Clinical trials: Dry Eye, completed
Dry Eye
Efficacy of 0.38% and 0.18% Sodium Hyaluronate Ocular Lubricants for Dry Eye in Adult Gazan Participants
The goal of this completed clinical trial was to determine if 0.38% and 0.18% sodium hyaluronate (SH) lubricant eye drops improve symptoms of moderate to severe dry eye disease (DED) in adult Gazan participants.
- Trial name
- NCT06851364
- Testing
- 0.38% Sodium Hyaluronate (SH) Eye Drops, 0.18% Sodium Hyaluronate Eye Drops, Normal Saline Eye Drops
- Where
- Palestinian Territories
- Volunteers
- 45 people
- Sponsor
- International Islamic University Malaysia
Dry Eye
A Study to Evaluate the Performance and Safety of CBL-101 Versus Vismed® Multi Eye Drops in the Management of Dry Eye
The primary objectives of this investigation are to show that the performance of CBL-101 Eye Drops is non-inferior to that of Vismed® Multi eye drops in subjects with moderate to severe keratoconjunctivitis sicca after 28 days…
- Trial name
- NCT02975102
- Testing
- CBL-101 Eye Drops, Vismed® Multi Eye Drops
- Where
- 2 sites in Belgium, France
- Volunteers
- 87 people
- Sponsor
- Laboratoire Chauvin
Dry Eye Syndrome, Myopia
Clinical Evaluation of a Daily Disposable Contact Lens in Symptomatic Weekly/Monthly Lens Wearers
The purpose of this study was to evaluate the reduction of contact lens-related dryness symptoms when symptomatic weekly/monthly contact lens wearers were switched to DAILIES® AquaComfort Plus® lenses for a two-week period using…
- Trial name
- NCT01614600
- Testing
- Nelfilcon A contact lenses
- Volunteers
- 88 people
- Sponsor
- Alcon Research
Daily Activities, Eye Health
Nursing Intervention of Blinking Exercises to Alleviate Dry Eye and Enhance Daily Life in Older Adults
The study aimed to evaluate the effect of blinking exercises in improving eye dryness and daily life in older adults. Participants aged 60 years and older of both genders, diagnosed with dry eyes and patients who were alert and…
- Trial name
- blinking dry (NCT07110467)
- Testing
- blinking exercises
- Where
- Saudi Arabia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Norther Private Collage of Nursing
Dry Eye
Dry Eye OmniLenz Application of Omnigen Research Study
Dry eye disease (DED) is a disease of the ocular surface characterised by ocular surface inflammation and damage and neurosensory abnormalities.
- Trial name
- DOORS (NCT04553432)
- Testing
- Amniotic membrane Omnigen[TM], Bandage soft Contact Lens OmniLenz[R]
- Where
- United Kingdom
- Volunteers
- 79 people
- Sponsor
- Aston University
Dry Eye Syndrome
Phase 2 Study to Evaluation the Safety and Efficacy of Orally Administered KL7016 in Patients With Dry Eye Syndrome
This is a controlled study to determine the effectiveness and safety of KL7016 in the treatment of adult patients with dry eye syndrome (DES).
- Trial name
- NCT02092207
- Testing
- KL7016 900mg, KL7016 600mg
- Where
- 9 sites in South Korea
- Volunteers
- 147 people
- Sponsor
- Yungjin Pharm. Co., Ltd.
Dry Eye Syndromes
Feasibility of IPL for Reducing Dry Eye Symptoms Caused by MGD
The purpose of this study is to evaluate if, in patients with meibomian gland dysfunction (MGD), treatment with the Lumenis M22 Intense Pulsed Light (IPL) system causes a reduction in dry eye symptoms post-treatment, compared to…
- Trial name
- NCT02621593
- Testing
- M22-IPL
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Lumenis Be Ltd.
Healthy, Sicca Syndrome
A Longitudinal, Observational Biomarker Study in Participants With Primary Sjogren's Syndrome
The main objective of the study is to characterize the gene expression in immune and epithelial cells in salivary gland biopsy samples and blood of pSS (primary Sjögren's syndrome) and non-pSS participants including healthy…
- Conditions
- Healthy, Sicca Syndrome, Sjögren's Syndrome
- Trial name
- NCT02422407
- Testing
- Biopsy
- Where
- 4 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Biogen
Dry Eye
Efficacy and Safety of Fluorometholone (FML) in Dry Eye Disease (Keratoconjunctivitis Sicca)
Hypothesis: Fluorometholone (FML) 0.1% eyedrops topically applied 4 times a day for 22 days is more efficient than artificial tears (Liquifilm) in dry eye disease (DED) and ameliorates the worsening of the disease after exposure…
- Trial name
- FML (NCT02051023)
- Testing
- FML 0.1% eyedrops, Liquifilm artificial tears eyedrops
- Where
- 2 sites in Spain
- Volunteers
- 41 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Dry Eye Syndromes, Sjogren's Syndrome
TrueTear in Sjogren's Disease Patients
The purpose of this study is to evaluate acute tear production produced by the intranasal tear neurostimulator in participants with Sjögrens syndrome and aqueous tear deficiency.
- Trial name
- NCT03719885
- Testing
- TrueTear Intranasal Tear Neurostimulator
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dry Eye Disease
Safety and Efficacy of Two Different Concentrations (0.5% and 1%) of Progesterone Topical Gel Compared to Placebo in Patients Diagnosed With Moderate to Severe Dry Eye Syndrome
Multicenter, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group, Phase 2 clinical trial. The study objective is to evaluate the safety and efficacy of two different concentrations (0.5% and 1%) of progesterone topical…
- Trial name
- ProGIFT (NCT04645446)
- Testing
- Pro-ocular gel
- Where
- 4 sites in Italy
- Volunteers
- 96 people
- Sponsor
- SIFI SpA
Dry Eye Disease (DED), Meibomian Gland Dysfunction
Treatment Effect of Intense Pulsed Light and Thermal Pulsation Therapy on Meibomian Gland Dysfunction-associated Dry Eye Disease: a Randomized Trial
The goal of this clinical trial is to understand novel treatment methods for meibomian gland dysfunction (MGD)-associated dry eye disease (DED) by comparing two treatment modalities- intense pulsed light (IPL) and thermal…
- Trial name
- NCT06745089
- Testing
- Intense pulsed light, thermal pulsation therapy, Ocular lubricant
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- National Yang Ming Chiao Tung University
Dry Eye Disease, Ocular Comfort
Bromfenac 0.09% vs Ketorolac 0.4% for Cyclosporine Induction Phase
To compare bromfenac 0.09% and ketorolac 0.4% when used concomitantly with cyclosporine ophthalmic emulsion 0.05% in improving patient comfort during the induction phase of treatment for chronic dry eye disease
- Trial name
- NCT00520260
- Testing
- bromfenac, ketorolac
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Florida Eye Microsurgical Institute
Graft vs Host Disease, Sjogren's Syndrome
Potential of Transplanted Stem Cells to Mature Into Salivary Gland and Cheek Cells
This study will examine whether transplanted stem cells can turn into salivary gland cells in stem cell recipients. If so, stem cells might be used to restore salivary gland function in patients with Sjogren's syndrome and other…
- Trial name
- NCT00023491
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dry Eye
A Study Evaluating HBM9036 Efficacy and Safety on Moderate to Severe Dry Eye
The objective of this study is to compare the safety and efficacy of 0.25% HBM9036 (HL036) Ophthalmic Solution to placebo for the treatment of the Chinese subjects with moderate and severe dry eye.
- Trial name
- NCT04633213
- Testing
- HBM9036 0.25% Ophthalmic Solution
- Where
- China
- Volunteers
- 577 people
- Sponsor
- Harbour BioMed (Guangzhou) Co. Ltd.
Dry Eye Syndrome
Evaluate the Safety and Efficacy of a New Artificial Tear for Use After LASIK Surgery
This study will evaluate the safety and efficacy of a new artificial tear for the treatment of dry eye that may occur after LASIK surgery
- Trial name
- NCT00544713
- Testing
- Carboxymethylcellulose and Glycerin based artificial tear, Carboxymethylcellulose
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Allergan
Allergic Conjunctivitis, Dry Eye Disease (DED)
Clinical and Biological Evaluation of NAAGA Versus Azelastine Eye Drops in Allergic Subjects With Tear Film Dysfunction
This randomized, single-blind study aims to compare the efficacy and safety of N-acetyl-aspartyl-glutamate (NAAGA) and azelastine hydrochloride eye drops in patients with allergic conjunctivitis associated with tear film…
- Trial name
- NCT06800274
- Testing
- NAAGA (N-acetyl-aspartyl-glutamate) 49 mg/mL, azelastine hydrochloride 0.05%
- Where
- Italy
- Volunteers
- 134 people
- Sponsor
- Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona
Dry Eye
The DEPOT Study (Dry Eye Prescription Options for Therapy)
Assessing DEXTENZA efficacy and safety when placed within the lower eyelid canaliculus for dry eye flares in comparison to topical loteprednol suspension.
- Trial name
- NCT04911361
- Testing
- Dexamethasone
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Research Insight LLC
Xerostomia, Sjogren's Syndrome
Topical Management of Xerostomia With Dry Mouth Products
Objectives: To assess the effects of topical dry mouth products (toothpaste and mouthwash) containing olive oil, parsley oil, provitamin B5, allantoin, betaine and xylitol in Primary Sjögren's syndrome patients with xerostomia.
- Trial name
- NCT03611283
- Testing
- Mouthwash treatment, Toothpaste treatment
- Volunteers
- 28 people
- Sponsor
- Rosa María López-Pintor Muñoz
Retinitis Pigmentosa, Macula Off
Transcorneal Electrical Stimulation Therapy for Retinal Disease
Transcorneal stimulation may enable neurons to survive degeneration processes via enhanced secretion of neurotrophic substances and direct stimulation of neurons.
- Conditions
- Retinitis Pigmentosa, Macula Off, Primary Open Angle Glaucoma, Hereditary Macular Degeneration
- Trial name
- NCT00804102
- Testing
- Transcorneal Electrical Stimulation, DTL-electrode attached without energy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Okuvision GmbH
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