Clinical trials: Dry Eye, completed
Dry Eye Disease
Evaluation of Ocular Comfort With ISTA Tears vs Systane
To assess the comfort preference of ISTA Tears vs Systane in patients with dry eye disease (DED)
- Trial name
- NCT01650584
- Testing
- ISTA Tears, Systane
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Bausch & Lomb Incorporated
Allergic Conjunctivitis, Dry Eye
PMCF Study to Evaluate Performance and Safety of "Optrex Double Action Soothing and Lubricating Drops"
Allergic conjunctivitis (or ocular allergy) and dry eye disease (DED) are two major ocular surface disorders affecting millions of people.
- Conditions
- Allergic Conjunctivitis, Dry Eye, Dry Eye Disease
- Trial name
- NCT05824000
- Testing
- Eye drops for itchy and water eyes
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- C.O.C. Farmaceutici S.r.l.
Dry Eye Disease
Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease
The purpose of this trial is to compare the effectiveness and safety of INS365 Ophthalmic Solution with Placebo when applied topically in subjects with dry eye disease.
- Trial name
- NCT00403715
- Testing
- diquafosol tetrasodium (INS365) Ophthalmic Solution
- Volunteers
- 500 people
- Sponsor
- Merck Sharp & Dohme LLC
Dry Eye Syndromes
Investigation of Maintaining Visual Performance Achieved With Cyclosporine Therapy
This study will evaluate the safety and efficacy of cyclosporine 0.05% ophthalmic emulsion (Restasis®) in patients with dry eye disease.
- Trial name
- IMPACT (NCT02121847)
- Testing
- cyclosporine 0.05% ophthalmic emulsion, carboxymethylcellulose-based lubricant eye drops
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Allergan
Ametropia
Prospective Study Evaluating Dry Eye in Patients Operated on for Ametropia by LASIK Surgery and Treated With REPADROP
LASIK is a refractive surgery technique widely used in France. Postoperatively, the classic treatment after LASIK consists of instilling drops to reduce dry eyes.
- Trial name
- PREPADROP (NCT04654455)
- Testing
- Describe the evolution of dry eye between 1 month and 3 months post-LASIK
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Sjogren's Syndrome
Safety and Efficacy Study of Subcutaneous Belimumab and Intravenous Rituximab Co-administration in Subjects With Primary Sjogren's Syndrome
This study is a multi-national, multi-center, double-blind (sponsor open), randomized, placebo-controlled trial in subjects with active primary Sjögren's syndrome designed to understand the safety and tolerability profile of…
- Trial name
- NCT02631538
- Testing
- Belimumab, Rituximab
- Where
- 36 sites in Argentina, Canada and 8 more
- Volunteers
- 86 people
- Sponsor
- GlaxoSmithKline
Healthy, Dry Eye
Punctal Plug Study to Determine the Safety and Retention Times of Various Lengths of Canalicular Stents in Volunteers
The purpose of this study was to determine the safety and retention times of two different lengths (10 mm and 20 mm) of the MINI MONOKA canicular stent when inserted in the eye for up to three months in subjects with or without…
- Trial name
- NCT00743249
- Testing
- MINI MONOKA canalicular stent, 10 mm, MINI MONOKA canalicular stent, 20 mm
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye
Phase 1 Study for Safety and Tolerability of HL036
To evaluate the safety, local tolerability and pharmacokinetic characteristics after administration of eye-drop HL036 in healthy Korean male volunteers
- Trial name
- NCT02717208
- Testing
- HL036, Vehicle
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HanAll BioPharma Co., Ltd.
Dry Eye
Evaluation of Comfort in Subjects With Moderate Dry Eye Disease
The purpose of this study is to evaluate the comfort of an ocular lubricant in dry eye subjects. This study will be conducted in Canada and Australia.
- Trial name
- NCT04830956
- Testing
- FID123238, Systane Hydration
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Alcon Research
Dry Eye Syndrome
Study of SkQ1 as Treatment for Dry-eye Syndrome
The purpose of this study is to evaluate whether SkQ1 ophthalmic solutions are safe and effective compared to placebo for the treatment of the signs and symptoms of dry eye syndrome.
- Trial name
- VISTA-1 (NCT03764735)
- Testing
- Low Dose - SkQ1, High dose - SkQ1, SkQ1 (Vehicle)
- Where
- 7 sites in United States
- Volunteers
- 452 people
- Sponsor
- Mitotech, SA
Moderate to Severe Dry Eye Syndrome
Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease
This clinical trial is to investigate whether nonsteroid anti-inflammatory drops have therapeutic effect on moderate to severe dry eye patients.And compare the efficacy of the two nonsteroid anti-inflammatory drops with topical…
- Trial name
- NCT01562795
- Testing
- nonsteroid anti-inflammatory drops, corticosteroids, artificial tear substitute
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Wenzhou Medical University
Ocular Surface Disease, Glaucoma, Open-Angle
Ocular Surface Disease Changes After iStent or iStent Inject Implantation With Phacoemulsification
This prospective interventional single-arm trial evaluates measures changes in ocular surface disease parameters in eyes with mild to moderate open-angle glaucoma (OAG) on 1-4 glaucoma medications who undergo phacoemulsification…
- Trial name
- NCT04452279
- Testing
- iStent or iStent inject implantation with concomitant cataract surgery
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Vance Thompson Vision
Dry Eye
The Impact of Eyelid Hygiene on Ocular Surface
Dry eye is one of the most common eye diseases and it is known to be an ever-increasing public health problem in risky groups. Physical conditions (heat, light, humidity,ventilation), anesthetic gases, chemical-containing…
- Trial name
- NCT04789824
- Testing
- eyelid hygiene
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Saglik Bilimleri Universitesi
Graft-versus-host-disease, Ocular Graft-versus-host Disease
The Effects and Safety of 5% Lifitegrast Ophthalmic Solution in Subjects With Dry Eye Disease in Ocular Graft-versus-Host Disease
The objective of this study is to evaluate the clinical efficacy of 5% lifitegrast ophthalmic solution in subjects with dry eye disease secondary to ocular Graft-versus-Host Disease compared to placebo.
- Trial name
- NCT04792580
- Testing
- Lifitegrast 5% Ophthalmic Solution
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Richard W Yee, MD
Dry Eye Disease
A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease
The purpose of this study is to evaluate the effect of AR-15512 ophthalmic solution 0.003% (0.003% AR-15512) on ocular surface characteristics of subjects with dry eye disease (DED).
- Trial name
- NCT06544694
- Testing
- 0.003% AR-15512 ophthalmic solution, Artificial Tears
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Alcon Research
Sjögren's Syndrome
HRR as a Novel Biomarker in Sjögren's Syndrome
Sjögren's syndrome (SS) is an autoimmune disorder characterized by chronic salivary and lacrimal gland dysfunction leading to dry mouth (xerostomia) and dry eye (xerophthalmia) sensation (1).
- Trial name
- NCT05633524
- Testing
- blood sample analysis
- Where
- China
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Dry Eye Syndromes
Effect of Single Instillation of Three Different Topical Lubricants on Tear Film Thickness in Patients With Dry Eye Syndrome
The prevalence and incidence of dry eye syndrome (DES) is constantly increasing. Several therapeutic strategies have been proposed, but still no ideal regimen has been found.
- Trial name
- NCT03161080
- Testing
- Neovis Total Multi® Eye Drops, Vismed Multi® Eye Drops, Hydrabak® Eye Drops
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Meibomian Gland Dysfunction, Evaporative Dry Eye
Dextenza With ILUX for Treatment of MGD
To evaluate the benefit of treatment with a physician administered intracanalicular dexamethasone insert in evaporative dry eye disease (DED) patients with meibomian gland disfunction (MGD) and underlying inflammation undergoing…
- Trial name
- NCT04658927
- Testing
- Dexamethasone, 0.4mg, Prednisone acetate, Control
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Warrenville Eyecare
Cataract
Analysis of Cataract Surgery Induced Dry Eye
This is a retrospective study to determine if rates of osmolarity and dry eye disease symptoms increase following cataract surgery.
- Trial name
- NCT01471561
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- TearLab Corporation
Dry Eye Disease, Meibomian Gland Dysfunction
Effect of Sunflower Lecithin Supplementation on Meibomian Gland Function in Adults With Dry Eye Disease
This prospective study will evaluate the effect of oral sunflower lecithin dietary supplementation on meibomian gland function in adults with dry eye disease.
- Trial name
- NCT06058559
- Testing
- Sunflower lecithin, Olive oil
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- George Washington University
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