Clinical trials: Dry Eye, completed
Dry Eye
Evaluation of FID 114657 on Tear Film Lipid Layer Thickness
To evaluate the effects of FID 114657 on the tear film lipid layer thickness of patients with dry eye.
- Trial name
- NCT00848068
- Testing
- FID 114657, OPTIVE Lubricant Eye Drops
- Volunteers
- 40 people
- Sponsor
- Alcon Research
Advanced Dry Macular Degeneration
Alpha MSH in Ocular Disease
The purpose of this study is gain a better understanding of a molecule called alpha melanocyte stimulating hormone (alpha MSH) and its potential role in your retinal disease.
- Trial name
- NCT03451578
- Testing
- Alpha MSH assay
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Dry Eye Disease
Study of Safety and Performance of a Novel Ocular Lubricant in Subjects With Dry Eye Disease
The purpose of this study is to evaluate and demonstrate the efficacy and safety of an investigational ocular lubricant formulation in patients with mild to moderate dry eye disease (DED).
- Trial name
- NCT06444516
- Testing
- FID123300 ocular lubricant
- Where
- 9 sites in United States
- Volunteers
- 188 people
- Sponsor
- Alcon Research
Neovascular Age-related Macular Degeneration
An Extension Study Assessing the Efficacy and Safety of Brolucizumab in a Treat-to-Control Regimen in Patients With Neovascular Age-related Macular Degeneration Who Have Completed the CRTH258A2303 (TALON) Study
The purpose of this extension study was to evaluate the efficacy and safety of brolucizumab used in a Treat-to-Control-regimen for treatment of patients with neovascular age-related macular degeneration who have completed the…
- Trial name
- TALON Ext (NCT04597632)
- Testing
- brolucizumab
- Where
- 60 sites in United States, Australia and 14 more
- Volunteers
- 248 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye
The Effect of Hinge Location on Corneal Sensation and Dry Eye After LASIK: A Systematic Review and Meta-analysis
The purpose of this study is to investigate the possible effect of hinge location on corneal sensation and dry eye syndrome after laser in situ keratomileusis (LASIK).
- Trial name
- NCT01507025
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yifan Feng
Bullous Keratopathy, Corneal Erosion
AONDA Therapeutic Indication Study I
This study will be used to support assessment of AIR OPTIX® NIGHT \& DAY® AQUA (AONDA) Soft Contact Lenses' safety and performance in accordance with updated European Union Medical Device Regulation (EU MDR) requirements.
- Conditions
- Bullous Keratopathy, Corneal Erosion, Entropion, Corneal Edema
- Trial name
- NCT05891106
- Testing
- Lotrafilcon A contact lenses
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- Alcon Research
Dry Eye Syndrome
Evaluation of the Corneal Residence Time of Chitosan-N-acetylcysteine Eye Drops in Patients With Dry Eye Syndrome After Single and Multiple Instillation
In the elderly population, dry eye syndrome is a highly prevalent ocular disease. One mainstay of therapy for patients suffering from dry eye syndrome is the use of topically administered lubricants.
- Trial name
- NCT01753752
- Testing
- Chitosan- N- Acetylcysteine eye drops
- Where
- Austria
- Volunteers
- 32 people
- Sponsor
- Gerhard Garhofer
Sjogren's Syndrome
Umbilical Cord Mesenchymal Stem Cell Secretome in Patients With Sjogren's Syndrome
This randomized, placebo-controlled, double-blind trial evaluated the safety and efficacy of umbilical cord mesenchymal stem cell (UC-MSC) secretome, given as an add-on to standard therapy, in women with Sjogren's syndrome.
- Trial name
- NCT07910526
- Testing
- Umbilical cord mesenchymal stem cell-derived secretome
- Where
- 2 sites in Indonesia
- Volunteers
- 29 people
- Sponsor
- Universitas Sebelas Maret Hospital
Retinitis Pigmentosa, Macula Off
Transcorneal Electrical Stimulation Therapy for Retinal Disease
Transcorneal stimulation may enable neurons to survive degeneration processes via enhanced secretion of neurotrophic substances and direct stimulation of neurons.
- Conditions
- Retinitis Pigmentosa, Macula Off, Primary Open Angle Glaucoma, Hereditary Macular Degeneration
- Trial name
- NCT00804102
- Testing
- Transcorneal Electrical Stimulation, DTL-electrode attached without energy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Okuvision GmbH
Dry Eye Syndromes
Refractive Surgery and Optive Compatibility Study
To assess the compatibility of Optive with refractive surgery (PRK and LASIK) post-operatively.
- Trial name
- NCT00469157
- Testing
- Optive
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Innovative Medical
Dry Eye Syndromes
Treatment Regimens in Meibomian Gland Dysfunction
This study seeks to explore the relevance of inflammation in dry eye patients with MGD and compare the efficacy of LipiFlow treatment followed by lid hygiene and lubricant treatment with Systane Ultra or LipiFlow treatment…
- Trial name
- NCT05594745
- Testing
- Lifitegrast Ophthalmic, Systane Free, Lipiflow
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tauber Eye Center
Dry Eye
Clinical Efficacy of Topical Hydrocortisone 0.335% (Softacort®) in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation
Dry eye disease (DED) is a highly prevalent ocular condition and induces a significant burden to the affected patients. Regardless of the underlying etiology, DED is associated with increased inflammation of the entire ocular…
- Trial name
- NCT03907865
- Testing
- Softacort
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Dry Eye
Comfort Associated With The Use Of Eyelid Cleansing Products Available For The Management Of Demodex Folliculorum
This aim of this study to quantify the subjective ocular awareness of different eyelid cleansing wipes available for the management of Demodex folliculorum.
- Trial name
- SPANIEL (NCT03987230)
- Testing
- Sensitive Eyes® Plus Saline Solution, Oust™ Demodex® Wipes™, I-LID N LASH PLUS® Eyelid Cleanser
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Dry Eye Disease
Safety Study of Tivanisiran to Treat Dry Eye
This study will examine the safety of tivanisiran sodium eye drops versus vehicle when dosed once daily for 1 year in subjects with signs and symptoms of dry eye disease (DED).
- Trial name
- FYDES (NCT05310422)
- Testing
- Tivanisiran sodium ophthalmic solution, Vehicle ophthalmic solution
- Where
- 25 sites in United States
- Volunteers
- 301 people
- Sponsor
- Sylentis, S.A.
Dry Eye Syndromes
TearLab Refractive Surgery Dry Eye Study
The primary objective of this study is to determine how pre \& post-operative tear osmolarity levels relate to rates of dry eye symptoms related to refractive surgery and if differences exist in patients who are pre-treated with…
- Trial name
- NCT01176045
- Where
- 8 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- TearLab Corporation
Dry Eye Disease
Study of Diquafosol Tetrasodium Ophthalmic Solution in Subjects With Dry Eye Disease
The purpose of this trial is to assess the effectiveness and safety of 2% diquafosol tetrasodium ophthalmic solution versus placebo following 6 weeks of treatment in subjects with mild to moderate dry eye disease.
- Trial name
- NCT00403975
- Testing
- diquafosol tetrasodium ophthalmic solution, 2%
- Volunteers
- 640 people
- Sponsor
- Merck Sharp & Dohme LLC
Neovascular Age-related Macular Degeneration (nAMD)
Study to Evaluate the Safety and Effectiveness of Intravitreal Injections (IVI) of Brolucizumab in Patients With Neovascular Age-related Macular Degeneration (nAMD)
The purpose of this study was to generate additional safety and effectiveness data in Indian neovascular age-related macular degeneration (nAMD) patients that more closely resemble the real-world population intended to be treated…
- Trial name
- NCT05269966
- Testing
- Injection Brolucizumab
- Where
- 10 sites in India
- Volunteers
- 105 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye, Dry Eye Syndromes
Intra-Nasal Mechanical Stimulation (INMEST) As a Treatment Method for the Relief of Symptoms of Dry Eye
The purpose of the study is to investigate the degree of symptom relief in people with signs or symptoms of dry eyes after self-treatment at home with the Walther System delivering INMEST (intranasal mechanical stimulation).
- Trial name
- NCT05887336
- Testing
- Walther System, Non preserved ocular lubricants, Eye lid procedure
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 106 people
- Sponsor
- Abilion Medical Systems AB
Age-Related Macular Degeneration
Long Term Follow Up of Sub-retinal Transplantation of hESC Derived RPE Cells in Patients With AMD
The purpose of his study is to evaluate the long term safety and tolerability of MA09-hRPE cellular therapy in patients with advanced dry Age-Related Macular Degeneration (AMD) from one to five years following the surgical…
- Trial name
- NCT02463344
- Testing
- MA09-hRPE
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- Astellas Institute for Regenerative Medicine
Dry Eye
An Exploratory Crossover Clinical Trial to Compare the Activity of Reproxalap and Lifitegrast in a Dry Eye Disease Chamber
An Exploratory, Single-Center, Double-Masked, Crossover Clinical Trial to Assess Safety and Tolerability of 0.25% Reproxalap Ophthalmic Solution Compared to Xiidra® in Subjects with Dry Eye Disease in a Dry Eye Chamber
- Trial name
- NCT05102409
- Testing
- Reproxalap Ophthalmic Solution (0.25%), Xiidra® (5% lifitegrast ophthalmic solution)
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Aldeyra Therapeutics, Inc.
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