Clinical trials: Dry Eye, completed
Keratoconjunctivitis Sicca
Study of Rebamipide Eye Drops to Treat Dry Eye
The purpose of this study is to determine the potential safety and effectiveness of rebamipide eye drops, an investigational eye drop being developed for the treatment of keratoconjunctivitis sicca (dry eye).
- Trial name
- NCT00201955
- Testing
- Rebamipide 1%, Rebamipide 2%
- Where
- 60 sites in United States
- Volunteers
- 762 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Keratoconus, Dry Eye
Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus
Drug delivery platforms are an innovative exciting advancement in ophthalmology. They allow patients to eliminate topical medications which are generally associated with lack of compliance, difficulty of use and requiring help…
- Conditions
- Keratoconus, Dry Eye, Allergy
- Trial name
- NCT04418999
- Testing
- dexamethasone ophthalmic insert 0.4 mg, for intracanalicular use, Loteprednol Etabonate 0.38% Ophthalmic Gel/Jelly
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Illinois College of Optometry
Dry Eye Disease (DED)
Effectiveness of Systane PRO for Mild to Moderate Dry Eye Disease
The primary objective of this study is to show that consistent use of Systane PRO over a 30 period will significantly improve the signs and symptoms of Dry Eye Disease and decrease patients' ocular surface disease index score for…
- Trial name
- SYSTANEPRO1 (NCT07639034)
- Testing
- Systane Pro Topical Ophthalmic
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Gordon Schanzlin New Vision
Dry Eye Disease
Evaluating the Safety, Tolerability, and Efficacy of GRF312 5% in Participants With Dry Eye Disease (DED).
This is a Phase 2, multi-site, double-masked, randomized, vehicle-controlled, study designed to evaluate the safety, tolerability, and efficacy in adult participants with DED.
- Trial name
- NCT07264517
- Testing
- GRF312 5%
- Where
- 10 sites in United States
- Volunteers
- 103 people
- Sponsor
- Instituto Grifols, S.A.
Keratoconjunctivitis Sicca
A 1-Year Study in Multiple Clinics Testing Rebamipide Eye Drops for Dry Eye Compared With a Placebo
The purpose of this study is to determine the potential safety and effectiveness of rebamipide eye drops, an investigational eye drop being developed for the treatment of keratoconjunctivitis sicca (dry eye).
- Trial name
- NCT00201981
- Testing
- Rebamipide 1%, Rebamipide 2%
- Where
- 63 sites in United States
- Volunteers
- 755 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Dry Eye, Graft-versus-host-disease
Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease
The purpose of this Phase 1/2 study is to compare the safety and tolerability of four times a day (QID) dosing of a non-preserved topical ocular drop formulation of 10 vol/vol % and 30 vol/vol % of FD hPL to vehicle control eye…
- Conditions
- Dry Eye, Graft-versus-host-disease, Ocular Discomfort
- Trial name
- NCT03414645
- Testing
- CAM-101 10%, Vehicle Control, CAM-101 30%
- Where
- 6 sites in United States
- Volunteers
- 64 people
- Sponsor
- Cambium Bio Limited
Visual Fatigue, Dry Eye
Evaluation of New Color Temperature Adjustment Mode in Preventing Dry Eye and Visual Fatigue
The purpose of this study was to investigate the effects of visual fatigue and dry eye level under different correlated color temperature modes, and to evaluate the effect of new designed dynamic color temperature change modes on…
- Trial name
- NCT07201493
- Testing
- color temperature change mode
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Dry Eye
RCI001 Eye Drops 0.25% in Healthy Adult Male Participants
This study is being conducted to evaluate the safety, tolerability, and pharmacokinetics of RCI001 eye drops 0.25% in healthy adult male participants.
- Trial name
- NCT07640867
- Testing
- RCI001 Eye Drops 0.25%
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rudacure
Eye Pain
Pilot Study of TENS for Ocular Pain
Approximately 20% of Veterans have a diagnosis of dry eye (DE) syndrome which is often accompanied by ocular pain that significantly impacts activities of daily living.
- Trial name
- NCT05531643
- Testing
- High frequency forehead TENS, Low frequency forehead TENS
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- VA Office of Research and Development
Dry Eye, Dry Eye Syndromes
Efficacy and Safety Safety of Nutritears® in Adults With Dry Eye Syndrome
This is a prospective, randomized, double-blind, parallel, placebo-controlled, clinical interventional study. The purpose of this study is to evaluate the efficacy and safety of Nutritears®, a dietary supplement of OmniActive…
- Trial name
- NCT05481450
- Testing
- Blink NutriTears
- Where
- 3 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Dry Eye, Meibomian Gland Dysfunction (Disorder)
Meibomian Gland Changes in Ocular Prosthesis Users
This observational cross-sectional study aims to evaluate meibomian gland loss and dry eye symptoms in patients using unilateral ocular prostheses.
- Conditions
- Dry Eye, Meibomian Gland Dysfunction (Disorder), Anophthalmic Socket Syndrome, Ocular Prostheses
- Trial name
- MGPRO (NCT07621952)
- Testing
- Oculus Keratograph 5M
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Dry Eye, MGD-Meibomian Gland Dysfunction
Comparative Effects of USB-Powered Warm Compress and Self-Heating Eye Mask in the Management of Meibomian Gland Dysfunction
Why was this study done? People with Meibomian Gland Dysfunction (MGD) often have dry, irritated eyes because the tiny oil glands in their eyelids do not work properly.
- Trial name
- NCT07618169
- Testing
- USB-Powered Warm Compress, Self-Heating Eye Mask
- Where
- Saudi Arabia
- Volunteers
- 15 people
- Sponsor
- King Saud University
Dry Eye Syndrome (DES)
Impact of Filtration on Autologous Serum Eye Drops
Dry eye disease accounts for nearly 25% of ophthalmology consultations, making it a commonly encountered condition. When conventional treatments fail autologous serum in the form of eye drops, have been proposed as a therapeutic…
- Trial name
- IFILCOSA (NCT07407101)
- Testing
- Serum dosage of TGF-β, IGF-1, EGF, Fibronectin and Vitamin A
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Limoges
Dry Eye Disease, Meibomian Gland Dysfunction
Preoperative iLux on Cataract Surgery Derived Dry Eye Disease Due to Meibomian Gland Dysfunction
This prospective study will investigate the effect of pre-operative Systane iLux system administration in treated cataract induced dry eye disease.
- Conditions
- Dry Eye Disease, Meibomian Gland Dysfunction, Cataract Senile, Dry Eye Syndromes
- Trial name
- NCT06483750
- Testing
- Systane iLux Treatment
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- George Washington University
Dry Eye Disease
Evaluation of Tear Film Quality and Stability in Subjects With Dry Eye Disease Using OC-01 (Varenicline Solution) Nasal Spray 0.03 mg as Compared to Vehicle Control Nasal Spray
A randomized, controlled, double-masked, investigator-initiated trial to evaluate tear film quality and stability in subjects with dry eye disease using OC-01 (varenicline solution) nasal spray 0.03 mg as compared to vehicle…
- Trial name
- TSUNAMI (NCT05514041)
- Testing
- Varenicline solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stephenson Eye Associates
Dry Eye
Electroacupuncture for Mild-to-moderate Dry Eye
To determine if electroacupuncture acts as an dry eye treatment rather than a placebo, and identify if benefits are linked to corneal subbasal nerve changes and neuroimmunomodulatory indicators.
- Trial name
- NCT05552820
- Testing
- Verum Electroacupuncture
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Dry Eye Syndrome
Safety and Efficacy of BRM421 for Dry Eye Syndrome
The objective of this study is to compare the safety and efficacy of BRM421 Ophthalmic Solution to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- NCT03066219
- Testing
- BRM421
- Where
- 2 sites in United States
- Volunteers
- 157 people
- Sponsor
- BRIM Biotechnology Inc.
Dry Eye Syndrome
Safety and Efficacy of BRM421 for Dry Eye Syndrome Treatment
The objective of this study is to compare the safety and efficacy of BRM421 Ophthalmic Solution to placebo for the treatment of the signs and symptoms of dry eye.
- Trial name
- NCT04343287
- Testing
- BRM421
- Where
- 4 sites in United States
- Volunteers
- 220 people
- Sponsor
- BRIM Biotechnology Inc.
Dry Eye
A Study Evaluating HBM9036 Efficacy and Safety on Moderate to Severe Dry Eye
The objective of this study is to compare the safety and efficacy of 0.25% HBM9036 (HL036) Ophthalmic Solution to placebo for the treatment of the Chinese subjects with moderate and severe dry eye.
- Trial name
- NCT04633213
- Testing
- HBM9036 0.25% Ophthalmic Solution
- Where
- China
- Volunteers
- 577 people
- Sponsor
- Harbour BioMed (Guangzhou) Co. Ltd.
Dry Eye Disease (DED)
Observe the Effects of Far Infrared Eye Masks on Acupoints Around the Eyes in Patients With Dry Eye Syndrome
Dry eye disease (DED) is a multifactorial ocular surface condition characterized by instability of the tear film. DED is common in ophthalmic and optometric clinical practice, and meibomian gland dysfunction (MGD) has been…
- Trial name
- NCT07060131
- Testing
- Far Infrared Eye Masks
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- China Medical University Hospital