Clinical trials: Drugs, Investigational
Cadmium Exceeds the Standard
Safety Study of GMDTC Injection in Participants With Excessive Cadmium
This trial is a randomized, double-blind, single-center, single-dose escalating Phase I clinical trial designed to evaluate the safety, tolerability, and pharmacokinetic characteristics of GMDTC for injection after repeated…
- Trial name
- NCT06199349
- Testing
- GMDTC for injection, Normal saline
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jianersheng (Zhuhai) Pharmaceutical Technology Co., Ltd.
Acute Renal Failure (ARF), Acute Tubular Necrosis
Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF)
Use of QRX-3 in hospitalized patients with pediatric and adult patients with acute tubular necrosis renal failure
- Trial name
- QRX3 in ARF (NCT07161843)
- Testing
- QRX-3
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ebima Clifford Okundaye
Healthy Participants
An Investigational Study to Evaluate the Effect of Rifampin on the Singe Dose of Experimental Medication BMS-986224 in Healthy Participants
The purpose of this study is to investigate if the blood levels of experimental medication BMS-986224 will be changed when given together with Rifampin, an antibiotic that affects specific enzymes involved with the breakdown of…
- Trial name
- NCT03563950
- Testing
- Rifampin, BMS-986224
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Osteoarthritis
A Study to Assess the Safety and Efficacy of an Investigational Drug in Patients With Osteoarthritis (0663-071)(COMPLETED)
This study was conducted to assess the safety and tolerability of the drug and to evaluate its efficacy in the treatment of osteoarthritis of the hip or knee in men and women.
- Trial name
- NCT00269191
- Testing
- MK0663, etoricoxib / Duration of Treatment 12 Weeks
- Volunteers
- 528 people
- Sponsor
- Organon and Co
Contraceptive Usage
A Prospective Observational Study of the Performance of Zarin in Kenya
This will be a non-comparative prospective observational study of women using Zarin as a primary method of contraception in Kenya.
- Trial name
- NCT01334190
- Where
- Kenya
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- FHI 360
Rheumatoid Arthritis
Investigational Drug Versus an Approved Drug in Patients With Rheumatoid Arthritis (0663-072)
The purpose of this study is to evaluate the long-term safety of an investigational drug versus an approved drug for the relief of pain in patients with rheumatoid arthritis.
- Trial name
- NCT00092742
- Testing
- MK0663, etoricoxib, Comparator: Diclofenac sodium
- Volunteers
- 4,086 people
- Sponsor
- Organon and Co
Transthyretin (TTR)-Mediated Amyloidosis, Familial Amyloidotic Polyneuropathy (FAP)
The Study of an Investigational Drug, Revusiran (ALN-TTRSC), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Whose Disease Has Continued to Worsen Following Liver Transplant
The purpose of this study was to evaluate the safety and effectiveness of revusiran (ALN-TTRSC) in adults with transthyretin-mediated amyloidosis (ATTR), whose disease has continued to worsen after liver transplantation.
- Conditions
- Transthyretin (TTR)-Mediated Amyloidosis, Familial Amyloidotic Polyneuropathy (FAP), ATTR Amyloidosis, Familial Amyloid Neuropathies
- Trial name
- NCT02595983
- Testing
- Revusiran
- Where
- 6 sites in France, Germany and 4 more
- Volunteers
- 12 people
- Sponsor
- Alnylam Pharmaceuticals
Experimental Pain
Gender, Pain, and Placebo Analgesia
The response to standard pain stimuli in males and females is investigated, together with the effect of informing participants about the effect of a painkiller. Physiological response to pain is recorded.
- Trial name
- NCT00314392
- Testing
- Information (behavior)
- Where
- Norway
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Dysmenorrhea
An Investigational Drug Study in the Treatment of Primary Dysmenorrhea (0663-064)
The purpose of this study is to evaluate the pain relieving effect and safety of an investigational drug in women with moderate to severe primary dysmenorrhea (painful menstruation).
- Trial name
- NCT00092729
- Testing
- etoricoxib (MK0663), Comparator: naproxen sodium
- Volunteers
- 129 people
- Sponsor
- Organon and Co
Psoriasis
An Investigational Study to Evaluate Experimental Medication BMS-986165 Compared to Placebo and a Currently Available Treatment in Participants With Moderate-to-Severe Plaque Psoriasis
The purpose of this study is to investigate the experimental medication BMS-986165 compared to placebo and a currently available treatment in participants with moderate to severe plaque psoriasis.
- Trial name
- POETYK-PSO-2 (NCT03611751)
- Testing
- BMS-986165, Apremilast
- Where
- 205 sites in United States, Australia and 14 more
- Volunteers
- 1,020 people
- Sponsor
- Bristol-Myers Squibb
Unresectable or Metastatic Melanoma, Progressive Brain Metastasis
Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma
This is a clinical study to compare the efficacy and safety of HBI-8000 combined with nivolumab to Placebo combined with nivolumab in patients with unresectable or metastatic melanoma.
- Trial name
- NCT04674683
- Testing
- HBI-8000 in combination with nivolumab
- Where
- 139 sites in United States, Australia and 15 more
- Volunteers
- 450 people
- Sponsor
- HUYABIO International, LLC.
Adolescent Health, Adolescent Problem Behavior
The Seattle Social Development Project: An Implementation of the Raising Healthy Children Intervention
The Seattle Social Development Project (SSDP) included a three-part intervention for teachers, parents, and students in grades 1 to 6.
- Trial name
- SSDP (NCT04075019)
- Testing
- The Raising Healthy Children intervention, including teacher training, child skill development, and parent training
- Volunteers
- 808 people, healthy volunteers welcome
- Sponsor
- University of Washington
Chronic Pain
To Evaluate the Food Effect and the Absorption Profile of Ibuprofen Modified-Release Tablets 800 mg
An open-label, randomized, 3-way crossover study to evaluate the pharmacokinetics of investigational product "Ibuprofen Modified-Release Tablets 800 mg" in comparison to the reference standard "Ibuprofen Regular-Release Tablets…
- Trial name
- NCT05329454
- Testing
- Ibuprofen Tablets
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Overseas Pharmaceuticals, Ltd.
Drug Abuse
A Family-based Intervention for Drug-abusing Adults in Hong Kong
To develop a family-based intervention with components of engagement, family roles, affection, and competence and verify its effectiveness on drug abstinence and family functioning for drug-abusing adults in Hong Kong; To compare…
- Trial name
- NCT04725266
- Testing
- Family-based intervention, routine care
- Where
- Hong Kong
- Volunteers
- 82 people
- Sponsor
- The University of Hong Kong
Dysautonomia, Familial, Baroreflex Failure Syndrome
Carbidopa for the Treatment of Excessive Blood Pressure Variability
The overall study objectives are to determine whether carbidopa (Lodosyn®) is safe and well tolerated and to assess whether it can inhibit catecholamine-induced paroxysmal hypertension and normalize or reduce the exaggerated…
- Trial name
- CarbiFD (NCT02553265)
- Testing
- Carbidopa Low-Dose, Carbidopa High-Dose
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- NYU Langone Health
Schizophrenia
A Study to Determine the Maximum Tolerated Dose of an Investigational Drug in Subjects With Schizophrenia
A study to determine the maximum tolerated dose of an investigational drug in subjects with schizophrenia
- Trial name
- NCT03627195
- Testing
- DSP-1349M
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Sumitomo Pharma America, Inc.
Carcinoma, Renal Cell
Study of Orellanine in Metastatic Clear-Cell or Papillary Renal Cell Carcinoma
A phase I/II, open-label, study to determine the safety and preliminary efficacy of orellanine in patients with metastatic clear-cell or papillary renal carcinoma who have failed standard-of-care therapy.
- Trial name
- NCT05287945
- Testing
- Orellanine
- Where
- 10 sites in United States, France and 3 more
- Volunteers
- 75 people
- Sponsor
- Oncorena AB
Healthy
Pre-calculated Doses of Medication for Pediatric Resuscitation, a Simulation Experimental Trial
Dosage errors are common in the stressful situation of a pediatric resuscitation. In addition to that, studies have reported that delays to provide medication is associated to worst survival rate for very sick children.
- Trial name
- NCT02563912
- Testing
- Handbook, Medication chart
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Justine's Hospital
Epilepsy, Intermittent Fasting
IF-MCT 16:8: Investigating the Influence of Intermittent Fasting With and Without MCTs in Patients With Drug-resistant Epilepsy
The objective of the prospective monocentric pilot trial is to investigate the influence of intermittent fasting with or without a once-daily intake with medium chain triglycerides (MCTs) on the frequency of seizures in patients…
- Trial name
- IF-MCT16:8 (NCT06013761)
- Testing
- IF 16:8 as active comparator vs. IF MCT 16:8 as experimental arm
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- University Hospital Marburg
Bronchiolitis, Bronchitis
Effect of AI-Assisted Discharge Education on Parents of Children With Bronchitis/Bronchiolitis
This randomized controlled trial aims to evaluate the effects of artificial intelligence-assisted discharge education on mothers of children hospitalized with bronchitis/bronchiolitis.
- Trial name
- NCT07774494
- Testing
- AI-Assisted Written Discharge Education, AI-Assisted Video Discharge Education, Routine Discharge Education
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Osmaniye Korkut Ata University