortalize, and store serum, DNA, and lymphocytes from these…
- Trial name
- ILIAD (NCT00360646)
- Where
- 6 sites in United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Drug Induced Liver Injury
Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia
Drug-induced liver injury (DILI) can lead to potentially fatal complications, such as acute liver failure and even death. In clinical practice, glucocorticoids have been considered in some cases of DILI, especially patients with…
- Trial name
- NCT06922669
- Testing
- Methylprednisolone, Magnesium isoglycyrrhizinate, Glutathione
- Where
- China
- Volunteers
- 232 people
- Sponsor
- General Hospital of Shenyang Military Region
Drug-Induced Acute Liver Injury
The Multi-Center, Randomized, Double-blind, Positive Controlled Clinical Trial of Bicyclol in the Treatment of Acute DILI
The study adopted the design of multi-center, randomized, double-blind, positive control drug, superiority test, using the double-blind double-simulating skills.
- Trial name
- NCT05063500
- Testing
- bicyclol, 25mg/ tablet, polyene phosphatidylcholine capsules, 228mg/ particle.
- Where
- 2 sites in China
- Volunteers
- 360 people
- Sponsor
- Drug Induced Liver Disease Study Group
Drug-induced Liver Injury
Establishment of Drug-induced Liver Injury Databases and Application of Circulating microRNA(miRNA)
The purpose of the study is to establish drug-induced liver injury databases in China, make criteria for Chinese drug-induced liver injury patients and evaluate the application of certain circulating miRNA in diagnosis or…
- Trial name
- NCT02061826
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Beijing Ditan Hospital
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Chronic Liver Disease
Efficacy and Safety of Plasma Exchange Compared to Standard Medical Therapy in Patients With Severe Drug Induced Liver Injury With or Without Underlying Chronic Liver Disease.
In this randomized study subject will be randomized into two groups Group A will receive Standard Medical Treatment (Albumin + High Caloric Diet) Group B will continue Standard Medical Treatment with High Volume Plasma Exchange.
- Trial name
- NCT04015570
- Testing
- High Volume Plasma Exchange, Standard Medical Treatment
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Drug-induced Liver Injury,Chronic
36 Weeks Short-Term Optimization Treatment of Glucocorticosteroid in the Patients With Chronic Recurrent DILI
This study is to observe the efficacy and safety of 36 weeks short-term optimization treatment of glucocorticosteroid in the patients with chronic recurrent drug-induced liver injury (DILI).
- Trial name
- NCT03266146
- Testing
- 36 Weeks Methylprednisolone, 48 weeks Methylprednisolone
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Beijing 302 Hospital
Non Alcoholic Fatty Liver, Hepatitis B
Combi-elastography Assessment of Chronic Liver Disease Multi-center Study
HITACH developed a new combi-elastography imaging technology combines shear wave imaging and strain imaging technology. In the study, not only the F index which is related to the stage of liver fibrosis can be obtained, but also…
- Conditions
- Non Alcoholic Fatty Liver, Hepatitis B, Drug-induced Liver Injury
- Trial name
- NCT04625166
- Where
- China
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Drug Induced Liver Injury, Pruritus
Drug-induced Liver Injury: Itching Study
Idiosyncratic drug-induced liver injury (DILI) is an unpredictable adverse hepatic reaction to a medication used in its therapeutic dose.
- Trial name
- NCT06446609
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Hepatitis, Tuberculosis
Anti-tuberculosis (TB) Drug Levels and Correlation With Drug Induced Hepatotoxicity
The purpose of the study is to estimate plasma drug levels ( free and total drug levels ) of rifampicin and other antituberculosis drugs and compare these drug levels in patients who develop drug induced hepatotoxicity versus…
- Trial name
- NCT01456845
- Where
- India
- Volunteers
- 110 people
- Sponsor
- All India Institute of Medical Sciences
Drug Induced Liver Injury
Identifying Changes in Blood (Potential Biomarkers) in Individuals With Drug-Induced Liver Injury
The purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver.
- Trial name
- NCT01000766
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill