Clinical trials: Dry Eye
Dry Eye
Artificial Tears, Tear Lipids and Tear Film Dynamics
Dry eye disease (DED) is pervasive with some reports estimating over 16 million adults diagnosed in the United States. Currently, artificial tears remain an integral part of managing dry eyes and are mainly used for symptomatic…
- Trial name
- AlconAT (NCT05705518)
- Testing
- Systane Complete PF, Refresh Relieva PF, Refresh Optive Mega-3 PF
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Dry Eye
Keratometric Tear Breakup Time and Fluorescein Tear Breakup Time
The purpose of the research is to determine if putting fluorescein onto the eye (most common test done for dry eye syndrome) is an accurate way to measure dry eye symptoms.
- Trial name
- NCT00854906
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Ocular Dryness
Clinical Investigation on the Use of Ophthalmic Solution Based on Sodium Hyaluronate in Treatment of Eye Discomfort
The purpose of this study is to assess the performance and safety resulting from the treatment of an ophthalmic solution for the ocular discomfort and in particular in presence of ocular dryness.
- Trial name
- NCT05777798
- Testing
- Hyalistil Bio PF
- Where
- 2 sites in Italy
- Volunteers
- 28 people
- Sponsor
- SIFI SpA
Healthy, Dry Eye
Punctal Plug Study to Determine the Safety and Retention Times of Various Lengths of Canalicular Stents in Volunteers
The purpose of this study was to determine the safety and retention times of two different lengths (10 mm and 20 mm) of the MINI MONOKA canicular stent when inserted in the eye for up to three months in subjects with or without…
- Trial name
- NCT00743249
- Testing
- MINI MONOKA canalicular stent, 10 mm, MINI MONOKA canalicular stent, 20 mm
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Primary Sjögren's Syndrome
Efficacy and Safety of S95011 in Primary Sjögren's Syndrome Patients
The purpose of this study is to assess the effect of multiple intravenous infusions of S95011 compared to placebo in reducing disease activity in patients with primary Sjögren's syndrome.
- Trial name
- NCT04605978
- Testing
- S95011 concentrate for solution for infusion
- Where
- 19 sites in United States, Australia and 5 more
- Volunteers
- 48 people
- Sponsor
- Institut de Recherches Internationales Servier
Age-related Macular Degeneration
Efficacy and Safety of Two Different Brolucizumab 6 mg Dosing Regimens in Neovascular Age-related Macular Degeneration
The purpose of this study was to evaluate the efficacy and safety of two different brolucizumab 6 mg dosing regimens in patients with visual impairment due to age-related macular degeneration (AMD) who have previously received…
- Trial name
- FALCON (NCT04679935)
- Testing
- Brolucizumab
- Where
- 19 sites in Germany, Switzerland
- Volunteers
- 52 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye
Safety and Efficacy of Dexamethasone Ophthalmic Insert (Dextenza®) in the Management of Clinically Significant Dry Eye
To determine efficacy and safety profile of dexamethasone 0.4mg lacrimal insert in dry eye related ocular surface inflammation.
- Trial name
- NCT04498468
- Testing
- Sustained Release Dexamethasone, 0.4 mg, E-Caprolactone-L-Lactide copolymer (PCL) punctal plug
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Dry Eye Syndromes
Safety and Efficacy Study of New Eye Drop Formulations With Refresh Tears® in Patients With Dry Eye Disease
This study will investigate the safety, efficacy and acceptability of two new eye drop formulations compared with Refresh Tears® in patients with dry eye disease.
- Trial name
- NCT01294384
- Testing
- carboxymethylcellulose sodium based New Eye Drop Formulation 1, carboxymethylcellulose sodium based New Eye Drop Formulation 2, carboxymethylcellulose sodium based Eye Drops
- Where
- 2 sites in Australia, Canada
- Volunteers
- 305 people
- Sponsor
- Allergan
Dry Eye Syndrome
Safety and Efficacy of an Artificial Tear for the Treatment of Dry Eye
The efficacy, safety and acceptability of a new artificial tear in subjects with dry eye will be compared to a currently-available artificial tear
- Trial name
- NCT00514852
- Testing
- Carboxymethylcellulose and Glycerin based artificial tear, Carboxymethylcellulose
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- Allergan
Dry Eye
Study of VVN001 Ophthalmic Solution in Dry Eye Disease
This is a Phase 2a, multi-center, double-masked, randomized, vehicle-controlled, parallel-group study designed to evaluate the safety and tolerability and to explore the efficacy activity of VVN001 ophthalmic solution versus…
- Trial name
- NCT04556838
- Testing
- VVN001 Ophthalmic Solution 1%, VVN001 Ophthalmic Solution 5%, Vehicle
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- VivaVision Biotech, Inc
Dry Eye Syndromes
An Observational Study of OPTIVE PLUS® for the Treatment of Dry Eye Disease
This is an observational study of OPTIVE PLUS® in patients with dry eye disease in a routine clinical setting. Treatment decisions are made by the physician and reflect the physician's current standard of care.
- Trial name
- NCT01711424
- Testing
- OPTIVE PLUS®
- Where
- Germany
- Volunteers
- 1,209 people
- Sponsor
- Allergan
Dry Eye Disease, Endothelial Cell
A Clinical Trial to Evaluate the Corneal Endothelial Health of DED Subjects Treated With Cyclosporine
The objective of this trial is to evaluate the effect of cyclosporine ophthalmic solution, 0.1% on corneal endothelial cell health in comparison to a hypotonic saline solution in subjects with Dry Eye Disease (DED)
- Trial name
- NCT06329661
- Testing
- Cyclosporine ophthalmic solution, 0.1%, Saline solution, 0.6%
- Where
- 6 sites in United States
- Volunteers
- 204 people
- Sponsor
- Novaliq GmbH
Dry Eye Disease
A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of Reproxalap Ophthalmic Solution in Subjects With Dry Eye Disease
A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Safety of 0.25% Reproxalap Ophthalmic Solution in Subjects with Dry Eye Disease
- Trial name
- NCT04735393
- Testing
- Reproxalap Ophthalmic Solution (0.25%)
- Where
- United States
- Volunteers
- 757 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Dry Eye
To Assess the Efficacy and Safety of OTX-DED for the Short-term Treatment of Signs and Symptoms of Dry Eye Disease
To assess the efficacy and safety of OTX-DED for the short-term treatment of signs and symptoms of dry eye disease.
- Trial name
- NCT04747977
- Testing
- OTX-DED
- Where
- 15 sites in United States
- Volunteers
- 172 people
- Sponsor
- Ocular Therapeutix, Inc.
Dry Eye Disease
IVW-1001 Phase 1/2 in Subjects With Dry Eye Disease
Double-masked, dose-response, trial of IVW-1001 in subjects with dry eye disease.
- Trial name
- NCT06400459
- Testing
- IVW-1001 Ophthalmic Eyelid Wipe 0.1%, IVW-1001 Ophthalmic Eyelid Wipe 0.2%
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- IVIEW Therapeutics Inc.
Sjogren's Syndrome, Dry Eye
Nasal Spray Study in Sjogren's Dry Eye Disease
This study will investigate how well OC-01 (varenicline) nasal spray can treat the signs and symptoms of dry eye disease in those Sjogren's Syndrome.
- Trial name
- NCT05700422
- Testing
- Varenicline Nasal Spray
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Pennsylvania
Dry Eye
A Study to Evaluate the Performance and Safety of CBL-101 Versus Vismed® Multi Eye Drops in the Management of Dry Eye
The primary objectives of this investigation are to show that the performance of CBL-101 Eye Drops is non-inferior to that of Vismed® Multi eye drops in subjects with moderate to severe keratoconjunctivitis sicca after 28 days…
- Trial name
- NCT02975102
- Testing
- CBL-101 Eye Drops, Vismed® Multi Eye Drops
- Where
- 2 sites in Belgium, France
- Volunteers
- 87 people
- Sponsor
- Laboratoire Chauvin
Dry Eye Disease
Physician's Evaluation of Cyclosporine Ophthalmic Emulsion 0.05%
The objective of this retrospective chart review is to evaluate the patient characteristics, treatment variations and efficacy of a second trial of Cyclosporine Ophthalmic Emulsion 0.05% therapy in chronic dry eye patients who…
- Trial name
- NCT00827255
- Testing
- Cyclosporine Ophthalmic Emulsion 0.05%
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Allergan
Eyes Dry Chronic
ESBA105 in Patients With Severe Dry Eye
The purpose of this study was to evaluate the efficacy of ESBA105 over vehicle in reducing the ocular symptoms of dry eye disease, as measured by a mean global Visual Analog Scale (VAS) discomfort score.
- Trial name
- NCT01338610
- Testing
- ESBA105 ophthalmic solution, ESBA105 vehicle
- Where
- United States
- Volunteers
- 334 people
- Sponsor
- Alcon Research
Dry Eye Syndrome
Safety and Efficacy of Two Artificial Tears in Dry Eye Subjects
This study will evaluate the safety, efficacy, and acceptability of two artificial tears compared to a currently available artificial tear in subjects with dry eye.
- Trial name
- NCT01010282
- Testing
- Glycerin and Polysorbate 80 based artificial tear, Formulation 1: Carboxymethylcellulose sodium, glycerin and Polysorbate 80, based artificial tear, Formulation 2: Carboxymethylcellulose sodium, glycerin, and Polysorbate 80 based artificial tear
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- Allergan