Clinical trials: Dry Eye
Geographic Atrophy, Age-related Macular Degeneration
Intravitreal LFG316 in Patients With Age-related Macular Degeneration (AMD)
This study was conducted in two parts; Part A and Part B: Part B was initially planned to include two cohorts. Cohort 2 was cancelled following an interim analysis for efficacy in Part A of the study, and not due to any safety…
- Trial name
- NCT01527500
- Testing
- LFG316, LFG316 Lower dose
- Where
- 19 sites in United States
- Volunteers
- 158 people
- Sponsor
- Novartis Pharmaceuticals
Sjogren Syndrome, Mixed Connective Tissue Disease
A Study to Evaluate the Safety, Tolerability and Efficacy of MHV370 in Participants With Sjogren's Syndrome (SjS) or Mixed Connective Tissue Disease (MCTD)
This study was a basket trial designed to establish safety, tolerability and efficacy of MHV370 in Sjögren's Syndrome (SjS) and Mixed Connective Tissue Disease (MCTD).
- Trial name
- NCT04988087
- Testing
- MHV370
- Where
- 10 sites in China, Germany and 4 more
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Syndromes
A Safety and Efficacy Study of a New Eye Drop Formulation in Patients With Dry Eye Disease.
This study will evaluate the safety and efficacy of a new eye drop formulation in patients with dry eye disease.
- Trial name
- NCT02553772
- Testing
- Carboxymethylcellulose Based Eye Drop, Carboxymethylcellulose Sodium 0.5%
- Where
- 13 sites in United States, Australia
- Volunteers
- 242 people
- Sponsor
- Allergan
Chalazion, Dry Eye Syndromes
Treatment of Meibomian Gland Dysfunction and Evaporative Dry Eye
The objective of this study is to evaluate the clinical utility, safety and effectiveness of the Manual Mini System compared to standardized warm compress therapy for application of controlled, localized heat therapy in adult…
- Trial name
- NCT00832130
- Testing
- Manual Mini System, iHeat Portable Warm Compress Therapy
- Where
- 11 sites in United States
- Volunteers
- 139 people
- Sponsor
- TearScience, Inc.
Meibomian Gland Dysfunction, Dry Eye
Treatment of Meibomian Gland Dysfunction and Dry Eye in Contact Lens Wearers
The pilot study objective is to evaluate the potential benefits of LipiFlow® System treatment of contact lens wearers with meibomian gland dysfunction and evaporative dry eye by assessing for improvement in meibomian gland…
- Trial name
- NCT02102464
- Testing
- LipiFlow treatment
- Where
- 6 sites in United States, Canada
- Volunteers
- 55 people
- Sponsor
- TearScience, Inc.
Dry Eye Syndrome, Keratoconjunctivitis Sicca
Acute Tear Production Following Single Use of the Oculeve Intranasal Neurostimulator
The primary objective of this study is to evaluate acute tear production as measured by tear meniscus height (TMH) captured by optical coherence tomography (OCT) after single use of the Oculeve Intranasal Neurostimulator (OIN) in…
- Trial name
- NCT02798289
- Testing
- Oculeve Intranasal Neurostimulator
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Oculeve, Inc.
Dry Eye Disease
Effect of Cequa™ in Subjects With Dry Eye Disease
This is a Phase 4, multicenter, single arm, 12 week study in subjects with dry eye disease, which is inadequately controlled by cyclosporine 0.05% ophthalmic emulsion.
- Trial name
- NCT04357795
- Testing
- CequaTM (Cyclosporine 0.09%) ophthalmic solution
- Where
- 5 sites in United States
- Volunteers
- 135 people
- Sponsor
- Sun Pharmaceutical Industries Limited
Dry Eye
RPS InflammaDry Detector™ to Determine MMP-9 Levels in Tears
The RPS InflammaDry Detector™ is intended to detect elevated MMP-9 in human tears to aid in the diagnosis of patients with signs or symptoms of dry eye disease, in conjunction with other methods of clinical evaluation.
- Trial name
- NCT01313351
- Testing
- RPS InflammaDry Detector™
- Where
- 8 sites in United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Rapid Pathogen Screening
Blepharitis, Meibomianitis
Treatment of Patients With Blepharitis and Facial Rosacea
To determine the safety and efficacy of sub-antimicrobial dose COL-101 in the treatment of patients who have both blepharitis and facial rosacea
- Conditions
- Blepharitis, Meibomianitis, Dry Eye
- Trial name
- NCT00560703
- Testing
- COL-101 (doxycycline, USP) capsules
- Where
- 8 sites in United States
- Volunteers
- 70 people
- Sponsor
- Galderma R&D
Dry Eye Disease (DED)
Long-Term Safety and Tolerability of NOV03 (Perfluorohexyloctane) in Subjects Who Completed Trial NVU-003 (Kalahari Study)
The objectives of this trial are to evaluate the safety and tolerability of perfluorohexyloctane (NOV03) ophthalmic solution during long-term use in subjects with Dry Eye Disease (DED) associated with MGD (Meibomian Gland…
- Trial name
- NCT04140227
- Testing
- NOV03
- Where
- 28 sites in United States
- Volunteers
- 256 people
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye Disease
Evaluation of the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (the RAINIER Study)
The objective of this study is to evaluate the safety and effectiveness of OC-02 nasal spray compared to placebo on signs and symptoms of dry eye disease (DED).
- Trial name
- NCT03633461
- Testing
- OC-02 (simpinicline) nasal spray
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Oyster Point Pharma, Inc.
Keratoconjunctivitis Sicca
Trial of CF101 to Treat Patients With Dry Eye Disease
Eligible patients with dry eye will be treated with CF101 or placebo twice daily for 24 weeks. Disease activity will be assessed using evaluations of ocular surface integrity, tear production, and patient symptoms.
- Trial name
- NCT01235234
- Testing
- CF101
- Where
- Israel
- Volunteers
- 236 people
- Sponsor
- Can-Fite BioPharma
Dry Eye Syndromes
Evaluation of Maintaining Visual Performance in Participants Who Engage in Electronic Visual Tasking While Using Restasis®
This study will evaluate the efficacy of Restasis® in participants with dry eye disease who engage in electronic visual tasking.
- Trial name
- EMPOWER (NCT02554981)
- Testing
- Cyclosporine 0.05% Ophthalmic Emulsion
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Allergan
Dry Eye Disease
Evaluation of Ocular Comfort With ISTA Tears vs Systane
To assess the comfort preference of ISTA Tears vs Systane in patients with dry eye disease (DED)
- Trial name
- NCT01650584
- Testing
- ISTA Tears, Systane
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Bausch & Lomb Incorporated
Diabetic Macular Edema
Multiple Dose Safety and Efficacy of LKA651 in Patients With Diabetic Macular Edema
The primary objectives of this study were to evaluate the safety and efficacy of LKA651 in patients with macular edema from diabetic macular edema (DME),
- Trial name
- NCT03927690
- Testing
- LKA651, Lucentis
- Where
- 22 sites in United States, Germany and 3 more
- Volunteers
- 91 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Disease
Research Study To See How Well An Eye Drop (SURF-200) Works, What Side Effects There Are, And To Compare It With Vehicle In Subjects With An Episodic Flare-Up of Dry Eye Disease
SURF-200 is being studied in people experiencing an episodic flare-up of their dry eye disease. SURF-200 is an investigational drug (which means the study drug is currently being tested) in the form of a sterile eye drop.
- Trial name
- NCT04734210
- Testing
- 0.02% Betamethasone Sodium Phosphate, 0.04% Betamethasone Sodium Phosphate
- Where
- 28 sites in United States
- Volunteers
- 139 people
- Sponsor
- Surface Ophthalmics, Inc.
Myopia
A Prospective Study of Two Daily Disposable Contact Lenses
The purpose of this study was to evaluate the performance of a novel silicone hydrogel contact lens, DAILIES TOTAL1® (DT1) compared to the standard hydrogel material in 1-DAY ACUVUE® MOIST® (1DAVM) contact lens in contact lens…
- Trial name
- NCT01636986
- Testing
- Delefilcon A contact lenses, Etafilcon A contact lenses
- Volunteers
- 62 people
- Sponsor
- Alcon Research
Neovascular Age-related Macular Degeneration (nAMD)
Study to Evaluate the Safety and Effectiveness of Intravitreal Injections (IVI) of Brolucizumab in Patients With Neovascular Age-related Macular Degeneration (nAMD)
The purpose of this study was to generate additional safety and effectiveness data in Indian neovascular age-related macular degeneration (nAMD) patients that more closely resemble the real-world population intended to be treated…
- Trial name
- NCT05269966
- Testing
- Injection Brolucizumab
- Where
- 10 sites in India
- Volunteers
- 105 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Syndromes
Safety Study of OPC-12759 Ophthalmic Solution
The purpose of this study is to assess the safety of OPC-12759 ophthalmic solution in healthy subjects.
- Trial name
- NCT01471093
- Testing
- OPC-12759 Ophthalmic solution, OPC-12759 Ophthalmic suspension
- Where
- Japan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Dry Eye Syndrome
Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye
The primary objective of this study was to assess the efficacy and safety of different doses of rhNGF when administered as eye drops to patients with dry eye.
- Trial name
- NCT02101281
- Testing
- rhNGF 20 µg/mL, rhNGF 4 µg/mL
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Dompé Farmaceutici S.p.A