Clinical trials: Drugs of Abuse
Methamphetamine Addiction
A Pilot Trial of Dextroamphetamine for Methamphetamine Dependence
The purpose of this study is to assess the safety and effectiveness dextroamphetamine to help methamphetamine users quit or cut down on their use. The study lasts for 9 weeks.
- Trial name
- 1D (NCT00630682)
- Testing
- Dextroamphetamine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- California Pacific Medical Center Research Institute
Opiate Addiction
Comparison of Buprenorphine/Naloxone With Naltrexone in Opioid Dependent Adolescents
This study is designed to determine the relative effectiveness of buprenorphine/naloxone (Suboxone) pharmacotherapy versus naltrexone pharmacotherapy for treatment retention, relapse prevention and opioid craving reduction among…
- Trial name
- NCT01015066
- Testing
- Buprenorphine/naloxone, Naltrexone
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Smoking Cessation, Alcohol Abuse
Varenicline in Drug Treatment
The aim of this study is to assess the efficacy of varenicline compared to placebo in tobacco dependent individuals who are undergoing concurrent treatment for alcohol dependence.
- Trial name
- ViRT (NCT01286584)
- Testing
- varenicline
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- Centre for Addiction and Mental Health
Posttraumatic Stress Disorders, Combat Disorders
Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders
In comparison to the general population, U.S. military and Veterans are at an increased risk for developing both substance use disorders (SUD) and Post Traumatic Stress Disorder (PTSD).
- Conditions
- Posttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug Dependence
- Trial name
- COPE (NCT01338506)
- Testing
- Concurrent Treatment with Prolonged Exposure (COPE)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Medical University of South Carolina
Stigma, Activity Space
Health Outcomes by Neighborhood - Baltimore
Background: Researchers have been studying patterns of mood and drug use in specific neighborhoods. This study will look at environmental factors that may affect drug use, addiction, and treatment seeking in Baltimore…
- Conditions
- Stigma, Activity Space, Social Networks, HIV Status
- Trial name
- NCT01571752
- Where
- United States
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Abuse
A First Study in Healthy Volunteers of a New Mobile Phone Application Measuring the Eyes Before and After Medication
This is a pre-market, explorative, early feasibility, pilot, controlled clinical investigation designed to collect initial clinical data on the medical device Previct Drugs.
- Trial name
- NCT05731999
- Testing
- Previct Drugs
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Kontigo Care AB
Cannabis Dependence
A Trial of N-Acetylcysteine (an Over-the-Counter Medicine) in Adolescents Who Smoke Marijuana
This study is investigating how N-Acetylcysteine (NAC), an over-the-counter medication, will reduce marijuana use when combined with Contingency Management, a behavioral treatment.
- Trial name
- NCT01005810
- Testing
- N-Acetylcysteine, Contingency Management
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Medical University of South Carolina
Drug Safety
Safety and Tolerability of Namisol in the Elderly
The results of phase I Namisol® study (Klumpers et al. Br J Clin Pharmacol, 2012), implicate that Namisol® may have a favorable PK and PD characteristics and is safe to use in people.
- Trial name
- THC (NCT01740960)
- Testing
- delta-9-tetrahydrocannabinol
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Drug Abuse Prevention
A Web-Based Intervention to Prevent Drug Abuse Among Adolescent Girls
This study is designed to develop and test a gender-specific, web-based drug abuse prevention program. Study participants will be adolescent girls aged 13 and 14 years who will complete all measures online.
- Trial name
- NCT01813123
- Testing
- RealTeen
- Where
- United States
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- Columbia University
Substance Abuse, Offenders
Effects of Manualized Treatment in a Seamless System
The specific aims of this project are: 1. To conduct a randomized block experiment to test the effectiveness of different models of the seamless supervision/treatment system and traditional criminal justice supervision on…
- Conditions
- Substance Abuse, Offenders, Criminal Thinking, HIV Risk Behaviors
- Trial name
- Man Tx (NCT01372033)
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- George Mason University
HIV, Illicit Drug User
STRIBILD in Non-Nucleoside Resistant Patients (SINNR STUDY)
The SINNR study will evaluate the virologic efficacy (viral load <50 copies/mL)and safety of STRIBILD administered for 48 weeks to HIV-infected current or recent illicit drug users.
- Trial name
- SINNR (NCT02306577)
- Testing
- STRIBILD
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Vancouver Infectious Diseases Centre
Marijuana Dependence
The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep
Heavy marijuana users report experiencing trouble sleeping when they try to quit, but this has not been carefully studied. This research is being done to learn more about sleep function in heavy marijuana users, and to determine…
- Trial name
- NCT00893269
- Testing
- eszopiclone, ramelteon, zolpidem
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pain, Abuse, Drug
Analgesic and Subjective Effects of Terpenes
The purpose of this research is to assess the analgesic and subjective effects of terpenes administered alone and in combination of THC.
- Trial name
- NCT04451863
- Testing
- Low THC, High THC, Low Myrcene
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hepatitis C
A Direct obserVed therApy vs fortNightly CollEction Study for HCV Treatment - ADVANCE HCV Study
Hepatitis C is a blood borne virus that can seriously damage the liver. An estimated 50,000 Scots have been infected with Hepatitis C virus (HCV). The main driver for spread of HCV infection is intravenous drug use.
- Trial name
- ADVANCE (NCT03236506)
- Testing
- Elbasvir/Grazoprevir 50 MG-100 MG Oral Tablet, Psychological intervention, Sofosbuvir 400 MG
- Where
- 2 sites in United Kingdom
- Volunteers
- 129 people
- Sponsor
- University of Dundee
Drug Abuse
Brief Intervention for Drug Abusing Adolescents
The purpose of this clinical trail is to evaluate the efficacy of a brief, cognitive-behavioral therapeutic intervention for adolescents reporting mild or moderate drug abuse (MMDA).
- Trial name
- NCT00350909
- Testing
- brief intervention (cognitive-behavioral therapy)
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Opioid-Related Disorders, Opiate Addiction
Cross-Sectional Study to Define and Validate "Doctor/Pharmacy Shopping" as Outcomes Suggestive of Abuse and/or Addiction
The purpose of this study is to formulate definitions of doctor/pharmacy shopping and evaluate its association with abuse/addiction
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02668549
- Testing
- DB review for Doctor/Pharmacy Shopping Behavior
- Volunteers
- 164,923 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Marijuana Abuse
Effects of Citicoline on Brain Function and Behavior in Marijuana-Dependent Individuals
The Three Aims of this study are (only studies for Aim 1 were completed) 1. Measure the impact of citicoline on marihuana use patterns in subjects' individualized natural settings and responses to marihuana challenge using…
- Trial name
- NCT00158249
- Testing
- citicoline
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Drug Abuse
Behavioral and Subjective Efficacy of Ramelteon in Subjects With a History of Polydrug Abuse
The purpose of this study is to determine the relative abuse potential of ramelteon, once daily (QD), compared to triazolam in subjects with a history of drug abuse.
- Trial name
- NCT00671632
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Takeda
Opioid-Related Disorders, Opiate Dependence
Acceptability and Safety of Switching From Subutex or Other Opioid Drug Dependence Therapy to Suboxone (NIS P05444)
The purpose of this study is to evaluate the acceptability and safety of switching to Suboxone® (buprenorphine plus naloxone) and the effect of the switch on medication dispensing.
- Conditions
- Opioid-Related Disorders, Opiate Dependence, Drug Abuse
- Trial name
- NCT00725608
- Testing
- buprenorphine/naloxone
- Where
- Austria
- Volunteers
- 339 people
- Sponsor
- Indivior Inc.
Alcohol Abuse
Pilot Test of Computerized MET to Reduce Adolescent Alcohol Use
The goal of this project is to conduct a pilot study evaluating feasibility, acceptability, and estimating the effect size of a new computerized Motivational Enhancement Therapy (cMET) intervention for alcohol-involved adolescent…
- Trial name
- NCT01796158
- Testing
- cASBI+cMET, cASBI
- Where
- United States
- Sponsor
- Boston Children's Hospital